Patents Assigned to The Health Research Institute
  • Conditioned medium obtained from stem cells and its use in therapy
    Patent number: 8911963
    Abstract: Described herein are conditioned medium and processed conditioned medium, each of which comprises secreted stem cell factors; compositions containing conditioned medium and/or processed conditioned medium and a delivery polymer. The conditioned medium, processed conditioned medium and compositions may be used to promote blood vessel growth and healing of injured tissues.
    Type: Grant
    Filed: April 5, 2011
    Date of Patent: December 16, 2014
    Assignee: MedStar Health Research Institute, Inc.
    Inventors: Stephen E. Epstein, Mary Susan Burnett, Amir Najafi
  • DIAGNOSTIC ASSAY TO PREDICT CARDIOVASCULAR RISK
    Publication number: 20140350129
    Abstract: This invention relates to the area of cardiovascular disorders and specifically relates to methods of diagnostic tests using a combination of markers to predict an individual's risk for developing coronary artery disease (CAD) and related diseases, such as angina pectoris and peripheral vascular disease and, more particularly, to determine an individual's risk of myocardial infarction, death, and stroke. Exemplary biomarkers include C-reactive protein (CRP), fibrin degradation products (FDPs), Heat Shock Protein 70 (HSP70), and/or anti-CMV antibody.
    Type: Application
    Filed: March 1, 2012
    Publication date: November 27, 2014
    Applicants: Genway Biotech, Inc., Emory University, Medstar Health Research Institute
    Inventors: Sergey Sikora, Stephen Epstein, Arshed A. Quyyumi
  • Cathepsin S inhibitors
    Patent number: 8895497
    Abstract: Cathepsin S inhibitors having formula (I), (II), (III) or (IV) as shown in the specification. These inhibitors can be used to treat cancer and autoimmune/inflammatory diseases.
    Type: Grant
    Filed: December 6, 2010
    Date of Patent: November 25, 2014
    Assignees: DCB-USA, LLC, National Tsing Hua University, National Health Research Institutes
    Inventors: Chun-Cheng Lin, Wun-Shaing Wayne Chang, Biing-Jiun Uang, Jang-Yang Chang, Jo-Chun Chen, Hsing-Pang Hsieh
  • Dual-curvature phased array high-intensity focused ultrasound transducer for tumor therapy
    Patent number: 8888706
    Abstract: A transducer for use with a high intensity focused ultrasound medical system has transducer elements that are made from a piezocomposite material bonded together in turn with an adhesive. The elements are deployed along a surface of a geometric structure with two curvatures. The structure is a truncated curved cylinder. The transducer also includes electrodes, each of which is arranged on a corresponding one of the transducer elements for exciting the transducer elements to emit ultrasonic waves in response to electrical signals applied to the electrodes to steer the waves to form a common focus zone in a desired heating area.
    Type: Grant
    Filed: August 4, 2009
    Date of Patent: November 18, 2014
    Assignee: National Health Research Institutes
    Inventors: Gin-Shin Chen, Hsu Chang, Win-Li Lin
  • Polynucleotides that home to atherosclerotic plaque
    Patent number: 8853378
    Abstract: Described herein are homing polypeptides that home to atherosclerotic plaque(s) in mammals and nucleic acids that encode such polypeptides. Also described are methods for detecting and treating conditions or disorders associated with, or characterized, by elevated levels of homing polypeptides that home to atherosclerotic plaque and/or vulnerable plaque.
    Type: Grant
    Filed: October 9, 2010
    Date of Patent: October 7, 2014
    Assignees: Georgetown University, MedStar Health Research Institute, Inc.
    Inventors: Anton Wellstein, Stephen E. Epstein, Mary Susan Burnett
  • Map kinase kinase kinase kinase 3 (MAP4K3) as a biomarker and therapeutic target for autoimmune disease, cancer, inflammation and IL-17-associated disease
    Patent number: 8846311
    Abstract: Methods for identifying a therapeutic agent for treating a Germinal Center Kinase (GCK)-Like Kinase (GLK)-mediated disease are disclosed. Methods for detecting a modulation of GLK signaling by a test compound are disclosed. Also disclosed are methods for detecting the presence and/or severity of an autoimmune disease and/or cancer.
    Type: Grant
    Filed: July 13, 2012
    Date of Patent: September 30, 2014
    Assignee: National Health Research Institutes
    Inventors: Tse-Hua Tan, Huai-Chia Chuang
  • COMPOSITIONS AND METHODS FOR TREATING CLOSTRIDIUM DIFFICILE-ASSOCIATED DISEASES
    Publication number: 20140271700
    Abstract: Described herein are isolated polypeptides each containing one or more receptor-binding sites of toxin A (tcdA) of Clostridium difficile (Cd), nucleic acids encoding the polypeptides, and methods of using the polypeptides and nucleic acids.
