Patents Assigned to The George Washington University
  • METHOD OF TREATING LOW BLOOD PRESSURE
    Publication number: 20180133282
    Abstract: A method for treating a patient suffering from one of septic shock, acute kidney injury, severe hypotension, cardiac arrest, and refractory hypotension, but not from myocardial infarction, is provided. The method includes administering a therapeutically effective dose of Angiotensin II, or Ang II, to the patient.
    Type: Application
    Filed: January 12, 2018
    Publication date: May 17, 2018
    Applicant: The George Washington University a Congressionally Chartered Not-for-Profit Corporation
    Inventor: Lakhmir Chawla
  • BLOOD BIOMARKERS FOR APPENDICITIS AND DIAGNOSTICS METHODS USING BIOMARKERS
    Publication number: 20180135127
    Abstract: The invention relates to methods and kits for diagnosing and/or treating appendicitis in a subject, comprising obtaining a biological sample from said subject; detecting RNA expression levels of at least three or more biomarkers in the biological sample and comparing the expression levels of said at least three or more biomarkers to a control sample wherein an increase or decrease in the level of expression of said at least three or more biomarkers as compared to the control sample is indicative of appendicitis.
    Type: Application
    Filed: October 22, 2015
    Publication date: May 17, 2018
    Applicant: The George Washington University a Congressionally Chartered Not-for-Profit Corporation
    Inventors: Lakhmir S. Chawla, Timothy A. McCaffrey
  • SMART RELEASE SYSTEM FOR GROWTH FACTOR DELIVERY AND COMBINED BONE AND VASCULAR GROWTH
    Publication number: 20180015207
    Abstract: Embodiments of the present invention relate to structures and systems having a three-dimensional biomimetic structure with a porous biomimetic three-dimensional scaffold and a coating deposited onto a surface of the porous biomimetic three-dimensional scaffold as well as methods of using and fabricating the like.
    Type: Application
    Filed: July 14, 2017
    Publication date: January 18, 2018
    Applicant: The George Washington University a Congressionally Chartered Not-for-Profit Corporation
    Inventors: Haitao Cui, Wei Zhu, Benjamin Holmes, Lijie Grace Zhang
  • Method of treating low blood pressure
    Patent number: 9867863
    Abstract: A method for treating a patient suffering from one of septic shock, acute kidney injury, severe hypotension, cardiac arrest, and refractory hypotension, but not from myocardial infarction, is provided. The method includes administering a therapeutically effective dose of Angiotensin II, or Ang II, to the patient.
    Type: Grant
    Filed: December 15, 2016
    Date of Patent: January 16, 2018
    Assignee: The George Washington University a Congressionally Chartered Not-for-Profit Corporation
    Inventor: Lakhmir Chawla
  • Emergent network defense
    Patent number: 9860276
    Abstract: A system and method are provided of a node for use in a network having a plurality of nodes. The node is configured to identify neighboring node(s) within a predetermined closeness of said node, measured by any of physical, logical, network hops, network link, or vertices analysis closeness. The node determines a level of nervousness of itself and sends and/or receives communication as to the level of nervousness to the neighboring node(s).
    Type: Grant
    Filed: September 18, 2013
    Date of Patent: January 2, 2018
    Assignee: The George Washington University
    Inventors: Earl N. Crane, Sara M. Crane, Julie C. Ryan
  • BLOOD BIOMARKERS FOR RESPIRATORY INFECTIONS
    Publication number: 20170369946
    Abstract: Methods and kits for diagnosing and/or treating a lower respiratory infection in a subject include obtaining a biological sample from the subject; detecting RNA expression levels of one or more biomarkers in the biological sample and comparing the expression levels of the one or more three biomarkers to at least one invariant control marker wherein an increase or decrease in the level of expression of the one or more biomarkers as compared to the at least one invariant control marker is indicative of a lower respiratory infection.
