Abstract: Blockade of immune checkpoints such as cytotoxic T-lymphocyte antigen-4 (CTLA-4) and programmed death-1 (PD-1) shows promise in patients with cancer. Inhibitory antibodies directed at these receptors have been shown to break immune tolerance and promote anti-tumor immunity. These agents work particularly well in patients with a certain category of tumor. Such tumors may be particularly susceptible to treatment because of the multitude of neoantigens which they produce.

Abstract: The present invention is directed to spatial-spectral filtering for multi-material CT decomposition. The invention includes a specialized filter that spectrally shapes an x-ray beam into a number of beamlets with different spectra. The filter allows decomposition of an object/anatomy into different material categories (including different biological types: muscle, fat, etc. or exogenous contrast agents that have been introduced: e.g iodine, gadolinium, etc.). The x-ray beam is spectrally modulated across the face of the detector using a repeating pattern of filter materials. Such spatial-spectral filters allow for collection of many different spectral channels using “source-side” control. However, in contrast to other spectral techniques that provide mathematically complete projection data, spatial-spectral filtered data is sparse in each spectral channel—making traditional projection-domain or image-domain material decomposition difficult to apply.

Abstract: The present invention provides both methods and devices for termination of arrhythmias, such as ventricular or atrial tachyarrhythmias. The device and method involves application of alternating current (AC) for clinically significant durations at selected therapeutic frequencies through the cardiac tissue to a subject experiencing arrhythmia. Methods are also provided to minimize or eliminate pain during defibrillation.

Abstract: A computer-implemented method, a computer system, and a non-transitory computer readable medium are provided that perform a method for determining an auscultation quality metric (AQM). The computer-implemented method includes obtaining an acoustic signal representative of pulmonary sounds from a patient; determining a plurality of derived signals from the acoustic signal; performing a regression analysis on the plurality of derived signals; and determining the AQM from the regression analysis.

Abstract: The invention of the instant application discloses spirocyclic guanidine compounds of general formula (I), shown below, and their use in methods of treating cancer

Abstract: Methods and systems for connection-driven generation of robotic user interfaces and modification of robotic properties include detecting a connection of a robotic peripheral to a robot; obtaining a peripheral property set corresponding to the robotic peripheral, wherein the peripheral property set includes one or more properties of the robotic peripheral; modifying, based on the peripheral property set, a robotic property set that includes one or more properties of the robot to provide a modified robotic property set; generating, during runtime, a robotic graphical user interface (“RGUI”) dynamically based on the peripheral property set, wherein the RGUI provides at least one user-accessible interface to control the robot and the robotic peripheral; and controlling, based on the modified robotic property set, the robot and the robotic peripheral in response to user input received via the RGUI.

Abstract: Prodrugs of mebendazole and methods for their use in treating a disease, disorder, or disorder, including cancer, are disclosed.

Abstract: An electrode includes at least one of sulfur (S) or selenium (Se), and a functionalized metal organic framework (R-MOF), the functionalized metal organic framework (R-MOF) having a functional group (R) attached to an organic portion of a metal organic framework (MOF). The functionalized metal organic framework (R-MOF) is adapted to react with at least one of electrochemically accessible sulfur (S) or selenium (Se) to capture at least one of lithium polysulfide or sodium polysulfide via covalent attachment of sulfur (S) or selenium (Se), respectively, to the functional group (R) of the functionalized metal organic framework (R-MOF).

Abstract: A closed-loop implantable neurostimulator system for mitigating chronic pain, the closed-loop implantable neurostimulator system including a neuromodulation device comprising one or more electrodes configured to measure a physiological signal of a subject and deliver an electrical stimulation signal to a target area in the subject and a controller, in communication with the one or more electrodes, comprising a processor and a computer-readable memory storing a trained healthy computer model, the controller configured to analyze the physiological signal that is measured using the trained healthy computer model to identify a corrective electrical stimulation signal that, when delivered by the one or more electrodes to the target area, reduces pathological neuronal events in the target area while preserving acute pain response.

Abstract: Provided herein are methods of detecting a ophthalmologic genetic disease in a subject that include matching properties of captured images and/or videos with properties of an ocular pathology model that is trained on a plurality of reference images and/or videos of ocular cells of reference subjects, which properties of the ocular pathology model are indicative of the pathology. Related systems and computer program products are also provided.

Abstract: An attachment for a drill includes an inner housing configured to be coupled to the drill. The attachment also includes an outer housing positioned at least partially around the inner housing. The attachment also includes a vertical guide coupled to or integral with the inner housing. The attachment also includes a horizontal guide coupled to or integral with the outer housing. The attachment also includes a guide adapter configured to move along the vertical guide and the horizontal guide. The inner housing and the vertical guide are configured to move vertically with respect to the outer housing and the guide adapter, and the inner housing and the guide adapter are configured to move laterally with respect to the horizontal guide and the outer housing.

