Abstract: Pathologies of joints arising from improper force distributions are addressed by displacement of targeted connective and muscle tissues surrounding the joint in order to realign force vectors and alter moment arms loading the joint.

Abstract: Apparatus and associated methods relate to a multi-purpose functional ruck weight (FRW). The FRW includes a packing mode, a two-handed swinging mode, and a dumbbell mode. The FRW is a weight reflectively mirrored about a bisecting longitudinal axis. The weight includes a top and a bottom surface. The FRW includes a swing handle defined by a first aperture extending through the top and bottom surfaces. The weight may be carried in a rucksack against the user's body in a packing mode. The first aperture may be configured such that the first and second hand of the user, in a two-handed swinging mode, are spatially distributed and oriented along intersecting axes. The grip handle may be configured, in a dumbbell mode, such that the user's first hand is inserted through the second and third aperture to grip the grip handle at the center of the FRW.

Abstract: Methods and apparatus are provided for applying an fragment of a neurotoxin such as the active light chain (LC) of the botulinum toxin (BoNT), such as one of the serotype A, B, C, D, E, F or G botulinum toxins, via permeabilization of targeted cell membranes to enable translocation of the botulinum neurotoxin light chain (BoNT-LC) molecule across the targeted cell membrane to the cell cytosol where a therapeutic response is produced in a mammalian system. The methods and apparatus include use of catheter based delivery systems, non-invasive delivery systems, and transdermal delivery systems.

Abstract: Methods and apparatus are provided for applying an fragment of a neurotoxin such as the active light chain (LC) of the botulinum toxin (BoNT), such as one of the serotype A, B, C, D, E, F or G botulinum toxins, via permeabilization of targeted cell membranes to enable translocation of the botulinum neurotoxin light chain (BoNT-LC) molecule across the targeted cell membrane to the cell cytosol where a therapeutic response is produced in a mammalian system. The methods and apparatus include use of catheter based delivery systems, non-invasive delivery systems, and transdermal delivery systems.

Abstract: A multi-material electrode device is disclosed. The multi-material electrode device includes a first electrode, a dielectric material coupled to the first electrode, and a second electrode coupled to the dielectric material. In the multi-material electrode device, the first electrode and the second electrode do not include the same material.

Abstract: Prostheses and methods for treating canine cruciate ligament disease are disclosed comprising placement of a specifically configured implant on the femur or tibia to displace targeted muscle or connective tissue associated with the stifle joint so as to reduce cranial tibial thrust.

Abstract: A parallel plate capacitor including a cathode core that further includes a pair of parallel electrodes and a dielectric material layer positioned between the pair of parallel electrodes. The capacitor also includes a dielectric liquid medium, where the cathode core is at least partially submerged in the dielectric liquid medium.

Abstract: An exercise assembly has a target. At least one compression loop is coupled to the target. A rotatable member is coupled to the at least one compression loop. A support locks the rotatable member at a desired angle. At least one clamp is coupled to the support securing the exercise assembly to a building structure, wherein the at least one clamp moves in a forward and rearward direction relative to the building structure. At least one horizontal locking mechanism is coupled to the support securing the exercise assembly to the building structure, wherein the at least one horizontal locking mechanism moves in a horizontal direction relative to the building structure.

Abstract: An education and/or training system comprises a user interface configured to (a) present a lesson to a user, and (b) detect a first user characteristic of the user; a user performance analysis engine coupled to the user interface and configured to obtain, from the user interface, an indication the first user characteristic; an adaptation engine coupled to and configured to receive inputs from the user performance analysis engine; and a lesson presentation engine coupled to the adaptation engine and to the user interface and configured to receive inputs from the adaptation engine, provide inputs to the user performance analysis engine, and provide information to the user interface to enable the user interface to present the lesson to the user.

Abstract: A method for impacting a suture anchor into bone comprises providing an implantable suture anchor and providing an impactor device for impacting the suture anchor into the bone. The suture anchor is coupled to a distal portion of the impactor device. Positioning the suture anchor engages the anchor with the bone at an implantation site, and powering the impactor device impacts the suture anchor thereby implanting the suture anchor into the bone. The frequency of impaction is less than 20 KHz. The impactor device is then decoupled from the suture anchor, and the impactor device may be removed from the implantation site.

Abstract: Selectively placed implants are specifically configured and dimensioned to address pathologies of the shoulder joint arising from improper force distribution. By using appropriately sized and positioned implants as described herein, displacement of targeted connective and muscle tissues acting on the shoulder is accomplished in order to realign force vectors and/or alter moment arms loading the joint to achieve therapeutic effects without cutting bone and with minimal cutting of the connective tissues.

