Patents Assigned to The Cleveland Clinic Foundation
  • Implantable temporary nerve conduction blocking method and system
    Patent number: 10471257
    Abstract: Systems and methods of reducing pain after surgery in the thoracic or abdominal region and managing chronic nerve pain in the thoracic or abdominal region are provided. Such methods involve an electrode assembly that has a proximal portion and a distal portion with the distal portion including a plurality of electrodes. At least one electrode of the plurality of electrodes is placed over each of a plurality of intercostal nerve bundles in the patient's body. The proximal portion of the electrode assembly is connected to a pulse generator. An electromagnetic field is applied to the plurality of intercostal nerve bundles. The plurality of electrodes is removed from the patient's body after an intercostal nerve block sufficient to alleviate the patient's pain has been achieved.
    Type: Grant
    Filed: May 16, 2017
    Date of Patent: November 12, 2019
    Assignee: THE CLEVELAND CLINIC FOUNDATION
    Inventors: Usman Ahmad, Sudish Murthy, Jonathan Sakai
  • Maxillomandibular fixation devices
    Patent number: 10470806
    Abstract: A maxillomandibular fixation (MMF) device having an arch bar with a plurality of spaced tabs and gaps, and further having apertured mounting plate members mounted onto the arch bar, each mounting plate member having a slot to receive a tab on the arch bar, whereby the mounting plate members may be repositioned laterally along the arch bar from one tab to another prior to affixing the MMF device to the maxilla or mandible of a patient in order to position the mounting plate members at locations where the underlying tooth root will not be damaged by insertion of a bone screw.
    Type: Grant
    Filed: February 7, 2018
    Date of Patent: November 12, 2019
    Assignees: KLS-MARTIN, L.P., THE CLEVELAND CLINIC FOUNDATION
    Inventors: Klaus Kohler, Jennifer Pinto, Thomas S. Johnston, Jr., Francis A. Papay
  • Performance test for evaluation of neurological function
    Patent number: 10470679
    Abstract: This disclosure relates to a system and method to implement a performance test to help evaluate a patient's neurological and cognitive function. The performance test can be executed by the patient autonomously using a portable computing device, such as a tablet computer or smart phone. The portable computing device can be programmed to execute a set of modules configured to assess motor and cognitive performance, such as a manual function test module, a cognitive processing speed test module, and a movement assessment test module. The set of modules can also include a collection module to aggregate test data from the manual function test module, the cognitive processing speed test module, and the movement assessment test module.
    Type: Grant
    Filed: December 10, 2013
    Date of Patent: November 12, 2019
    Assignee: THE CLEVELAND CLINIC FOUNDATION
    Inventors: Jay L. Alberts, Richard A. Rudick, David D. Schindler, Joshua Hirsch, Stephen M. Rao, Francois Bethoux, Susan Linder, Deborah Miller
  • Breast cancer vaccine
    Patent number: 10463724
    Abstract: Compositions and methods for immunization against human breast cancer are disclosed. A breast cancer vaccine comprises an immunogenic polypeptide comprising human ?-lactalbumin.
    Type: Grant
    Filed: September 11, 2015
    Date of Patent: November 5, 2019
    Assignee: The Cleveland Clinic Foundation
    Inventors: Vincent K. Tuohy, Justin M. Johnson, Ritika Jaini
  • Alignment of manipulable sensor assembly
    Patent number: 10456062
    Abstract: A method for aligning a manipulable sensor assembly includes determination of a replica surface, which represents a field of view of a manipulable sensor assembly associated with an object when the object is located in a desired position and oriented at a desired orientation. Electromagnetic radiation and/or sound reflected from a surface of the region of interest is detected to provide a surface map of the region of interest, which is compared to the replica surface to determine a rotation and/or a translation for the manipulable sensor assembly to bring the surface map into alignment with the replica surface. The position and/or the orientation of the object are altered. The detection of reflected electromagnetic radiation or sound, comparison of the surfaces, and alteration of the position and orientation of the object are repeated until the surface map is in alignment with the replica surface.
