Patents Assigned to The Medical College of Wisconsin, Inc.
  • Patent number: 11385307
    Abstract: A resonant coil system with improved sensitivity and signal-to-noise performance is described. A primary coil is tuned to a first resonance frequency and inductively coupled to a secondary coil that is separately tuned to a second resonance frequency. The primary and secondary coils form a resonant system with a resonance frequency that is a function of the primary and secondary coil resonance frequencies. The resonance frequency of the coil system is less than both the primary resonance frequency and the secondary resonance frequency. The mutual inductance between the two coils is high and the resonance frequency of the coil system's parallel mode is well separated from that of the anti-parallel mode.
    Type: Grant
    Filed: September 18, 2017
    Date of Patent: July 12, 2022
    Assignee: The Medical College of Wisconsin, Inc.
    Inventors: Richard R. Mett, James S. Hyde, Jason W. Sidabras
  • Patent number: 11372066
    Abstract: Systems and methods for quantitative susceptibility mapping (“QSM”) using magnetic resonance imaging (“MRI”) are described. Localized magnetic field information is used when performing the inversion to compute quantitative susceptibility maps. The localized magnetic field information can include multi-resolution subvolumes obtained by segmenting, or dividing, a field shift map. In some instances, a trained machine learning algorithm, such as a trained neural network, can be implemented to convert the localized magnetic field information into quantitative susceptibility data. These local susceptibility maps can be combined to form a composite quantitative susceptibility map of the imaging volume.
    Type: Grant
    Filed: February 7, 2019
    Date of Patent: June 28, 2022
    Assignee: The Medical College of Wisconsin, Inc.
    Inventors: Kevin M. Koch, Andrew S. Nencka, Juan Liu
  • Patent number: 11369662
    Abstract: The present invention provides a CXCL121 peptide engineered to resist peptide-induced dimerization by maintaining steric repulsion of the chemokine helix, pharmaceutical compositions thereof, and methods of using said dimer in the treatment of cancer, inflammatory disorders, autoimmune disease, and HIV/AIDS.
    Type: Grant
    Filed: January 17, 2020
    Date of Patent: June 28, 2022
    Assignee: The Medical College of Wisconsin, Inc.
    Inventors: Brian Volkman, Joshua Ziarek, Christopher Veldkamp, Francis Peterson
  • Patent number: 11364035
    Abstract: A swallow exerciser device that exercises and thereby strengthens the muscles involved in swallowing includes a rigid shell, an adjustable fastener, and an inflatable pad. The rigid shell has a longitudinal dimension such that the shell extends above and below the larynx of the subject when the swallow exerciser device is positioned over the larynx of the subject. The adjustable fastener is dimensioned to secure the shell around a neck of the subject with the shell positioned over the larynx of the subject. The inflatable pad is connected to a proximal surface of the shell. The inflatable pad is dimensioned to apply resistance to force of at least one swallowing muscle of the subject when the shell positioned over the larynx of the subject and when the inflatable pad is in an inflated position. The swallow exerciser device can be used in a method for improving swallowing function in a subject.
    Type: Grant
    Filed: January 30, 2020
    Date of Patent: June 21, 2022
    Assignees: The Medical College of Wisconsin, Inc., University of Southern California
    Inventors: Reza Shaker, Anisa Shaker
  • Patent number: 11358968
    Abstract: Described here are EET analogs conjugated to folate receptor ligands such as folic acid or folic acid analogs recognized by and selectively bound by folate receptors and other folate binding proteins and the use of such conjugated EET analogs for targeted delivery of therapeutic agents to folate-receptor bearing cell populations. More particularly, provided herein are EET analogs conjugated to folate receptor ligands and uses of such conjugated EET analogs as kidney targeted therapeutics.
    Type: Grant
    Filed: September 14, 2018
    Date of Patent: June 14, 2022
    Assignee: The Medical College of Wisconsin, Inc.
    Inventors: John D. Imig, John R. Falck, Abdul Hye Khan, Adeniyi Adebesin
  • Patent number: 11352382
    Abstract: The present invention relates to mito-lonidamine compounds, compositions and methods of use in the treatment of cancer.
