Patents Assigned to The Medical College of Wisconsin, Inc.
-
Patent number: 12012602Abstract: The present invention provides constructs comprising modified riboswitches to regulate expression of a transgene within a subject. Methods of treating a disease, specifically an eye disease, are also contemplated.Type: GrantFiled: March 9, 2018Date of Patent: June 18, 2024Assignee: The Medical College of Wisconsin, Inc.Inventors: Daniel M. Lipinski, Chris A. Reid
-
Patent number: 12005270Abstract: Systems and methods for accelerated online adaptive radiation therapy (“ART”) are described. The improvements to online ART are generally provided based on the use of textural analysis and machine learning algorithms implemented with a hardware processor and a memory. The described systems and methods enable more efficient and accurate online adaptive replanning (“OLAR”), which can also be implemented in clinically acceptable timeframes. For example, OLAR can be reduced from taking 10-30 minutes down to 5-10 minutes.Type: GrantFiled: June 26, 2019Date of Patent: June 11, 2024Assignee: The Medical College of Wisconsin, Inc.Inventors: X. Allen Li, Ying Zhang, Sara Lim, Jingqiao Zhang, Ergun Ahunbay, Ranjeeta Thapa, Haidy Nasief
-
Patent number: 12006511Abstract: The present disclosure provides soluble truncated mutant programmed death-ligand 1 (PD-L1) peptides. Polynucleotides and vectors encoding the soluble truncated mutant PD-L1 peptides are also provided. Further, methods of using the soluble truncated mutant peptides to promote differentiation of CD4+ effector T (Th1) cells into Foxp3+ regulatory T (Treg) cells are provided.Type: GrantFiled: April 14, 2020Date of Patent: June 11, 2024Assignees: The Medical College of Wisconsin, Inc., University of Virginia Patent FoundationInventors: Kaothara Oluwakemi Adeyanju, Jeffrey A. Medin, Robert Blake Hill, Lawrence G. Lum
-
Patent number: 11998757Abstract: Reperfusion injury is limited during endovascular therapies (e.g., revascularization and/or reperfusion of end organ tissues) by conditioning the tissues against reperfusion injury using an optical fiber catheter to deliver far red and near infrared (R/NIR) light to the tissues. The light may be multiple wavelength or single wavelength light, and may have one or more wavelengths selected from the range of 510 to 830 nm. The R/NIR light may be delivered concurrently with the endovascular therapy, or in other instances may be delivered before or after a particular therapy.Type: GrantFiled: March 22, 2022Date of Patent: June 4, 2024Assignee: The Medical College of Wisconsin, Inc.Inventors: Nicole Lohr, Michael Salinger
-
Publication number: 20240156467Abstract: A compression device is used to increase intra-luminal pressure within the upper esophageal sphincter of a patient in order relieve an impact of an abnormal or defective upper esophageal sphincter anatomy, physiology, or functionality. In one implementation, the compression device is used in conjunction with an external pressure sensing device to determine the external pressure that is to be applied to the cricoid for a specific patient. The compression device can be a means for the management and/or treatment of abnormal upper esophageal sphincter functionality, or a means for strengthening an esophageal sphincter of a subject, or a means for curing esophageal reflux disease of a subject, or a means for improving vocal function in a subject, or a means for managing lung aspiration, or a means for applying cricoid pressure during anesthesia intubation, or a means for stabilizing body structures such as during medical imaging or radiation treatment.Type: ApplicationFiled: November 20, 2023Publication date: May 16, 2024Applicant: The Medical College of Wisconsin, Inc.Inventors: Nick T. Maris, James S. Miller, Reza Shaker, Timothy Bachman, Nathan Schlueter, Eugene Paul Maloney, Eric David North, Paul Raine, Peter Alex
-
Patent number: 11974812Abstract: Laser-Speckle Contrast imaging apparatus configured to assess and quantify motion associated with an object and, in a specific case of an eye—retinal vascular anatomy and hemodynamics and generate substantially contrast-free maps of retinal blood flow over a wide field-of-view at up to 590 fps and under short exposure durations (>50 ?s), is applicable for diagnosis, study, and management of neurodegenerative conditions (i.e. mild cognitive impairment and Alzheimer's disease) and systemic cardiovascular diseases (i.e. athero- and arteriosclerosis, coronary artery occlusion, and hypertension). The apparatus employs a) a set of apertures substantially blocking light, delivered from a source of light to an illumination arm of the apparatus, from impinging onto an axial point of the front surface of the lens of the illumination arm, and b) polarization gating between the illumination and light-collecting arms of the apparatus.Type: GrantFiled: March 21, 2022Date of Patent: May 7, 2024Assignees: The Medical College of Wisconsin, Inc., Coherence Consulting LLCInventors: Dwani Patel, Al Hafeez Dhalla, Christian B. Viehland, Daniel M. Lipinski
-