    Type: Application
    Filed: March 13, 2014
    Publication date: September 18, 2014
    Applicant: National Health Research Institutes
    Inventors: Pele Choi-Sing Chong, Jui-Hsin Huang, Chih-Hsiang Leng
  • ULTRASOUND PROBE STRUCTURE OF GUIDING THE PUNCTURE NEEDLE
    Publication number: 20140257110
    Abstract: An ultrasound probe structure dedicated for guiding the puncture needle. It has a passage in the center of the structure and the diameter of the passage is equal to the outer diameter of puncture needle. The bony and non-bony tissues can be distinguished according to the strength of the echoes so that the puncture needle can be guided to avoid hitting the bony tissue before or during insertion.
    Type: Application
    Filed: March 5, 2014
    Publication date: September 11, 2014
    Applicants: National Health Research Institutes, National Yang-Ming University
    Inventors: Yin CHANG, Ching-Hsin CHEN
  • CAGED PLATINUM NANOCLUSTERS FOR ANTICANCER CHEMOTHERAPEUTICS
    Publication number: 20140234413
    Abstract: A caged platinum nanocluster complex is disclosed. The complex comprises (a) an amine-terminated dendrimer; and (b) a platinum nanocluster comprising platinum oxides, the platinum nanocluster being confined inside of the amine-terminated dendrimer. The complex exhibits cytotoxicity to cancer cells. A double-caged platinum nanocluster complex is also disclosed, which comprises polyethylene glycol (PEG) coated on the surface of a dendrimer caged platinum nanocluster complex. The double-caged caged platinum nanocluster complex comprises pH-sensitive bonds on the surface thereof. Also disclosed are methods of preparing and using the same.
    Type: Application
    Filed: February 18, 2014
    Publication date: August 21, 2014
    Applicant: NATIONAL HEALTH RESEARCH INSTITUTES
    Inventor: Shu-Yi LIN
  • RECOMBINANT BCG STRAINS WITH ENHANCED ABILITY TO INHIBIT INTRACELLULAR MYCOBACTERIAL GROWTH
    Publication number: 20140212455
    Abstract: A recombinant bacterial cell strain is disclosed. It comprises: a) a first vector comprising a fusion transgene encoding Ag85B-CFP10 fusion protein, the fusion transgene being operably linked to a promoter effective for expression of the Ag85B-CFP10 fusion protein; and b) a second vector comprising a transgene encoding interleukin-12 (IL-12), the transgene being operably linked to a promoter effective for expression of the IL-12 protein. A method of inhibiting intracellular growth of Mycobacterium in a subject is also disclosed.
    Type: Application
    Filed: April 3, 2014
    Publication date: July 31, 2014
    Applicant: NATIONAL HEALTH RESEARCH INSTITUTES
    Inventor: Horng-Yunn DOU
  • Method of producing lipidated polypeptides
    Patent number: 8771990
    Abstract: A method of producing a recombinant lipidated polypeptide in E. coli. The method includes providing an E. coli host cell adapted to express a recombinant lipidated polypeptide; and culturing the E. coli host cell in a minimal medium under conditions that allow expression of the polypeptide in lipidated form.
    Type: Grant
    Filed: November 15, 2011
    Date of Patent: July 8, 2014
    Assignee: National Health Research Institutes
    Inventors: Chih-Hsiang Leng, Chi-Ling Tseng, Shih-Jen Liu, Hsin-Wei Chen, Pele Choi-Sing Chong
  • MESOPOROUS SILICA NANOPARTICLES FOR OIL ABSORPTION
    Publication number: 20140178505
    Abstract: A method for prevention and/or treatment of steatorrhea in a subject, is disclosed.
    Type: Application
    Filed: December 20, 2013
    Publication date: June 26, 2014
    Applicant: NATIONAL HEALTH RESEARCH INSTITUTES
    Inventors: Shin-Hsun CHENG, Wei-Neng Liao, Chung-Shi Yang, Leu-Wei Lo
  • PRIMERS, SNP MARKERS AND METHOD FOR GENOTYPING MYCOBACTERIUM TUBERCULOSIS
    Publication number: 20140162260
    Abstract: The present application provides a primer set for genotyping M. tuberculosis selected from the group consisting of primer sets 1-25 (SEQ ID Nos. 1-50), and also provides an extension primer for genotyping M. tuberculosis selected from one of the group consisting of SEQ ID Nos. 51-75. The present application provides a combination of single-nucleotide polymorphism markers of M. tuberculosis. Further, the present application provides a method and a kit for genotyping M. tuberculosis.
    Type: Application
    Filed: November 26, 2013
    Publication date: June 12, 2014
    Applicant: National Health Research Institutes
    Inventors: Shih-Feng TSAI, Chien-Hsing LIN, Horng-Yunn DOU
  • Solid phase gold nanoparticle synthesis
    Patent number: 8734844
    Abstract: A method of synthesizing ligand-conjugated gold nanoparticles (AuNPs) is disclosed. The method comprises: a) providing an amine-modified silica particle; b) providing a solution comprising Au+3 ions; c) suspending the amine-modified silica particle in the solution comprising Au+3 ions; d) allowing the Au3+ ions to be adsorbed and/or immobilized onto the surface of the amine-modified silica particle; e) exposing the Au3+ ions immobilized onto the surface of the amine-modified silica particle to radiation to obtain bare gold nanoparticles (AuNPs) adsorbed and/or immobilized onto the surface of the amine-modified silica particle, wherein the bare AuNPs are without organic surface modifications; and f) reacting a ligand with the bare AuNPs adsorbed and/or immobilized onto the surface of the amine-modified SiNP and thereby obtain ligand-conjugated gold nanoparticles (AuNPs).
