Patents Assigned to The Feinstein Institute for Medical Research
  • Patent number: 10933240
    Abstract: Methods for electrical modulation of inflammation or serum TNF levels in a subject.
    Type: Grant
    Filed: February 11, 2019
    Date of Patent: March 2, 2021
    Assignee: The Feinstein Institutes for Medical Research
    Inventors: Adam M. Kressel, Valentin A. Pavlov, Sangeeta S. Chavan, Kevin J. Tracey
  • Patent number: 10926086
    Abstract: Methods are disclosed for preventing systemic infection or controlling metastases or providing a vaccine adjuvant in a subject, the methods comprising stimulating one or more peripheral nerves innervating one or more lymph nodes of the subject.
    Type: Grant
    Filed: February 8, 2017
    Date of Patent: February 23, 2021
    Assignee: The Feinstein Institutes for Medical Research
    Inventors: Sangeeta S. Chavan, William M. Hanes, Kevin J. Tracey
  • Patent number: 10919882
    Abstract: Synthesis of O-benzotriazole and O-imidazole synthons are described. Uses of synthons in synthesis of azapeptides and other peptidomimetics, azapeptides and other peptidomimetics synthesized from the synthons and uses of azapeptides and other peptidomimetics are also described.
    Type: Grant
    Filed: May 8, 2020
    Date of Patent: February 16, 2021
    Assignee: THE FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH
    Inventors: Yousef Al-Abed, Kai Fan Cheng
  • Patent number: 10912712
    Abstract: Devices, systems and methods for stimulating (e.g., noninvasively) a subject's inflammatory reflex are provided to reduce bleed time. The method may include the step of non-invasively stimulating the inflammatory reflex (e.g., the vagus nerve, the splenic nerve, the hepatic nerve, the facial nerve, and the trigeminal nerve) of a subject, such as by mechanical stimulation, in a manner which significantly reduces bleed time in the subject. Devices for non-invasively stimulating the inflammatory reflex may include a movable tip or actuator that is controlled to mechanically stimulate the ear. The devices may be hand-held or wearable, and may stimulate the cymba conchae region of the subject's ear.
    Type: Grant
    Filed: September 26, 2017
    Date of Patent: February 9, 2021
    Assignee: The Feinstein Institutes for Medical Research
    Inventors: Kevin J. Tracey, Howland Shaw Warren, Michael Allen Faltys, Carol Ann Amella, Christopher Czura, Jared M. Huston
  • Publication number: 20210000908
    Abstract: The present invention is related to the use of HMGB1 antagonists such as K883 in the treatment and/or prevention and/or inhibition of severe sepsis in mammals, e.g., humans, and pharmaceutical compositions for the same comprising HMGB1 antagonists in an effective amount to treat and/or prevent and/or inhibit this condition.
    Type: Application
    Filed: May 8, 2020
    Publication date: January 7, 2021
    Applicant: THE FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH
    Inventor: Yousef Al-Abed
  • Patent number: 10857197
    Abstract: Methods of treating HMGB1-mediated inflammation by administering a therapeutically effective amount of an MD2-antagonist to a subject in need thereof are described. The novel MD2 antagonist tetrapeptide P5779 is also described.
    Type: Grant
    Filed: December 14, 2015
    Date of Patent: December 8, 2020
    Assignee: THE FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH
    Inventors: Kevin J. Tracey, Huan Yang, Yousef Al-Abed
  • Publication number: 20200353037
    Abstract: The present invention is related to the use of HMGB1 antagonists, specifically derivatives of K883 in the treatment and/or prevention and/or inhibition of neuropathy pain, and in particular diabetic neuropathy in mammals, e.g., humans, and pharmaceutical compositions for the same comprising HMGB1 antagonists in an effective amount to treat and/or prevent and/or inhibit this condition.
    Type: Application
    Filed: May 8, 2020
    Publication date: November 12, 2020
    Applicant: THE FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH
    Inventors: Yousef Al-Abed, Huan Yang
  • Publication number: 20200352887
    Abstract: The present invention is related to HMGB1 antagonists and, in particular, HMGB1 tetramer peptidomimetics which have been stabilized with at least one azatide linkage, such as K883. The present invention is also related to pharmaceutical compositions comprising HMGB1 antagonists such as K883.
    Type: Application
    Filed: May 8, 2020
    Publication date: November 12, 2020
    Applicant: THE FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH
    Inventors: Yousef Al-Abed, Huan Yang
  • Publication number: 20200354318
    Abstract: Thioesters, thiocarbamates, thiocarbazates, semithiocarbazates, peptides, aza-amino acid conjugates, and azapeptides; and a chemoselective and site-specific functionalization protocol of protected thiocarbazates and semithiocarbazates are described. The protocol features the use of Mitsunobu reaction to alkylate specifically the nitrogen atom close to the acylthiol moiety with alcohols to produce protected mono-substituted thiocarbazates that can be stored for months, activated under mild conditions at low temperature using halonium reagents and integrated orthogonally to make substituted semicarbazides that can be used, e.g., as synthons in synthesis of aza-amino acid conjugates, azapeptides and other peptidomimetics.
    Type: Application
    Filed: May 8, 2020
    Publication date: November 12, 2020
    Applicant: THE FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH
    Inventors: Yousef Al-Abed, Ahmad Altiti
  • Publication number: 20200354418
    Abstract: The present invention is related to the use of HMGB1 antagonists in the treatment and/or prevention and/or inhibition of acute lung injury in mammals, e.g., humans, and pharmaceutical compositions for the same comprising HMGB1 antagonists, in particular K883, in an effective amount to treat and/or prevent and/or inhibit this condition.