    Type: Application
    Filed: January 12, 2016
    Publication date: December 28, 2017
    Applicant: The George Washington University a Congressionally Chartered Not-for-Profit Corporation
    Inventors: Timothy A. Mccaffrey, Lakhmir S. Chawla
  • BLOOD BIOMARKERS FOR APPENDICITIS AND DIAGNOSTICS METHODS USING BIOMARKERS
    Publication number: 20170356908
    Abstract: The invention relates to methods and kits for diagnosing and/or treating appendicitis in a subject, comprising performing one or more assays configured to detect one or more biomarkers on a body fluid sample obtained from the subject to provide one or more assay result(s) and correlating the assay result(s) to the occurrence or nonoccurrence of appendicitis in the subject or likelihood of the future outcome to the subject.
    Type: Application
    Filed: October 22, 2015
    Publication date: December 14, 2017
    Applicants: The George Washington University A Congressionally Chartered Not-For-Profit Corporation, Astute Medical, Inc.
    Inventors: Lakhmir S. Chawla, Timothy A. McCaffrey, Paul McPherson, James Patrick Kampf
  • System and method for mass production of graphene platelets in arc plasma
    Patent number: 9839896
    Abstract: A system and method for producing graphene includes a discharge assembly and a substrate assembly. The discharge assembly includes a cathode and an anode, which in one embodiment are offset from each other. The anode produces a flux stream that is deposited onto a substrate. A collection device removes the deposited material from the rotating substrate. The flux stream can be a carbon vapor, with the deposited flux being graphene.
    Type: Grant
    Filed: November 19, 2014
    Date of Patent: December 12, 2017
    Assignee: The George Washington University
    Inventors: Michael Keidar, Alexey Shashurin
  • Process for electrosynthesis of energetic molecules
    Patent number: 9758881
    Abstract: A process for the production of energetically rich compounds comprising: using externally supplied thermal energy to heat an electrolyzable compound to a temperature greater than the ambient temperature; generating electricity from a solar electrical photovoltaic component; subjecting the heated electrolyzable compound to electrolysis with the solar generated electricity to generate an energetically rich electrolytic product.
    Type: Grant
    Filed: February 12, 2010
    Date of Patent: September 12, 2017
    Assignee: The George Washington University
    Inventor: Stuart Licht
  • DOPED GRAPHITIC CARBON NITRIDES, METHODS OF MAKING AND USES OF THE SAME
    Publication number: 20170232427
    Abstract: Carbon-doped graphitic carbon nitride (g-C3N4) compositions are synthesized from the chemical precursors melamine, cyanuric acid and barbituric acid. Phosphorus-doped g-C3N4 compositions are synthesized from the chemical precursors melamine, cyanuric acid and etidronic acid. Carbon- and phosphorus-doped g-C3N4 compositions, when in the presence of UV or visible light, can be used in water treatment systems to photocatalytically degrade persistent organic micropollutants such as pharmaceuticals and personal care products (PPCPs), endocrine disrupting compounds (EDCs), pesticides, and herbicides. Carbon- and phosphorus-doped g-C3N4 compositions can also be applied to surfaces of household and public items to kill protozoa, eukaryotic parasites, algal pathogens, bacteria, fungi, prions, viruses, or other microorganisms, preventing the transfer thereof between users.
    Type: Application
    Filed: February 16, 2017
    Publication date: August 17, 2017
    Applicant: The George Washington University
    Inventors: Danmeng Shuai, Qinmin ZHENG
  • SYSTEM AND METHOD FOR MASS PRODUCTION OF GRAPHENE PLATELETS IN ARC PLASMA
    Publication number: 20170217776
    Abstract: A system and method for producing graphene includes a heating block, substrate, motor and collection device. The substrate is arranged about the heating block and is configured to receive heat from the heating block. A motor is connected to the substrate to rotate the substrate about the heating block. A cathode and anode are configured to direct a flux stream for deposit onto the rotating substrate. A collection device removes the deposited material from the rotating substrate. A heating element is embedded in the heating block and imparts heat to the heating block. The heating block is made of cement or other material that uniformly disperses the heat from the heating element throughout the heating block. The flux stream can be a carbon vapor, with the deposited flux being graphene.