    Type: Grant
    Filed: January 3, 2019
    Date of Patent: June 7, 2022
    Assignees: The Medical College of Wisconsin, Inc., Aix-Marseille Universite
    Inventors: Balaraman Kalyanaraman, Micael J. Hardy, Olivier Ouari
  • Patent number: 11344199
    Abstract: Systems and methods obtain functional connectivity data in the whole brain to detect and predict brain disorders. This whole brain data is regionalized and then manipulated to derive functional connectivity data sets that can be used to show measured functional connectivity changes. This whole brain data may also be analyzed to determine changes in functional activity in both increased and decreased neural network connectivity. By identifying and then quantifying the functional connectivity differences between healthy and diseased subjects, a classification for individual subjects can be made.
    Type: Grant
    Filed: March 15, 2011
    Date of Patent: May 31, 2022
    Assignee: The Medical College of Wisconsin, Inc.
    Inventors: Shi-Jiang Li, Gang Chen, Barney D. Ward, Zhilin Wu, Piero Antuono
  • Publication number: 20220145391
    Abstract: This invention relates to methods and compositions for assessing amount(s) of total cell-free DNA in a subject. Such amount(s) can be used to determine risk in a subject, which subjects are non-transplant subjects, such as surgical subjects, in some preferred embodiments.
    Type: Application
    Filed: June 16, 2021
    Publication date: May 12, 2022
    Applicant: The Medical College of Wisconsin, Inc.
    Inventors: Aoy Tomita Mitchell, Michael Mitchell
  • Patent number: 11274114
    Abstract: The present invention provides mito-metformin compounds, pharmaceutical compositions thereof, and methods of using the mito-metformin compounds in the treatment of cancer.
    Type: Grant
    Filed: August 13, 2015
    Date of Patent: March 15, 2022
    Assignees: The Medical College of Wisconsin, Inc., AIX-Marseille Universite, Iowa State University Research Foundation, Inc.
    Inventors: Balaraman Kalyanaramn, Micael J. Hardy, Marcos Lopez, Olivier Ouari, Jacek Michal Zielonka
  • Patent number: 11229683
    Abstract: Methods and compositions comprising hematopoietic growth factor proteins and/or protein analogs thereof and/or combinations thereof and angiotensin converting enzyme inhibitors to treat the acute and long term adverse effects of radiation exposure in subjects who have been or will be exposed to radiation are disclosed.
    Type: Grant
    Filed: September 19, 2016
    Date of Patent: January 25, 2022
    Assignees: Bolder Biotechnology, Inc., Indiana University Research and Technology Corporation, The Medical College of Wisconsin, Inc.
    Inventors: George N. Cox, Christie M. Orschell, Meetha Manek Medhora, Brian Fish
  • Patent number: 11197820
    Abstract: Provided herein are methods and composition for trans-tympanic membrane delivery of therapeutic agents such as antimicrobial agents, anti-inflammatory agents, and anti-biofilm agents to the middle ear for rapid, localized treatment and prevention of diseases and conditions associated with a middle ear infection. In particular, provided herein are cationic, anionic, and polymer-based nanoparticles that provide a platform for delivery of therapeutic cargo, as well as cationic, anionic, and polymer-based nanoparticles compositions for rapid, localized delivery of therapeutic agents to the middle ear.
    Type: Grant
    Filed: April 27, 2020
    Date of Patent: December 14, 2021
    Assignee: The Medical College of Wisconsin, Inc.
    Inventors: Amit Joshi, Joseph Edward Kerschner, Wenzhou Hong, Gayatri Sharma
  • Patent number: 11154212
    Abstract: Systems and methods for estimating quantitative histological features of a subject's tissue based on medical images of the subject are provided. For instance, quantitative histological features of a tissue are estimated by comparing medical images of the subject to a trained model that relates histological features to multiple different medical image contrast types, whether from one medical imaging modality or multiple different medical imaging modalities. In general, the trained model is generated based on medical images of ex vivo samples, in vitro samples, in vivo samples or combinations thereof, and is based on histological features extracted from those samples. A machine learning algorithm, or other suitable learning algorithm, is used to generate the trained model. The trained model is not patient-specific and thus, once generated, can be applied to any number of different individual subjects.
    Type: Grant
    Filed: September 11, 2015
    Date of Patent: October 26, 2021
    Assignee: The Medical College of Wisconsin, Inc.
    Inventor: Peter Sherman Laviolette
  • Publication number: 20210301320
    Abstract: This invention relates to methods and compositions for assessing an amount of non-native nucleic acids in a sample, such as from a subject, and/or noise, background or discordance quality check (QC). The methods and compositions provided herein can be used to determine risk of a condition, such as cancer, in a subject.