    Type: Application
    Filed: May 8, 2020
    Publication date: November 12, 2020
    Applicant: THE FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH
    Inventor: Yousef Al-Abed
  • Publication number: 20200354404
    Abstract: Compounds for use in synthesis of peptidomimetic agents; synthesis of peptidomimetic agents; peptidomimetic diagnostic and therapeutic agents; and uses of the compounds and peptidomimetic agents in drug discovery, diagnosis, prevention and treatment of diseases are described.
    Type: Application
    Filed: May 8, 2020
    Publication date: November 12, 2020
    Applicant: THE FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH
    Inventor: Yousef Al-Abed
  • Publication number: 20200354344
    Abstract: Synthesis of O-benzotriazole and O-imidazole synthons are described. Uses of synthons in synthesis of azapeptides and other peptidomimetics, azapeptides and other peptidomimetics synthesized from the synthons and uses of azapeptides and other peptidomimetics are also described.
    Type: Application
    Filed: May 8, 2020
    Publication date: November 12, 2020
    Applicant: THE FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH
    Inventors: Yousef Al-Abed, Kai Fan Cheng
  • Publication number: 20200319190
    Abstract: Methods are disclosed for treating ovarian tumors and ovarian and pancreatic cancers using computed and normalized relative ratios of plasma levels of phospholipids, particularly lysophosphatidylcholine, lysophosphatidylethanolamine, phosphatidylcholine, phosphatidylethanolamine and sphingomyelin.
    Type: Application
    Filed: April 7, 2020
    Publication date: October 8, 2020
    Applicant: The Feinstein Institutes for Medical Research
    Inventor: Junhwan Kim
  • Publication number: 20200237241
    Abstract: Methods and systems are described for detecting the likelihood of patent ductus arteriosus (PDA) in an infant using electrocardiogram and photoplethysmographic pulse signals obtained from the upper body and foot of the infant.
    Type: Application
    Filed: April 14, 2020
    Publication date: July 30, 2020
    Applicants: The Feinstein Institutes For Medical Research, Jerusalem College of Technology
    Inventors: Robert Koppel, Meir Nitzan
  • Publication number: 20200179600
    Abstract: The present disclosure relates to systems, methods and devices to monitor, diagnose and/or treat diseases or disorders comprising a calibration phase and a real-time diagnostic, treatment or monitoring phase, the calibration phase correlating a plurality of nerve activity measurements from a chronically implanted electrode in a subject with a plurality of concurrent measurements of levels of cytokines and/or glucose in the blood to obtain a functional relationship between blood cytokine and/or glucose levels and vagus nerve activity, and the diagnostic, treatment or monitoring phase analyzing the subject's real-time vagus nerve activity in accordance with the previously obtained functional relationship to initiate a treatment method.
    Type: Application
    Filed: April 19, 2018
    Publication date: June 11, 2020
    Applicant: THE FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH
    Inventors: Theodoros Zanos, Todd Levy, Emily Battinelli, Kevin J. Tracey, Chad E. Bouton, Sangeeta Chavan, Harold Silverman
  • Patent number: 10667928
    Abstract: A prosthesis including a socket configured to receive a residual limb, a pylon attached to the socket, the pylon comprising at least one fin, and an artificial foot attached to an end portion of the pylon.
    Type: Grant
    Filed: May 2, 2018
    Date of Patent: June 2, 2020
    Assignee: THE FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH
    Inventor: Todd Goldstein
  • Patent number: 10654919
    Abstract: Methods of diagnosis and methods of treatment and prevention for autism spectrum disorder are provided using decoy antigens to maternal brain-reactive antibodies.
    Type: Grant
    Filed: September 30, 2016
    Date of Patent: May 19, 2020
    Assignee: The Feinstein Institutes for Medical Research
    Inventors: Betty A. Diamond, Simone Mader, Lior Brimberg, Peter Gregersen
  • Patent number: 10653326
    Abstract: Methods and systems are described for detecting the likelihood of patent ductus arteriosus (PDA) in an infant using electrocardiogram and photoplethysmographic pulse signals obtained from the upper body and foot of the infant.
    Type: Grant
    Filed: August 27, 2015
    Date of Patent: May 19, 2020
    Assignees: The Feinstein Institutes for Medical Research, Jerusalem College of Technology
    Inventors: Robert Koppel, Meir Nitzan
  • Publication number: 20200101293
    Abstract: Methods are disclosed for treating a subject having a disease or disorder comprising stimulating a nerve of the subject with a corrective stimulus pattern derived from a disease-specific, condition-specific, endogenous mediator-specific or pharmacologic agent-specific neurogram in an amount and manner effective to treat the disease or disorder.
    Type: Application
    Filed: November 26, 2019
    Publication date: April 2, 2020
    Applicant: THE FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH
    Inventors: Kevin J. Tracey, Sangeeta S. Chavan
  • Patent number: 10561846
    Abstract: A method of inhibiting the release of a proinflammatory cytokine in a cell is disclosed. The method comprises treating the cell with a cholinergic agonist. The method is useful in patients at risk for, or suffering from, a condition mediated by an inflammatory cytokine cascade, for example endotoxic shock. The cholinergic agonist treatment can be effected by stimulation of an efferent vagus nerve fiber, or the entire vagus nerve.
    Type: Grant
    Filed: December 23, 2018
    Date of Patent: February 18, 2020
    Assignee: The Feinstein Institutes for Medical Research
    Inventors: Kevin J. Tracey, Jared M. Huston