Abstract: The present invention provides novel antibodies and antigen binding fragments thereof that bind to human CD30. Also presented are single chain variable antibodies, chimeric antigen receptors and uses thereof. Methods of treating cancer are also disclosed.

Abstract: The present invention provides a CCL20 locked dimer polypeptide, pharmaceutical compositions thereof, and methods of using said dimer in the treatment of psoriasis and psoriatic arthritis.

Abstract: Systems and methods for designing and fabricating three-dimensional objects with precisely computed material compositions for use in enhancing electromagnetic fields for magnetic resonance imaging (“MRI”) are provided. As examples, the fabricated object can be designed to reduce magnetic field inhomogeneities in the main magnetic field of an MRI system, or to reduce inhomogeneities in a transmit radio frequency (“RF”) field (i.e., a B1 field). As examples, the object can be a shim; a housing or other part of an RF coil; a medical device, such as a surgical implant; or component used in a medical device, such as a housing for an implantable medical device.

Abstract: A method of detecting the presence of a prostate cancer in a human subject comprising the steps of (a) obtaining a histologically normal prostate tissue sample from the patient and (b) quantifying the epithelial thickness or gland lumen roundness of the tissue, wherein an increase in epithelial thickness or a decrease in gland lumen roundness indicates the presence of prostate cancer or a prostate cancer field defect.

Abstract: Provided herein are engineered non-catalytic, non-toxic tetanus toxin variants and methods of using such engineered tetanus toxin variants as low dose, protective vaccines that are non-toxic and more potent than their respective chemically inactivated toxoids. In addition, provided herein are conjugate vaccine carriers comprising engineered tetanus toxin variants and methods of using such conjugate vaccines to elicit T-cell dependent immune memory responses which can target a broad spectrum of microbial pathogens as a single vaccine.

Abstract: Certain embodiments of the present invention are directed to therapeutic intervention in patients with eye-length-related disorders to prevent, ameliorate, or reverse the effects of the eye-length-related disorders. Embodiments of the present invention include methods for early recognition of patients with eye-length-related disorders, therapeutic methods for inhibiting further degradation of vision in patients with eye-length-related disorders, reversing, when possible, eye-length-related disorders, and preventing eye-length-related disorders. Additional embodiments of the present invention are directed to particular devices used in therapeutic intervention in patients with eye-length-related disorders.

Abstract: A method of detecting the presence of a prostate cancer in a human subject comprising the steps of (a) obtaining a histologically normal prostate tissue sample from the patient and (b) quantifying the epithelial thickness or gland lumen roundness of the tissue, wherein an increase in epithelial thickness or a decrease in gland lumen roundness indicates the presence of prostate cancer or a prostate cancer field defect.

Abstract: N-benzylbenzamides that act as dual soluble epoxide hydrolase (sEH)/peroxisome proliferator-activated receptor ? (PPAR?) modulators and are useful as medications in the treatment of Metabolic Syndrome (MetS) cluster diseases, including diabetes. Methods of making and using the same are further provided.

Abstract: Systems and methods are described for computing a quantitative index that characterizes Alzheimer's disease (“AD”) risk events based on a temporally ordered sequence of biomarker events. In general, the systems and methods described here implement a modified event-based probabilistic (“EBP”) model to calculate the risk index from biomarker data.

Abstract: A resonant coil system with improved sensitivity and signal-to-noise performance is described. A primary coil is tuned to a first resonance frequency and inductively coupled to a secondary coil that is separately tuned to a second resonance frequency. The primary and secondary coils form a resonant system with a resonance frequency that is a function of the primary and secondary coil resonance frequencies. The resonance frequency of the coil system is less than both the primary resonance frequency and the secondary resonance frequency. The mutual inductance between the two coils is high and the resonance frequency of the coil system's parallel mode is well separated from that of the anti-parallel mode.

Abstract: Systems and methods for quantitative susceptibility mapping (“QSM”) using magnetic resonance imaging (“MRI”) are described. Localized magnetic field information is used when performing the inversion to compute quantitative susceptibility maps. The localized magnetic field information can include multi-resolution subvolumes obtained by segmenting, or dividing, a field shift map. In some instances, a trained machine learning algorithm, such as a trained neural network, can be implemented to convert the localized magnetic field information into quantitative susceptibility data. These local susceptibility maps can be combined to form a composite quantitative susceptibility map of the imaging volume.

Abstract: The present invention provides a CXCL121 peptide engineered to resist peptide-induced dimerization by maintaining steric repulsion of the chemokine helix, pharmaceutical compositions thereof, and methods of using said dimer in the treatment of cancer, inflammatory disorders, autoimmune disease, and HIV/AIDS.

Abstract: A swallow exerciser device that exercises and thereby strengthens the muscles involved in swallowing includes a rigid shell, an adjustable fastener, and an inflatable pad. The rigid shell has a longitudinal dimension such that the shell extends above and below the larynx of the subject when the swallow exerciser device is positioned over the larynx of the subject. The adjustable fastener is dimensioned to secure the shell around a neck of the subject with the shell positioned over the larynx of the subject. The inflatable pad is connected to a proximal surface of the shell. The inflatable pad is dimensioned to apply resistance to force of at least one swallowing muscle of the subject when the shell positioned over the larynx of the subject and when the inflatable pad is in an inflated position. The swallow exerciser device can be used in a method for improving swallowing function in a subject.

Abstract: Described here are EET analogs conjugated to folate receptor ligands such as folic acid or folic acid analogs recognized by and selectively bound by folate receptors and other folate binding proteins and the use of such conjugated EET analogs for targeted delivery of therapeutic agents to folate-receptor bearing cell populations. More particularly, provided herein are EET analogs conjugated to folate receptor ligands and uses of such conjugated EET analogs as kidney targeted therapeutics.

Abstract: The present invention relates to mito-lonidamine compounds, compositions and methods of use in the treatment of cancer.

Abstract: Systems and methods obtain functional connectivity data in the whole brain to detect and predict brain disorders. This whole brain data is regionalized and then manipulated to derive functional connectivity data sets that can be used to show measured functional connectivity changes. This whole brain data may also be analyzed to determine changes in functional activity in both increased and decreased neural network connectivity. By identifying and then quantifying the functional connectivity differences between healthy and diseased subjects, a classification for individual subjects can be made.

Abstract: This invention relates to methods and compositions for assessing amount(s) of total cell-free DNA in a subject. Such amount(s) can be used to determine risk in a subject, which subjects are non-transplant subjects, such as surgical subjects, in some preferred embodiments.

Abstract: The present invention provides mito-metformin compounds, pharmaceutical compositions thereof, and methods of using the mito-metformin compounds in the treatment of cancer.

Abstract: Methods and compositions comprising hematopoietic growth factor proteins and/or protein analogs thereof and/or combinations thereof and angiotensin converting enzyme inhibitors to treat the acute and long term adverse effects of radiation exposure in subjects who have been or will be exposed to radiation are disclosed.

Abstract: Provided herein are methods and composition for trans-tympanic membrane delivery of therapeutic agents such as antimicrobial agents, anti-inflammatory agents, and anti-biofilm agents to the middle ear for rapid, localized treatment and prevention of diseases and conditions associated with a middle ear infection. In particular, provided herein are cationic, anionic, and polymer-based nanoparticles that provide a platform for delivery of therapeutic cargo, as well as cationic, anionic, and polymer-based nanoparticles compositions for rapid, localized delivery of therapeutic agents to the middle ear.