    Type: Application
    Filed: November 9, 2020
    Publication date: September 30, 2021
    Applicant: The Medical College of Wisconsin, Inc.
    Inventors: Aoy Tomita Mitchell, Karl Stamm
  • Patent number: 11116748
    Abstract: The present invention provides methods for using reutericyclin or an analog thereof to reduce weight gain or induce weight loss in a mammal. Also provided herein are methods for using reutericyclin-producing Lactobacillus reuterii bacteria as a probiotic to reduce weight gain or to induce weight loss, particularly for subjects receiving an antibiotic or xenobiotic treatment.
    Type: Grant
    Filed: July 15, 2019
    Date of Patent: September 14, 2021
    Assignee: The Medical College of Wisconsin, Inc.
    Inventors: John Richard Kirby, Orlando Grajo De Leon
  • Patent number: 11083739
    Abstract: The present invention provides mito-magnolol compounds, pharmaceutical compositions thereof, and methods of using the mito-magnolol compounds in the treatment of cancer, especially anti-cancer therapy or kinase resistant cancers.
    Type: Grant
    Filed: December 13, 2019
    Date of Patent: August 10, 2021
    Assignees: THE MEDICAL COLLEGE OF WISCONSIN, INC., AIX-MARSEILLE UNIVERSITE
    Inventors: Balaraman Kalyanaraman, Jacek Michal Zielonka, Gang Cheng, Micael Joël Hardy, Olivier Ouari
  • Publication number: 20210238125
    Abstract: N-benzylbenzamides that act as dual soluble epoxide hydrolase (sEH)/peroxisome proliferator-activated receptor ? (PPAR?) modulators and are useful as medications in the treatment of Metabolic Syndrome (MetS) cluster diseases, including diabetes. Methods of making and using the same are further provided.
    Type: Application
    Filed: December 23, 2020
    Publication date: August 5, 2021
    Applicants: The Medical College of Wisconsin, Inc., Johann Wolfgang Goethe-Universität Frankfurt
    Inventors: John David Imig, Md. Abdul Hye Khan, Eugen Proschak, Rene Blocher
  • Patent number: 11048102
    Abstract: Certain embodiments of the present invention are directed to therapeutic intervention in patients with eye-length-related disorders to prevent, ameliorate, or reverse the effects of the eye-length-related disorders. Embodiments of the present invention include methods for early recognition of patients with eye-length-related disorders, therapeutic methods for inhibiting further degradation of vision in patients with eye-length-related disorders, reversing, when possible, eye-length-related disorders, and preventing eye-length-related disorders. Additional embodiments of the present invention are directed to particular devices used in therapeutic intervention in patients with eye-length-related disorders.
    Type: Grant
    Filed: August 31, 2020
    Date of Patent: June 29, 2021
    Assignee: The Medical College of Wisconsin, Inc.
    Inventors: Jay Neitz, Maureen Neitz
  • Publication number: 20210162009
    Abstract: The present disclosure provides methods of using the CXCL12-?2 locked dimer polypeptide to mobilize cancer cells and hematopoietic stem cells into the bloodstream of a subject.
    Type: Application
    Filed: December 7, 2018
    Publication date: June 3, 2021
    Applicant: THE MEDICAL COLLEGE OF WISCONSIN, INC.
    Inventors: Michael DWINELL, Bryon JOHNSON, Brian VOLKMAN, Francis PETERSON
  • Publication number: 20210139969
    Abstract: This invention relates to methods and compositions for assessing an amount of total cell-free DNA, such as from a transplant subject. The methods and composition provided herein can be used to determine risk of complications following transplantation, including infection, cardiac arrest, and death, in a subject.
    Type: Application
    Filed: June 20, 2018
    Publication date: May 13, 2021
    Applicant: The Medical College of Wisconsin, Inc.
    Inventors: Aoy Tomita Mitchell, Michael Mitchell
  • Publication number: 20210139988
    Abstract: This invention relates to methods and compositions for assessing an amount of donor-specific fraction of cell-free DNA, such as from a subject. The methods and compositions provided herein can be used to determine risk of a condition, such as transplant organ injury (e.g., cellular injury), cellular rejection grade, antibody-mediated rejection, cardiac allograft vasculopathy, and/or cardiac arrest in a transplant subject.
    Type: Application
    Filed: June 20, 2018
    Publication date: May 13, 2021
    Applicant: The Medical College of Wisconsin, Inc.
    Inventors: Aoy Tomita Mitchell, Michael Mitchell