Patents Assigned to The Health Research Institute
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Patent number: 10047078Abstract: Aminothiazole compounds of Formula (I) shown herein and pharmaceutical compositions containing one of such compounds.Type: GrantFiled: January 30, 2017Date of Patent: August 14, 2018Assignee: National Health Research InstitutesInventors: Weir-Torn Jiaang, Tsu Hsu
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Patent number: 10004796Abstract: The present invention relates to a recombinant adenoviral vector for generating immunity against enterovirus infection. In one embodiment, the recombinant adenoviral vector of the invention comprises an expression cassette encoding a PI protein and a 3 CD protease of an enterovirus. In another embodiment, the recombinant adenoviral vector of the invention comprises an expression cassette encoding a 3C protease or a 3CD protease of an enterovirus. The present invention also relates to a vaccine composition comprising the recombinant adenoviral vector as described. A method of inducing an immune response in a subject against enterovirus infection using the recombinant adenoviral vector and the vaccine composition is provided. Further provided is a method for producing virus like particles of an enterovirus by expressing the adenoviral vector as described herein in mammalian cells.Type: GrantFiled: March 26, 2015Date of Patent: June 26, 2018Assignee: National Health Research InstitutesInventors: Yen-Hung Chow, Yueh-Liang Tsou, Pele Choi-Sing Chong
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Patent number: 10000732Abstract: A microfluidic dual-well device is disclosed. The device comprises: (a) a first substrate having a first end, a second end, and a culture microwell forming portion; (b) a plurality of culture microwells; (c) a second substrate having a first end, a second end, and a capture microwell forming portion, the two ends of the second substrate being respectively bounded to the two ends of the first substrate; (d) a plurality of capture microwells; (e) a microfluidic channel; (f) a microfluidic inlet port; and (g) a microfluidic outlet port; wherein the microfluidic channel is in fluidic connections with the culture microwells, the capture microwells, and the inlet and outlet ports. Methods of capturing and transferring a single cell or a single cell colony for culture, and method of transferring a target cell from a polydimethylsiloxane (PDMS) structure of culture microwells to a culture plate for culture are also disclosed.Type: GrantFiled: May 19, 2016Date of Patent: June 19, 2018Assignee: NATIONAL HEALTH RESEARCH INSTITUTESInventors: Chia-Hsien Hsu, Ching-Hui Lin, Hao-Chen Chang, Ing-Ming Chiu
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Patent number: 9926298Abstract: Heterocyclic compounds of Formula (I) shown herein. Also disclosed are pharmaceutical compositions containing the heterocyclic compounds and methods of using the heterocyclic compounds to mobilize hematopoietic stem cells and endothelial progenitor cells into the peripheral circulation. Further provided are methods for treating tissue injury, cancer, inflammatory disease, and autoimmune disease with the heterocyclic compounds.Type: GrantFiled: September 22, 2017Date of Patent: March 27, 2018Assignee: National Health Research InstitutesInventors: Kak-Shan Shia, Jiing-Jyh Jan, Lun Kelvin Tsou, Chiung-Tong Chen, Yu-Sheng Chao
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Patent number: 9868975Abstract: The invention utilizes virtual screening strategy to seek for current market drugs as anti-schizophrenia therapy drug repurposing. Drug repurposing strategy finds new uses other than the original medical indications of existing drugs. Finding new indications for such drugs will benefit patients who are in needs for a potential new therapy sooner since known drugs are usually with acceptable safety and pharmacokinetic profiles. In this study, repurposing marketed drugs for DAAO inhibitor as new schizophrenia therapy was performed with virtual screening on marketed drugs and its metabolites. The identified and available drugs and compounds were further confirmed with in vitro DAAO enzymatic inhibitory assay.Type: GrantFiled: April 30, 2015Date of Patent: January 16, 2018Assignees: National Taiwan University, National Chiao Tung University, National Health Research InstitutesInventors: Yufeng Jane Tseng, Yu-Li Liu, Chung-Ming Sun, Hai-Gwo Hwu, Chih-Min Liu, Wen-Sung Lai
