Abstract: A microneedle array is provided for administrating a drug or other substance into a biological tissue. The array includes a base substrate; a primary funnel portion extending from one side of the base substrate; and two or more solid microneedles extending from the primary funnel portion, wherein the two or more microneedles comprise the substance of interest. Methods for making an array of microneedles are also provided. The method may include providing a non-porous and gas-permeable mold having a two or more cavities each of which defines a microneedle; filling the cavities with a fluid material which includes a substance of interest and a liquid vehicle; drying the fluid material to remove at least a portion of the liquid vehicle and form a plurality of microneedles that include the substance of interest, wherein the filling is conducted with a pressure differential applied between opposed surfaces of the mold.

Abstract: Compositions that selectively bind to coronaviruses, including but not limited to SARS-COV-2 and methods of use thereof are provided. The disclosed antibodies and antigen-binding fragments were developed against SARS-CoV-2. The antibodies bind to the spike protein of coronaviruses. The disclosed antibodies are useful for diagnosing, detecting, preventing, and treating coronavirus infections.

Abstract: Described herein are improved composite anodes and lithium-ion batteries made therefrom. Further described are methods of making and using the improved anodes and batteries. In general, the anodes include a porous composite having a plurality of agglomerated nanocomposites. At least one of the plurality of agglomerated nanocomposites is formed from a dendritic particle, which is a three-dimensional, randomly-ordered assembly of nanoparticles of an electrically conducting material and a plurality of discrete non-porous nanoparticles of a non-carbon Group 4A element or mixture thereof disposed on a surface of the dendritic particle. At least one nanocomposite of the plurality of agglomerated nanocomposites has at least a portion of its dendritic particle in electrical communication with at least a portion of a dendritic particle of an adjacent nanocomposite in the plurality of agglomerated nanocomposites.

Abstract: The present invention features methods and composition directed to treating neuronal injury, CNS lesion, and/or promoting axon regeneration using a phosphine sulfide-stabilized phosphine.

Abstract: Compositions and methods are described for a polymer hydrogel created by a cycloaddition reaction between an azide and an alkyne that proceeds rapidly without catalyst to produce the polymer hydrogel in less than ninety seconds. The polymer hydrogel can be used in in vivo applications for the localized delivery of therapeutic agent in aqueous solutions. An example of therapeutic delivery of a protein in a mouse model is demonstrated.

Abstract: In an embodiment, an alloy is exposed to a hydrophilic solvent at least until at least one Group I or Group II element is substantially removed so as to produce a nanomaterial that substantially includes a metal, semimetal or non-metal material and that exhibits a desired set of microstructure characteristics. The hydrophilic solvent is configured to be reactive with respect to the at least one Group I or Group II element and substantially unreactive with respect to the metal, semimetal or non-metal material. In another embodiment, an active material is infiltrated into pores of a nanoporous metal or metal oxide, after which the infiltrated nanoporous metal or metal oxide material is annealed to produce an active material-based nanocomposite material. A protective coating layer is deposited on at least part of a surface of the active material-based nanocomposite material.

Abstract: Methods of generating spinal cord glutamatergic interneurons (V2a interneurons) from human pluripotent stem cells (hPSCs) are provided. A method of the present disclosure may include culturing a first population of hPSCs in vitro in a neural induction medium that includes: a retinoic acid signaling pathway activator; a sonic hedgehog (Shh) signaling pathway activator; and a Notch signaling pathway inhibitor, wherein the culturing results in generation of a second population of cultured cells containing CHX10+ V2a interneurons. Also provided are non-human animal models that include the hPSC-derived spinal cord glutamatergic interneurons, and methods of producing the non-human animal models.

Abstract: Review systems and methods facilitate active reading by providing a flexible environment in which users can examine documents. A review system can comprise a virtual workspace, a document view region, a preview region, and optional document objects. The virtual workspace can simulate a desktop or other physical workspace. The document view region can display a portion of an open document at a magnification sufficient for reading. The preview region can display the document at a magnification sufficient to enable the general layout of the entire document to be determined. The document objects can be created from the document through tools of the review system. These document objects can be independently moveable throughout the virtual workspace as needed to facilitate the user's active reading process.

Abstract: A computational framework for designing a constellation that includes a plurality of cube satellites (CubeSats) includes an orbit propagation module, a coverage estimation module, a connectivity estimation module and an annealing module. The orbit propagation module receives a plurality of static parameters for the constellation and determines a position vector, a ground track and sub-satellite points for each of the plurality of CubeSats. The coverage estimation module receives the plurality of static parameters for the constellation and estimates Earth coverage for the constellation. The connectivity estimation module receives the plurality of static parameters for the constellation and determines active inter-satellite links (ISL) in the constellation. The annealing module receives input from the orbit propagation module, the coverage estimation module and the connectivity module and employs an annealing algorithm that generates a constellation design.

Abstract: Disclosed herein is a composite electrode comprising a charge-conducting material, a charge-providing material bound to the charge-conducting material, and a plurality of single-walled carbon nanotubes bound to a surface of the charge-providing material. High-capacity electroactive materials that assure high performance are a prerequisite for ubiquitous adoption of technologies that require high energy/power density lithium (Li)-ion batteries, such as smart Internet of Things (IoT) devices and electric vehicles (EVs). Improved electrode performance and lifetimes are desirable. The disclosed electrode can have a Coulombic efficiency of 99% or greater, and a stable capacity retention after 100 cycles or more. Also disclosed herein are methods of making a composite electrode.