    Type: Grant
    Filed: January 8, 2014
    Date of Patent: October 29, 2019
    Assignee: THE CLEVELAND CLINIC FOUNDATION
    Inventors: Joseph P. Iannotti, Wael K. Barsoum, Jason A. Bryan, Pete O'Neill
  • Systems and methods for safe, precise stereotactic implantation
    Patent number: 10456212
    Abstract: The present disclosure relates generally to precise stereotactic implantation of an instrument (e.g., a recording electrode, a stimulating electrode, a biopsy instrument, a catheter, a delivery device, and the like) into a target area in a patient's brain. As such, one aspect of the present disclosure can relate to a stereotactic device that can be used to accomplish the precise implantation of the instrument. The stereotactic device can include a body to secure the stereotactic device to the patient's head. In some instances, the body can have a u-shape. The stereotactic device can also include a guide attached between sides of the body to move an instrument holder into place above a target area. The guide can be locked in position to lock the instrument holder in the place to facilitate injection of the instrument into the target area.
    Type: Grant
    Filed: April 29, 2016
    Date of Patent: October 29, 2019
    Assignee: THE CLEVELAND CLINIC FOUNDATION
    Inventors: Jorge A. Gonzalez-Martinez, John Gale, Anthony Shawan
  • Bone void filler preparation system
    Patent number: 10456502
    Abstract: A method of recovering progenitor cells from bone marrow aspirate. A bone void filler preparation container is provided. The bone void filler preparation container has an inlet port and an outlet port. A bone graft matrix having a particle size of between about 1,000 ?m and about 2,000 ?m is placed in the bone void filler preparation container. A bone marrow aspirate is passed through the bone void filler preparation container. Progenitor cells in the bone marrow aspirate are retained in the bone void filler preparation container. A selection ratio of the progenitor cells retained in the bone void filler preparation container to a total number of nucleated cells retained in the bone void filler preparation container is greater than about 3.
    Type: Grant
    Filed: September 7, 2017
    Date of Patent: October 29, 2019
    Assignees: Fortus Medical, Inc., The Cleveland Clinic Foundation
    Inventors: Robert Assell, Andrew Freeman, George Muschler
  • Storing structured and unstructured clinical information for information retrieval
    Patent number: 10445378
    Abstract: A computer-implemented method can include acquiring data from at least one data source, the acquired data including health data for a patient. The acquired data can be transformed into episode model data according to a context-specific data model and the episode model data can be stored in a database. The method also includes generating at least one inverted index document for at least a portion of an episode for the patient based on the episode model data.
    Type: Grant
    Filed: June 14, 2016
    Date of Patent: October 15, 2019
    Assignee: THE CLEVELAND CLINIC FOUNDATION
    Inventor: Madhu Sasidhar
  • SYSTEM AND METHOD FOR DELIVERING FLUID INTERNALLY OF A PATIENT'S BODY
    Publication number: 20190290895
    Abstract: A fluid distribution system for delivering fluid internally of a body comprises a hollow needle and an implantable access port. The needle has a tip with a predetermined shape. The access port includes (a) a housing that includes at least two fluid outlets, (b) a septum received in the housing, and (c) a valve member rotatable in the housing. The valve member includes valve fluid inlet and outlet openings and a valve inlet passage extending from the inlet opening to the outlet opening. The valve inlet passage has a shape complementary to the shape of the needle tip. The valve member is rotatable into (i) a first position in which the valve fluid outlet opening communicates with a first housing fluid outlet and (ii) a second position in which the valve fluid outlet opening communicates with a second housing fluid outlet.
