Patents Assigned to THE GOVERNMENT OF UNITED STATES, REPRESENTED BY THE SECRETARY OF THE
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Patent number: 11618922Abstract: Diagnostic biomarkers for diagnosing immune suppression/dysfunction. The diagnostic biomarkers are genes and/or transcripts that are up or down regulated compared to normal expression when a subject has been stressed either mentally and/or physically. The invention also relates to a method of detecting comprised or suppressed immune response in a subject by comparing certain diagnostic biomarkers in the subject to a control set of diagnostic biomarkers.Type: GrantFiled: October 20, 2014Date of Patent: April 4, 2023Assignee: The Government of the United States, as Represented by the Secretary of the ArmyInventors: Seid Muhie, Marti Jett, Rasha Hammamieh
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Patent number: 11602592Abstract: Systems and methods for Endovascular Perfusion Augmentation for Critical Care (EPACC) are provided. The system may include a catheter having an expandable aortic blood flow regulation device disposed on the distal end of the catheter for placement within an aorta of a patient. The system may also include a catheter controller unit that causes the expandable aortic blood flow regulation device to expand and contract to restrict blood flow through the aorta.Type: GrantFiled: July 10, 2019Date of Patent: March 14, 2023Assignees: The Regents of the University of California, Government Of The United States As Represented By The Secretary Of The Air ForceInventors: Michael Austin Johnson, Lucas Paul Neff, Timothy Williams
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Publication number: 20230070932Abstract: A semiconductor structure configured to implement an optically controlled field effect transistor (FET). In one embodiment, a normally-off, optically controlled FET is realized as a semiconductor structure comprising various regions configured to implement a voltage controlled, normally on, high voltage FET region having integrated thereon a photoconductive region configured to reduce a gate-to-source voltage of the FET in response to light incident upon the photoconductive region so as to turn the FET on.Type: ApplicationFiled: September 9, 2022Publication date: March 9, 2023Applicant: Government of the United States as Represented by the Secretary of the Air ForceInventor: Joseph Neil Merrett
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Patent number: 11596411Abstract: Systems and methods for partial aortic occlusion are provided. The system may include a catheter having an expandable aortic blood flow regulation device disposed on the distal end of the catheter for placement within an aorta of a patient, and a catheter controller unit that causes the device to expand and contract to restrict blood flow through the aorta. The system also may include sensors for measuring blood pressure distal and proximal to the expandable device.Type: GrantFiled: October 18, 2019Date of Patent: March 7, 2023Assignees: The Regents of the University of California, Government of the United States as Represented by the Secretary of the Air ForceInventors: Michael Austin Johnson, Timothy K. Williams, Lucas Paul Neff
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Publication number: 20230060414Abstract: A system for distributed dual-function radar-communication comprises a plurality of dual-function radar transmitters positioned within a region of interest, each configured to transmit at least one radar waveform, with each transmitter for having a minimum transmit power, a maximum transmit power, and a working transmit power, a plurality of radar receivers positioned within the region of interest, each configured to receive the radar waveforms, at least one controller communicatively connected to at least one connected transmitter of the plurality of dual-function radar transmitters, configured to calculate a vector of transmit power values for the plurality of dual-function radar transmitters. A method of transmitting a radar waveform is also disclosed.Type: ApplicationFiled: April 21, 2020Publication date: March 2, 2023Applicant: Government of the United States, as represented by the Secretary of the Air ForceInventors: Ammar Ahmed, Yimin Daniel Zhang, Braham Himed
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Publication number: 20230069784Abstract: An apparatus for mounting and securing medical/surgical devices may be attached to a litter 40. The medical/surgical devices may include, for example, IV holders 186, aspirators 144, cardiac monitors 148, defibrillators 150, infusion pumps 152, ventilators 146 and other devices. The apparatus frame assembly 10 includes rails 12, 14, 16, 18, 20, 46, 48, 50, 52 having cross-sections of standard surgical rails, for attachment of slidable rail clamps 84, 104. Medical device mounts 108, 110, 112 are attached to the slidable rail clamps. The medical device mounts have height and/or rotational adjustment to improve patient access and view. The apparatus may be mounted longitudinally anywhere along the litter to maximize access to the patient.Type: ApplicationFiled: March 3, 2021Publication date: March 2, 2023Applicant: THE GOVERNMENT OF THE UNITED STATES, AS REPRESENTED BY THE SECRETARY OF THE ARMYInventors: Mark Brown, Scott Walters, Mark Easterday, Jay Bartlett, Jaime Lee
