Patents Assigned to The Medical College of Wisconsin, Inc.
  • Publication number: 20240156467
    Abstract: A compression device is used to increase intra-luminal pressure within the upper esophageal sphincter of a patient in order relieve an impact of an abnormal or defective upper esophageal sphincter anatomy, physiology, or functionality. In one implementation, the compression device is used in conjunction with an external pressure sensing device to determine the external pressure that is to be applied to the cricoid for a specific patient. The compression device can be a means for the management and/or treatment of abnormal upper esophageal sphincter functionality, or a means for strengthening an esophageal sphincter of a subject, or a means for curing esophageal reflux disease of a subject, or a means for improving vocal function in a subject, or a means for managing lung aspiration, or a means for applying cricoid pressure during anesthesia intubation, or a means for stabilizing body structures such as during medical imaging or radiation treatment.
    Type: Application
    Filed: November 20, 2023
    Publication date: May 16, 2024
    Applicant: The Medical College of Wisconsin, Inc.
    Inventors: Nick T. Maris, James S. Miller, Reza Shaker, Timothy Bachman, Nathan Schlueter, Eugene Paul Maloney, Eric David North, Paul Raine, Peter Alex
  • Patent number: 11974812
    Abstract: Laser-Speckle Contrast imaging apparatus configured to assess and quantify motion associated with an object and, in a specific case of an eye—retinal vascular anatomy and hemodynamics and generate substantially contrast-free maps of retinal blood flow over a wide field-of-view at up to 590 fps and under short exposure durations (>50 ?s), is applicable for diagnosis, study, and management of neurodegenerative conditions (i.e. mild cognitive impairment and Alzheimer's disease) and systemic cardiovascular diseases (i.e. athero- and arteriosclerosis, coronary artery occlusion, and hypertension). The apparatus employs a) a set of apertures substantially blocking light, delivered from a source of light to an illumination arm of the apparatus, from impinging onto an axial point of the front surface of the lens of the illumination arm, and b) polarization gating between the illumination and light-collecting arms of the apparatus.
    Type: Grant
    Filed: March 21, 2022
    Date of Patent: May 7, 2024
    Assignees: The Medical College of Wisconsin, Inc., Coherence Consulting LLC
    Inventors: Dwani Patel, Al Hafeez Dhalla, Christian B. Viehland, Daniel M. Lipinski
  • Patent number: 11969265
    Abstract: Systems and methods for training and implementing a machine learning algorithm to generate feature maps depicting spatial patterns of features associated with osteolysis, synovitis, or both. MRI data, including multispectral imaging data, are input to the trained machine learning algorithm to generate the feature maps, which may indicate features such as a location and probability of a pathology classification, a severity of synovitis, a type of synovitis, a synovial membrane thickness, and other features associated with osteolysis or synovitis. In some implementations, synovial anatomy are segmented in the MRI data before inputting the MRI data to the machine learning algorithm. These segmented MRI data may be generated using another trained machine learning algorithm.
    Type: Grant
    Filed: March 4, 2019
    Date of Patent: April 30, 2024
    Assignees: The Medical College of Wisconsin, Inc., New York Society for the Relief of the Ruptured and Crippled, Maintaining the Hospital for Special Surgery
    Inventors: Kevin M. Koch, Andrew S. Nencka, Robin A. Karr, Bradley J. Swearingen, Hollis Potter, Matthew F. Koff
  • Patent number: 11959096
    Abstract: Provided herein are methods of reducing or eliminating undifferentiated pluripotent stem cells, where the methods comprise contacting an effective amount of a compound to a heterogeneous cell population or sample comprising or suspected of comprising differentiated cell types and undifferentiated pluripotent stem cells, whereby the contacting selectively reduces or eliminates undifferentiated pluripotent stem cells from the cell population or sample. Also provided are methods for obtaining a population of stem cell-derived cell types substantially free of undifferentiated pluripotent stem cells as well as isolated populations of such of stem cell-derived cell types.
    Type: Grant
    Filed: September 18, 2020
    Date of Patent: April 16, 2024
    Assignees: The Medical College of Wisconsin, Inc., The Government of the United States of America as Represented by the Secretary of the Department of Health and Human Services NIH, Office of Technology Transfer
    Inventors: Rebekah L. Gundry, Kenneth R. Boheler, Erin M. Kropp
  • Patent number: 11911010
    Abstract: A medical instrument port is described for use with a surgical mask or other protective face covering. The medical instrument port provides a sealed pathway through which a medical instrument can be passed without exposing the clinician to aerosolized droplets expelled from the patient's respiratory system when the medical instrument is introduced into the patient's nasal and/or oral passages.
    Type: Grant
    Filed: May 5, 2021
    Date of Patent: February 27, 2024
    Assignee: The Medical College of Wisconsin, Inc.
