Patents Assigned to The Georgia State University Research Foundation
  • Enzyme sensors, methods for preparing and using such sensors, and methods of detecting protease activity
    Patent number: 8481272
    Abstract: Embodiments of the present disclosure provide for enzyme sensors, protease sensors, methods for producing and using the enzyme and protease sensors, methods of detecting and/or measuring protease activity, methods for characterizing protease cellular activity, fusion proteins, polynucleotides, and vectors corresponding to the enzyme and protease sensors, kits, and the like.
    Type: Grant
    Filed: August 6, 2007
    Date of Patent: July 9, 2013
    Assignee: Georgia State University Research Foundation, Inc.
    Inventors: Jenny J. Yang, Ning Chen
  • INDUCTION AND STABILIZATION OF ENZYMATIC ACTIVITY IN MICROORGANISMS
    Publication number: 20130122565
    Abstract: The present invention is directed to methods for inducing desired activity in enzymes or microorganisms capable of producing the enzymes. The invention is further directed to methods of stabilizing activity in microorganisms. In specific embodiments, the invention provides methods for inducing and stabilizing nitrile hydratase activity, amidase activity, and asparaginase I activity. The invention further provides compositions comprising enzymes or microorganisms having induced and/or stabilized activity.
    Type: Application
    Filed: November 2, 2012
    Publication date: May 16, 2013
    Applicant: GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC.
    Inventor: Georgia State University Research Foundation, Inc
  • INHIBITORS OF HIF AND ANGIOGENESIS
    Publication number: 20130116275
    Abstract: Inhibitors of the Hypoxia Inducible Factor (HIF) and angiogenesis and their methods of use including the treatment of cancer, hypoxia related pathologies, disorders leading to ischemia, for example stroke and ischemic heart disease, and non-cancerous angiogenic diseases are provided.
    Type: Application
    Filed: April 20, 2011
    Publication date: May 9, 2013
    Applicants: GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, EMORY UNIVERSITY
    Inventors: Erwin G. Van Meir, Binghe Wang
  • Surfactant-based monolithic columns, methods for making the same, and method for using the same
    Patent number: 8435410
    Abstract: A method for making a surfactant-based monolithic column is provided. The method comprises providing a mixture comprising at least one surfactant monomer, at least one crosslinker, at least one initiator, and at least one porogen and polymerizing the mixture to form the surfactant-based monolithic column. The present disclosure also provides a surfactant-based monolithic column, a method for separating molecules, and a process for preparing a surfactant monomer.
    Type: Grant
    Filed: March 30, 2009
    Date of Patent: May 7, 2013
    Assignee: Georgia State University Research Foundation, Inc.
    Inventors: Shahab Ahmed Shamsi, Congying Gu, Jun He
  • Analyte sensors, methods for preparing and using such sensors, and methods of detecting analyte activity
    Patent number: 8420327
    Abstract: Embodiments of the present disclosure provide for analyte sensors, methods for producing and using the analyte sensors, methods of detecting and/or measuring analyte activity, methods for characterizing analyte cellular activity, methods of detecting pH change in a system, method of controlling the concentration of an analyte in a system, fusion proteins, polynucleotides, and vectors corresponding to the analyte sensors, kits, and the like.
    Type: Grant
    Filed: December 14, 2007
    Date of Patent: April 16, 2013
    Assignee: Georgia State University Research Foundation
    Inventors: April L. Ellis, Yiming Ye, Angela Holder, Yun Huang, Michael Kirberger, Jenny Jie Yang, Jin Zou, Wei Yang
  • Biological-based catalyst to delay plant development processes
    Patent number: 8389441
    Abstract: The present invention is directed to methods for delaying a plant development process comprising exposing a plant or plant part to one or more bacteria or enzymes. In specific embodiments, the one or more bacteria are selected from the group consisting of Rhodococcus spp., Pseudomonas chloroaphis, Brevibacterium ketoglutamicum, and a mixture comprising any combination of these bacteria. Apparatuses for delaying a plant development process comprising a catalyst that comprises one or more of the above bacteria.
    Type: Grant
    Filed: April 11, 2011
    Date of Patent: March 5, 2013
    Assignee: Georgia State University Research Foundation, Inc.