Abstract: A split flap display is provided. The display includes a wall frame mounted on a wall. The wall frame includes a plurality of panel guides extending outwardly therefrom, a breakout board mounted thereon, and a plurality of cantilevered snap locks extending outwardly therefrom. An array of carousel modules is mounted in a cabinet. The array includes a single row and a plurality of columns. The cabinet includes a locking slot adapted to releasably receive a free end of one of the plurality of cantilevered snap locks and a slide lock configured for longitudinal translation engagement with the free end of one of the plurality of cantilevered snap locks, such that translation of the slide lock displaces the free end of the cantilevered snap lock out of engagement with the locking slot. When the free end of the cantilevered snap lock is out of engagement with the locking slot, the array can be removed from the wall frame.

Abstract: Various devices, systems and methods for knotless suturing of tissue are disclosed. These devices allow sutures to be anchored to bone, and more specifically provide a suture anchor which eliminates the need for knotting the suture. Thus, damaged tissue may be re-attached to a substrate tissue. The anchors have a minimum of moving parts may be suited to being a single molded polymer construction. The anchors will find particular utility in hip and shoulder arthroscopy, e.g. labral re-attachment and similar procedures.

Abstract: A hand-held display device includes a container having a front display having a perimeter, a top side, a left side, a right side, and a bottom side, together all defining the perimeter of the front display, and a back side. The front display includes a plurality of display portions. Each display portion provides an array of display markers. The display markers are configured to display a first side when an electrical current is passed therethrough and a second side when the electrical current is not passed therethrough. A plurality of controllers is mounted on the container. The plurality of controllers equals the plurality of display portions. Each controller is configured to selectively pass the electrical current through a predetermined configuration of the display markers in a respective one of the first plurality of display portions, such that a predetermined indicia is displayed.

Abstract: Pathology of the human spine can arise from excessive and/or uneven loading of regions within the spinal vertebrae and the intervertebral disc. Methods and apparatus are disclosed that enable displacement of soft tissue around the spine in a less invasive manner, thereby altering the mechanical load distribution within the spine to achieve a therapeutic effect.

Abstract: Methods and apparatus are provided for applying an fragment of a neurotoxin such as the active light chain (LC) of the botulinum toxin (BoNT), such as one of the serotype A, B, C, D, E, F or G botulinum toxins, via permeabilization of targeted cell membranes to enable translocation of the botulinum neurotoxin light chain (BoNT-LC) molecule across the targeted cell membrane to the cell cytosol where a therapeutic response is produced in a mammalian system. The methods and apparatus include use of catheter based delivery systems, non-invasive delivery systems, and transdermal delivery systems.

Abstract: A system for delivering a therapeutic agent to a nasopharyngeal mucosa target comprises a foam generating mechanism, a gas, a therapeutic agent in liquid form that inhibits mucus production, and a delivery device. Actuation of the foam generating mechanism entraps gaseous bubbles from the gas in the liquid thereby forming a foam. The therapeutic agent is dispersed in the foam which has an expanded configuration adapted to fill a nasopharyngeal space and deliver the therapeutic agent to the mucosa targets. The delivery device is for delivering the foam to the nasopharyngeal space. The foam may also have a collapsed configuration for removal from the nasopharyngeal space or for concentration of the therapeutic agent onto the mucosa.

Abstract: Methods and apparatus are provided for applying an fragment of a neurotoxin such as the active light chain (LC) of the botulinum toxin (BoNT), such as one of the serotype A, B, C, D, E, F or G botulinum toxins, via permeabilization of targeted cell membranes to enable translocation of the botulinum neurotoxin light chain (BoNT-LC) molecule across the targeted cell membrane to the cell cytosol where a therapeutic response is produced in a mammalian system. The methods and apparatus include use of catheter based delivery systems, non-invasive delivery systems, and transdermal delivery systems.

Abstract: Pathology of the human knee can arise from excessive and/or uneven loading of regions within the joint. Methods and apparatus are disclosed that enable displacement of soft tissue around the knee, without displacing or severing bone thereby altering the mechanical load distribution within the joint in a less invasive manner than previous techniques.

Abstract: Methods and apparatus are provided for applying an fragment of a neurotoxin such as the active light chain (LC) of the botulinum toxin (BoNT), such as one of the serotype A, B, C, D, E, F or G botulinum toxins, via permeabilization of targeted cell membranes to enable translocation of the botulinum neurotoxin light chain (BoNT-LC) molecule across the targeted cell membrane to the cell cytosol where a therapeutic response is produced in a mammalian system. The methods and apparatus include use of catheter based delivery systems, non-invasive delivery systems, and transdermal delivery systems.