    Type: Application
    Filed: November 8, 2016
    Publication date: August 3, 2017
    Applicant: The George Washington University
    Inventors: Michael Keidar, Alexey Shashurin
  • Use of NK-1 receptor antagonists for treating hypomagnesemia, neurogenic inflammation, and cardiac dysfunction associated with EGFR-blocking drugs
    Patent number: 9687493
    Abstract: The present disclosure provides methods for alleviating or preventing the negative physiological side effects associated with the administration of EGFR blocking therapeutics. The disclosure provides, inter alia, methods for treating or preventing: hypomagnesemia, cardiac dysfunction, and skin lesions, which are induced by EGFR blocking drugs, by administering an NK-1 receptor antagonist.
    Type: Grant
    Filed: September 28, 2016
    Date of Patent: June 27, 2017
    Assignee: THE GEORGE WASHINGTON UNIVERSITY
    Inventors: William B. Weglicki, Iu Tong Mak
  • Apparatus for molten salt electrolysis with solar photovoltaic electricity supply and solar thermal heating of molten salt electrolyte
    Patent number: 9683297
    Abstract: A process for the production of energetically rich compounds comprising: using externally supplied thermal energy to heat an electrolyzable compound to a temperature greater than the ambient temperature; generating electricity from a solar electrical photovoltaic component; subjecting the heated electrolyzable compound to electrolysis with the solar generated electricity to generate an energetically rich electrolytic product.
    Type: Grant
    Filed: September 7, 2012
    Date of Patent: June 20, 2017
    Assignee: The George Washington University
    Inventor: Stuart Licht
  • Electrical stimulation of the claustrum/piriform cortex for treatment of epilepsy
    Patent number: 9669214
    Abstract: An electrical stimulation device provides stimulation of a person's claustrum and piriform cortex to treat seizures for persons having epilepsy, and to improve consciousness in individuals with disorders of consciousness such as coma. The stimulation device includes a stimulator that generates a stimulation signal, and one or more electrodes located near the target brain regions (Claustrum/piriform cortex). The electrode receives the stimulation signal from said stimulator and imparts the stimulation signal to the target brain regions.
    Type: Grant
    Filed: March 25, 2016
    Date of Patent: June 6, 2017
    Assignee: The George Washington University
    Inventor: Mohamad Z. Koubeissi
  • Plasmonic mode III-V laser as on-chip light source
    Patent number: 9667032
    Abstract: A plasmonic light source includes a substrate and a square nano-cavity formed on the substrate. The nano-cavity includes a quantum well structure. The quantum well structure includes III-V materials. A plasmonic metal is formed as an electrode on the square nano-cavity and is configured to excite surface plasmons with the quantum well structure to generate light. Complementary metal oxide semiconductor (CMOS) devices are formed on the substrate.
    Type: Grant
    Filed: November 13, 2015
    Date of Patent: May 30, 2017
    Assignees: INTERNATIONAL BUSINESS MACHINES CORPORATION, THE GEORGE WASHINGTON UNIVERSITY
    Inventors: Ning Li, Ke Liu, Devendra K. Sadana, Volker J. Sorger
  • Compounds for inhibiting 1-deoxy-D-xylulose-5-phosphate reductoisomerase
    Patent number: 9593136
    Abstract: In particular, the compound is effective to inhibit Dxr in Mycobacterium tuberculosis (Mtb). The present invention relates to compounds having general formula (I) or (II) where X is an acidic group, such as carboxylate, phosphonate, sulfate, and tetrazole; Ar is a substituted or unsubstituted aromatic or heteroaromatic group; and n is 0, 1, 2, 3, or 4, preferably 2, 3, or 4. The compounds inhibits 1-deoxy-D-xylulose-5-phosphate reductoisomerase (Dxr), particularly Dxr in Mycobacterium tuberculosis (Mtb).
