Patents Assigned to The Feinstein Institute for Medical Research
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Methods and apparatuses for reducing bleeding via coordinated trigeminal and vagal nerve stimulation
Patent number: 12220579Abstract: Disclosed are apparatuses and methods for reducing or limiting blood loss and reducing bleed time in a subject by combined vagus and trigeminal stimulation. The apparatuses and methods may activate (e.g., electrically) one or more branches of the trigeminal nerve and may concurrently (at overlapping or near-overlapping time) independently activate the vagus nerve. This activation may be invasive or non-invasive.Type: GrantFiled: January 18, 2022Date of Patent: February 11, 2025Assignee: The Feinstein Institutes for Medical ResearchInventor: Kirk R. Manogue -
Patent number: 12172014Abstract: A method of reducing cortical spreading depolarization in an animal having a brain injury includes: affixing to the animal one or more electrodes that are electrically connected to a neurostimulation device; and providing to the animal, by the neurostimulation device, via the one or more electrodes, electrical stimulation of the animal's trigeminal nerve, thereby reducing cortical spreading depolarization in the animal. The method may reduce at least one detrimental effect of cortical spreading depolarization on the injured animal brain.Type: GrantFiled: April 26, 2019Date of Patent: December 24, 2024Assignee: The Feinstein Institutes For Medical ResearchInventors: Chunyan Li, Raj Kumar Narayan
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Patent number: 12146886Abstract: Provided is a method of non-invasively diagnosing endometriosis in a subject comprising maintaining or culturing stromal cells, obtained from a menstrual effluent or discharge sample from the subject. Also provided is a method of non-invasively diagnosing fertility in a subject. Also provided is a kit for non-invasively diagnosing endometriosis in a subject. Also provided is a method of treating endometriosis in a subject. Also provided is a method of preventing the progression or development of endometriosis in a subject.Type: GrantFiled: March 6, 2019Date of Patent: November 19, 2024Assignee: The Feinstein Institutes for Medical ResearchInventors: Christine Metz, Peter K. Gregersen, Laura Warren
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Patent number: 12121493Abstract: A system for assisting with a chest compression treatment being administered to a patient. In one aspect, the system for assisting with chest compression treatment includes at least one sensor configured to measure blood flow data, one or more processors, in communication with the at least one sensor, and an output device configured to provide the output indication to the rescuer. The one or more processors are configured to perform operations including receiving the blood flow data from the at least one sensor, based on the blood flow data, generating arterial blood flow data and venous blood flow data, providing an estimation of chest compression effectiveness based on the arterial blood flow data and the venous blood flow data, the estimation being based on at least one peak comparison of arterial blood flow and venous blood flow, and generating an output indication of the estimation of chest compression effectiveness.Type: GrantFiled: August 14, 2020Date of Patent: October 22, 2024Assignees: THE FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH, ZOLL MEDICAL CORPORATIONInventors: Joshua Lampe, Christopher L. Kaufman, Lance Becker
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Patent number: 12109255Abstract: Compositions and methods are provided comprising choline acetyltransferase (ChAT) and PEGylated ChAT for treating hypertension.Type: GrantFiled: December 11, 2019Date of Patent: October 8, 2024Assignee: THE FEINSTEIN INSTITUTES FOR MEDICAL RESEARCHInventors: Kevin J. Tracey, Sangeeta S. Chavan, Andrew Stiegler, Jian Hua Li
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Patent number: 12109405Abstract: Disclosed are apparatuses and methods for reducing or limiting bleeding (e.g., blood loss and/or bleeding time) in an animal by trigeminal stimulation. The apparatuses and methods may activate one or more branches of the trigeminal nerve. This activation may be invasive or non-invasive.Type: GrantFiled: April 20, 2023Date of Patent: October 8, 2024Assignee: The Feinstein Institutes for Medical ResearchInventors: Jared M. Huston, Jason R. Fritz, Seema G. Amin, Christopher J. Czura, Kevin J. Tracey
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Patent number: 12053442Abstract: The present disclosure relates to compositions, methods of preparation of the compositions, and methods including administration of said compositions for the prevention of neurological damage associated with cerebral ischemia.Type: GrantFiled: November 16, 2021Date of Patent: August 6, 2024Assignee: THE FEINSTEIN INSTITUTES FOR MEDICAL RESEARCHInventors: Lance Becker, Rishabh Charan Choudhary