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Patent number: 11583578Abstract: The invention relates to pharmaceutical compositions comprising at least one antigen and an adjuvant composition, where the adjuvant composition comprises a saponin and a liposome. The liposome of the composition comprises monophosphoryl lipid A (MPLA), cholesterol and a phospholipid that is in a liquid crystalline state at greater than or equal to 23° C., and the concentration of cholesterol to lipid in the liposome is greater than 50% (mol/mol). The antigen in the composition is a soluble Plasmodium falciparum recombinant circumsporozoite protein (rCSP) comprising the amino acid sequence of SEQ ID NO:1, or a P. falciparum rCSP peptide that is at least 95% identical to the amino acid sequence of SEQ ID NO:1.Type: GrantFiled: April 27, 2018Date of Patent: February 21, 2023Assignees: The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., The Government Of The United States, As Represented By The Secretary Of The ArmyInventors: Sheetij Dutta, Zoltan Beck, Carl Alving, Gary Matyas
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Publication number: 20230046545Abstract: A method for determining the likelihood that a pixel in a video image sequence represents true motion in the image. Light from a scene is captured to yield an original image having a sequence of frames. A prototype image is created from the original image as a geometrically accurate representation of the scene which is substantially free of contamination. A tilt variance-Gaussian mixture model and/or multi-variate Gaussian model, based upon optical turbulence statistics associated with the scene, is developed. Each pixel in the original image sequence of frames is evaluated against the prototype image using a probability density function, to yield a likelihood that the respective pixel represents true motion.Type: ApplicationFiled: July 9, 2022Publication date: February 16, 2023Applicant: Government of the United States as represented by the Secretary of the Air ForceInventors: Richard Van Hook, Russell Hardie
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Patent number: 11575585Abstract: A communication system provides multimedia communications within and between armored ground combat vehicles (GCVs). The system includes client computers within the armored GCVs providing distributed and interconnected multimedia communications among the client computers. The multimedia communication may include a one-to-one communication, a text communication to a group, an audio communication to a group, or a video communication to a group. Logic providing the distributed and interconnected multimedia communications is not located at a single client computer. The client computers display graphical user interfaces (GUIs) enabling soldiers to select parameters of the communication system with some GUIs providing presence discovery among the armored GCVs. One of the plurality of client computers acts as an origination station and other client computers may be configured as receiving communication station(s).Type: GrantFiled: September 25, 2019Date of Patent: February 7, 2023Assignee: Government of the United States, as represented by the Secretary of the ArmyInventors: Olatunde O. Bamgboye, Eric Bennett
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Publication number: 20230019900Abstract: The present disclosure describes methods and systems for predicting if a subject has an increased risk of having or developing venous thromboembolism, including prior to the detection of symptoms thereof and/or prior to onset of any detectable symptoms thereof. The present disclosure also describes a method of generating a model for predicting venous thromboembolism.Type: ApplicationFiled: December 3, 2020Publication date: January 19, 2023Applicants: Henry M. Jackson Foundation for the Advancement of Military Medicine, The Government of the United States, as represented by the Secretary of the Army, The United States of America, as Represented by the Secretary of the NavyInventors: Matthew J. Bradley, Eric A Elster, Vivek Khatri, John S Oh, Seth A Schobel