    Type: Grant
    Filed: May 17, 2011
    Date of Patent: May 27, 2014
    Assignee: National Health Research Institutes
    Inventors: Chia-Hung Lee, Wei-Neng Liao, Shih-Hsun Cheng, Jen-Kun Chen, Chung-Shi Yang, Leu-Wei Lo, Yeu-Kuang Hwu, Fong-Sian Lin
  • APPARATUS AND METHODS FOR PERFORMING OPTICAL TOMOGRAPHY ON DOSIMETERS FOR CALIBRATING RADIOTHERAPY EQUIPMENT
    Publication number: 20140125969
    Abstract: An apparatus and method for performing tomography are disclosed herein. The apparatus includes an emitter for scanning an object with a detection beam, a diffuser for scattering a transmitted portion of the detection beam that passes through the object in order to generate a scattered signal, and at least one detector for detecting a portion of the scattered signal. The diffuser has a diffusive surface area, and the detector has a total detection area that is smaller than the diffusive surface area.
    Type: Application
    Filed: November 4, 2013
    Publication date: May 8, 2014
    Applicant: LAWSON HEALTH RESEARCH INSTITUTE
    Inventor: Kevin James Jordan
  • COMBINATION THERAPY FOR HEPATITIS C VIRUS INFECTION
    Publication number: 20140127158
    Abstract: A method of treating hepatitis C virus infection, comprising administering to a subject in need thereof (a) an effective amount of at least one HCV inhibitor selected from the group consisting of an HCV NS3 inhibitor, an HCV NS5B inhibitor, ribavirin, and an IFN-?; and (b) an effective amount of an anti-HCV compound of formula (I).
    Type: Application
    Filed: November 6, 2013
    Publication date: May 8, 2014
    Applicant: National Health Research Institute
    Inventors: Andrew Yueh, Yu-Sheng Chao
  • Preparation and purification of subunit vaccine for (NM) group B isolates
    Patent number: 8716512
    Abstract: A method for preparing and purifying recombinant lipoprotein Ag473 of Neisseria meningitidis (NM) group B isolates. The method can be used in large-scale production of vaccines for Neisseria meningitidis (NM) group B.
    Type: Grant
    Filed: August 11, 2011
    Date of Patent: May 6, 2014
    Assignee: National Health Research Institutes
    Inventors: Shih-Yang Hsieh, Pele Choi-Sing Chong, Chang-Ling Lin, Chih-Hsiang Leng
  • Quinoline compounds and their use for treating viral infection
    Patent number: 8710079
    Abstract: Quinoline compounds of formula (I): in which A, B, D, E, F, G, R1, R2, R3, X, Y, n, p, and q are defined herein. Also disclosed is a method for treating a viral infection with a compound of formula (I).
    Type: Grant
    Filed: April 21, 2011
    Date of Patent: April 29, 2014
    Assignee: National Health Research Institutes
    Inventors: Hsing-Pang Hsieh, Tsu-An Hsu, Jiann-Yih Yeh, Yu-Sheng Chao
  • METHOD AND SYSTEM FOR DESTROYING ADIPOSE TISSUE NON-INVASIVELY AND ACCELERATING LIPID METABOLISM
    Publication number: 20140107535
    Abstract: The present disclosure is to destroy adipose tissue non-invasively by using focused ultrasound (FUS) and to increase the treatment efficiency by the synergy of the novel FUS and electrical stimulation. Lipid can be released from the destroyed adipocytes and stay in the interstitial fluid of undestroyed adipocytes. In the meanwhile or after the treatment of FUS, a passive exercise of muscle in thighs or other parts is performed by electrical stimulation to consume energy. Therefore, metabolism of the free lipid can be enhanced by supplying energy to the muscles. The ultrasound treatment of the present disclosure is able to increase the treatment area, and while in combination with electrical stimulation, it can efficiently remove lipids in the circulation.
    Type: Application
    Filed: October 11, 2013
    Publication date: April 17, 2014
    Applicants: National Cheng Kung University, National Health Research Institutes
    Inventors: Chou-Ching Lin, Gin-Shin Chen
  • Glycoside compounds
    Patent number: 8697658
    Abstract: Compounds of formula (I): wherein X, Y, and Z are defined herein. Also disclosed are pharmaceutical compositions and therapeutical methods related to these compounds.
    Type: Grant
    Filed: December 13, 2012
    Date of Patent: April 15, 2014
    Assignee: National Health Research Institutes
    Inventors: Jinq-Chyi Lee, Yu-Sheng Chao