Abstract: Compositions and methods for treating or inactivating viruses in a subject in need thereof are provided herein. Exemplary compositions include nucleic acids encoding an RNA-guided endonuclease and a guide RNA that is complementary to a target sequence in a virus. The RNA-guided endonuclease specifically targets viral nucleic acid sequences for destruction and suppression of that virus in a host cell in vitro or in vivo.

Abstract: Disclosed herein is a method of accessing a cache, the method comprising: mapping respective physical line addresses (PLAs) of a plurality of PLAs to respective cache locations of a plurality of cache locations in a cache, each PLA of the plurality of PLAs having an associated memory line; encrypting, with a block cipher using a first key, a first PLA of the plurality of PLAs to provide a first encrypted line address (ELA), the first ELA having an associated first encrypted cache location; upon receiving a request to access a first memory line associated with the first PLA, encrypting, using the first key, the first PLA into the first ELA to determine the associated first encrypted cache location; and accessing the first encrypted cache location. Also disclosed herein are systems for implementing the same.

Abstract: Certain examples of the present disclosure relate to systems and methods for controlling a vehicle. In particular, the present disclosure provides systems and methods for moving an aerial vehicle by decoupling the pitch- and roll-movement from thrust production. This decoupling can occur by shifting the center of gravity of the vehicle to create a moment about a desired axis. Some examples describe single-shaft rotary vehicles, while other examples describe coaxial rotary vehicles. The vehicles described herein may include a first mass moveable from a first position to a second position to create at least one of a rolling moment or a pitching moment to alter the direction of movement of the vehicle. A second mass may also be provided to alter the rolling moment or pitching moment. Methods for controlling the vehicles are also provided herein.

Abstract: Disclosed herein are systems and methods for identifying and mitigating Flush-based cache attacks. The systems and methods can include adding a zombie bit to a cache line. The zombie bit can be used to track the status of cache hits and misses to the flushed line. A line that is invalidated due to a Flush-Caused Invalidation can be marked as a zombie line by marking the zombie bit as valid. If another hit, or access request, is made to the cache line, data retrieved from memory can be analyzed to determine if the hit is benign or is a potential attack. If the retrieved data is the same as the cache data, then the line can be marked as a valid zombie line. Any subsequent hit to the valid zombie line can be marked as a potential attack. Hardware- and software-based mitigation protocols are also described.

Abstract: Core-shell nanostructures with platinum overlayers conformally coating palladium nano-substrate cores and facile solution-based methods for the preparation of such core-shell nanostructures are described herein. The obtained Pd@Pt core-shell nanocatalysts showed enhanced specific and mass activities towards oxygen reduction, compared to a commercial Pt/C catalyst.

Abstract: A space-based communications network (100) includes at least one central ground station (116) having a transceiver that is configured to communicate with satellites, such as cube satellites (110). The cube satellites (110) form an ad hoc network of orbital cube satellites, in which each of the cube satellites (110) communicate with each other. One of the cube satellites communicates with the ground station (116). A ground-based control system (1000) communicates with the central ground station (116). The control system (1000) continuously determines a configuration of the ad hoc network (100) and communicates network control information for the cube satellites (110) to maintain communications in the ad hoc network (100). The cube satellites (110) disseminate the network control to each other via the ad hoc network (100).

Abstract: A radiation detector (100) includes an insulating substrate (110), which includes a material that undergoes a change in an electrical property when subjected to ionizing radiation. A conductive film (112) is disposed in relation to a surface of the substrate. The conductive film (112) has a resistance that is a function of a state of the electrical property. A resistance measuring device measures resistance across the conductive film (112). The resistance measured by the resistance measuring device indicates an amount of ionizing radiation to which the substrate (110) has been subjected. In a method of determining exposure to a type of radiation, a boron nitride substrate is exposed to a radiation environment. A resistance is measured across a conductive film disposed in relation to the boron nitride substrate. Radiation exposure is calculated as a function of the resistance.

Abstract: The present disclosure relates to a photovoltaic (PV) device that includes a first junction constructed with a first alloy and having a bandgap between about 1.0 eV and about 1.5 eV, and a second junction constructed with a second alloy and having a bandgap between about 0.9 eV and about 1.3 eV, where the first alloy includes III-V elements, the second alloy includes III-V elements, and the PV device is configured to operate in a thermophotovoltaic system having an operating temperature between about 1500° C. and about 3000° C.

Abstract: A carbon molecular sieve (CMS) membrane having improved separation characteristics for separating olefins from their corresponding paraffins is comprised of carbon with at most trace amounts of sulfur and a group 13 metal. The CMS membrane may be made by pyrolyzing a precursor polymer devoid of sulfur in which the precursor polymer has had a group 13 metal incorporated into it, wherein the metal is in a reduced state. The pyrolyzing for the precursor having the group 13 metal incorporated into it is performed in a nonoxidizing atmosphere and at a heating rate and temperature such that the metal in a reduced state (e.g., covalently bonded to carbon or nitrogen or in the metal state).

Abstract: In a method of making a carbon fiber, PAN (poly(acrylonitrile-co methacrylic acid)) is dissolved into a solvent to form a PAN solution. The PAN solution is extruded through a spinneret, thereby generating at least one precursor fiber. The precursor fiber is passed through a cold gelation medium, thereby causing the precursor fiber to gel. The precursor fiber is drawn to a predetermined draw ratio. The precursor fiber is continuously stabilized to form a stabilized fiber. The stabilized fiber is continuously carbonized thereby generating the carbon fiber. The carbon fiber is wound onto a spool. A carbon fiber has a fiber tensile strength in a range of 5.5 GPa to 5.83 GPa. The carbon fiber has a fiber tensile modulus in a range of 350 GPa to 375 GPa. The carbon fiber also has an effective diameter in a range of 5.1 ?m to 5.2 ?m.