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Patent number: 11555894Abstract: The present disclosure relates to an adaptive, free-space optical system. The system may have a controller and a digital micromirror (DMM) array responsive to the controller. The digital micromirror may include a plurality of independently controllable micromirror elements forming a receiver for receiving optical signals from an environmental scene. At least two of the plurality of independently controllable micromirror elements are steerable in different directions to receive optical signals emanating from two or more locations within the environmental scene. A beam steering subsystem forms a portion of the micromirror array and is in communication with the controller for receiving control signals from the controller. A detector is used to receive an incoming free space optical signal imaged by at least one of the micromirror elements.Type: GrantFiled: March 12, 2020Date of Patent: January 17, 2023Assignees: Lawrence Livermore National Security, LLC, The Government of the United States, as represented by the Secretary of the Air ForceInventors: Robert Matthew Panas, Phillip Harris Paul, Harris J. Hall, Lavern A. Starman
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Patent number: 11557984Abstract: A footwear system can employ a brake and/or a clutch, such as a one-way clutch, to convert human motion into usable electricity. The brake and one-way clutch can be used together, such as on opposite ends of a spring. During a storage phase, the brake can be engaged and the one-way clutch disengaged so the spring stores an energy. After the storage phase, the brake can be removed to initiate the release phase since the brake is not stopping the spring, but the one-way clutch allows the stored energy to be released.Type: GrantFiled: August 26, 2019Date of Patent: January 17, 2023Assignee: The Government of the United States, as represented by the Secretary of the ArmyInventor: Nathan Sharpes
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Patent number: 11550173Abstract: There is set forth herein an integrated photonics structure having a waveguide disposed within a dielectric stack of the integrated photonics structure, wherein the integrated photonics structure further includes a field generating electrically conductive structure disposed within the dielectric stack; and a heterogenous structure attached to the integrated photonics structure, the heterogenous structure having field sensitive material that is sensitive to a field generated by the field generating electrically conductive structure.Type: GrantFiled: November 18, 2020Date of Patent: January 10, 2023Assignees: THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, GOVERNMENT OF THE UNITED STATES, AS REPRESENTED BY THE SECRETARY OF THE AIR FORCE, MORTON PHOTONICS INCORPORATIONInventors: Douglas Coolbaugh, Douglas La Tulipe, Paul A. Morton, Nicholas G. Usechak
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Publication number: 20230003177Abstract: The present invention relates to resin compositions, fiber reinforced polymeric structures and electromagnetic induction processes for making same. Such magnetic induction processes are pulsed processes that can be optionally coupled with cooling steps between pulses. The aforementioned fiber reinforced polymeric structures can take forms that include, but are not limited to, pipes; pressure vessels, including rocket motor cases and fire extinguishers; golf club shafts; tennis and badminton racquets; skis; snowboards; hockey sticks; fishing rods; bicycle frames; boat masts; oars; paddles; baseball bats; and softball bats. In addition, such fiber reinforced polymeric structures can be supplemented with other materials, such as a rocket propellant, to form articles, for example, a rocket motor.Type: ApplicationFiled: November 19, 2020Publication date: January 5, 2023Applicants: Government of the United States, represented by the Secretary of the Air Force, Government of Japan, as represented by the Commissioner of the Acquisition, Technology and Logistics, IHI Aerospace Co., Ltd.Inventors: Gregory R. YANDEK, Takayuki EDANAGA, Seiki HASHINO, Hiroshi SATO, Masaaki SATAKE, Masanori SAKAINO
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Real-time estimation of human core body temperature based on non-invasive physiological measurements
Patent number: 11540723Abstract: A method of estimating a body temperature of an individual based on physiological data including a heart rate received from at least one sensor 510 and received environmental data. The physiological data and the environmental data are inputted into a model present on a processor 520. The model generates an estimated body temperature and an estimated physiological condition based on the inputs. The processor 520 compares the estimated physiological condition to a measured physiological condition in the physiological data. A controller 530 modifies at least one parameter in the model when the difference between the estimated physiological condition and the measured physiological condition is above a threshold.Type: GrantFiled: September 28, 2020Date of Patent: January 3, 2023Assignee: The Government of the United States as represented by the Secretary of the ArmyInventors: Jaques Reifman, Srinivas Laxminarayan, Vineet Rakesh, Sridhar Ramakrishnan, Jianbo Liu -
