Abstract: Novel aza analogues of dicationic terphenyl compounds for use in combating microbial infections are described. Also described are processes for synthesizing the compounds.
Type:
Grant
Filed:
May 17, 2006
Date of Patent:
January 24, 2012
Assignees:
The University of North Carolina at Chapel Hill, Georgia State University Research Foundation, Inc.
Inventors:
Richard R. Tidwell, David W. Boykin, W. David Wilson, Reto Brun, Karl Werbovetz, Mohamed A. Ismail, Reem K. Arafa
Abstract: A dual band photodetector for detecting infrared and ultraviolet optical signals is disclosed. Aspects include homojunction and heterojunction detectors comprised of one or more of GaN, AlGaN, and InGaN. In one aspect ultraviolet/infrared dual-band detector is disclosed that is configured to simultaneously detect UV and IR.
Type:
Grant
Filed:
October 19, 2010
Date of Patent:
January 10, 2012
Assignee:
Georgia State University Research Foundation, Inc.
Inventors:
A. G. Unil Perera, Steven George Matsik
Abstract: In one embodiment, facilitating classroom interaction includes sending a message containing a question to be answered from a mobile device located within a classroom at which a class is being taught, receiving the message with a central server and identifying the class to which the message pertains, and displaying the question on a display device located within the classroom.
Type:
Application
Filed:
June 7, 2011
Publication date:
December 8, 2011
Applicant:
Georgia State University Research Foundation
Abstract: A nanostructure is used to generate a highly localized nanoscale optical field. The field is excited using surface plasmon amplification by stimulated emission of radiation (SPASER). The SPASER radiation consists of surface plasmons that undergo stimulated emission, but in contrast to photons can be localized within a nanoscale region. A SPASER can incorporate an active medium formed by two-level emitters, excited by an energy source, such as an optical, electrical, or chemical energy source. The active medium may be quantum dots, which transfer excitation energy by radiationless transitions to a resonant nanosystem that can play the same role as a laser cavity in a conventional laser. The transitions are stimulated by the surface plasmons in the nanostructure, causing the buildup of a macroscopic number of surface plasmons in a single mode.
Type:
Grant
Filed:
April 30, 2009
Date of Patent:
September 13, 2011
Assignees:
Ramot At Tel-Aviv University Ltd, The Georgia State University Research Foundation
Abstract: The present invention is directed to methods for delaying a plant development process comprising exposing a plant or plant part to one or more bacteria or enzymes. In specific embodiments, the one or more bacteria are selected from the group consisting of Rhodococcus spp., Pseudomonas chloroaphis, Brevibacterium ketoglutamicum, and a mixture comprising any combination of these bacteria. Apparatuses for delaying a plant development process comprising a catalyst that comprises one or more of the above bacteria.
Type:
Application
Filed:
April 11, 2011
Publication date:
July 28, 2011
Applicant:
GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC.
Inventors:
George E. Pierce, Sangeeta Ganguly, Gene K. Drago
Abstract: The present invention provides selenium derivatives of nucleosides, nucleoside phosphoramidites, nucleotides, nucleotide triphosphates, oligonucleotides, polynucleotides, and larger nucleic acids and methods for their synthesis. Selenium derivatives of both ribonucleic acids and deoxyribonucleic acids, as well as methods for their synthesis, crystallization and uses in structural determinations, particularly by X-ray crystallographic techniques are disclosed. The selenium derivatives of the present invention are also useful as food supplements.
Type:
Grant
Filed:
September 18, 2009
Date of Patent:
July 19, 2011
Assignee:
Georgia State University Research Foundation, Inc.
Abstract: Disclosed herein are antimicrobial compositions, kits, and articles of manufacture. Further disclosed herein are methods for treating surfaces, including tissue, inter alia, wounds, with the disclosed compositions.
