Patents Assigned to The Health Research Institute
  • Treatment of neurodegenerative disorders with thiourea compounds
    Patent number: 8198284
    Abstract: A method for treating a neurodegenerative disorder. The method includes administering to a subject in need thereof an effective amount of one or more thiourea compounds of formula (I) or (II): Each variable in formula (I) or (II) is defined herein. Also disclosed is use of these thiourea compounds to reduce microglia-mediated neuro-inflammation or enhancing microglial phagocytosis of A?.
    Type: Grant
    Filed: March 24, 2009
    Date of Patent: June 12, 2012
    Assignee: National Health Research Institutes
    Inventors: Feng-Shiun Shie, Jyh-Haur Chern, Yu-Sheng Chao
  • F1B-TMIR PLASMID VECTOR AND TRANSGENIC MOUSE
    Publication number: 20120144507
    Abstract: A trifusion reporter plasmid is described that comprises a plasmid operably coupled to a mammalian FGF1B promoter that is operably coupled to a bioluminescence gene fused to a fluorescence gene fused to a nuclear medical imaging gene. The new reporter allows in vivo or ex vivo detection of gene expression in three different ways, in addition to traditional in vitro detection methods. Transgenic animals containing this new trifusion reporter and uses of same are described.
    Type: Application
    Filed: January 26, 2012
    Publication date: June 7, 2012
    Applicant: National Health Research Institutes
    Inventors: Kurt M. Lin, Ing-Ming Chiu
  • SOLID PHASE GOLD NANOPARTICLE SYNTHESIS
    Publication number: 20120130053
    Abstract: A method of synthesizing ligand-conjugated gold nanoparticles (AuNPs) is disclosed. The method comprises: a) providing an amine-modified silica particle; b) providing a solution comprising Au+3 ions; c) suspending the amine-modified silica particle in the solution comprising Au+3 ions; d) allowing the Au3+ ions to be adsorbed and/or immobilized onto the surface of the amine-modified silica particle; e) exposing the Au3+ ions immobilized onto the surface of the amine-modified silica particle to radiation to obtain bare gold nanoparticles (AuNPs) adsorbed and/or immobilized onto the surface of the amine-modified silica particle, wherein the bare AuNPs are without organic surface modifications; and f) reacting a ligand with the bare AuNPs adsorbed and/or immobilized onto the surface of the amine-modified SiNP and thereby obtain ligand-conjugated gold nanoparticles (AuNPs).
    Type: Application
    Filed: May 17, 2011
    Publication date: May 24, 2012
    Applicant: NATIONAL HEALTH RESEARCH INSTITUTES
    Inventors: CHIA-HUNG LEE, WEI-NENG LIAO, SHIH-HSUN CHENG, JEN-KUN CHEN, CHUNG-SHI YANG, LEU-WEI LO, YEU-KUANG HWU, FONG-SIAN LIN
  • METHOD OF PRODUCING LIPIDATED POLYPEPTIDES
    Publication number: 20120122154
    Abstract: A method of producing a recombinant lipidated polypeptide in E. coli. The method includes providing an E. coli host cell adapted to express a recombinant lipidated polypeptide; and culturing the E. coli host cell in a minimal medium under conditions that allow expression of the polypeptide in lipidated form.
    Type: Application
    Filed: November 15, 2011
    Publication date: May 17, 2012
    Applicant: National Health Research Institutes
    Inventors: Chih-Hsiang Leng, Chi-Ling Tseng, Shih-Jen Liu, Hsin-Wei Chen, Pele Choi-Sing Chong
  • LIPIDATED POLYEPITOPE VACCINES
    Publication number: 20120121628
    Abstract: This invention relates to, inter alia, an isolated lipidated polypeptide including a lipid moiety at the N-terminus and a plurality of epitopes, and methods of making and using the polypeptide.
    Type: Application
    Filed: November 15, 2011
    Publication date: May 17, 2012
    Applicant: National Health Research Institutes
    Inventors: Chih-Hsiang Leng, Chi-Ling Tseng, Hsueh-Hung Liu, Shih-Jen Liu, Hsin-Wei Chen, Pele Choi-Sing Chong
  • Multiple-Frequency Ultrasonic Phased Array Driving System
    Publication number: 20120123302
    Abstract: An apparatus for sonicating a patient includes an ultrasound array having a plurality of transducers; a driving module for driving said transducers; and a control kernel for causing said driving module to drive said transducers concurrently at two different frequencies.
    Type: Application
    Filed: November 15, 2010
    Publication date: May 17, 2012
    Applicant: National Health Research Institutes
    Inventors: Hao-Li Liu, Hsu Chang, Sheng-Fu Chen
  • Generating gating signals for thermal therapy
    Patent number: 8175676
    Abstract: A method of inducing thermal effect at a moving target includes receiving a first data characterizing a repeated motion of the moving target; processing the first data to determine a treatment plan, including determining a plan for directing a signal at the moving target; and controlling the signal directed at the moving target according to the treatment plan to induce a thermal effect.