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Patent number: 12037419Abstract: Fusion proteins of C1q peptides and HMBG1 A-box or HMBG1 B-box, or C1q peptides and DWESY peptide are provided, and methods of use thereof.Type: GrantFiled: October 12, 2021Date of Patent: July 16, 2024Assignee: The Feinstein Institutes for Medical ResearchInventor: Betty A. Diamond
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Publication number: 20240197828Abstract: Milk fat globule-epidermal growth factor—factor VIII (MFG-E8) derived oligopeptides and pharmaceutical compositions containing the oligopeptides are provided for treating sepsis and inflammatory conditions.Type: ApplicationFiled: December 13, 2023Publication date: June 20, 2024Applicant: THE FEINSTEIN INSTITUTES FOR MEDICAL RESEARCHInventors: Ping Wang, Colleen Nofi, Monowar Aziz, Max Brenner
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Publication number: 20240199561Abstract: Provided is a compound, including a compound of Formula I: or a pharmaceutically acceptable salt thereof, wherein W is a direct bond or an optionally substituted C, and if W is a direct bond, then X1, X2, X3, and X4 are each independently H, OH, or an electrophile, and optionally one pair selected from X1 and X2, X2 and X3, and X3 and X4 forms a five-membered ring including one or more heteroatom, wherein the one or more heteroatom is selected from O, N, and S, and the five-membered ring is optionally substituted with a ?C, an ?S, or an electrophile, and Y1, Y2, Y3, Y4 and Y5 are each independently selected from H, CH3, OH, O—CH3, and NO2, and an electrophile, and optionally Y2 and Y3 form a five-membered ring including one or more heteroatom, wherein the one or more heteroatom is selected from O, N, and S, and the five-membered ring is optionally substituted with a ?C, ?S, or an electrophile.Type: ApplicationFiled: January 19, 2022Publication date: June 20, 2024Applicants: COLD SPRING HARBOR LABORATORY, VICHEM CHEMIE RESEARCH, LTD., THE FEINSTEIN INSTITUTES FOR MEDICAL RESEARCHInventors: Nicholas TONKS, Carla-Maria GAUSS, Prabhadevi VENKATARAMANI, Leemor JOSHUA-TOR, Elad ELKAYAM, Yousef Al ABED, Kai Fan CHENG, Ahmad ALTITI, Laszlo ORFI, Istvan SZABADKAI, Balint SZOKOL, Zoltan HORVATH
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Patent number: 11938324Abstract: A system and method for determining parameters of stimulation electrical signals for vagus nerve stimulation is discussed. Initial parameters of the signals are selected to provide reliable response to stimulation in physiological measurements of a subject. One or more physiological and neurological indices are determined based on a vagus nerve response model. For a selected vagus nerve activation, the electrical parameters of the signals are varied while monitoring changes in physiological parameters and values of the indices. The electrical parameters are varied until desired response in the physiological measurements and the values of the indices is observed. The electrical parameters are then stored as preferred parameters and can be used to activate the selected vagus nerve of the subject.Type: GrantFiled: May 20, 2021Date of Patent: March 26, 2024Assignee: The Feinstein Institutes for Medical ResearchInventors: Stavros Zanos, Yao-Chuan Chang
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Patent number: 11903626Abstract: A fastener includes an elongate fastener body defining a longitudinal axis substantially central thereto. The fastener body has a continuous outer fastener shell laterally surrounding the longitudinal axis. The fastener shell longitudinally separates a fastener head end and a fastener tip end. A tool-engaging feature is provided on the fastener head end. A plurality of teeth are located on the fastener shell and extend substantially laterally outward from the longitudinally axis. The fastener shell is comprised of at least one undulate face and at least one substantially flat face. The plurality of teeth are located only on the undulate faces. Each tooth is longitudinally separated from adjacent teeth along an undulate face. A method of installing the fastener into a receiving structure is also described.Type: GrantFiled: May 4, 2021Date of Patent: February 20, 2024Assignees: THE GENERAL HOSPITAL CORPORATION, THE FEINSTEIN INSTITUTES FOR MEDICAL RESEARCHInventors: Stanley E. Asnis, Peter D. Asnis
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Patent number: 11883461Abstract: The present invention is related to the use of HMGB1 antagonists such as K883 in the treatment and/or prevention and/or inhibition of severe sepsis in mammals, e.g., humans, and pharmaceutical compositions for the same comprising HMGB1 antagonists in an effective amount to treat and/or prevent and/or inhibit this condition.Type: GrantFiled: August 30, 2022Date of Patent: January 30, 2024Assignee: THE FEINSTEIN INSTITUTES FOR MEDICAL RESEARCHInventor: Yousef Al-Abed
