Patents Assigned to The Curators of the University of Missouri
-
Patent number: 10294489Abstract: A transgenic soybean plant or parts thereof, resistant to soybean cyst nematodes, transformed to express Glyma18g02570, Glyma18g02580, or Glyma18g02590, or a variant thereof. Also provided is a method of making such a plant. Also provided is an artificial DNA construct encoding Glyma18g02570, Glyma18g02580, or Glyma18g02590, or a variant thereof.Type: GrantFiled: March 18, 2014Date of Patent: May 21, 2019Assignees: BOARD OF TRUSTEES OF SOUTHERN ILLINOIS UNIVERSITY, THE CURATORS OF THE UNIVERSITY OF MISSOURIInventors: Khalid Meksem, Shiming Liu, Pramod Kaitheri Kandoth, Melissa G. Mitchum, David Lightfoot
-
Patent number: 10294252Abstract: The present disclosure provides a new series of compounds exhibiting high fluorescence quantum yields in the solid state. In one embodiment, the compounds include a series of 2,3,4,5-tetraphenylgermoles with the same or different 1,1-substituents. In another embodiment, substituted germafluorenes, germa-fluoresceins/rhodamines, and germapins are described. These germanium heterocycles possess ideal photophysical and thermostability properties, which makes them excellent candidates for chemical or biological sensors, host materials for electroluminescent devices and solar cells, and emissive and for electron-transport layer components in organic light emitting diode devices.Type: GrantFiled: June 11, 2013Date of Patent: May 21, 2019Assignee: The Curators of the University of MissouriInventors: Janet Braddock-Wilking, Teresa Lynn Bandrowsky, James Bryan Carroll, II
-
Patent number: 10295487Abstract: Devices and methods are provided for measuring temperatures and pHs of a sample in situ using NMR spectroscopy, and for sealing one or more ends of a capillary tube after a reference material has been added to the capillary tube, which is used in an in situ NMR temperature measurement device. A method for measuring a pH of a sample in situ using NMR spectroscopy includes providing an in situ NMR pH measurement device. This device includes a sample housing member configured to house a target sample, at least one pH sensor configured to exhibit an NMR spectral change due to a change in pH value of the target sample, and a pH sensor containment member configured to house the at least one pH sensor. The target sample is added to the sample housing member. NMR spectra are obtained to then determine the pH of the target sample.Type: GrantFiled: October 15, 2015Date of Patent: May 21, 2019Assignee: The Curators of the University of MissouriInventors: Ming Huang, Lingyu Chi, Rex E. Gerald, II, Jie Huang, Annalise R. Pfaff, Klaus Woelk
-
Publication number: 20190135838Abstract: The present invention relates to novel boron cluster compounds and their use as sodium channel blockers. The invention also provides methods for making and using the compounds.Type: ApplicationFiled: January 3, 2019Publication date: May 9, 2019Applicant: The Curators of the University of MissouriInventors: George R. Kracke, Yulia Sevryugina, Marion Frederick Hawthorne
-
Publication number: 20190127775Abstract: Disclosed are devices and methods for preparing pre-metabolized compound libraries and for screening compound metabolites in a high throughput format. The devices and methods disclosed herein increase the chemical diversity of a chemical library prior to screening, and thereby enhance the number and value of hits identified in such chemical screening efforts.Type: ApplicationFiled: January 10, 2017Publication date: May 2, 2019Applicant: CURATORS OF THE UNIVERSITY OF MISSOURIInventor: William G. Gutheil
-
Publication number: 20190132957Abstract: A method for producing a metal foil comprising depositing metal onto an oxidizable substrate to form a metal film on the substrate; oxidizing the substrate at an interface between the metal film and the substrate; and removing the metal film from the substrate to yield a metal foil. A method for forming a thin metal film comprising pre-polarizing a single-crystal Si substrate by application of a potential which is negative of a potential at which Si oxidizes, which pre-polarization occurs in the presence of metal ions to form metal growth nucleation sites on the substrate, followed by application of a potential at which both oxidation of Si and electrodeposition of the metal occur to grow the metal film and oxidize the Si to SiOx, which potential is more positive than the potential applied in the pre-polarization step.Type: ApplicationFiled: November 1, 2018Publication date: May 2, 2019Applicant: The Curators of the University of MissouriInventor: Jay A. Switzer
-
Publication number: 20190130077Abstract: Sensors arranged on a chair on which a subject is seated detect a physical characteristic of the subject during administration of a cognitive health assessment. An assessment processor coupled to the sensors executes computer-executable instructions causing the processor to determine a contemporaneous reaction corresponding to each of the questions as a function of the detected physical characteristic. And the subject is assigned a cognitive health assessment score based on the subject's answers and determined reactions.Type: ApplicationFiled: November 1, 2017Publication date: May 2, 2019Applicant: The Curators of the University of MissouriInventors: Debraj De, Sajal K. Das, Mignon Makos
-
Publication number: 20190127361Abstract: Certain compounds of formula I: I and salts including pharmaceutically acceptable salts thereof are disclosed. Also disclosed are pharmaceutical compositions comprising a compound of formula I, processes for preparing compounds of formula I, intermediates useful for preparing compounds of formula I and therapeutic methods using a compound of formula I.Type: ApplicationFiled: June 16, 2017Publication date: May 2, 2019Applicants: Rutgers, The State University of New Jersey, The Curators of the University of MissouriInventors: William J. Welsh, Raymond Birge, Vladyslav Kholodovych, Youyi Peng, Thomas Walter Comollo, Stanley G. Kimani, Kamlendra Singh