    Type: Application
    Filed: May 5, 2017
    Publication date: September 26, 2019
    Applicant: The Cleveland Clinic Foundation
    Inventor: Michael A. VOGELBAUM
  • IDENTIFYING THE EPILEPTOGENIC ZONE FROM NONSEIZURE RECORDINGS USING NETWORK FRAGILITY THEORY
    Publication number: 20190290185
    Abstract: A method of identifying an epileptogenic zone of a subjects brain includes: receiving a plurality N of physiological brain signals that extend over a duration, each of the plurality N of physiological brain signals acquired from the subjects brain; calculating within a time window a state transition matrix based on at least a portion of each of the plurality N of physiological brain signals, wherein the state transition matrix is a linear time invariant model of a network of N nodes corresponding to the plurality N of physiological brain signals; calculating a minimum norm of a perturbation on the state transition matrix that causes the network to transition from a stable state to an unstable state; and assigning a fragility metric to each of the plurality N of physiological brain signals based on the minimum norm of the perturbation for that physiological brain signal.
    Type: Application
    Filed: November 10, 2017
    Publication date: September 26, 2019
    Applicants: The Johns Hopkins University, The Cleveland Clinic Foundation
    Inventors: Sridevi SARMA, Adam LI, Jorge GONZALEZ-MARTINEZ
  • Nerve stimulation to promote neuroregeneration
    Patent number: 10420939
    Abstract: Temporary or sub-threshold electrical stimulation to promote recovery of a damaged or injured nerve. Methods include promoting neuroregeneration of a nerve iatrogenically injured during a medical procedure performed on a target site of a patient's body. Methods include placing an electrical lead in electrical communication with the injured or damaged nerve. Methods further include temporarily stimulating the nerve and/or applying sub-threshold stimulation to the nerve to promote neuroregeneration of the nerve. The nerve can be a peripheral nerve.
    Type: Grant
    Filed: March 9, 2017
    Date of Patent: September 24, 2019
    Assignee: THE CLEVELAND CLINIC FOUNDATION
    Inventors: Bradley C. Gill, Yaw A. Nyame, Eric A. Klein
  • Apparatus and related method to facilitate testing via a computing device
    Patent number: 10420497
    Abstract: This disclosure relates to a device to mechanically and electrically connect with a touch screen computing device, such as a tablet computer. The device can include a platform that can be moved into and out of physical contact with a surface of a touch screen. During engagement with the surface, the moveable platform electrically interacts with the touch screen (e.g., via capacitive coupling) to enable detection by the touch screen of contact members (e.g., pegs) even in the absence of user contact with the pegs.
    Type: Grant
    Filed: April 18, 2016
    Date of Patent: September 24, 2019
    Assignees: THE CLEVELAND CLINIC FOUNDATION, BIOGEN MA, INC.
    Inventors: Jay L. Alberts, David D. Schindler, Jane Rhodes, Wendy Gabel, Jim Best
  • Pre-loaded multiport delivery device
    Patent number: 10413435
    Abstract: A pre-loaded stent graft delivery device and stent graft, the stent graft delivery device. The stent graft has at least one fenestration or side arm and the fenestration is preloaded with an indwelling guide wire. The indwelling guide wire are configured to receive the access sheaths. A handle assembly at a distal end of the guide wire catheter. The handle includes a multiport manifold with access ports to the auxiliary lumens in the pusher catheter. Upon deployment of the stent graft into the vasculature of a patient, the indwelling guide wire can be used to facilitate catheterization of a side branch or target vessel through the fenestration or be used to stabilize the access sheath during catheterization, advancement of the access sheath into the target vessel and deployment of a covered or uncovered stent therein through the access sheath.
    Type: Grant
    Filed: August 21, 2018
    Date of Patent: September 17, 2019
    Assignees: The Cleveland Clinic Foundation, Cook Medical Technologies LLC
    Inventors: Roy K. Greenberg, Krasnodar Ivancev, David Ernest Hartley, Werner D. Ducke, Erik E. Rasmussen
  • Protection against stress-mediated damage from ionizing radiation
    Patent number: 10406206
    Abstract: The use and screening of modulators of apoptosis is disclosed. The modulators may be, for example, modulator of NF-?B activity. The modulators may be used, for example, in the treatment of NF-?B-mediated diseases, conditions, and injuries.