Abstract: Compounds with the following structures and their analogs are provided. Compositions that include these structures can be used to inhibit glucose transporters and stop or decrease the proliferation of cancer, treat possible organ rejection and treat autoimmune disease.

Abstract: A composite material can include a gel and at least one nanostructure disposed within the gel. A method for healing a soft tissue defect can include applying a composite material to a soft tissue defect, wherein the composite material includes a gel and a nanostructure disposed within the gel. A method for manufacturing a composite material for use in healing soft tissue defects can include providing a gel and disposing nanofibers within the gel.

Abstract: A test environment apparatus having processing circuitry is provided for testing an embedded system-under-test. The processing circuitry may be configured to implement the system-under-test for interaction with external test participants via messaging and control operation of an inner agent and an outer agent. The inner agent may be implemented within a virtual machine that is also implementing the system-under-test and the outer agent may be implemented external to the virtual machine implementing the system-under-test. The inner agent and the outer agent may be controlled to operate collaboratively to trigger captures of snapshots that store current states of the system-under-test at respective times and trigger a rollback of the system-under-test based on a timestamp of a delayed message using a snapshot for a selected time that provides a state of the system-under-test prior to the timestamp to permit subsequent delivery of the delayed message with the system-under-test in a rollback state.

Abstract: A microfluidic apparatus is provided that includes a thermoelectrically-activated pixel array, a microfluidic chip, and control circuitry. The pixel array may include a plurality of thermal pixels, with each thermal pixel including a thermoelectric device. The microfluidic chip may include a microfluidic channel disposed adjacent to the thermal pixels such that thermal energy generated by the thermal pixels is received by the microfluidic channel to form a localized spot within the microfluidic channel corresponding to each thermal pixel. The control circuitry may be electrically coupled to each of the thermal pixels and configured to control the thermal energy being generated by each thermal pixel to control a temperature at each localized spot within the microfluidic channel.

Abstract: Disclosed herein are system, method, and computer program product embodiments for performing a set of operations on one or more encrypted numbers to be an approximation of performing an algebraic operation on the one or more encrypted number. A server can receive from a client, a public key of a fully homomorphic encryption scheme and one or more encrypted numbers, and perform a set of operations comprising a square root function, a rectified linear activation function (ReLU), or a multiplicative inverse function on the one or more encrypted numbers to generate an encrypted operational result. The encrypted operational result generated by the set of operations can be an approximation of performing an algebraic operation on the one or more encrypted number. The server can further transmit to the client the encrypted operational result.

Abstract: An unpowered respiratory protective headset for personal protective equipment and personal protective bodysuits with an unpowered respiratory protective headset, the unpowered respiratory protective headset having a respiratory mask having a flexible mask body having an interface section and defining a mask air inlet and a mask air outlet, an inhalation valve in the mask air inlet and an exhalation valve in the mask air outlet, and a hood having a hood body and a transparent face shield attached to the hood body. The hood has an air inlet and an air outlet and the air inlet, the mask air inlet, the mask air outlet and the air outlet are configured relative to each other to direct air flow across an inner surface of the transparent face shield to prevent or reduce fogging of the transparent face shield during inhalation and exhalation by a subject.

Abstract: A DNA plasmid useful for diagnostic and therapeutic gene therapy is disclosed. Improvements to gene therapy methods known in the art are provided to ensure cancer-targeting, high efficacy, and long durability of expression. The DNA plasmid is combined with compositions of polymeric nanoparticles for non-viral gene therapy to treat cancer, including hepatocellular carcinoma and prostate cancer.

Abstract: A sweat sensor includes a first conductor and a second conductor that are parallel with one another. The sweat sensor also includes a channel disposed between the first and second conductors. The channel is configured to receive a sample of sweat. A measure of capacitance between the first and second conductors changes based at least partially upon a volume of the sweat in the channel.

Abstract: An example imaging apparatus that can operate at shortwave infrared (SWIR) wavelengths are provided. An example imaging apparatus may include a fiber optic bundle, a distal lens, an illumination assembly, and an imaging detector. The fiber optic bundle may comprise a plurality of fibers and may be configured to guide light energy at a SWIR wavelength. The distal lens may be disposed on a distal end of the fiber optic bundle and the distal lens configured to focus light energy at the SWIR wavelength. The illumination assembly may be configured to output illumination at the SWIR wavelength adjacent to the distal end of the fiber optic bundle toward an object. The imaging detector may be operably coupled to a proximal end of the fiber optic bundle and configured to receive imaging light energy at the SWIR wavelength reflected from the object and guided through the fiber optic bundle.