-
Publication number: 20190128999Abstract: Microwave and millimeter wave imaging. An antenna array in communication with a signal source comprises a plurality of antennas by which a signal generated by the signal source is transmitted incident to an object located remotely from the antenna array and by which a signal reflected from the object is received by the antenna array. The signals transmitted by the antennas collectively have an effective electric field resembling a plane-wave within a target region in front of the antenna array. A plurality of detectors each connected to one of the antennas is configured to simultaneously receive the reflected signal and provide an output signal representative thereof. An image processor configured to execute an imaging algorithm generates a multi-dimensional profile representative of the object based on the output signals from the detectors.Type: ApplicationFiled: October 25, 2018Publication date: May 2, 2019Applicant: The Curators of the University of MissouriInventors: Matthew J. Horst, Reza Zoughi, Mohammad Tayeb Ghasr
-
Patent number: 10273522Abstract: An improved system and method is provided for detecting viable bacteria in a suspension sample. A sample of a suspension in which bacterial presence is suspected is collected from a source and a portion of the sample transferred to a microfluidic unit. A series of analysis signals at different frequencies are applied to the sample portion. An impedance is measured via a signal analyzer for the sample portion for each of the analysis signals to define an impedance data set. An initial bulk capacitance value is determined for a model circuit based on the impedance dataset. After a predetermined time period, a new bulk capacitance value is determined for on another portion of the sample. The difference between the new bulk capacitance and the initial bulk capacitance value is compared to a threshold value to determine if viable bacterial is present in the sample.Type: GrantFiled: December 6, 2013Date of Patent: April 30, 2019Assignees: The Curators of the University of Missouri, University of Notre Dame de LacInventors: Shramik Sengupta, Sachidevi Puttaswamy, Hsueh-Chia Chang
-
Patent number: 10273527Abstract: The present invention provides a new and improved oligonucleotide detection method based on the nanopore technology with a probe containing a complementary sequence to the target oligonucleotide and a terminal extension at the probe's 3? terminus, 5? terminus, or both termini. The improved nanopore sensor with the probe enables sensitive, selective, and direct detection, differentiation and quantification of target oligonucleotides such as miRNAs. The inventive detection method may also be employed as a non-invasive and cost-effective diagnostic method for cancer detection based on miRNA levels in the patient's blood sample.Type: GrantFiled: July 13, 2016Date of Patent: April 30, 2019Assignee: The Curators of the University of MissouriInventors: Li-Qun Gu, Yong Wang, Kai Tian
-
Patent number: 10274492Abstract: Disclosed herein are example embodiments of a transformative sensor apparatus that is capable of detecting and quantifying the presence of a substance of interest such as a specified bacteria within a sample via changes in impedance exhibited by a detection electrode array. In an example embodiment, sensitivity is improved by including a focusing electrode array in a rampdown channel to focus a concentration of the substance of interest into a detection region. The focusing electrodes include an opposing pair of electrodes in a rampdown orientation. The focusing electrode may also include tilted thin film finger electrodes extending from the rampdown electrodes. In another example embodiment, trapping electrodes are positioned to trap a concentration of the substance of interest onto the detection electrode array.Type: GrantFiled: April 8, 2016Date of Patent: April 30, 2019Assignee: THE CURATORS OF THE UNIVERSITY OF MISSOURIInventors: Mahmoud Almasri, Shibajyoti Ghosh Dastider, Shuping Zhang, Majed El Dweik, Nuh Sadi Yuksek, Ibrahem Jasim, Jiayu Liu
-
Patent number: 10259158Abstract: A freeform extrusion fabrication process for producing three-dimensional ceramic, metal and functionally gradient composite objects, including the steps of filling a plurality of paste sources with a respective plurality of aqueous paste compositions, operationally connecting respective syringes containing respective aqueous paste compositions to a mixing chamber, moving a first aqueous paste composition from a first respective paste source into the mixing chamber, moving a second aqueous paste composition from a second respective paste source into the mixing chamber, mixing the first and second aqueous paste compositions to define a first admixture having a first admixture composition, extruding the first admixture onto a surface to define an extruded layer having a first admixture composition, surrounding the sides of the extruded layer with an oil bath, radiatively drying the extruded layer.Type: GrantFiled: April 15, 2016Date of Patent: April 16, 2019Assignee: The Curators of the University of MissouriInventors: Ming C Leu, Amir Ghazanfari, Wenbin Li, Gregory E. Hilmas, Robert G Landers
-
Publication number: 20190100539Abstract: A polyarylborane comprising a substituted polyhedral borane comprising at least 3 exohedrally bonded aryl groups, wherein the substituted polyhedral borane is homo- or hetero-, and each exohedrally bonded aryl group is independently homo- or hetero-, substituted or unsubstituted, and monocyclic or polycyclic. Also, molecules and materials comprising the polyarylborane, and methods for making the polyarylboranes.Type: ApplicationFiled: March 6, 2017Publication date: April 4, 2019Applicant: THE CURATORS OF THE UNIVERSITY OF MISSOURIInventor: Mark W. Lee, Jr.
