Abstract: The present disclosure provides a method of producing uniformly sized organoids/multicellular spheroids using a microfluidic device having an array of microwells. The method involves several successive steps. First, a microfluidic device containing parallel rows of microwells that are connected with a supplying channel is filled with a wetting agent. The wetting agent is a liquid that is immiscible in water. For example, the wetting agent may be an organic liquid such as oil. In the next step, the agent in the supplying channel and the microwells is replaced with a suspension of cells in an aqueous solution that contains a precursor for a hydrogel. Next, the aqueous phase in the supplying channel is replaced with the agent, which leads to the formation of an array of droplets of cell suspension in the hydrogel precursor solution, which were compartmentalized in the wells. The droplets are then transformed into cell-laden hydrogels.

Abstract: Fully homomorphic encryption integrated circuit (IC) chips, systems and associated methods are disclosed. In one embodiment, a method of operation for a number theoretic transform (NTT) butterfly circuit is disclosed. The (NTT) butterfly circuit includes a high input word path cross-coupled with a low word path. The high input word path includes a first adder/subtractor, and a first multiplier. The low input word path includes a second adder/subtractor, and a second multiplier. The method includes selectively bypassing the second adder/subtractor and the second multiplier, and reconfiguring the low and high input word paths into different logic processing units in response to different mode control signals.

Abstract: A new class of mass-tag polymers is provided, which include enriched metal isotopes such as zirconium and hafnium mass tags. The chemistry of these new mass tags are different from that of lanthanide mass tags, and opens up new mass channels that can be used in mass cytometry. These polymers may be used for mass cytometry, therapeutic delivery of a radioactive isotope, or screening of a therapeutic isotope. Aspects include a kit, method of making, and method of using a polymer, isotopic composition, or both. A kit may include a polymer. The polymer may include pendant groups that chelate an enriched isotope, such as zirconium and/or hafnium. The kit may include an isotopic composition comprising an enriched zirconium or hafnium isotope. Polymers may be conjugated to a biologically active material. Aspects may also include making a kit. Aspects include use of a kit, such as for mass cytometry.

Abstract: The present disclosure provides electrical architecture for electrochemical impedance spectroscopy (EIS). An EIS circuit comprises at least two current regulators and an electrical energy storage device, which are connected with one or more electrochemical cells in a configuration that decouples power flowing into the respective current regulators. The presence of the electrical energy storage device enables each regulator to operate simultaneously at lower power levels while inducing the desired EIS perturbation current. Operation at low power allows lower volume and cost for the same current compared to only dissipative or non-dissipative current regulators. Further, the electrical energy storage device allows the power flowing through the current regulators to be varied independently in order to achieve the desired EIS perturbation current while a minimum amount of heat is generated in the circuit, thus allowing the circuit to occupy minimal size and incur minimal cost.

Abstract: Disclosed are crosslinked particles (e.g., microparticles) that are capable of storing and releasing drugs. The particles can be macroparticles, microparticles, or nanoparticles and can be composed of polyester backbones. The particles can be loaded with a drug. The particles can degrade in vivo to release the drug. The particles can be prepared by crosslinking functionalized polyester backbones and loaded with a given drug. The particles of the present disclosure can be injected with a syringe. In some embodiments, the particles of the present disclosure are administered in connection with a surgery and release the drug after the site of the surgery for a period of 1-6 months.

Abstract: A fortified salt mixture includes sodium chloride salt grains and a multi-supplement food-additive admixed with the sodium chloride salt grains. The multi-supplement food additive includes particles, and each particle includes a core having a first supplement and a binder, a coating on the core, and a second supplement in the core and/or in the coating. A method for fortifying salt ncludes combining a first supplement, a second supplement, a binder and a coating to yield a multi-supplement food-additive; and admixing the multi-supplement food-additive with sodium chloride salt grains.

Abstract: Energy-efficient epipolar imaging is applied to the ToF domain to significantly expand the versatility of ToF sensors. The described system exhibits 15+ m range outdoors in bright sunlight; robustness to global transport effects such as specular and diffuse inter-reflections; interference-free 3D imaging in the presence of many ToF sensors, even when they are all operating at the same optical wavelength and modulation frequency; and blur- and distortion-free 3D video in the presence of severe camera shake. The described embodiments are broadly applicable in consumer and robotics domains.

Abstract: The present application pertains to methods of using indole-oxadiazole compounds of Formula I to modulate cannabinoid receptor activity: I In particular diseases, disorders or conditions that benefit from modulating cannabinoid receptor activity, such as non-alcoholic steatohepatitis (NASH), non-alcoholic fatty liver disease (NAFLD), schizophrenia, bipolar disorder, psychosis, metabolic syndrome, type-2 diabetes, dyslipidaemia, obesity, eating disorders, cardiovascular diseases and disorders, and other conditions as described herein, may be treated. Also included in the present application are certain novel compounds of Formula Ia and pharmaceutical compositions comprising these compounds.

