Abstract: Semiconductor optical modulators are described that utilize bipolar junction transistor (BJT) structure within the optical modulator. The junctions within the BJT can be designed and biased to increase modulator efficiency and speed. An optical mode may be located in a selected region of the BJT structure to improve modulation efficiency. The BJT structure can be included in optical waveguides of interferometers and resonators to form optical modulators.

Abstract: Using the Meissner effect in superconductors, demonstrated here is the capability to create an arbitrarily high magnetic flux density (also sometimes referred to as “flux squeezing”). This technique has immediate applications for numerous technologies. For example, it allows the generation of very large magnetic fields (e.g., exceeding 1 Tesla) for nuclear magnetic resonance (NMR), magnetic resonance imaging (MRI), the generation of controlled magnetic fields for advanced superconducting quantum computing devices, and/or the like. The magnetic field concentration/increased flux density approaches can be applied to both static magnetic fields (i.e., direct current (DC) magnetic fields) and time-varying magnetic fields (i.e., alternating current (AC) magnetic fields) up to microwave frequencies.

Abstract: A back-gate carbon nanotube field effect transistor (CNFETs) provides: (1) reduced parasitic capacitance, which decreases the energy-delay product (EDP) thus improving the energy efficiency of digital systems (e.g., very-large-scale integrated circuits) and (2) scaling of transistors to smaller technology nodes (e.g., sub-3 nm nodes). An exemplary back-gate CNFET includes a channel. A source and a drain are disposed on a first side of the channel. A gate is disposed on a second side of the channel opposite to the first side. In this manner, the contacted gate pitch (CGP) of the back-gate CNFET may be scaled down without scaling the physical gate length (LG) or contact length (LC). The gate may also overlap with the source and/or the drain in this architecture. In one example, an exemplary CNFET was demonstrated to have a CGP less than 30 nm and 1.6× improvement to EDP compared to top-gate CNFETs.

Abstract: Methods and products for automated real-time ovarian follicular detection, monitoring and analysis are provided. The devices and methods allow for remote or local analysis, while minimizing or eliminating the need for technician review of the output images. The methods are useful in human and non-human subjects including companion animals and other animals such as endangered species.

Abstract: A network device includes a transceiver configured to concurrently transmit signals and receive signals within a single frequency band resulting in radio-frequency signal interference. The device includes an analog canceler configured to mitigate the signal interference. The device includes a neural network that receives data that describes characteristics of the signal interference and provides coefficients for the analog canceler as outputs. The neural network-generated coefficients are applied to the analog canceler which uses them to cancel the signal interference.

Abstract: The invention provides for systems, methods, and compositions for altering expression of target gene sequences and related gene products. Provided are structural information on the Cas protein of the CRISPR-Cas system, use of this information in generating modified components of the CRISPR complex, vectors and vector systems which encode one or more components or modified components of a CRISPR complex, as well as methods for the design and use of such vectors and components. Also provided are methods of directing CRISPR complex formation in eukaryotic cells and methods for utilizing the CRISPR-Cas system. In particular the present invention comprehends optimized functional CRISPR-Cas enzyme systems, wherein the guide sequence is modified by secondary structure to increase the specificity of the CRISPR-Cas system and whereby the secondary structure can protect against exonuclease activity and allow for 5? additions to the guide sequence.

Abstract: A wearable article comprising a knitted fabric formed in the shape of a glove. A force sensing element coupled to the fabric, the force sensing element comprising a resistive sensing system and a fluidic sensing system comprising one or more soft tubes coupled to a surface of the wearable glove wherein the resistive and fluid sensing systems correspond to first and second different sensor modalities which are physically decoupled. Control circuitry is coupled to receive signals from both the resistive sensing system and the fluidic sensing system and to combine resistive and fluidic sensing system signals provided thereto to perform at least one of: pose estimation, environment sensing, human state sensing, and static and dynamic task identification.

Abstract: A certification method, system, and computer program product include certifying an adversarial robustness of a convolutional neural network by deriving an analytic solution for a neural network output using an efficient upper bound and an efficient lower bound on an activation function and applying the analytic solution in computing a certified robustness.

Abstract: A device, comprising: a flexible carrier; a release layer that is formed on the flexible carrier; a releasable substrate formed over the release layer; and a semiconductor structure that is formed over the releasable substrate.