    Inventors: George E. Pierce, Sangeeta Ganguly, Gene K. Drago
  • INDUCTION AND STABILIZATION OF ENZYMATIC ACTIVITY IN MICROORGANISMS
    Publication number: 20130035232
    Abstract: Provided herein are methods for inducing and stabilizing an enzyme activity. Optionally, the enzyme is in a microorganism capable of producing the enzyme. In some embodiments, the enzyme can be nitrile hydratase, amidase, or asparaginase I. Provided are compositions comprising enzymes or microorganisms having induced and/or stabilized activity. Also provided are methods of delaying a plant development process by exposing a plant or plant part to the enzymes or microorganisms having induced and/or stabilized activity.
    Type: Application
    Filed: January 24, 2011
    Publication date: February 7, 2013
    Applicant: GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC.
    Inventors: George E. Pierce, Trudy Ann Tucker
  • Contrast agents and methods for preparing contrast agents
    Patent number: 8367040
    Abstract: Contrast agents comprising a scaffold protein having at least one operative integrated metal ion binding site.
    Type: Grant
    Filed: April 20, 2012
    Date of Patent: February 5, 2013
    Assignee: Georgia State University Research Foundation, Inc.
    Inventors: Jenny Jie Yang, Zhi-Ren Liu
  • Synthesis of selenium-derivatized nucleosides, nucleotides, phosphoramidites, triphosphates and nucleic acids
    Patent number: 8354524
    Abstract: The present invention provides selenium derivatives of nucleosides, nucleoside phosphoramidites, nucleotides, nucleotide triphosphates, oligonucleotides, polynucleotides, and larger nucleic acids and methods for their synthesis. Selenium derivatives of both ribonucleic acids and deoxyribonucleic acids, as well as methods for their synthesis, crystallization and uses in structural determinations, particularly by X-ray crystallographic techniques are disclosed. The selenium derivatives of the present invention are also useful as food supplements.
    Type: Grant
    Filed: June 29, 2011
    Date of Patent: January 15, 2013
    Assignee: Georgia State University Research Foundation, Inc.
    Inventor: Zhen Huang
  • Method for stabilizing activity of enzymes or microorganisms producing the enzymes
    Patent number: 8323942
    Abstract: The present invention is directed to methods for inducing desired activity in enzymes or microorganisms capable of producing the enzymes. The invention is further directed to methods of stabilizing activity in microorganisms. In specific embodiments, the invention provides methods for inducing and stabilizing nitrile hydratase activity, amidase activity, and asparaginase I activity. The invention further provides compositions comprising enzymes or microorganisms having induced and/or stabilized activity.
    Type: Grant
    Filed: April 3, 2009
    Date of Patent: December 4, 2012
    Assignee: Georgia State University Research Foundation
    Inventors: George E. Pierce, Gene K. Drago, Sangeeta Ganguly
  • Contrast Agents and Methods for Preparing Contrast Agents
    Publication number: 20120269735
    Abstract: Contrast agents comprising a scaffold protein having at least one operative integrated metal ion binding site.
    Type: Application
    Filed: April 20, 2012
    Publication date: October 25, 2012
    Applicant: GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC.
    Inventors: Jenny J. Yang, Zhi-Ren Liu
  • Photo-Inactivated Viruses and Systems and Methods of Using the Same
    Publication number: 20120270292
    Abstract: The present disclosure relates generally to systems and methods for the photo-inactivation of microorganisms. More specifically, the present invention is directed towards the photo-inactivation of microorganisms, such as viruses, using at least one furanocoumarin and broad spectrum pulsed light. For example, an aspect of the present invention includes a method for inactivating a herpesvirus, such as herpes B virus or herpes virus papio 2 using a psoralen and broad spectrum pulsed light.
    Type: Application
    Filed: December 20, 2010
    Publication date: October 25, 2012
    Applicant: GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION
    Inventors: Julia Hilliard, David Katz
  • TRUSTED QUERY NETWORK SYSTEMS AND METHODS
    Publication number: 20120180106
    Abstract: Systems and methods are disclosed with which queries can be sent to various clients of a trusted query network in a trusted query network message. In one embodiment, each registered client receives the message and determines whether or not it will participate in the query. If so, the client adds to the message in a first data round a true response to the query and obfuscation data, and then forwards the message on to the next client (or back to the client that initiated the query if each client has added its data to the message). In a second round, the message is again sent to each participating client, which this time removes its obfuscation data. Once each client has removed its obfuscation data, a final result is obtained that can be sent to each of the clients.
    Type: Application
    Filed: July 16, 2010
    Publication date: July 12, 2012
    Applicant: GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC.