    Type: Grant
    Filed: January 24, 2017
    Date of Patent: September 10, 2019
    Assignee: The Cleveland Clinic Foundation
    Inventor: Andrei V. Gudkov
  • Corneal stiffening for treating astigmatism
    Patent number: 10398763
    Abstract: Methods are provided for treating astigmatism in an eye of a patient. An axis of greater curvature of the eye is determined. A stiffening process is applied to a cornea of the eye in a pattern defined from the axis of greater curvature of the eye.
    Type: Grant
    Filed: January 28, 2014
    Date of Patent: September 3, 2019
    Assignee: THE CLEVELAND CLINIC FOUNDATION
    Inventors: William J. Dupps, Ibrahim Seven
  • Excising endocap
    Patent number: 10398461
    Abstract: An endoscopic endocap for excising a target portion of a native tissue from a remaining portion of the native tissue during a surgical procedure includes an annular main body. The main body has a proximal end and an oppositely disposed distal end. The distal end includes an extension that protrudes longitudinally beyond a remaining portion of the distal end. An outer surface of the distal end, and an inner surface of the main body, extend longitudinally between the proximal and distal ends. The inner surface defines at least one lumen with an opening terminating at the terminal portion of the distal end. At least one excisor is disposed on the extension with the excisor laterally spaced from the outer surface of the annular main body. The excisor remains stationary with respect to the lumen during use of the excisor to excize the target portion of the native tissue.
    Type: Grant
    Filed: November 7, 2014
    Date of Patent: September 3, 2019
    Assignee: THE CLEVELAND CLINIC FOUNDATION
    Inventors: Amit Bhatt, Yutaka Saito
  • Motion-assisted systems, devices and methods for minimizing obstruction of medical devices
    Patent number: 10391285
    Abstract: Systems, devices and methods for minimizing or preventing catheter or other medical device occlusion. Mechanical motion is applied to the inner and outer walls of the catheter to minimize blood clots or other biological substances from obstructing the catheter and to help maintain catheter patency.
    Type: Grant
    Filed: June 11, 2014
    Date of Patent: August 27, 2019
    Assignee: THE CLEVELAND CLINIC FOUNDATION
    Inventors: Jamshid Karimov, Kiyotaka Fukamachi, Ray Dessoffy
  • Anti-ar agent and radiation therapy for androgen receptor positive cancer
    Patent number: 10391173
    Abstract: Provided herein are compositions, systems, kits, and methods for treating cancer in a subject with androgen receptor positive cancer cells by sensitizing such cancer cells with anti-androgen receptor therapy (e.g., Enzalutamide or anti-androgen antibody), and then treating with radiation therapy.
    Type: Grant
    Filed: April 21, 2017
    Date of Patent: August 27, 2019
    Assignee: THE CLEVELAND CLINIC FOUNDATION
    Inventor: Mohamed Abazeed
  • Flavonoid IL-17A inhibitors
    Patent number: 10385034
    Abstract: The present invention describes compounds according to formula I: and compounds according to formula II: and additional related flavonoid compounds, as well as the use of the compounds in methods for the prevention or treatment of IL-17A-mediated disease in a subject.
    Type: Grant
    Filed: September 8, 2015
    Date of Patent: August 20, 2019
    Assignee: THE CLEVELAND CLINIC FOUNDATION
    Inventors: Xiaoxia Li, Caini Liu, Jun Qin, Liang Zhu, Koichi Fukuda
  • Devices and methods for tissue graft delivery
    Patent number: 10383657
    Abstract: One aspect of the present disclosure relates to a cannula for passing a tissue graft through soft tissue. The cannula can comprise an elongated body including oppositely disposed first and second ends and an axis that extends between the first and second ends. The elongated body can further include a passage extending between the first and second ends. The second end can include a curved portion that terminates at a sharpened, pointed tip configured to pierce and/or cut soft tissue at the surgical repair site. The tip can be axially offset from the axis of the elongated body at an angle that is less than 180°.
    Type: Grant
    Filed: December 1, 2015
    Date of Patent: August 20, 2019
    Assignee: THE CLEVELAND CLINIC FOUNDATION
    Inventors: Kathleen A. Derwin, Joseph P. Iannotti, Ryan A. Milks