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Publication number: 20180009750Abstract: A 5-methoxytryptophan and its derivatives are disclosed, wherein the 5-methoxytryptophan and its derivatives are represented by the following formula (I): wherein R1, R2, R3, R4, R5, and n are defined in the specification. In addition, the present invention also provides novel used of the 5-methoxytryptophan and its derivatives for treating inflammatory-related disease and cancers.Type: ApplicationFiled: January 13, 2016Publication date: January 11, 2018Applicant: National Health Research InstitutesInventors: Cheng-Chin KUO, Kenneth Kun-Yu WU
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Patent number: 9864032Abstract: A magnetic resonance imaging system to be used over a target area of a subject includes first and second RF coils for receiving an RF signal from the subject. The first RF coil is fixed to a position device and movable over the target area of subject. The second RF coil is larger than the first RF coil and has a larger field of view than the first RF coil. The system further includes an image processing device programmed to process RF signals coupled from the first RF coil and the second RF coil to form an MRI image.Type: GrantFiled: January 5, 2010Date of Patent: January 9, 2018Assignee: National Health Research InstitutesInventors: Hsu Chang, Ching Yao, San-Chao Hwang
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Patent number: 9862703Abstract: Heterocyclic compounds of Formula (I) shown herein. Also disclosed are pharmaceutical compositions containing the heterocyclic compounds and methods of using the heterocyclic compounds to mobilize hematopoietic stem cells and endothelial progenitor cells into the peripheral circulation. Further provided are methods for treating tissue injury, cancer, inflammatory disease, and autoimmune disease with the heterocyclic compounds.Type: GrantFiled: September 21, 2015Date of Patent: January 9, 2018Assignee: National Health Research InstitutesInventors: Kak-Shan Shia, Jiing-Jyh Jan, Lun Kelvin Tsou, Chiung-Tong Chen, Yu-Sheng Chao
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Patent number: 9846167Abstract: Methods for identifying subjects having bone loss by detecting bone microparticles in a sample of their bodily fluid are disclosed. Methods for monitoring bone loss and assessing efficacy of bone loss therapies by detecting bone microparticles in bodily fluid samples are also disclosed. Compounds for use as a negative control in the disclosed methods are provided as well as kits comprising such compounds.Type: GrantFiled: March 26, 2014Date of Patent: December 19, 2017Assignee: Lawson Health Research InstituteInventors: Hon Sing Leong, Leonard Luyt, Colleen Nicole Biggs, Andre St. Amant, John D. Lewis, Leonard Minuk
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Patent number: 9827228Abstract: Disclosed is an in vitro screening method for identifying an antagonist-to-agonist allosteric modifier of a mu-opioid receptor and an in vivo method for confirming that a test compound is such a modifier of a mu-opioid receptor. Also disclosed is a method for treating an opioid receptor-associated condition using a compound of Formula (I) and a pharmaceutical composition containing the same.Type: GrantFiled: July 12, 2016Date of Patent: November 28, 2017Assignees: National Health Research Institutes, Regents of the University of MinnesotaInventors: Shau-Hua Ueng, Shiu-Hwa Yeh, Horace Loh, Yu-Sheng Chao
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Patent number: 9782385Abstract: An artificial tears solution combination is composed mainly of an anti-inflammation and anti-oxidation material, a liquid viscosity-enhancing agent, and an artificial tears solution. The artificial tears solution combination is capable keeping moisture, and meanwhile having anti-inflammation and anti-oxidation capabilities. As such, it can prolong the liquid retention on ocular surfaces, to effective reduce the repeated dosing, and shorten the schedule for the dry eye syndrome.Type: GrantFiled: April 29, 2016Date of Patent: October 10, 2017Assignee: NATIONAL HEALTH RESEARCH INSTITUTESInventors: Feng-Huei Lin, Hsu-Wei Fang, Ching-Li Tseng, Ya-Jung Hung