    Inventors: B. Tucker Woodson, David M. Poetker, Guilherme Garcia, Bonnie Patricia Freudinger, David R. Friedland, Todd A. Loehrl
  • Patent number: 11899288
    Abstract: Certain embodiments of the present invention are directed to therapeutic intervention in patients with eye-length-related disorders to prevent, ameliorate, or reverse the effects of the eye-length-related disorders. Embodiments of the present invention include methods for early recognition of patients with eye-length-related disorders, therapeutic methods for inhibiting further degradation of vision in patients with eye-length-related disorders, reversing, when possible, eye-length-related disorders, and preventing eye-length-related disorders. Additional embodiments of the present invention are directed to particular devices used in therapeutic intervention in patients with eye-length-related disorders.
    Type: Grant
    Filed: June 26, 2023
    Date of Patent: February 13, 2024
    Assignee: The Medical College of Wisconsin, Inc.
    Inventors: Jay Neitz, Maureen Neitz
  • Patent number: 11897910
    Abstract: The present invention provides mito-honokiol or mito-magnolol compounds, pharmaceutical compositions thereof, and methods of using the mito-honokiol or mito-magnolol compounds in the treatment of cancer.
    Type: Grant
    Filed: November 16, 2020
    Date of Patent: February 13, 2024
    Assignees: The Medical College of Wisconsin, Inc., Aix-Marseille Universite
    Inventors: Balaraman Kalyanaraman, Jacek Michal Zielonka, Gang Cheng, Micael J. Hardy, Olivier Ouari, Ming You
  • Publication number: 20240026437
    Abstract: This invention relates to methods and compositions for assessing an amount of total cell-free DNA, such as from a transplant subject. The methods and composition provided herein can be used to determine risk of complications following transplantation, including infection, cardiac arrest, and death, in a subject.
    Type: Application
    Filed: June 28, 2023
    Publication date: January 25, 2024
    Applicant: The Medical College of Wisconsin, Inc.
    Inventors: Aoy Tomita Mitchell, Michael Mitchell
  • Patent number: 11823800
    Abstract: Systems and methods are described for segmenting medical images, such as magnetic resonance images, using a deep learning model that has been trained using random dropped inputs, standardized inputs, or both. Medical images can be segmented based on anatomy, physiology, pathology, other properties or characteristics represented in the medical images, or combinations thereof. As one example, multi-contrast magnetic resonance images are input to the trained deep learning model in order to generate multiple segmented medical images, each representing a different segmentation class.
    Type: Grant
    Filed: October 11, 2019
    Date of Patent: November 21, 2023
    Assignee: The Medical College of Wisconsin, Inc.
    Inventors: Robert Thaddeus Wujek, Kathleen Marie Schmainda
  • Patent number: 11819186
    Abstract: A compression device is used to increase intra-luminal pressure within the upper esophageal sphincter of a patient in order relieve an impact of an abnormal or defective upper esophageal sphincter anatomy, physiology, or functionality. In one implementation, the compression device is used in conjunction with an external pressure sensing device to determine the external pressure that is to be applied to the cricoid for a specific patient. The compression device can be a means for the management and/or treatment of abnormal upper esophageal sphincter functionality, or a means for strengthening an esophageal sphincter of a subject, or a means for curing esophageal reflux disease of a subject, or a means for improving vocal function in a subject, or a means for managing lung aspiration, or a means for applying cricoid pressure during anesthesia intubation, or a means for stabilizing body structures such as during medical imaging or radiation treatment.
    Type: Grant
    Filed: July 13, 2020
    Date of Patent: November 21, 2023
    Assignees: The Medical College of Wisconsin, Inc., Respiratory Technology Corporation
    Inventors: Nick T. Maris, James S. Miller, Reza Shaker, Timothy Bachman, Nathan Schlueter, Eugene Paul Maloney, Eric David North, Paul Raine, Peter Alex
  • Patent number: 11815745
    Abstract: Certain embodiments of the present invention are directed to therapeutic intervention in patients with eye-length-related disorders to prevent, ameliorate, or reverse the effects of the eye-length-related disorders. Embodiments of the present invention include methods for early recognition of patients with eye-length-related disorders, therapeutic methods for inhibiting further degradation of vision in patients with eye-length-related disorders, reversing, when possible, eye-length-related disorders, and preventing eye-length-related disorders. Additional embodiments of the present invention are directed to particular devices used in therapeutic intervention in patients with eye-length-related disorders.
    Type: Grant
    Filed: October 20, 2022
    Date of Patent: November 14, 2023
    Assignee: The Medical College of Wisconsin, Inc.
    Inventors: Jay Neitz, Maureen Neitz
  • Patent number: 11771749
    Abstract: The present disclosure provides compositions and methods of eliciting an anti-tumor immune response and treating cancer comprising at least one peptide of KRAS.
    Type: Grant
    Filed: February 5, 2018
    Date of Patent: October 3, 2023
    Assignees: The Medical College of Wisconsin, Inc., National Institutes of Health (NIH)
    Inventors: Jing Pan, Ming You, Ronald Lubet
  • Patent number: 11773434
    Abstract: This invention relates to methods and compositions for assessing an amount of total cell-free DNA, such as from a transplant subject. The methods and composition provided herein can be used to determine risk of complications following transplantation, including infection, cardiac arrest, and death, in a subject.