Type:
Application
Filed:
July 27, 2009
Publication date:
July 7, 2011
Applicant:
GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC
Inventors:
Charles Derby, Binghe Wang, Phang C. Tai, Ko-Chun Ko, Michiya Kamio
Abstract: Disclosed herein are novel dicationic teraryl compounds and their aza analogues, including compounds of Formula (IIe): wherein p and q are each 0 and each A, Y and Z is CR4. An exemplary compound of Formula (IIe) is: Methods for combating microbial infections, such as parasitic Leishmania species, with novel dicationic terphenyl compounds and their aza analogues are included. Processes for synthesizing novel dicationic terphenyl compounds and their aza analogues are disclosed along with methods for evaluation of the compounds as potential anti-protozoan agents.
Type:
Grant
Filed:
January 25, 2007
Date of Patent:
June 21, 2011
Assignees:
The University of North Carolina at Chapel Hill, Georgia State University Research Foundation, Inc.
Inventors:
Richard R. Tidwell, David W. Boykin, W. David Wilson, Reto Brun, Laixing Hu, Karl Werbovetz, Mohamed A. Ismail, Reem K. Arafa
Abstract: The present invention is directed to methods for delaying a plant development process comprising exposing a plant or plant part to one or more bacteria or enzymes. In specific embodiments, the one or more bacteria are selected from the group consisting of Rhodococcus spp., Pseudomonas chloroaphis, Brevibacterium ketoglutamicum, and a mixture comprising any combination of these bacteria. Apparatuses for delaying a plant development process comprising a catalyst that comprises one or more of the above bacteria.
Type:
Grant
Filed:
April 2, 2007
Date of Patent:
May 17, 2011
Assignee:
Georgia State University Research Foundation, Inc.
Inventors:
George E. Pierce, Sangeeta Ganguly, Gene K. Drago
Abstract: A dual band photodetector for detecting infrared and ultraviolet optical signals is disclosed. Aspects include homojunction and heterojunction detectors comprised of one or more of GaN, AlGaN, and InGaN. In one aspect ultraviolet/infrared dual-band detector is disclosed that is configured to simultaneously detect UV and IR.
Type:
Application
Filed:
October 19, 2010
Publication date:
March 3, 2011
Applicant:
GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC.
Abstract: A dual band photodetector for detecting infrared and ultraviolet optical signals is disclosed. Aspects include homojunction and heterojunction detectors comprised of one or more of GaN, AlGaN, and InGaN. In one aspect ultraviolet/infrared dual-band detector is disclosed that is configured to simultaneously detect UV and IR.
Type:
Grant
Filed:
October 23, 2006
Date of Patent:
November 23, 2010
Assignee:
Georgia State University Research Foundation, Inc.
Abstract: Novel fused ring dicationic anti-protozoan compounds. Representative protozoan species include but are not limited to Trypanosoma brucei rhodesiense (T.b.r.) and Plasmodium falciparum. Prodrugs of these compounds can be used as an oral treatment for malaria and human African trypanosomiasis.
Type:
Grant
Filed:
November 18, 2004
Date of Patent:
November 2, 2010
Assignees:
The University of North Carolina at Chapel Hill, Georgia State University Research Foundation, Inc.
Inventors:
David W. Boykin, Richard R. Tidwell, W. David Wilson, Reto Brun, Reem K. Arafa, Chad E. Stephens
Abstract: Systems and methods for at or near room temperature of infrared detection are disclosed. Embodiments of the disclosure include high temperature split-off band infrared detectors. One embodiment, among others, comprises a first barrier and a second barrier with an emitter disposed between the first and second barrier, each barrier being a layer of a first semiconductor material and the emitter being a layer of a second semiconductor material.
Type:
Grant
Filed:
September 4, 2007
Date of Patent:
August 31, 2010
Assignee:
Georgia State University Research Foundation, Inc.
Abstract: The present invention relates to novel 2,5-bis{[alkyl (or aryl) imino] aminophenyl}furans and thiophenes of the general formula in which R1, R2, R3 and R4 are each independently selected from the group consisting of H, alkyl, alkoxy, halide, and alkylhalide groups; R5 is H, alkyl or aryl; R6 is H, alkyl, aryl, or NR7R8, in which R7 and R8 are each independently selected from the group consisting of H, alkyl and aryl; and X is O, S or NR9, in which R9 is H or alkyl, and to the use of such compounds.
