Patents Assigned to The George Washington University
  • NANOPHOTONIC PRODUCTION, MODULATION AND SWITCHING OF IONS BY SILICON MICROCOLUMN ARRAYS
    Publication number: 20140008528
    Abstract: The production and use of silicon microcolumn arrays that harvest light from a laser pulse to produce ions are described. The systems of the present invention seem to behave like a quasi-periodic antenna array with ion yields that show profound dependence on the plane of laser light polarization and the angle of incidence. By providing photonic ion sources, this enables enhanced control of ion production on a micro/nano scale and direct integration with miniaturized analytical devices.
    Type: Application
    Filed: September 9, 2013
    Publication date: January 9, 2014
    Applicant: The George Washington University
    Inventors: Akos VERTES, Bennett N. Walker
  • SYSTEM AND METHOD FOR MASS PRODUCTION OF GRAPHENE PLATELETS IN ARC PLASMA
    Publication number: 20130327637
    Abstract: A system and method for producing graphene includes a heating block, substrate, motor and collection device. The substrate is arranged about the heating block and is configured to receive heat from the heating block. A motor is connected to the substrate to rotate the substrate about the heating block. A cathode and anode are configured to direct a flux stream for deposit onto the rotating substrate. A collection device removes the deposited material from the rotating substrate. A heating element is embedded in the heating block and imparts heat to the heating block. The heating block is made of cement or other material that uniformly disperses the heat from the heating element throughout the heating block. The flux stream can be a carbon vapor, with the deposited flux being graphene.
    Type: Application
    Filed: June 5, 2013
    Publication date: December 12, 2013
    Applicant: The George Washington University
    Inventors: Michael KEIDAR, Alexey SHASHURIN
  • Method for isolating nuclei
    Patent number: 8546134
    Abstract: This invention relates to methods of isolating cell nuclei from the other cell components in cell samples, e.g., cell samples from cell cultures or tissue samples. The method does not comprise ultracentrifugation or super-centrifugation rather the method comprises centrifuging cell samples in a table-top conventional centrifuge or microfuge. The method also comprises the use of buffers that are substantially devoid of protease inhibitor or enzyme treatments. The methods facilitate separation of nuclei from nuclear outer membranes leaving the cellular structures and inner membranes of nuclei intact. The method also provides for rapid and consistent results.
    Type: Grant
    Filed: December 6, 2010
    Date of Patent: October 1, 2013
    Assignees: The George Washington University, The United States of America as Represented by the Department of Veteran Affairs
    Inventor: Takako Nagata
  • Flexible IC/microfluidic integration and packaging
    Publication number: 20130243655
    Abstract: A flexible IC/microfluidic hybrid integration and packaging method and resulting device. A single flexible elastomer substrate, such as polydimethylsiloxane (PDMS), has dedicated microchannels filled with liquid metals (or low melting point solders) to provide electrical interconnects to a solid-state IC die, such as CMOS, and additional microchannels for hybrid integration with microfluidics without performing any post-processing on the IC die. The liquid metal used can be a gallium-indium-tin eutectic alloy (also called Galinstan).
    Type: Application
    Filed: December 14, 2012
    Publication date: September 19, 2013
    Applicant: The George Washington University
    Inventors: Zhenyu LI, Mona E. ZAGHLOUL, Bowei ZHANG, Can E. KORMAN
  • Nanophotonic production, modulation and switching of ions by silicon microcolumn arrays
    Patent number: 8530833
    Abstract: The production and use of silicon microcolumn arrays that harvest light from a laser pulse to produce ions are described. The systems of the present invention seem to behave like a quasi-periodic antenna array with ion yields that show profound dependence on the plane of laser light polarization and the angle of incidence. By providing photonic ion sources, this enables enhanced control of ion production on a micro/nano scale and direct integration with miniaturized analytical devices.
    Type: Grant
    Filed: January 11, 2012
    Date of Patent: September 10, 2013
    Assignee: The George Washington University
    Inventors: Akos Vertes, Bennett N. Walker
  • Unobtrusive driver drowsiness detection system and method
    Patent number: 8519853
    Abstract: A drowsiness detection system and method uses Empirical Mode Decomposition (EMD) signal processing to detect whether a vehicle driver is drowsy. The system uses a decomposed component of the steering wheel signal to extract specific features representing the steering control degradation phases. The system classifies the measured features into alert or drowsy state. The detection system is independent of the road geometry and automatically compensates steering control performance variability between drivers. The system is accurate in detecting the drowsy periods and drowsy-related lane departures. The detection system is unobtrusive and can be applied on-line.