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Patent number: 9750804Abstract: A method for treating an inflammatory disease or an immune disorder includes administering to a subject in need of such treatment an antagonist against ENO1. The antagonist binds ENO1 and inhibits ENO1 plasminogen receptor activity. The antagonist may be an anti-human ENO1 antibody, or an scFv, Fab, or F(ab)2 fragment thereof, that specifically binds to human ENO1 (GenBank: AAH50642.1) for the treatment of an inflammatory disease or an immune disorder, which may be multiple sclerosis, rheumatoid arthritis, Crohn's disease, ulcerative colitis, systemic Lupus erythematosus, chronic obstructive pulmonary disease (COPD), asthma, allergy, psoriasis, type 1 diabetes mellitus, artherosclerosis or osteoporosis.Type: GrantFiled: December 22, 2014Date of Patent: September 5, 2017Assignees: Development Center for Biotechnology, National Health Research InstitutesInventors: Shih-Chong Tsai, Mingl Chang, Ta-Tung Yuan, Shih-Chi Tseng, Shyi-Jou Chen, Wei-Tso Chia, Hsin-Yun Wang, Neng-Yao Shih, Ko-Jiunn Liu, Li-Tzong Chen
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Publication number: 20170247660Abstract: The present application provides progenitor cells and a preparing method thereof. The preparing method comprises obtaining a tissue sample containing myometrium from uterus, treating the tissue sample with collagenase, and culturing the treated tissue sample to obtain the progenitor cells, wherein the progenitor cell is multipotent and immunomodulatory. The present application also provides a method for treating a degenerative disease, an ischemic disease or a disease caused by abnormal immune response comprising administering the progenitor cells to a patient subjecting the disease.Type: ApplicationFiled: September 16, 2015Publication date: August 31, 2017Applicant: National Health Research InstitutesInventors: Lin-Ju YEN, Ko-Jiunn LIU, Men-Luh YEN
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Publication number: 20170246212Abstract: The present application provides a method of upregulating an expression of immumodulatory cells in vitro comprising treating the immumodulatory cells with IL-25 to increase an expression of PD-L1. The present application also provides a method for treatment of immune disorders by the aforementioned methods. The present application also provides a method to suppress an expression of immumodulatory cells comprising suppressing an expression of PD-L1. The immumodulatory cells can be human monocytes or hMSCs. The present application further provides a method for treatment of immune-evasive diseases by using the aforementioned method to suppress an expression of immumodulatory cells.Type: ApplicationFiled: August 26, 2015Publication date: August 31, 2017Applicant: National Health Research InstitutesInventors: Linju YEN, Ko-Jiunn LIU, Huey-Kang SYTWU
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Publication number: 20170224776Abstract: The present application provides a composition and methods to enhance nerve regeneration utilizing at least one component of neural stem cells or IL12p40. The composition comprises neural stem cells and a neurotrophic factor, which is constructed by IL12p40 as at least one subunit. The methods to enhance nerve regeneration comprise providing a nerve regeneration composition comprising a neurotrophic factor containing IL12p40 as at least one subunit to a subject. The composition of the methods can further comprise neural stem cells.Type: ApplicationFiled: August 14, 2015Publication date: August 10, 2017Applicant: National Health Research InstitutesInventors: Ing-Ming CHIU, Ya-Hui CHI, Don-Ching LEE