    Type: Grant
    Filed: June 29, 2012
    Date of Patent: March 14, 2017
    Assignees: The George Washington University, George Mason University, St. Jude Children's Research Hospital, Inc., The United States of America, as Represented by the Secretary, Department of Health and Human Services
    Inventors: Helena I. Boshoff, Cynthia S. Dowd, Emily R. Jackson, Kylene Kehn-Hall, Richard E. Lee, Robin Lee, Geraldine San Jose
  • Method of treating low blood pressure
    Patent number: 9572856
    Abstract: A method for treating a patient suffering from one of septic shock, acute kidney injury, severe hypotension, cardiac arrest, and refractory hypotension, but not from myocardial infarction, is provided. The method includes administering a therapeutically effective dose of Angiotensin II, or Ang II, to the patient.
    Type: Grant
    Filed: December 16, 2009
    Date of Patent: February 21, 2017
    Assignee: The George Washington University a Congressionally Chartered Not-for-Profit Corporation
    Inventor: Lakhmir Chawla
  • Highly Selective Nanostructure Sensors and Methods of Detecting Target Analytes
    Publication number: 20170038326
    Abstract: A nanostructure sensing device comprises a semiconductor nanostructure having an outer surface, and at least one of metal or metal-oxide nanoparticle clusters functionalizing the outer surface of the nanostructure and forming a photoconductive nanostructure/nanocluster hybrid sensor enabling light-assisted sensing of a target analyte.
    Type: Application
    Filed: October 19, 2016
    Publication date: February 9, 2017
    Applicants: University of Maryland, College Park, United States of America, as Represented by the Secretary of Commerce, George Mason University, The George Washington University
    Inventors: Abhishek Motayed, Geetha Aluri, Albert V. Davydov, Mulpuri V. Rao, Vladimir P. Oleshko, Ritu Bajpai, Mona E. Zaghloul
  • USE OF NK-1 RECEPTOR ANTAGONISTS FOR TREATING HYPOMAGNESEMIA, NEUROGENIC INFLAMMATION, AND CARDIAC DYSFUNCTION ASSOCIATED WITH EGFR-BLOCKING DRUGS
    Publication number: 20170014420
    Abstract: The present disclosure provides methods for alleviating or preventing the negative physiological side effects associated with the administration of EGFR blocking therapeutics. The disclosure provides, inter alia, methods for treating or preventing: hypomagnesemia, cardiac dysfunction, and skin lesions, which are induced by EGFR blocking drugs, by administering an NK-1 receptor antagonist.
    Type: Application
    Filed: September 28, 2016
    Publication date: January 19, 2017
    Applicant: THE GEORGE WASHINGTON UNIVERSITY
    Inventors: William B. WEGLICKI, Iu Tong MAK
  • Silicon-based, broadband, waveguide-integrated electro-optical switch
    Patent number: 9529158
    Abstract: An electro-optical switch or router includes a semiconductor oxide substrate and first, second, and third semiconductor waveguides disposed on the semiconductor oxide substrate. The third waveguide includes a transparent conducting oxide layer, an oxide layer, a metal layer, and first and second electrodes coupled to the third waveguide. The electrodes are configured to bias and unbiased the third waveguide to effect optical switching in the electro-optical switch. The oxide layer is disposed between the transparent conducting oxide layer and the metal layer. The switch may further include a semiconductor layer disposed under the transparent conducting oxide layer between the transparent conducting oxide layer and the semiconductor oxide substrate. The first electrode may be coupled to the transparent conducting oxide layer, and the second electrode may be coupled to the metal layer.
    Type: Grant
    Filed: October 30, 2014
    Date of Patent: December 27, 2016
    Assignee: The George Washington University
    Inventors: Volker J. Sorger, Chenran Ye, Ke Liu