Type:
Grant
Filed:
July 9, 2007
Date of Patent:
June 29, 2010
Assignees:
The University of North Carolina at Chapel Hill, Duke University, Georgia State University Research Foundation, Inc.
Inventors:
David W. Boykin, Richard R. Tidwell, W. David Wilson, John R. Perfect, Chad F. Stephens
Abstract: The present invention provides selenium derivatives of nucleosides, nucleoside phosphoramidites, nucleotides, nucleotide triphosphates, oligonucleotides, polynucleotides, and larger nucleic acids and methods for their synthesis. Selenium derivatives of both ribonucleic acids and deoxyribonucleic acids, as well as methods for their synthesis, crystallization and uses in structural determinations, particularly by X-ray crystallographic techniques are disclosed. The selenium derivatives of the present invention are also useful as food supplements.
Type:
Application
Filed:
September 18, 2009
Publication date:
June 3, 2010
Applicant:
GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC.
Abstract: Embodiments of the present disclosure provide for enzyme sensors, protease sensors, methods for producing and using the enzyme and protease sensors, methods of detecting and/or measuring protease activity, methods for characterizing protease cellular activity, fusion proteins, polynucleotides, and vectors corresponding to the enzyme and protease sensors, kits, and the like.
Type:
Application
Filed:
August 6, 2007
Publication date:
March 4, 2010
Applicant:
GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC.
Abstract: The present invention provides selenium derivatives of nucleosides, nucleoside phosphoramidites, nucleotides, nucleotide triphosphates, oligonucleotides, polynucleotides, and larger nucleic acids and methods for their synthesis. Selenium derivatives of both ribonucleic acids and deoxyribonulcleic acids, as well as methods for their synthesis, crystallization and uses in structural determinations, particularly by X-ray crystallographic techniques are disclosed. The selenium derivatives of the present invention are also useful as food supplements.
Type:
Grant
Filed:
March 22, 2002
Date of Patent:
September 22, 2009
Assignee:
Georgia State University Research Foundation, Inc.
Abstract: The present invention is directed to methods for inducing desired activity in enzymes or microorganisms capable of producing the enzymes. The invention is further directed to methods of stabilizing activity in microorganisms. In specific embodiments, the invention provides methods for inducing and stabilizing nitrile hydratase activity, amidase activity, and asparaginase I activity. The invention further provides compositions comprising enzymes or microorganisms having induced and/or stabilized activity.
Type:
Application
Filed:
April 3, 2009
Publication date:
August 13, 2009
Applicant:
GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC.
Inventors:
George E. Pierce, Gene K. Drago, Sangeeta Ganguly
Abstract: A nanostructure is used to generate a highly localized nanoscale optical field. The field is excited using surface plasmon amplification by stimulated emission of radiation (SPASER). The SPASER radiation consists of surface plasmons that undergo stimulated emission, but in contrast to photons can be localized within a nanoscale region. A SPASER can incorporate an active medium formed by two-level emitters, excited by an energy source, such as an optical, electrical, or chemical energy source. The active medium may be quantum dots, which transfer excitation energy by radiationless transitions to a resonant nanosystem that can play the same role as a laser cavity in a conventional laser. The transitions are stimulated by the surface plasmons in the nanostructure, causing the buildup of a macroscopic number of surface plasmons in a single mode.
Type:
Grant
Filed:
January 5, 2004
Date of Patent:
August 4, 2009
Assignees:
Ramot At Tel-Aviv University Ltd, The Georgia State University Research Foundation
Abstract: The present invention is directed to methods for inducing desired activity in enzymes or microorganisms capable of producing the enzymes. The invention is further directed to methods of stabilizing activity in microorganisms. In specific embodiments, the invention provides methods for inducing and stabilizing nitrile hydratase activity, amidase activity, and asparaginase I activity. The invention further provides compositions comprising enzymes or microorganisms having induced and/or stabilized activity.
Type:
Grant
Filed:
January 30, 2007
Date of Patent:
May 12, 2009
Assignee:
Georgia State University Research Foundation, Inc.
Inventors:
George E. Pierce, Gene K. Drago, Sangeeta Ganguly