Patents Assigned to The Feinstein Institute for Medical Research
  • Patent number: 12220579
    Abstract: Disclosed are apparatuses and methods for reducing or limiting blood loss and reducing bleed time in a subject by combined vagus and trigeminal stimulation. The apparatuses and methods may activate (e.g., electrically) one or more branches of the trigeminal nerve and may concurrently (at overlapping or near-overlapping time) independently activate the vagus nerve. This activation may be invasive or non-invasive.
    Type: Grant
    Filed: January 18, 2022
    Date of Patent: February 11, 2025
    Assignee: The Feinstein Institutes for Medical Research
    Inventor: Kirk R. Manogue
  • Patent number: 12172014
    Abstract: A method of reducing cortical spreading depolarization in an animal having a brain injury includes: affixing to the animal one or more electrodes that are electrically connected to a neurostimulation device; and providing to the animal, by the neurostimulation device, via the one or more electrodes, electrical stimulation of the animal's trigeminal nerve, thereby reducing cortical spreading depolarization in the animal. The method may reduce at least one detrimental effect of cortical spreading depolarization on the injured animal brain.
    Type: Grant
    Filed: April 26, 2019
    Date of Patent: December 24, 2024
    Assignee: The Feinstein Institutes For Medical Research
    Inventors: Chunyan Li, Raj Kumar Narayan
  • Patent number: 12146886
    Abstract: Provided is a method of non-invasively diagnosing endometriosis in a subject comprising maintaining or culturing stromal cells, obtained from a menstrual effluent or discharge sample from the subject. Also provided is a method of non-invasively diagnosing fertility in a subject. Also provided is a kit for non-invasively diagnosing endometriosis in a subject. Also provided is a method of treating endometriosis in a subject. Also provided is a method of preventing the progression or development of endometriosis in a subject.
    Type: Grant
    Filed: March 6, 2019
    Date of Patent: November 19, 2024
    Assignee: The Feinstein Institutes for Medical Research
    Inventors: Christine Metz, Peter K. Gregersen, Laura Warren
  • Patent number: 12121493
    Abstract: A system for assisting with a chest compression treatment being administered to a patient. In one aspect, the system for assisting with chest compression treatment includes at least one sensor configured to measure blood flow data, one or more processors, in communication with the at least one sensor, and an output device configured to provide the output indication to the rescuer. The one or more processors are configured to perform operations including receiving the blood flow data from the at least one sensor, based on the blood flow data, generating arterial blood flow data and venous blood flow data, providing an estimation of chest compression effectiveness based on the arterial blood flow data and the venous blood flow data, the estimation being based on at least one peak comparison of arterial blood flow and venous blood flow, and generating an output indication of the estimation of chest compression effectiveness.
    Type: Grant
    Filed: August 14, 2020
    Date of Patent: October 22, 2024
    Assignees: THE FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH, ZOLL MEDICAL CORPORATION
    Inventors: Joshua Lampe, Christopher L. Kaufman, Lance Becker
  • Patent number: 12109255
    Abstract: Compositions and methods are provided comprising choline acetyltransferase (ChAT) and PEGylated ChAT for treating hypertension.
    Type: Grant
    Filed: December 11, 2019
    Date of Patent: October 8, 2024
    Assignee: THE FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH
    Inventors: Kevin J. Tracey, Sangeeta S. Chavan, Andrew Stiegler, Jian Hua Li
  • Patent number: 12109405
    Abstract: Disclosed are apparatuses and methods for reducing or limiting bleeding (e.g., blood loss and/or bleeding time) in an animal by trigeminal stimulation. The apparatuses and methods may activate one or more branches of the trigeminal nerve. This activation may be invasive or non-invasive.
    Type: Grant
    Filed: April 20, 2023
    Date of Patent: October 8, 2024
    Assignee: The Feinstein Institutes for Medical Research
    Inventors: Jared M. Huston, Jason R. Fritz, Seema G. Amin, Christopher J. Czura, Kevin J. Tracey
  • Patent number: 12053442
    Abstract: The present disclosure relates to compositions, methods of preparation of the compositions, and methods including administration of said compositions for the prevention of neurological damage associated with cerebral ischemia.
    Type: Grant
    Filed: November 16, 2021
    Date of Patent: August 6, 2024
    Assignee: THE FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH
    Inventors: Lance Becker, Rishabh Charan Choudhary
  • Patent number: 12037419
    Abstract: Fusion proteins of C1q peptides and HMBG1 A-box or HMBG1 B-box, or C1q peptides and DWESY peptide are provided, and methods of use thereof.