    Type: Grant
    Filed: September 30, 2008
    Date of Patent: May 8, 2012
    Assignee: National Health Research Institutes
    Inventors: Hsu Chang, Win-Li Lin, Ming-Chuan Hsu
  • Nucleic Acid and Amino Acid Sequences of Infectious Salmon Anaemia Virus and Their Use as Vaccines
    Publication number: 20120071630
    Abstract: The present invention provides the use of nucleic acid sequences and/or amino acid sequences in the preparation of a vaccine for the protection of fish against infectious salmon anaemia virus. Specifically, such vaccines contain at least one nucleic acid sequence which is derived from ISAV or synthetically prepared analogues thereof, or substantially homologous sequences. These nucleic acid sequences are transcripted and translated into peptide sequences which are incorporated into a vaccination strategy to induce and immune response to the surface antigens of ISAV and therefore ISAV itself. Therefore both the use of a vaccine against ISAV, and the incorporation of peptide sequences is herein described.
    Type: Application
    Filed: August 12, 2011
    Publication date: March 22, 2012
    Applicants: OTTAWA HEALTH RESEARCH INSTITUTE, NOVARTIS AG
    Inventors: STEVEN GRIFFITHS, RACHAEL JAME RITCHIE, JOEL HEPPELL
  • Fused bicyclic pyrimidine compounds as aurora kinase inhibitors
    Patent number: 8138194
    Abstract: Fused bicyclic pyrimidine compounds of formula (I): wherein R1, R3, R4, X1, X2, Y, Z, A, B, C, D, n, and the two bonds are defined herein. Also disclosed are a method for inhibiting Aurora kinase activity and a method for treating cancer with these compounds.
    Type: Grant
    Filed: April 22, 2009
    Date of Patent: March 20, 2012
    Assignee: National Health Research Institutes
    Inventors: Hsing-Pang Hsieh, Selvaraj Mohane Coumar, Tsu-An Hsu, Su-Ying Wu, Yu-Sheng Chao
  • F1B-TMIR plasmid vector and transgenic mouse
    Patent number: 8129181
    Abstract: A trifusion reporter plasmid is described that comprises a plasmid operably coupled to a mammalian FGF1B promoter that is operably coupled to a bioluminescence gene fused to a fluorescence gene fused to a nuclear medical imaging gene. The new reporter allows in vivo or ex vivo detection of gene expression in three different ways, in addition to traditional in vitro detection methods. Transgenic animals containing this new trifusion reporter and uses of same are described.
    Type: Grant
    Filed: July 24, 2009
    Date of Patent: March 6, 2012
    Assignee: National Health Research Institutes
    Inventors: Kurt M. Lin, Ing-Ming Chiu
  • ONE-POT SYNTHESIS OF LINEAR-LIKE POLYETHYLENIMINE FOR INTRACELLULAR IMAGING AND NUCLEIC ACID DELIVERY
    Publication number: 20120052573
    Abstract: A method of synthesizing polyethyleneimine with a substantially linear backbone is disclosed. The method comprises exposing ethylenediamine dissolved in a solution to electromagnetic radiation for a sufficient time to polymerize the ethylenediamine and thereby resulting in formation of polyethylenimine with a substantially linear backbone in the solution. A method of synthesizing a homopolymer with a substantially linear backbone is also disclosed. In addition, a composition comprising polyethylenimine synthesized from the aforementioned method is disclosed, in which the polyethylenimine comprises a backbone conformation that is substantially linear and has a distribution of molecular weights (MW) ranging from 1 kDa to 200 kDa; and the polyethyleneimine has no cytotoxicity at a concentration of 12 ?g/ml.
    Type: Application
    Filed: August 26, 2010
    Publication date: March 1, 2012
    Applicant: NATIONAL HEALTH RESEARCH INSTITUTES
    Inventors: Shu-Yi LIN, Fong-Sian LIN, Meng-Kai CHEN, Yu-Chen JAO, Lin-Ren TSAI, Hong-Yi LIN, Chung-Shi YANG, Yeu-Kuang HWU
  • COUMARIN COMPOUNDS AND THEIR USE FOR TREATING VIRAL INFECTION
    Publication number: 20120046238
    Abstract: A method for treating an infection with a virus. The method includes administering to a subject in need thereof an effective amount of one or more coumarin compounds of formula (I): wherein R1, R2, R3, R4, R5, R6, and X are defined herein. Also disclosed is a pharmaceutical composition including a coumarin compound.
    Type: Application
    Filed: November 10, 2011
    Publication date: February 23, 2012
    Applicant: National Health Research Institutes
    Inventors: Hsing-Pang Hsieh, Tsu-An Hsu, Jiann-Yih Yeh, Jim-Tong Horng, Shin-Ru Shih, Sui-yuan Chang, Yu-Sheng Chao
  • Immunogenic Compositions and Uses Thereof
    Publication number: 20120045468
    Abstract: Disclosed are methods of producing a purified EV71 virus antigen. Also disclosed are related immunogenic compositions and immunization methods.