    Type: Grant
    Filed: June 20, 2018
    Date of Patent: October 3, 2023
    Assignee: The Medical College of Wisconsin, Inc.
    Inventors: Aoy Tomita Mitchell, Michael Mitchell
  • Patent number: 11725234
    Abstract: This invention relates to methods and compositions for assessing an amount of total cell-free DNA, such as from a transplant subject. The methods and composition provided herein can be used to determine risk of complications following transplantation, including infection, cardiac arrest, and death, in a subject.
    Type: Grant
    Filed: June 20, 2018
    Date of Patent: August 15, 2023
    Assignee: The Medical College of Wisconsin, Inc.
    Inventors: Aoy Tomita Mitchell, Michael Mitchell
  • Patent number: 11721021
    Abstract: A method of detecting the presence of a prostate cancer in a human subject comprising the steps of (a) obtaining a histologically normal prostate tissue sample from the patient and (b) quantifying the epithelial thickness or gland lumen roundness of the tissue, wherein an increase in epithelial thickness or a decrease in gland lumen roundness indicates the presence of prostate cancer or a prostate cancer field defect.
    Type: Grant
    Filed: August 25, 2022
    Date of Patent: August 8, 2023
    Assignees: Wisconsin Alumni Research Foundation, The Medical College of Wisconsin, Inc.
    Inventors: David Frazier Jarrard, Bing Yang, Peter LaViolette
  • Patent number: 11707283
    Abstract: An esophageal device is used to recognize, diagnose, characterize, or relieve an impact of an abnormal or defective UES anatomy, physiology, or functionality. In one implementation, the esophageal device measures a UES response to esophageal fluid infusion to detect or characterize an abnormality or defective UES anatomy, physiology, or functionality. An Upper Esophageal Sphincter compression device is used to increase intra-luminal pressure within the Upper Esophageal Sphincter of a patient in order relieve an impact of an abnormal or defective UES anatomy, physiology, or functionality.
    Type: Grant
    Filed: April 21, 2020
    Date of Patent: July 25, 2023
    Assignee: THE MEDICAL COLLEGE OF WISCONSIN, INC.
    Inventor: Reza Shaker
  • Patent number: 11708412
    Abstract: The present invention relates to methods of treating hematologic cancers using a combination of inhibitors of PD-1 or PD-L1 and TIM-3, LAG-3 or CTLA4.
    Type: Grant
    Filed: December 23, 2019
    Date of Patent: July 25, 2023
    Assignees: Novartis AG, The Medical College of Wisconsin, Inc.
    Inventors: Bryon Duane Johnson, Robert Millman
  • Patent number: 11696701
    Abstract: Systems and methods for estimating quantitative histological features of a subject's tissue based on medical images of the subject are provided. For instance, quantitative histological features of a tissue are estimated by comparing medical images of the subject to a trained model that relates histological features to multiple different medical image contrast types, whether from one medical imaging modality or multiple different medical imaging modalities. In general, the trained model is generated based on medical images of ex vivo samples, in vitro samples, in vivo samples or combinations thereof, and is based on histological features extracted from those samples. A machine learning algorithm, or other suitable learning algorithm, is used to generate the trained model. The trained model is not patient-specific and thus, once generated, can be applied to any number of different individual subjects.
    Type: Grant
    Filed: October 25, 2021
    Date of Patent: July 11, 2023
    Assignee: The Medical College of Wisconsin, Inc.
    Inventor: Peter Sherman Laviolette
  • Patent number: 11667721
    Abstract: The present invention provides novel bispecific antibodies that bind to human CD30 and uses thereof. Methods of treating cancer using the bispecific antibodies described herein are also provided.
    Type: Grant
    Filed: September 24, 2019
    Date of Patent: June 6, 2023
    Assignees: Medical College of Wisconsin, Inc., University of Virginia Patent Foundation
    Inventors: Jeffrey A. Medin, Lawrence G. Lum, Robyn A. A. Oldham, Archana Thakur
  • Publication number: 20230138927
    Abstract: This invention relates to methods and compositions for assessing an amount of total cell-free DNA, such as from a subject having a pro-inflammatory response, such as a pro-inflammatory response associated with an infection, such as a COVID-19 infection. This invention also relates to compositions and methods for treating subjects having or suspected of having a pro-inflammatory response, such as a pro-inflammatory response associated with an infection, such as a COVID-19 infection. In embodiments, there is a risk of an inappropriate or detrimental pro-inflammatory response, such as in a subject with a COVID-19 infection. The methods and composition provided herein can be used to determine severity and risk of complications in a subject. The methods and composition provided herein can also be used to assess the effectiveness of a therapy in a subject, such as a COVID-19 subject.
    Type: Application
    Filed: October 6, 2022
    Publication date: May 4, 2023
    Applicant: The Medical College of Wisconsin, Inc.
    Inventors: Michael Mitchell, Aoy Tomita Mitchell