    Type: Grant
    Filed: November 5, 2009
    Date of Patent: August 27, 2013
    Assignee: The George Washington University
    Inventors: Azim Eskandarian, Ali Mortazavi
  • LASER ABLATION ELECTROSPRAY IONIZATION (LAESI) FOR ATMOSPHERIC PRESSURE, IN VIVO, AND IMAGING MASS SPECTROMETRY
    Publication number: 20130214150
    Abstract: The field of the invention is atmospheric pressure mass spectrometry (MS), and more specifically a process and apparatus which combine infrared laser ablation with electrospray ionization (ESI)
    Type: Application
    Filed: March 12, 2013
    Publication date: August 22, 2013
    Applicant: THE GEORGE WASHINGTON UNIVERSITY
    Inventor: THE GEORGE WASHINGTON UNIVERSITY
  • Laser ablation electrospray ionization (LAESI) for atmospheric pressure, in vivo, and imaging mass spectrometry
    Patent number: 8487244
    Abstract: The field of the invention is atmospheric pressure mass spectrometry (MS), and more specifically a process and apparatus which combine infrared laser ablation with electrospray ionization (ESI).
    Type: Grant
    Filed: October 12, 2011
    Date of Patent: July 16, 2013
    Assignee: The George Washington University
    Inventors: Akos Vertes, Peter Nemes
  • Three-dimensional molecular imaging by infrared laser ablation electrospray ionization mass spectrometry
    Patent number: 8487246
    Abstract: The field of the invention is atmospheric pressure mass spectrometry (MS), and more specifically a process and apparatus which combine infrared laser ablation with electrospray ionization (ESI).
    Type: Grant
    Filed: July 27, 2012
    Date of Patent: July 16, 2013
    Assignee: The George Washington University
    Inventors: Akos Vertes, Peter Nemes
  • Dual suspension system
    Patent number: 8480106
    Abstract: A dual suspension system includes a chassis, a suspension arm rotatably connected to the chassis, a wheel connection connected coupled to the suspension arm, a first lock connected to the chassis and the suspension arm, and a second lock connected between a differential housing and the chassis. The first and second locks each have an unlocked state and a locked state. When the first lock is unlocked, and the second lock is locked, the vehicle substantially provides independent suspension. When the first lock is locked, and the second lock is unlocked, the vehicle substantially provides solid axle suspension.
    Type: Grant
    Filed: July 22, 2010
    Date of Patent: July 9, 2013
    Assignee: The George Washington University
    Inventor: Shai S. Cohen
  • Method of suppressing human immunodeficiency virus (HIV) replication in a subject by administering a liver X receptor (LXR) agonist
    Patent number: 8470526
    Abstract: The present invention provides novel methods for treating and preventing coronary artery disease in HIV-1-infected individuals by interfering with Nef-mediated effect on ABCA1. The invention further provides novel methods for suppressing HIV infection by stimulating cholesterol efflux from cells by stimulating expression of ABCA1 in HIV-1-infected individuals. These methods take advantage of the finding that Nef, a regulatory protein of HIV-1, (1) diminishes expression of ATP-binding cassette transporter A1 (ABCA1), the main transporter of cholesterol from cells to extracellular acceptors; and (2) impairs cholesterol efflux from HIV-1-infected macrophages leading to cholesterol accumulation and formation of foam cells, which is a characteristic feature of atherosclerosis.
    Type: Grant
    Filed: September 28, 2006
    Date of Patent: June 25, 2013
    Assignee: The George Washington University
    Inventors: Michael Bukrinsky, Dmitri Sviridov
  • SPATIALLY-AND TEMPORALLY-RESOLVED MULTI-PARAMETER INTERFEROMETRIC RAYLEIGH SCATTERING SYSTEM AND METHOD
    Publication number: 20130141721
    Abstract: A system that simultaneously measures the translational temperature, bulk velocity, and density in gases by collecting, referencing, and analyzing nanosecond time-scale Rayleigh scattered light from molecules is described. A narrow-band pulsed laser source is used to probe two largely separated measurement locations, one of which is used for reference. The elastically scattered photons containing information from both measurement locations are collected at the same time and analyzed spectrally using a planar Fabry-Perot interferometer. A practical means of referencing the measurement of velocity using the laser frequency, and the density and temperature using the information from the reference measurement location maintained at constant properties is provided.
    Type: Application
    Filed: November 7, 2012
    Publication date: June 6, 2013
    Applicants: USA as represented by the Administrator of the National Aeronautics and Space Admi, The George Washington University
    Inventors: The George Washington University, United State of America as represented by the Ad- ministrator of the National Aeronnaitics and Space
  • VANADIUM BORIDE AIR MULTIPLE ELECTRON HIGH CAPACITY BATTERY
    Publication number: 20130134948
    Abstract: A battery and methods of forming vanadium boride nanoparticles of an anode within a battery, and a method for recharging an air battery. The battery comprises an anode and a cathode in electrochemical contact with each other through an electrically neutral ionic conductor (an electrolyte). The cathode may comprise a catalyst effective for the reduction of dissolved oxygen. An electrical discharge of the anode is performed via multiple electron oxidation of vanadium boride.
    Type: Application
    Filed: August 10, 2011
    Publication date: May 30, 2013
    Applicant: The George Washington University
    Inventor: Stuart Licht
  • PROCESS FOR IRON AND STEEL PRODUCTION
    Publication number: 20130134050
    Abstract: A method of producing iron by: solubilizing iron oxide as a lithiated iron oxide in a molten carbonate having lithium carbonate; and subjecting the lithiated iron oxide to electrolysis to obtain iron and oxygen. The molten alkali metal carbonate salt may further include lithium oxide. Additionally the lithium carbonate may be simultaneously subjected to electrolysis to produce steel instead of iron.