Patent number: 11969265Abstract: Systems and methods for training and implementing a machine learning algorithm to generate feature maps depicting spatial patterns of features associated with osteolysis, synovitis, or both. MRI data, including multispectral imaging data, are input to the trained machine learning algorithm to generate the feature maps, which may indicate features such as a location and probability of a pathology classification, a severity of synovitis, a type of synovitis, a synovial membrane thickness, and other features associated with osteolysis or synovitis. In some implementations, synovial anatomy are segmented in the MRI data before inputting the MRI data to the machine learning algorithm. These segmented MRI data may be generated using another trained machine learning algorithm.Type: GrantFiled: March 4, 2019Date of Patent: April 30, 2024Assignees: The Medical College of Wisconsin, Inc., New York Society for the Relief of the Ruptured and Crippled, Maintaining the Hospital for Special SurgeryInventors: Kevin M. Koch, Andrew S. Nencka, Robin A. Karr, Bradley J. Swearingen, Hollis Potter, Matthew F. Koff
-
Patent number: 11959096Abstract: Provided herein are methods of reducing or eliminating undifferentiated pluripotent stem cells, where the methods comprise contacting an effective amount of a compound to a heterogeneous cell population or sample comprising or suspected of comprising differentiated cell types and undifferentiated pluripotent stem cells, whereby the contacting selectively reduces or eliminates undifferentiated pluripotent stem cells from the cell population or sample. Also provided are methods for obtaining a population of stem cell-derived cell types substantially free of undifferentiated pluripotent stem cells as well as isolated populations of such of stem cell-derived cell types.Type: GrantFiled: September 18, 2020Date of Patent: April 16, 2024Assignees: The Medical College of Wisconsin, Inc., The Government of the United States of America as Represented by the Secretary of the Department of Health and Human Services NIH, Office of Technology TransferInventors: Rebekah L. Gundry, Kenneth R. Boheler, Erin M. Kropp
-
Patent number: 11911010Abstract: A medical instrument port is described for use with a surgical mask or other protective face covering. The medical instrument port provides a sealed pathway through which a medical instrument can be passed without exposing the clinician to aerosolized droplets expelled from the patient's respiratory system when the medical instrument is introduced into the patient's nasal and/or oral passages.Type: GrantFiled: May 5, 2021Date of Patent: February 27, 2024Assignee: The Medical College of Wisconsin, Inc.Inventors: B. Tucker Woodson, David M. Poetker, Guilherme Garcia, Bonnie Patricia Freudinger, David R. Friedland, Todd A. Loehrl
-
Patent number: 11899288Abstract: Certain embodiments of the present invention are directed to therapeutic intervention in patients with eye-length-related disorders to prevent, ameliorate, or reverse the effects of the eye-length-related disorders. Embodiments of the present invention include methods for early recognition of patients with eye-length-related disorders, therapeutic methods for inhibiting further degradation of vision in patients with eye-length-related disorders, reversing, when possible, eye-length-related disorders, and preventing eye-length-related disorders. Additional embodiments of the present invention are directed to particular devices used in therapeutic intervention in patients with eye-length-related disorders.Type: GrantFiled: June 26, 2023Date of Patent: February 13, 2024Assignee: The Medical College of Wisconsin, Inc.Inventors: Jay Neitz, Maureen Neitz
-
Patent number: 11897910Abstract: The present invention provides mito-honokiol or mito-magnolol compounds, pharmaceutical compositions thereof, and methods of using the mito-honokiol or mito-magnolol compounds in the treatment of cancer.Type: GrantFiled: November 16, 2020Date of Patent: February 13, 2024Assignees: The Medical College of Wisconsin, Inc., Aix-Marseille UniversiteInventors: Balaraman Kalyanaraman, Jacek Michal Zielonka, Gang Cheng, Micael J. Hardy, Olivier Ouari, Ming You
-
Publication number: 20240026437Abstract: This invention relates to methods and compositions for assessing an amount of total cell-free DNA, such as from a transplant subject. The methods and composition provided herein can be used to determine risk of complications following transplantation, including infection, cardiac arrest, and death, in a subject.Type: ApplicationFiled: June 28, 2023Publication date: January 25, 2024Applicant: The Medical College of Wisconsin, Inc.Inventors: Aoy Tomita Mitchell, Michael Mitchell
-
Patent number: 11823800Abstract: Systems and methods are described for segmenting medical images, such as magnetic resonance images, using a deep learning model that has been trained using random dropped inputs, standardized inputs, or both. Medical images can be segmented based on anatomy, physiology, pathology, other properties or characteristics represented in the medical images, or combinations thereof. As one example, multi-contrast magnetic resonance images are input to the trained deep learning model in order to generate multiple segmented medical images, each representing a different segmentation class.Type: GrantFiled: October 11, 2019Date of Patent: November 21, 2023Assignee: The Medical College of Wisconsin, Inc.Inventors: Robert Thaddeus Wujek, Kathleen Marie Schmainda