    Type: Grant
    Filed: October 12, 2021
    Date of Patent: July 16, 2024
    Assignee: The Feinstein Institutes for Medical Research
    Inventor: Betty A. Diamond
  • Publication number: 20240197828
    Abstract: Milk fat globule-epidermal growth factor—factor VIII (MFG-E8) derived oligopeptides and pharmaceutical compositions containing the oligopeptides are provided for treating sepsis and inflammatory conditions.
    Type: Application
    Filed: December 13, 2023
    Publication date: June 20, 2024
    Applicant: THE FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH
    Inventors: Ping Wang, Colleen Nofi, Monowar Aziz, Max Brenner
  • Publication number: 20240199561
    Abstract: Provided is a compound, including a compound of Formula I: or a pharmaceutically acceptable salt thereof, wherein W is a direct bond or an optionally substituted C, and if W is a direct bond, then X1, X2, X3, and X4 are each independently H, OH, or an electrophile, and optionally one pair selected from X1 and X2, X2 and X3, and X3 and X4 forms a five-membered ring including one or more heteroatom, wherein the one or more heteroatom is selected from O, N, and S, and the five-membered ring is optionally substituted with a ?C, an ?S, or an electrophile, and Y1, Y2, Y3, Y4 and Y5 are each independently selected from H, CH3, OH, O—CH3, and NO2, and an electrophile, and optionally Y2 and Y3 form a five-membered ring including one or more heteroatom, wherein the one or more heteroatom is selected from O, N, and S, and the five-membered ring is optionally substituted with a ?C, ?S, or an electrophile.
    Type: Application
    Filed: January 19, 2022
    Publication date: June 20, 2024
    Applicants: COLD SPRING HARBOR LABORATORY, VICHEM CHEMIE RESEARCH, LTD., THE FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH
    Inventors: Nicholas TONKS, Carla-Maria GAUSS, Prabhadevi VENKATARAMANI, Leemor JOSHUA-TOR, Elad ELKAYAM, Yousef Al ABED, Kai Fan CHENG, Ahmad ALTITI, Laszlo ORFI, Istvan SZABADKAI, Balint SZOKOL, Zoltan HORVATH
  • Patent number: 11938324
    Abstract: A system and method for determining parameters of stimulation electrical signals for vagus nerve stimulation is discussed. Initial parameters of the signals are selected to provide reliable response to stimulation in physiological measurements of a subject. One or more physiological and neurological indices are determined based on a vagus nerve response model. For a selected vagus nerve activation, the electrical parameters of the signals are varied while monitoring changes in physiological parameters and values of the indices. The electrical parameters are varied until desired response in the physiological measurements and the values of the indices is observed. The electrical parameters are then stored as preferred parameters and can be used to activate the selected vagus nerve of the subject.
    Type: Grant
    Filed: May 20, 2021
    Date of Patent: March 26, 2024
    Assignee: The Feinstein Institutes for Medical Research
    Inventors: Stavros Zanos, Yao-Chuan Chang
  • Patent number: 11903626
    Abstract: A fastener includes an elongate fastener body defining a longitudinal axis substantially central thereto. The fastener body has a continuous outer fastener shell laterally surrounding the longitudinal axis. The fastener shell longitudinally separates a fastener head end and a fastener tip end. A tool-engaging feature is provided on the fastener head end. A plurality of teeth are located on the fastener shell and extend substantially laterally outward from the longitudinally axis. The fastener shell is comprised of at least one undulate face and at least one substantially flat face. The plurality of teeth are located only on the undulate faces. Each tooth is longitudinally separated from adjacent teeth along an undulate face. A method of installing the fastener into a receiving structure is also described.
    Type: Grant
    Filed: May 4, 2021
    Date of Patent: February 20, 2024
    Assignees: THE GENERAL HOSPITAL CORPORATION, THE FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH
    Inventors: Stanley E. Asnis, Peter D. Asnis
  • Patent number: 11883461
    Abstract: The present invention is related to the use of HMGB1 antagonists such as K883 in the treatment and/or prevention and/or inhibition of severe sepsis in mammals, e.g., humans, and pharmaceutical compositions for the same comprising HMGB1 antagonists in an effective amount to treat and/or prevent and/or inhibit this condition.