-
Patent number: 10246722Abstract: Methods of inhibiting plant parasitic nematodes, methods of obtaining transgenic plants useful for inhibiting such nematodes, and transgenic plants that are resistant to plant parasitic nematodes through inhibition of plant nematode CLAVATA3/ESR (CLE) peptide receptor genes are provided. Methods for expressing genes at plant parasitic nematode feeding sites with plant nematode CLE peptide receptor gene promoters are also provided, along with nematode CLE peptide receptor gene promoters that are useful for expressing genes in nematode feeding sites as well as transgenic plants and nematode resistant transgenic plants comprising the promoters.Type: GrantFiled: July 13, 2012Date of Patent: April 2, 2019Assignees: The Curators of the University of Missouri, Cornell University, The United States of America, as Represented by the Secretary of AgricultureInventors: Melissa G. Mitchum, Amy Replogle, Jianying Wang, Xiaohong Wang, Shiyan Chen, Ping Lang
-
Publication number: 20190092742Abstract: The present invention provides novel compounds and methods for treating, preventing or inhibiting hepatitis B virus (HBV).Type: ApplicationFiled: September 27, 2018Publication date: March 28, 2019Applicants: THE CURATORS OF THE UNIVERSITY OF MISSOURI, Regents of the University of MInnesotaInventors: Stefan G. Sarafianos, Zhengqiang Wang, Andrew D. Huber, Jing Tang
-
Patent number: 10238772Abstract: A tissue scaffold for repair and regeneration of bone hard tissue or muscle, skin, or organ soft tissue, including load-bearing bone tissue, the scaffold comprising a core of biocompatible, biodegradable inorganic glass fibers; and a biocompatible, biodegradable, flexible polymer film surrounding the core and adhered to the core.Type: GrantFiled: March 17, 2014Date of Patent: March 26, 2019Assignee: The Curators of the University of MissouriInventors: Delbert E. Day, Ali Mohammadkhah
-
Patent number: 10240163Abstract: Provided are plants that express, or overexpress, a pPLAIII? protein. Constitutive or seed-specific expression of pPLAIII? protein in Arabidopsis increases seed oil content, the amount of C20 and C22 fatty acids, and the amount of C56, C58, and C60 triacylglycerols, effectively resulting in significantly higher oil yield per plant. Use of pPLAIII? is therefore an effective biotechnological tool to significantly increase plant yield, including oil, and the amount of high value long chain fatty acids in agricultural and horticultural crops, especially oilseed crops.Type: GrantFiled: September 25, 2015Date of Patent: March 26, 2019Assignees: Donald Danforth Plant Science Center, The Curators of the University of MissouriInventors: Xuemin Wang, Maoyin Li
-
Publication number: 20190083954Abstract: Carbon dioxide (CO2) capture materials comprising one or more 3D-printed zeolite monoliths for the capture and or removal of CO2 from air or gases in enclosed compartments, including gases or mixtures of gases having less than about 5% CO2. Methods for preparing 3D-printed zeolite monoliths useful as CO2 capture materials and filters, as well as methods of removing CO2 from a gas or mixture of gases in an enclosed compartment using 3D-printed zeolite monoliths are provided.Type: ApplicationFiled: September 20, 2018Publication date: March 21, 2019Applicant: The Curators of the University of MissouriInventors: Fateme Rezaei, Harshul V. Thakkar
-
Patent number: 10235884Abstract: A system, a method, and a computer program for utilizing a WiFi beacon for low-latency communication with smart computing devices. Embodiments of the invention use beacon-stuffed network announcement broadcast signals to promptly convey urgent safety information to pedestrians and other vulnerable road users and to warn them of approaching vehicles. This information can then be used to generate visual or audible alerts that are presented on a smart computing device of the vulnerable road user. Similarly, beacon-stuffed network announcement broadcast signals transmitted by pedestrians' smart computing devices can be used to warn vehicle operators of pedestrians in their path.Type: GrantFiled: January 23, 2015Date of Patent: March 19, 2019Assignee: The Curators of the University of MissouriInventors: Sejun Song, Baek-young Choi, Kaustubh Dhondge