-
Patent number: 11819186Abstract: A compression device is used to increase intra-luminal pressure within the upper esophageal sphincter of a patient in order relieve an impact of an abnormal or defective upper esophageal sphincter anatomy, physiology, or functionality. In one implementation, the compression device is used in conjunction with an external pressure sensing device to determine the external pressure that is to be applied to the cricoid for a specific patient. The compression device can be a means for the management and/or treatment of abnormal upper esophageal sphincter functionality, or a means for strengthening an esophageal sphincter of a subject, or a means for curing esophageal reflux disease of a subject, or a means for improving vocal function in a subject, or a means for managing lung aspiration, or a means for applying cricoid pressure during anesthesia intubation, or a means for stabilizing body structures such as during medical imaging or radiation treatment.Type: GrantFiled: July 13, 2020Date of Patent: November 21, 2023Assignees: The Medical College of Wisconsin, Inc., Respiratory Technology CorporationInventors: Nick T. Maris, James S. Miller, Reza Shaker, Timothy Bachman, Nathan Schlueter, Eugene Paul Maloney, Eric David North, Paul Raine, Peter Alex
-
Patent number: 11815745Abstract: Certain embodiments of the present invention are directed to therapeutic intervention in patients with eye-length-related disorders to prevent, ameliorate, or reverse the effects of the eye-length-related disorders. Embodiments of the present invention include methods for early recognition of patients with eye-length-related disorders, therapeutic methods for inhibiting further degradation of vision in patients with eye-length-related disorders, reversing, when possible, eye-length-related disorders, and preventing eye-length-related disorders. Additional embodiments of the present invention are directed to particular devices used in therapeutic intervention in patients with eye-length-related disorders.Type: GrantFiled: October 20, 2022Date of Patent: November 14, 2023Assignee: The Medical College of Wisconsin, Inc.Inventors: Jay Neitz, Maureen Neitz
-
Patent number: 11773434Abstract: This invention relates to methods and compositions for assessing an amount of total cell-free DNA, such as from a transplant subject. The methods and composition provided herein can be used to determine risk of complications following transplantation, including infection, cardiac arrest, and death, in a subject.Type: GrantFiled: June 20, 2018Date of Patent: October 3, 2023Assignee: The Medical College of Wisconsin, Inc.Inventors: Aoy Tomita Mitchell, Michael Mitchell
-
Patent number: 11771749Abstract: The present disclosure provides compositions and methods of eliciting an anti-tumor immune response and treating cancer comprising at least one peptide of KRAS.Type: GrantFiled: February 5, 2018Date of Patent: October 3, 2023Assignees: The Medical College of Wisconsin, Inc., National Institutes of Health (NIH)Inventors: Jing Pan, Ming You, Ronald Lubet
-
Patent number: 11725234Abstract: This invention relates to methods and compositions for assessing an amount of total cell-free DNA, such as from a transplant subject. The methods and composition provided herein can be used to determine risk of complications following transplantation, including infection, cardiac arrest, and death, in a subject.Type: GrantFiled: June 20, 2018Date of Patent: August 15, 2023Assignee: The Medical College of Wisconsin, Inc.Inventors: Aoy Tomita Mitchell, Michael Mitchell
-
Patent number: 11721021Abstract: A method of detecting the presence of a prostate cancer in a human subject comprising the steps of (a) obtaining a histologically normal prostate tissue sample from the patient and (b) quantifying the epithelial thickness or gland lumen roundness of the tissue, wherein an increase in epithelial thickness or a decrease in gland lumen roundness indicates the presence of prostate cancer or a prostate cancer field defect.Type: GrantFiled: August 25, 2022Date of Patent: August 8, 2023Assignees: Wisconsin Alumni Research Foundation, The Medical College of Wisconsin, Inc.Inventors: David Frazier Jarrard, Bing Yang, Peter LaViolette
-
Patent number: 11707283Abstract: An esophageal device is used to recognize, diagnose, characterize, or relieve an impact of an abnormal or defective UES anatomy, physiology, or functionality. In one implementation, the esophageal device measures a UES response to esophageal fluid infusion to detect or characterize an abnormality or defective UES anatomy, physiology, or functionality. An Upper Esophageal Sphincter compression device is used to increase intra-luminal pressure within the Upper Esophageal Sphincter of a patient in order relieve an impact of an abnormal or defective UES anatomy, physiology, or functionality.Type: GrantFiled: April 21, 2020Date of Patent: July 25, 2023Assignee: THE MEDICAL COLLEGE OF WISCONSIN, INC.Inventor: Reza Shaker