    Type: Application
    Filed: August 17, 2010
    Publication date: February 23, 2012
    Applicant: National Health Research Institutes
    Inventors: Pele Choi-Sing Chong, Chia-Chyi Liu, Meng-Shin Kuo, Ray Jui-Yuan Chang
  • Aryl substituted sulfonamide compounds and their use as anticancer agents
    Patent number: 8119683
    Abstract: Aryl substituted sulfonamide compounds of formula (I): wherein bond, X, Y, R1, R2, R3, m, and n are defined herein. Also disclosed is a method for treating cancer with these compounds.
    Type: Grant
    Filed: August 9, 2010
    Date of Patent: February 21, 2012
    Assignees: Taipei Medical University, DCB-USA LLC, National Health Research Institutes
    Inventors: Jing-Ping Liou, Jang-Yang Chang
  • Preparation and Purification of Subunit Vaccine for Neisseria Meningitidis (NM) Group B Isolates
    Publication number: 20120041179
    Abstract: A method for preparing and purifying recombinant lipoprotein Ag473 of Neisseria meningitidis (NM) group B isolates. The method can be used in large-scale production of vaccines for Neisseria meningitidis (NM) group B.
    Type: Application
    Filed: August 11, 2011
    Publication date: February 16, 2012
    Applicant: National Health Research Institutes
    Inventors: Shih-Yang Hsieh, Pele Choi-Sing Chong, Chang-Ling Lin, Chih-Hsiang Leng
  • Stem cells, nucleotide sequences and proteins therefrom
    Patent number: 8101407
    Abstract: The present invention provides novel stem cells, nucleotide sequences and proteins therefrom. More specifically, the present invention provides Pax7+/Myf5? stem cells and methods for identifying and isolating them. Also provided is a MEGF10 nucleotide sequence and protein.
    Type: Grant
    Filed: November 22, 2006
    Date of Patent: January 24, 2012
    Assignee: Ottawa Health Research Institute
    Inventors: Michael A. Rudnicki, Shihuan Kuang, Chet Holterman
  • Ultra-nanocrystalline diamond as a biomaterial for enhancing proliferation and differentiation of neural stem cells
    Patent number: 8101409
    Abstract: Compositions for promoting growth and/or differentiation of a stem cell are disclosed. The composition comprises: a) a diamond film; b) a stem cell cultured on the diamond film; and c) a medium bathing the stem cell. The stem cell may be a mammalian neural stem cell and the diamond film may comprise a hydrogen-terminated or an oxygen-terminated surface. The hydrogen-terminated surface promotes proliferation and differentiation of a neural stem cell into neurons, and the oxygen-terminated surface promotes a neural stem cell to proliferate and differentiate into oligodendrocytes.
    Type: Grant
    Filed: October 5, 2009
    Date of Patent: January 24, 2012
    Assignees: National Health Research Institutes, National Tsing Hua University
    Inventors: Ing-Ming Chiu, Ying-Chieh Chen, Don-Ching Lee, Nyan-Hwa Tai
  • Transgenic animal with monocyte chemotactic protein 1 promoter
    Patent number: 8076531
    Abstract: The present invention relates to a transgenic animal, which comprises in its genome a recombinant polynucleotide encoding one or more reporter proteins and a monocyte chemotactic protein-1 (MCP-1) promoter, wherein the one or more reporter proteins are expressed under the control of the MCP-1 promoter. A method for monitoring endogenous expression of MCP-1 in vivo is also provided, which is useful for identifying a regulator of the expression of MCP-1 or an anti-inflammatory agent.
    Type: Grant
    Filed: November 25, 2009
    Date of Patent: December 13, 2011
    Assignee: National Health Research Institutes
    Inventor: Kurt Ming-Chao Lin
  • Pyrrolidine compounds
    Patent number: 8071787
    Abstract: A compound of the following formula: wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, X, Y, and Z are as defined herein. Also disclosed is a method for inhibiting actively of fibroblast activation protein or for treating cancer or inflammation conditions with such a compound.
    Type: Grant
    Filed: February 19, 2010
    Date of Patent: December 6, 2011
    Assignee: National Health Research Institutes
    Inventors: Weir-Tong Jiaang, Xin Chen
  • Coumarin compounds and their use for treating cancer
    Patent number: 8058427
    Abstract: Coumarin compounds of formula (I): wherein R1, R2, R3, R4, R5, R6, and X are defined herein. Also disclosed is a method for treating cancer with coumarin compounds.
    Type: Grant
    Filed: June 10, 2009
    Date of Patent: November 15, 2011
    Assignee: National Health Research Institutes
    Inventors: Hsing-Pang Hsieh, Jang-Yang Chang, Ching-Chuan Kuo, Yu-Sheng Chao