Abstract: Disclosed herein are acoustic transmission systems comprising an acoustic wave generator configured to generate an acoustic wave and propagate the acoustic wave through a tissue of a specimen, and a non-Hermitian complementary metamaterial (NHCMM) configured to add a first amount of energy amplification coherently to the acoustic wave to account for energy loss in the acoustic wave as a result of the wave propagating through the tissue of the specimen. The acoustic wave generator can be an ultrasound generator, and the tissue can be a cranium.

Abstract: Systems and methods for time-shifted prefetching of predicted content for wireless users. Prefetching video data can include retrieving video data and feature data and generating a video candidate set including selected videos of the related video data. The method can further include determining predicted videos using a machine learning algorithm. The predicted videos can be videos of the video candidate set that are likely to be viewed by a user at a future time. The method can further include prefetching the predicted videos by downloading the predicted videos.

Abstract: Disclosed herein are hybrid membranes comprising: a microporous polymer, the microporous polymer comprising a continuous polymer phase permeated by a continuous pore phase; and an atomic scale inorganic material dispersed throughout the microporous polymer within the continuous pore phase. Methods of making and use of the hybrid membranes are also disclosed.

Abstract: Small form-factor MEMS devices and methods of using the devices are disclosed. An exemplary MEMS device includes an accelerometer contact microphone. Certain devices described herein comprise nanometer scale sensing gaps in the out-of-plane direction to increase vibration sensitivity in a vacuum casing. Certain devices described herein provide a differential sensing mechanism. The disclosure also describes accelerometer contact microphones having an operational bandwidth ranging from 0 Hz and 10,000 Hz. The vibration acceleration sensitivity of certain devices described herein is better 100 ?g?Hz.

Abstract: A hybrid scaling and patterning apparatus for producing thin films with multi-material, customized patterns is disclosed. The apparatus includes a slot die body integrated with multiple inlets and corresponding converging channels passing materials through the die body in a planar, continuous laminar flow. The hybrid scaling and patterning apparatus may be used in a method of preparing multi-material, patterned thin film materials.

Abstract: The invention is an improved method of making an improved carbon molecular sieve (CMS) membrane in which a precursor polymer (e.g., polyimide) is pyrolyzed at a pyrolysis temperature to form a CMS membrane that is cooled to ambient temperature (about 40° C. or 30° C. to about 20° C.). The CMS membrane is then reheated to a reheating temperature of at least 250° C. to 400° C. to form the improved CMS membrane. The CMS have a novel microstructure as determined by Raman spectroscopy. The improved CMS membranes have shown an improved combination of selectivity and permeance as well as stability for separating light hydrocarbon gas molecules such as C1 to C6 hydrocarbon gases (e.g., methane, ethane, propane, ethylene, propylene, butane, butylene).

Abstract: A system, apparatus, and/or method of determining a health condition of an animal is provided. First data may be received from a first sensor device. The first data may be indicative of an animal event of an animal. Second data may be received from a second sensor device. The second sensor may be separate and/or distinct from the first sensor device. The second data may confirm an occurrence of the animal event. The animal event may be a discharge event and/or a feeding event. The occurrence of the animal event may be identified based on the first data and the second data. The occurrence of the animal event may be displayed via a display device. A health condition of the animal may be determined based on the animal event. The determination of the health condition may be based on a quantity and/or a duration of the animal event.

Abstract: A battery electrode composition is provided that comprises a composite material comprising one or more nanocomposites. The nanocomposites may each comprise a planar substrate backbone having a curved geometrical structure, and an active material forming a continuous or substantially continuous film at least partially encasing the substrate backbone. To form an electrode from the electrode composition, a plurality of electrically-interconnected nanocomposites of this type may be aggregated into one or more three-dimensional agglomerations, such as substantially spherical or ellipsoidal granules.

Abstract: A microchannel for processing cells by compression of the cells including an inlet, ridges and an outlet. Each ridge including a compressive surface and a cell adhesion entity. The outlet configured to remove at least one of a first portion of the cells and a second portion of the cells from the microchannel. Each ridge oriented at an angle of from 25 degrees to 70 degrees relative to a center axis of the microchannel. The cell adhesion entity configured such that the first portion of the cells has a first adhesion property relative to the cell adhesion entity to follow a first trajectory through the microchannel. The cell adhesion entity further configured such that the second portion of the cells has a second adhesion property relative to the cell adhesion entity to follow a second trajectory through the microchannel. The first trajectory is different from the second trajectory.

Abstract: An apparatus including a first member including a first electrode, a second member coupled to the first member about an axis, including a second electrode, and a surface layer between the first electrode and the second electrode, the second member is rotatable with respect to the axis by an energy flow to change triboelectric charges on the electrodes, and to affect a flow of electrons between the electrodes. A self-powered sensor for detecting a chemical including a generator having an electrode, and a superhydrophobic surface layer for receiving an energy flow carrying triboelectric charges, the surface layer includes a TiO2 layer with nanostructures, and a power indicator indicative of whether the chemical is present based on power output of the triboelectric generator, the energy flow is a solution flow, the solution comprising the chemical and water, and the chemical removes at least one triboelectric charge from the water.