    Type: Grant
    Filed: August 30, 2022
    Date of Patent: January 30, 2024
    Assignee: THE FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH
    Inventor: Yousef Al-Abed
  • Patent number: 11880888
    Abstract: A method performed by a first microservice processor includes receiving a first user indication from a first computing device from a plurality of computing devices of a second user that indicates that a first user requested a service of the second user. A first user-specific data container object is generated that includes first user-specific data elements associated with the service provided to the first user. First user-specific service-necessity information data objects are obtained from electronic resources. The first user-specific data elements and the first user-specific service-necessity information data objects are inputted into a machine learning engine to obtain ranked reference-claim data objects. A chosen reference-claim data object from the ranked reference-claim data objects is chosen by the second user to justify providing the service to the first user.
    Type: Grant
    Filed: December 8, 2022
    Date of Patent: January 23, 2024
    Assignee: THE FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH, INC.
    Inventors: Howard B. Gold, Konstanine Costalas, John Charles Cheeseborough, Lawrence David Robertson
  • Patent number: 11872021
    Abstract: Methods and systems are described for detecting the likelihood of patent ductus arteriosus (PDA) in an infant using electrocardiogram and photoplethysmographic pulse signals obtained from the upper body and foot of the infant.
    Type: Grant
    Filed: September 28, 2022
    Date of Patent: January 16, 2024
    Assignees: The Feinstein Institutes for Medical Research, Jerusalem College of Technology
    Inventors: Robert Koppel, Meir Nitzan
  • Patent number: 11872371
    Abstract: The present disclosure relates to systems, methods and devices to monitor, diagnose and/or treat diseases or disorders comprising a calibration phase and a real-time diagnostic, treatment or monitoring phase, the calibration phase correlating a plurality of nerve activity measurements from a chronically implanted electrode in a subject with a plurality of concurrent measurements of levels of cytokines and/or glucose in the blood to obtain a functional relationship between blood cytokine and/or glucose levels and vagus nerve activity, and the diagnostic, treatment or monitoring phase analyzing the subject's real-time vagus nerve activity in accordance with the previously obtained functional relationship to initiate a treatment method.
    Type: Grant
    Filed: April 19, 2018
    Date of Patent: January 16, 2024
    Assignee: THE FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH
    Inventors: Theodoros Zanos, Todd Levy, Emily Battinelli, Kevin J. Tracey, Chad E. Bouton, Sangeeta Chavan, Harold Silverman
  • Patent number: 11857788
    Abstract: Disclosed are apparatuses and methods for reducing or limiting blood loss and reducing bleed time in a subject by combined vagus and trigeminal stimulation. The apparatuses and methods may activate (e.g., electrically) one or more branches of the trigeminal nerve and may concurrently (at overlapping or near-overlapping time) independently activate the vagus nerve. This activation may be invasive or non-invasive.
    Type: Grant
    Filed: January 4, 2023
    Date of Patent: January 2, 2024
    Assignee: The Feinstein Institutes for Medical Research
    Inventor: Kirk R. Manogue
  • Patent number: 11794013
    Abstract: Methods for electrical modulation of inflammation or serum TNF levels in a subject.
    Type: Grant
    Filed: February 24, 2021
    Date of Patent: October 24, 2023
    Assignee: The Feinstein Institutes for Medical Research
    Inventors: Adam M. Kressel, Valentin A. Pavlov, Sangeeta S. Chavan, Kevin J. Tracey
  • Patent number: 11771895
    Abstract: Disclosed are nerve stimulation assemblies adapted to apply stimulation signals to a person's nervous system. The assemblies are adapted to apply such signals to nerves terminating on the outer ear of a person, for example, the auricular branch of the vagus nerve. The assemblies comprise an ear canal extension adapted to fit within an ear canal of the person, a housing connected with the extension, and an electrode arm connected with the housing by a connection member. The connection member is adapted to articulate the electrode arm to position the electrode arm relative to the outer ear. An electrode is connected with a distal end of the arm. When the arm is articulated to a selected orientation and the extension is fitted in the ear canal, the electrode is in electrical contact with a portion of the outer ear innervated by a selected peripheral nerve, such as the vagus nerve.
    Type: Grant
    Filed: August 5, 2021
    Date of Patent: October 3, 2023
    Assignee: The Feinstein Institutes for Medical Research
    Inventor: Chad Edward Bouton
  • Patent number: D1038384
    Type: Grant
    Filed: December 2, 2022
    Date of Patent: August 6, 2024
    Assignees: University of South Florida, The Feinstein Institutes for Medical Research
    Inventors: Summer J. Decker, Jonathan Ford, Todd Hazelton, Todd Goldstein, Kami Kim, Michael Teng, John Sinnott