    Inventors: Richard Baskerville, Art Vandenberg, Daniele Bertolotti, Saravanaraj Duraisamy
  • HIGH PRESSURE CHEMICAL VAPOR DEPOSITION APPARATUSES, METHODS, AND COMPOSITIONS PRODUCED THEREWITH
    Publication number: 20120138952
    Abstract: A composition, reactor apparatus, method, and control system for growing epitaxial layers of group III-nitride alloys. Super-atmospheric pressure is used as a process parameter to control the epitaxial layer growth where the identity of alloy layers differ within a heterostructure stack of two or more layers.
    Type: Application
    Filed: August 12, 2010
    Publication date: June 7, 2012
    Applicant: GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC.
    Inventor: Nikolaus Dietz
  • Substituted pyridines as antiparasitic AZA teraryl compounds
    Patent number: 8188121
    Abstract: Novel aza analogues of dicationic terphenyl compounds for use in combating microbial infections are described. The compounds include those of Formula (III): wherein one of A1, Y1, and Z1 is N; Ar1 is phenylene; and Ar3 is a nitrogen-containing aromatic group.
    Type: Grant
    Filed: June 17, 2011
    Date of Patent: May 29, 2012
    Assignees: The University of North Carolina at Chapel Hill, Georgia State University Research Foundation, Inc.
    Inventors: Richard R. Tidwell, David W. Boykin, W. David Wilson, Reto Brun, Karl Werbovetz, Mohamed A. Ismail, Reem K. Arafa, Laixing Hu
  • COMPOUNDS AND COMPOSITIONS COMPRISING CDK INHIBITORS AND METHODS FOR TREATING CANCER
    Publication number: 20120121692
    Abstract: Disclosed herein are compounds suitable for use as antitumor agents, methods for treating cancer wherein the disclosed compounds are used in making a medicament for the treatment of cancer, methods for treating a tumor comprising, administering to a subject a composition comprising one or more of the disclosed cytotoxic agents, and methods for preparing the disclosed antitumor agents.
    Type: Application
    Filed: May 7, 2010
    Publication date: May 17, 2012
    Applicants: SHANDONG UNIVERSITY, GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION
    Inventors: Wen Fang Xu, Hao Fang, Yan Ling Li, Binghe Wang
  • Contrast agents and methods for preparing contrast agents
    Patent number: 8173105
    Abstract: Contrast agents comprising a scaffold protein having at least one operative integrated metal ion binding site.
    Type: Grant
    Filed: July 13, 2006
    Date of Patent: May 8, 2012
    Assignee: Georgia State University Research Foundation
    Inventors: Jenny J. Yang, Zhi-Ren Liu
  • SYNTHESIS OF SELENIUM-DERIVATIZED NUCLEOSIDES, NUCLEOTIDES, PHOSPHORAMIDITES, TRIPHOSPHATES AND NUCLEIC ACIDS
    Publication number: 20120065387
    Abstract: The present invention provides selenium derivatives of nucleosides, nucleoside phosphoramidites, nucleotides, nucleotide triphosphates, oligonucleotides, polynucleotides, and larger nucleic acids and methods for their synthesis. Selenium derivatives of both ribonucleic acids and deoxyribonucleic acids, as well as methods for their synthesis, crystallization and uses in structural determinations, particularly by X-ray crystallographic techniques are disclosed. The selenium derivatives of the present invention are also useful as food supplements.
    Type: Application
    Filed: June 29, 2011
    Publication date: March 15, 2012
    Applicant: GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC.
    Inventor: Zhen Huang
  • NOSCAPINE AND ANALOGS AND METHODS RELATED THERETO
    Publication number: 20120053199
    Abstract: The invention relates to the innate immune pathway and anti-inflammatory molecules with therapeutic properties. In some embodiments, the invention relates to compounds and pharmaceutical compositions and methods of using the compounds and compositions to treat inflammatory diseases including inflammation associated with auto-immune diseases.
    Type: Application
    Filed: August 24, 2011
    Publication date: March 1, 2012
    Applicants: GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, EMORY UNIVERSITY
    Inventors: Susu Zughaier, Ritu Aneja, David S. Stephens
  • CHARGED-BALANCED IMAGING AGENTS
    Publication number: 20120028291
    Abstract: The present invention relates to compositions for and methods of optically imaging tissues or cells using imaging agents having desirable in vivo properties that result in improved signal-to-background ratio.
    Type: Application
    Filed: February 5, 2010
    Publication date: February 2, 2012
    Applicants: GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC., BETH ISRAEL DEACONESS MEDICAL CENTER, INC.
    Inventors: John V. Frangioni, Maged M. Henary