    Type: Application
    Filed: October 25, 2012
    Publication date: May 30, 2013
    Applicant: The George Washington University
    Inventor: The George Washington University
  • Multivalent antihelminthic vaccine
    Patent number: 8444994
    Abstract: A multivalent anthelmintic vaccine targets both hookworm and schistosomiasis. The vaccine includes, at a minimum, a recombinant third-stage larval hookworm antigen, a recombinant adult stage hookworm antigen, and a recombinant schistosome antigen. Preferably, the hookworm antigens are Necator americanus antigens, although antigens from other hookworm species (e.g. Ancylostoma duodenale) may also be employed. The schistosome antigen is preferably a Schistosoma mansoni or a Schistosoma haematobium antigen although antigens from other schistosome species (e.g. Schistosoma japonicum) may also be employed. In some cases full or partial sequences of schistosome antigens may be fused with full or partial sequences of hookworm {Necator americanus) to produce recombinant chimeric antigens.
    Type: Grant
    Filed: June 30, 2009
    Date of Patent: May 21, 2013
    Assignees: The Albert B. Sabin Vaccine Institute, The George Washington University, The Council of the Queensland Institute of Medical Research
    Inventors: Peter Hotez, Alexander Loukas, Mark Pearson, Jeffrey Bethony, Bin Zhan, Gaddam Goud, Maria Elena Bottazzi, David Diemert, Ami Shah Brown, Peter Giacomautonio
  • Systems and Methods for Visualizing Ablated Tissue
    Publication number: 20130102862
    Abstract: Systems and methods for visualizing ablated tissue are disclosed. In some embodiments, a system for imaging tissue includes a catheter having an expandable balloon at a distal end, an illumination device positioned within the balloon for propagating light from an external light source for illuminating a tissue being treated to excite native nicotinamide adenine dinucleotide hydrogen (NADH) in the tissue, and an imaging device positioned within the balloon for detecting fluorescence from the illuminated tissue, the imaging device being configured to communicate detected NADH fluorescence to an external fluorescence camera.
    Type: Application
    Filed: September 22, 2012
    Publication date: April 25, 2013
    Applicant: THE GEORGE WASHINGTON UNIVERSITY
    Inventor: THE GEORGE WASHINGTON UNIVERSITY
  • Systems and Methods for Visualizing Ablated Tissue
    Publication number: 20130079645
    Abstract: Systems and methods for visualizing ablated tissue are disclosed. In some embodiments, a system for imaging tissue comprising: a catheter having a distal end and a proximal end; an inflatable balloon disposed about the distal end of the catheter; and an optical housing extending from the distal end of the catheter into the balloon, the optical housing being configured to position inside the balloon a light source for illuminating a tissue outside the balloon and a camera for imaging the illuminated tissue.
    Type: Application
    Filed: September 22, 2012
    Publication date: March 28, 2013
    Applicants: LUXCATH, LLC, THE GEORGE WASHINGTON UNIVERSITY
    Inventors: The George Washington University, LuxCath, LLC
  • APPARATUS FOR GENERATING MINI AND MICRO PLASMAS AND METHODS OF USE
    Publication number: 20130015766
    Abstract: Systems and methods for formation of an ultra high frequency atmospheric pressure plasma jet are presented. A magnetic loop has first and second ends and a gap for generating the plasmas. An inner arc provides RF power to the magnetic loop. Use of the described structure allows for generation of plasmas in air and in inert gases such as argon and helium. Various properties, including the non-thermal nature and shape of the plasma jet are discussed. Applications for utilizing the non-thermal plasma jet are provided.
    Type: Application
    Filed: May 11, 2012
    Publication date: January 17, 2013
    Applicant: The George Washington University
    Inventors: Mazdak TAGHIOSKOUI, Mona ZAGHLOUL
  • Compositions and Methods for Identifying Autism Spectrum Disorders
    Publication number: 20130012403
    Abstract: The compositions and methods described are directed to microRNA chips having a plurality of different oligonucleotides with specificity for genes associated with autism spectrum disorders. The invention further provides methods of identifying microRNA profiles for neurological and psychiatric conditions including autism spectrum disorders, methods of treating such conditions, and methods of identifying therapeutics for the treatment of such neurological and psychiatric conditions.
    Type: Application
    Filed: December 23, 2010
    Publication date: January 10, 2013
    Applicant: George Washington University
    Inventor: Valerie Wailin Hu
  • PROCESS FOR ELECTROSYNTHESIS OF ENERGETIC MOLECULES
    Publication number: 20130001072
    Abstract: A process for the production of energetically rich compounds comprising: using externally supplied thermal energy to heat an electrolyzable compound to a temperature greater than the ambient temperature; generating electricity from a solar electrical photovoltaic component; subjecting the heated electrolyzable compound to electrolysis with the solar generated electricity to generate an energetically rich electrolytic product.
    Type: Application
    Filed: September 7, 2012
    Publication date: January 3, 2013
    Applicant: The George Washington University
    Inventor: Stuart LICHT