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Patent number: 9714284Abstract: A HBS-specific antibody, a LHBS-specific antibody, a WT LHBS-specific antibody, an immunoassay kit comprising the antibodies, and a method of detecting pre-S2 deletion mutant LHBS using the immunoassay kit are disclosed herein. The method comprises incubating a biological sample with a first antibody to captured HBS proteins; detecting the LHBS and WT LHBS bound to the immobilized first antibody, respectively; and calculating the amount of the pre-S2 deletion mutant LHBS protein by subtracting the amount of the WT LHBS protein from that of the LHBS protein. Advantageously, by the method described herein, the amount of the pre-S2 deletion mutant LHBS, a potential high-risk marker for HCC incidence in chronic HBV carriers and recurrence in HCC patients after hepatectomy surgery, in a biological sample may be easily calculated without mutual influence between the WT and pre-S mutant LHBS while reducing the labor-intensive process for cloning each gene product before analysis.Type: GrantFiled: July 16, 2014Date of Patent: July 25, 2017Assignee: National Health Research InstitutesInventors: Wenya Huang, Ih-Jen Su, Yun-Ping Lee
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Patent number: 9527922Abstract: A humanized antibody, or a binding fragment thereof, wherein the humanized antibody binds human ENO1 (GenBank: AAH50642.1), wherein the antibody comprises a light chain variable region (VL) domain comprising a CDR1 having the amino acid sequence LCDR1 (RASENIYSYLT; SEQ ID NO: 6) and a CDR2 having the amino acid sequence LCDR2 (NAKTLPE; SEQ ID NO: 7) and a CDR3 having the amino acid sequence LCDR3 (QHHYGTPYT; SEQ ID NO: 8) and an antibody heavy chain variable region (VH) domain comprising a CDR1 having the amino acid sequence HCDR1 (GYTFTSCVMN; SEQ ID NO: 3), a CDR2 having the amino acid sequence HCDR2 (YINPYNDGTKYNEKFKG; SEQ ID NO: 4) and a CDR3 having the amino acid sequence HCDR3 (EGFYYGNFDN; SEQ ID NO: 5), wherein framework regions in the light chain variable region (VL) domain and the heavy chain variable region (VH) domain comprise amino acid sequences from a human immunoglobulin.Type: GrantFiled: December 31, 2014Date of Patent: December 27, 2016Assignees: Development Center for Biotechnology, DCB-USA LLC, National Health Research InstitutesInventors: Shih-Chong Tsai, Ta-Tung Yuan, Shih-Chi Tseng, Jiann-Shiun Lai, Chia-Cheng Wu, Chao-Yang Huang, Ya-Wei Tsai, Ying-Yung Lok, Chung-Hsiun Wu, Neng-Yao Shih, Ko-Jiunn Liu, Li-Tzong Chen
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Patent number: 9493518Abstract: Described herein are isolated polypeptides each containing one or more receptor-binding sites of toxin A (tcdA) of Clostridium difficile (Cd), nucleic acids encoding the polypeptides, and methods of using the polypeptides and nucleic acids.Type: GrantFiled: March 13, 2014Date of Patent: November 15, 2016Assignee: National Health Research InstitutesInventors: Pele Choi-Sing Chong, Jui-Hsin Huang, Chih-Hsiang Leng
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Patent number: 9457000Abstract: Ophthalmic irrigating solutions are disclosed. The ophthalmic irrigating solution comprises: a) ?-polyglutamic acid (?-PGA) and/or salt thereof in an amount effective to increase the viscosity of the irrigating solution, and b) an ophthalmically acceptable aqueous vehicle for the ?-PGA and/or salt thereof. Also disclosed is a method of irrigating ocular tissues of a patient, in which the method comprises introducing to the ocular tissues of the patient an ophthalmic irrigating solution comprising ?-PGA) and/or salt thereof in an amount sufficient to irrigate the ocular tissues of the patient.Type: GrantFiled: June 16, 2013Date of Patent: October 4, 2016Assignee: NATIONAL HEALTH RESEARCH INSTITUTESInventors: Yu-Chun Chen, Wen-Yu Su, Yen-Hsien Lee, Ko-Hua Chen, Feng-Huei Lin
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Patent number: 9433803Abstract: The present disclosure is to destroy adipose tissue non-invasively by using focused ultrasound (FUS) and to increase the treatment efficiency by the synergy of the novel FUS and electrical stimulation. Lipid can be released from the destroyed adipocytes and stay in the interstitial fluid of undestroyed adipocytes. In the meanwhile or after the treatment of FUS, a passive exercise of muscle in thighs or other parts is performed by electrical stimulation to consume energy. Therefore, metabolism of the free lipid can be enhanced by supplying energy to the muscles. The ultrasound treatment of the present disclosure is able to increase the treatment area, and while in combination with electrical stimulation, it can efficiently remove lipids in the circulation.Type: GrantFiled: October 11, 2013Date of Patent: September 6, 2016Assignees: National Health Research Institutes, National Cheng Kung UniversityInventors: Chou-Ching Lin, Gin-Shin Chen