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Patent number: 11880888Abstract: A method performed by a first microservice processor includes receiving a first user indication from a first computing device from a plurality of computing devices of a second user that indicates that a first user requested a service of the second user. A first user-specific data container object is generated that includes first user-specific data elements associated with the service provided to the first user. First user-specific service-necessity information data objects are obtained from electronic resources. The first user-specific data elements and the first user-specific service-necessity information data objects are inputted into a machine learning engine to obtain ranked reference-claim data objects. A chosen reference-claim data object from the ranked reference-claim data objects is chosen by the second user to justify providing the service to the first user.Type: GrantFiled: December 8, 2022Date of Patent: January 23, 2024Assignee: THE FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH, INC.Inventors: Howard B. Gold, Konstanine Costalas, John Charles Cheeseborough, Lawrence David Robertson
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Patent number: 11872021Abstract: Methods and systems are described for detecting the likelihood of patent ductus arteriosus (PDA) in an infant using electrocardiogram and photoplethysmographic pulse signals obtained from the upper body and foot of the infant.Type: GrantFiled: September 28, 2022Date of Patent: January 16, 2024Assignees: The Feinstein Institutes for Medical Research, Jerusalem College of TechnologyInventors: Robert Koppel, Meir Nitzan
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Patent number: 11872371Abstract: The present disclosure relates to systems, methods and devices to monitor, diagnose and/or treat diseases or disorders comprising a calibration phase and a real-time diagnostic, treatment or monitoring phase, the calibration phase correlating a plurality of nerve activity measurements from a chronically implanted electrode in a subject with a plurality of concurrent measurements of levels of cytokines and/or glucose in the blood to obtain a functional relationship between blood cytokine and/or glucose levels and vagus nerve activity, and the diagnostic, treatment or monitoring phase analyzing the subject's real-time vagus nerve activity in accordance with the previously obtained functional relationship to initiate a treatment method.Type: GrantFiled: April 19, 2018Date of Patent: January 16, 2024Assignee: THE FEINSTEIN INSTITUTES FOR MEDICAL RESEARCHInventors: Theodoros Zanos, Todd Levy, Emily Battinelli, Kevin J. Tracey, Chad E. Bouton, Sangeeta Chavan, Harold Silverman
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Methods and apparatuses for reducing bleeding via coordinated trigeminal and vagal nerve stimulation
Patent number: 11857788Abstract: Disclosed are apparatuses and methods for reducing or limiting blood loss and reducing bleed time in a subject by combined vagus and trigeminal stimulation. The apparatuses and methods may activate (e.g., electrically) one or more branches of the trigeminal nerve and may concurrently (at overlapping or near-overlapping time) independently activate the vagus nerve. This activation may be invasive or non-invasive.Type: GrantFiled: January 4, 2023Date of Patent: January 2, 2024Assignee: The Feinstein Institutes for Medical ResearchInventor: Kirk R. Manogue -
Patent number: 11794013Abstract: Methods for electrical modulation of inflammation or serum TNF levels in a subject.Type: GrantFiled: February 24, 2021Date of Patent: October 24, 2023Assignee: The Feinstein Institutes for Medical ResearchInventors: Adam M. Kressel, Valentin A. Pavlov, Sangeeta S. Chavan, Kevin J. Tracey
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Patent number: 11771895Abstract: Disclosed are nerve stimulation assemblies adapted to apply stimulation signals to a person's nervous system. The assemblies are adapted to apply such signals to nerves terminating on the outer ear of a person, for example, the auricular branch of the vagus nerve. The assemblies comprise an ear canal extension adapted to fit within an ear canal of the person, a housing connected with the extension, and an electrode arm connected with the housing by a connection member. The connection member is adapted to articulate the electrode arm to position the electrode arm relative to the outer ear. An electrode is connected with a distal end of the arm. When the arm is articulated to a selected orientation and the extension is fitted in the ear canal, the electrode is in electrical contact with a portion of the outer ear innervated by a selected peripheral nerve, such as the vagus nerve.Type: GrantFiled: August 5, 2021Date of Patent: October 3, 2023Assignee: The Feinstein Institutes for Medical ResearchInventor: Chad Edward Bouton
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Patent number: D1038384Type: GrantFiled: December 2, 2022Date of Patent: August 6, 2024Assignees: University of South Florida, The Feinstein Institutes for Medical ResearchInventors: Summer J. Decker, Jonathan Ford, Todd Hazelton, Todd Goldstein, Kami Kim, Michael Teng, John Sinnott