Abstract: The present description provides methods, assays and reagents for linearly expanding a peptide. The methods and/or linear expanded peptide described herein have several uses such as, but not limited to, peptide (protein) sequencing, high-resolution interrogation of the proteome and enabling ultrasensitive diagnostics critical for early detection of diseases.

Abstract: Corona phase molecular recognition (CoPhMoRe) that enables the molecular recognition of SARS-CoV-2 viral proteins without the need for antibody or enzymatic receptor incorporation.

Abstract: Embodiments disclosed herein are directed to engineered CRISPR-Cas effector proteins that comprise at least one modification compared to an unmodified CRISPR-Cas effector protein that enhances binding of the of the CRISPR complex to the binding site and/or alters editing preference as compared to wild type. In certain example embodiments, the CRISPR-Cas effector protein is a Type V effector protein. In certain other example embodiments, the Type V effector protein is Cpf1. Embodiments disclosed herein are directed to viral vectors for delivery of CRISPR-Cas effector proteins, including Cpf1. In certain example embodiments, the vectors are designed so as to allow packaging of the CRISPR-Cas effector protein within a single vector. There is also an increased interest in the design of compact promoters for packing and thus expressing larger transgenes for targeted delivery and tissue-specificity.

Abstract: The embodiments disclosed herein utilized RNA targeting effectors to provide a robust CRISPR-based diagnostic with attomolar sensitivity. Embodiments disclosed herein can detect broth DNA and RNA with comparable levels of sensitivity and can differentiate targets from non-targets based on single base pair differences. Moreover, the embodiments disclosed herein can be prepared in freeze-dried format for convenient distribution and point-of-care (POC) applications. Such embodiments are useful in multiple scenarios in human health including, for example, viral detection, bacterial strain typing, sensitive genotyping, and detection of disease-associated cell free DNA.

Abstract: The disclosure provides for systems, methods, and compositions for targeting and editing nucleic acids. In particular, the invention provides non-naturally occurring or engineered RNA-targeting systems comprising a RNA-targeting Cas13 protein, at least one guide molecule, and at least one adenosine deaminase protein or catalytic domain thereof.

Abstract: Described is a method and system for vehicle routing and request assignment which incorporates a prediction of future demand. The method seamlessly integrates sampled future requests into request assignments and vehicle routing.

Abstract: A computer, including a processor and a memory, the memory including instructions to be executed by the processor to receive an emitted polarized light beam at a lidar receiver that determines a polarization pattern and a distance to an object, wherein the polarization pattern is determined by comparing a linear polarization pattern and a circular polarization pattern and identify the object by processing the polarization pattern and the distance with a deep neural network, wherein the identity of the object can be metallic or non-metallic. The instructions can include further instructions to operate a vehicle based on the identified object.

Abstract: The present disclosure provides patterned biomaterials having organized cords and extracellular matrix embedded in a 3D scaffold. According, the present disclosure provides compositions and applications for patterned biomaterials. Pre-patterning of these biomaterials can lead to enhanced integration of these materials into host organisms, providing a strategy for enhancing the viability of engineered tissues by promoting vascularization.

Abstract: Disclosed are methods of forming an epimer or a dehydrated isomer of a pyranose monosaccharide or a pyranose saccharide residue in an oligosaccharide or a glycoside.

Abstract: An implantable medical device having a soft tissue interfacing surface comprises at least one soft actuatable capsule having a soft tissue interfacing deflectable membrane configured for cyclical deflection upon actuation of the capsule to modulate the biomechanics of the soft tissue interface during use. The actuatable capsule may comprise an actuation chamber containing a first fluid, a therapeutic chamber containing a second fluid, a deflectable membrane separating the actuation chamber and therapeutic chamber, and an actuation conduit in fluidic communication with the actuation chamber for pneumatic actuation of the actuation chamber. The therapeutic chamber comprises the soft tissue interfacing deflectable membrane which is configured to cyclically deflect during actuation of the capsule and modulate the biomechanics of the soft tissue interface by altering one or more of strain, fluid flow and cellular activity in peri-implant tissue at the soft tissue interface.

Abstract: Described is a cable comprising a plurality of high temperature superconductor (HTS) components, a plurality of electrically conductive segments extending along a length of the cable, each of the plurality of electrically conductive segments comprising one of the plurality of HTS components, and an electrically insulating material arranged between adjacent ones of the plurality of electrically conductive segments.