Publication number: 20220399542Abstract: A method of applying a separator ink onto a dried electrode of a lithium ion battery. The method includes preparing a separator ink suspension, applying the separator ink suspension onto the dried electrode, and drying the applied separator ink suspension.Type: ApplicationFiled: April 15, 2022Publication date: December 15, 2022Applicant: Government of the United States as represented by the Secretary of the Air ForceInventors: Michael F. Durstock, Ryan R. Kohlmeyer, Aaron J. Blake
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Publication number: 20220392576Abstract: A method of detecting and identifying pathogens in a sample comprising a plurality of genetic sequences. A plurality of electronic sequence reads corresponding to the plurality of genetic sequences is received and sampled to form a sample set. The sample set is iteratively and electronically compared to a plurality of pathogen sequences to create a detection group, which populates a putative genome data structure. A distance score is measured between each electronic sequence read of the sampled set to each pathogen sequence of the putative genome data structure. A hit score is calculated by comparing the distance score to a threshold value. A plurality of clusters of the electronic sequence reads of the sample set is formed to maximize the cluster hit score and to minimize a difference in distance scores of the cluster. A respective taxonomic group assigned to electronic reads of the sample set after clustering is displayed.Type: ApplicationFiled: July 29, 2022Publication date: December 8, 2022Applicant: Government of the United States as Represented by the Secretary of the Air ForceInventor: James C Baldwin
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Patent number: 11522417Abstract: Various embodiments associated with a segmented magnetic core are described. The segmented magnetic core can be made up of multiple singular structures so as to allow an individual singular structure to be removed with ease and without disturbing another magnetic core. This modular core design allows for a significant reduction in motor housing weight due to compatibility of the design with lightweight materials and the potential absence of extensive housing when so designed. This modular core design can be incorporated into a motor or a generator and this modular core design can be accomplished, in one example, by way of stacking and/or interlocking employing low cost assembly. In one example, a motor or a generator uses sensors to detect an operational failure in a magnetic core, notifying a user early of the failure.Type: GrantFiled: May 24, 2021Date of Patent: December 6, 2022Assignee: The Government of the United States, as represented by the Secretary of the ArmyInventor: Edward Dawidowicz
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Real-time estimation of human core body temperature based on non-invasive physiological measurements
Patent number: 11517203Abstract: An embodiment of the invention provides a method of estimating a body temperature of an individual where physiological data is received from at least one sensor 510. Environmental data is received and the physiological data and the environmental data are input into a model. The model generates an estimated body temperature and an estimated physiological condition based on the physiological data and the environmental data. A processor 520 compares the estimated physiological condition to a measured physiological condition in the physiological data. A controller 530 modifies at least one parameter in the model when the difference between the estimated physiological condition and the measured physiological condition is above a threshold.Type: GrantFiled: August 18, 2017Date of Patent: December 6, 2022Assignee: The Government of the United States, as Represented by the Secretary of the ArmyInventors: Jaques Reifman, Srinivas Laxminarayan, Vineet Rakesh, Sridhar Ramakrishnan, Jianbo Liu -
Patent number: 11519987Abstract: A method for temperature quantification using magnetic resonance fingerprinting (MRF) includes acquiring MRF data from a region of interest in a subject using an MRF pulse sequence with smoothly varying RF phase for MR resonant frequencies that is played out continuously. For each of a plurality of time intervals during acquisition of the MRF data the method further includes comparing a set of the MRF data associated with the time interval to an MRF dictionary to determine at least one quantitative parameter of the acquired MRF data, determining a temperature change based on the at least one quantitative parameter and generating a quantitative map of the temperature change in the region of interest. The region of interest can include aqueous and adipose tissue.Type: GrantFiled: April 5, 2021Date of Patent: December 6, 2022Assignees: Case Western Reserve University, The Regents of the University of Colorado, Government of the United States, As Represented by the Secretary of CommerceInventors: Kathryn Keenan, Megan Poorman, Rasim Boyacioglu, Mark A. Griswold