Abstract: There is provided a system, method, and computer program for digital enhancement of hippocampal replay. In an embodiment, the method includes: creating one or more digital memories, each digital memory created by: receiving a tag associated with the digital memory from a user; receiving a captured digital memory from the user; and associating one or more additional attributes with the digital memory; creating a replay session, the replay session comprising one or more digital memories, by: associating a target digital memory with the replay session; and associating one or more other digital memories with the replay session if such one or more other digital memories meet a measure of commonality with the target digital memory, the measure of commonality at least based on the additional attributes; and displaying the replay session to the user within a predetermined period.

Abstract: A system and method for detecting interactions between a first protein or fragment thereof (bait protein) and a second protein or fragment thereof (prey protein) comprising: (a) a bait construct comprising the bait protein, a first epitope tag and an intein N-terminal fragment (IN); and (b) a prey construct comprising the prey protein, a second epitope tag, and an intein C-terminal fragment (IC).

Abstract: The invention relates to a catalyst system for catalyzing conversion of carbon dioxide into multi-carbon compounds comprising a boron-doped copper catalytic material and associated methods.

Abstract: Described herein are systems and methods for detecting a target analyte in a sample with electrodes, comprising a linker and an antibody attached to the linker, and measuring an electrocatalytic signal changes generated by binding of an analyte in the sample to the antibody. Also disclosed herein are kits for electrochemical detection of protein analytes.

Abstract: The present application relates to the treatment of nematode infections.

Abstract: There is provided a system and method for optimizing depth imaging. The method including: illuminating one or more scenes with illumination patterns; capturing one or more images of each of the scenes; reconstructing the scenes; estimating the reconstruction error and a gradient of the reconstruction error; iteratively performing until the reconstruction error reaches a predetermined error condition: determining a current set of control vectors and current set of reconstruction parameters; illuminating the one or more scenes with the illumination patterns governed by the current set of control vectors; capturing one or more images of each of the scenes while the scene is being illuminated with at least one of the illumination patterns; reconstructing the scenes from the one or more captured images using the current reconstruction parameters; and estimating an updated reconstruction error and gradient; and outputting at least one of control vectors and reconstruction parameters.

Abstract: The present disclosure provides systems, methods, and computer-readable media for managing graphics processing unit (GPU) allocation for a virtual machine (VM). A first GPU driver, associated with a first GPU, is offloaded from an operating system (OS) of the VM. Then, the first GPU is deallocated from the VM. A second GPU is allocated to the VM, and a second GPU driver, associated with the second GPU, is loaded in the OS of the VM. To restore a GPU context from the first GPU within the second GPU, a GPU command log from the first GPU is replayed to the second GPU.

Abstract: Herein is described the design and synthesis of resorcylate aminopyrazole compounds. These compounds show broad, potent and fungal-selective Hsp90 inhibitory activity. These compounds also find use in treating Hsp90 related diseases.

Abstract: A semiconductor nanocrystal particle represented by Chemical Formula 1 and having a full width at half maximum (FWHM) of less than or equal to about 30 nanometers (nm) in the emission wavelength spectrum is provided: AxA?(3+??x)D(2+?)E(9+?).??Chemical Formula 1 In Chemical Formula 1, A is a first metal including Rb, Cs, or a combination thereof, A? is an organic substance derived from an ammonium salt, an organic material derived from an organic ligand, or an organic material including a combination thereof, D is a second metal including Sb, Bi, or a combination thereof E is Cl, Br, I, or a combination thereof, 1<x?3, ?1<?<1, 3+??x>0, ?1<?<1, and ?1<?<1.

Abstract: There is provide herein a compound of Formula (1): wherein R1, R2, R3, R4, and R5 are each independently H or an organic group.

Abstract: Disclosed herein are perovskite based optoelectronic devices made entirely via solution-processing at low temperatures (<150° C.) which provide for simple manufacturing, compatibility with flexible substrates, and perovskite-based tandem devices. These perovskite based optoelectronic devices are produced using an electron transport layer on which the perovskite layer is formed which is passivated using a ligand selected to reduce electron-hole recombination at the interface between the electron transport layer and the perovskite layer.

Abstract: A miR-1983 inhibitor comprising an anti-miR-1983 oligonucleotide that is complementary to at least part of CTCACCTGGAGCATGTTTTCT (SEQ ID NO: 1), the part comprising at least nucleotides 2 to 8 of CTCACCTGGAGCATGTTTTCT (SEQ ID NO: 1).