Abstract: Embodiments of the present disclosure relate generally to acoustically decoupled microelectromechanical system devices and, more particularly, to acoustically decoupled microelectromechanical system devices anchored upon phononic crystals. In some embodiments described herein, a device may comprise a resonator, a handle layer, and a pedestal disposed between the resonator and the handle layer, the pedestal connecting the resonator to the handle layer. In the devices described herein, the resonator and the handle layer may be non-coplanar. In some embodiments, the handle layer comprises a phononic crystal to acoustically decouple the resonator from the substrate of the handle layer.

Abstract: An ion trap (100) includes a first electrode pair (110) and a second electrode pair (130), each including a first conductive member (112) and a second conductive member (120) and facing each other so that the first conductive member (112) of the first electrode pair (110) is on a common plane with the second conductive member (120) of the second electrode pair (130) and so that the second conductive member (120) of the first electrode pair (110) is on a common plane with the first conductive member (112) of the second electrode pair (130), a gap (132) therebetween. A signal generator (210) generates a periodic signal (212) applied to the first conductive members (112). A phase shifter (216) generates a second periodic signal (218) that is 180 out of phase therewith applied to the second conductive members (120). Ions are trapped by a resulting electric field.

Abstract: Mesofluidic devices for culturing cell aggregates and methods of using the same are disclosed. An exemplary mesofluidic device comprises at least one fluid inlet, at least one fluid outlet, a plurality of fluid channels, and a plurality of culture chambers. Each culture chamber can comprise at least one chamber inlet and at least one chamber outlet. The at least one chamber inlet can be in fluid communication with the at least one fluid inlet via at least one of the plurality of fluid channels. The at least one chamber outlet can be in fluid communication with the at least one fluid outlet via at least one of the plurality of fluid channels. The mesofluidic device can be configured to contain a cell aggregate in each of the plurality of culture chambers.

Abstract: A method including receiving sound data captured by a wearable device of the user, the sound data indicative of contact between a first portion of the user wearing the wearable device and a second portion of the user wearing the wearable device; receiving motion data captured by the wearable device of the user, the motion data indicative of at least a movement of the first portion of the user wearing the wearable device; and determining, by a processor, based at least in part on the sound data and the motion data, a user input associated with the contact between a first portion of the user wearing the wearable device and a second portion of the user wearing the wearable device and the movement of the first portion of the user wearing the wearable device.

Abstract: The various embodiments of the disclosure relate generally to processes, methods, and systems for generating functional B cells ex vivo. It is particularly useful for ex vivo generation of antigen-specific germinal-center (GC) like B cells that are capable of efficient B cell expansion, immunoglobulin (Ig) class switching/class switching recombination (CSR), expression of germinal B cell phenotypes, antibody secretion, and somatic hypermutation (SHM) and resulting affinity maturation center phenotypes.

Abstract: An exemplary embodiment of the present invention provides a planar inductor including a substrate, a first magnetic layer, a conductive coil, and a second magnetic layer. The first magnetic layer can be disposed on at least a portion of the substrate. The conductive coil can be disposed on a first portion of the first magnetic layer. The second magnetic layer can be disposed on a second portion of the first magnetic layer and on at least a portion of the conductive coil.

Abstract: Disclosed herein are systems and methods for characterizing poroelastic materials. Indentation of a poroelastic solid by a spherical-tip tool is analyzed within the framework of Biot's theory. The present disclosure provides the response of the indentation force as well as the field variables as functions of time when the rigid indenter is loaded instantaneously to a fixed depth. Some embodiments of the present disclosure consider the particular case when the surface of the semi-infinite domain is permeable and under a drained condition. Compressibility of both the fluid and solid phases is taken into account. The solution procedure based on the McNamee-Gibson displacement function method is adopted.

Abstract: A deep neural network (DNN) can be trained based on a first training dataset that includes first images including annotated first objects. The DNN can be tested based on the first training dataset to determine first object predictions including first uncertainties. The DNN can be tested by inputting a second training dataset and outputting first object predictions including second uncertainties, wherein the second training dataset includes second images including unannotated second objects. A subset of images included in the second training dataset can be selected based on the second uncertainties, The second objects in the selected subset of images included in the second training dataset can be annotated. The DNN can be trained based on the selected subset of images included in the second training dataset including the annotated second objects.

Abstract: This disclosure relates to microcapsule particles for targeted delivery of drugs. In certain embodiments, the particles comprise polyelectrolyte polymers, e.g., layers of anionic polymers and cationic polymers. In certain embodiments, the particles have a fibrinogen coating. In certain embodiments, the particles contain a polysaccharide core and/or a polysaccharide coating encapsulating drugs, proteins, clotting agents, coagulation factors, or anticoagulants. In certain embodiments, this disclosure contemplates methods of using particles disclosed herein to prevent or reduce onset of or duration of bleeding. In certain embodiments, this disclosure contemplates methods of using particles disclosed herein to prevent or reduce onset of blood clotting.

Abstract: Separable microneedle arrays and microneedle patches are provided that may achieve sustained release of drug. The microneedle arrays may include one or more features that facilitate separation of the microneedles, such as a bubble structure. The microneedle arrays may include an effervescent material.