Patents Assigned to The Ohio State University Research Foundation
  • Publication number: 20210338593
    Abstract: Multistage delivery vehicles are disclosed which include a first stage particle and a second stage particle. The first stage particle is a micro or nanoparticle that contains the second stage particle. The second stage particle includes an active agent, such as a therapeutic agent or an imaging agent. The multistage delivery vehicle allows sequential overcoming or bypassing of biological barriers. The multistage delivery vehicle is administered as a part of a composition that includes a plurality of the vehicles. Methods of making the multistage delivery vehicles are also provided.
    Type: Application
    Filed: July 6, 2021
    Publication date: November 4, 2021
    Applicants: Board of Regents of the University of Texas System, The Ohio State University Research Foundation
    Inventors: Mauro Ferrari, Ennio Tasciotti, Jason Sakamoto
  • Publication number: 20210052732
    Abstract: Formulations for chemoprevention of oral cancer and precancerous lesions, and for methods for preparing the formulations are described.
    Type: Application
    Filed: August 31, 2020
    Publication date: February 25, 2021
    Applicants: THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION, THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Susan R. Mallery, Peter E. Larsen, Gary D. Stoner, Steven P. Schwendeman, Kashappa-Goud Desai
  • Patent number: 10384943
    Abstract: Method and processes for synthesizing single-wall carbon nanotubes is provided. A carbon precursor gas is contacted with metal catalysts deposited on a support material. The metal catalysts are preferably nanoparticles having diameters less than about 50 nm. The reaction temperature is selected such that it is near the eutectic point of the mixture of metal catalyst particles and carbon.
    Type: Grant
    Filed: August 1, 2017
    Date of Patent: August 20, 2019
    Assignees: HONDA MOTOR CO., LTD., THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION
    Inventors: Avetik Harutyunyan, Elena Pigos, Toshio Tokune
  • Publication number: 20190111000
    Abstract: Multistage delivery vehicles are disclosed which include a first stage particle and a second stage particle. The first stage particle is a micro or nanoparticle that contains the second stage particle. The second stage particle includes an active agent, such as a therapeutic agent or an imaging agent. The multistage delivery vehicle allows sequential overcoming or bypassing of biological barriers. The multistage delivery vehicle is administered as a part of a composition that includes a plurality of the vehicles. Methods of making the multistage delivery vehicles are also provided.
    Type: Application
    Filed: October 12, 2018
    Publication date: April 18, 2019
    Applicants: Board of Regents of the University of Texas System, The Ohio State University Research Foundation
    Inventors: Mauro Ferrari, Ennio Tasciotti, Jason Sakamoto
  • Patent number: 10253424
    Abstract: Provided is a particle that includes a first porous region and a second porous region that differs from the first porous region. Also provided is a particle that has a wet etched porous region and that does have a nucleation layer associated with wet etching. Methods of making porous particles are also provided.
    Type: Grant
    Filed: November 11, 2014
    Date of Patent: April 9, 2019
    Assignees: BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM, THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION
    Inventors: Mauro Ferrari, Xuewu Liu, Ming-Cheng Cheng
  • Patent number: 10143658
    Abstract: Multistage delivery vehicles are disclosed which include a first stage particle and a second stage particle. The first stage particle is a micro or nanoparticle that contains the second stage particle. The second stage particle includes an active agent, such as a therapeutic agent or an imaging agent. The multistage delivery vehicle allows sequential overcoming or bypassing of biological barriers. The multistage delivery vehicle is administered as a part of a composition that includes a plurality of the vehicles. Methods of making the multistage delivery vehicles are also provided.
    Type: Grant
    Filed: May 29, 2015
    Date of Patent: December 4, 2018
    Assignees: Board of Regents of the University of Texas System, The Ohio State University Research Foundation
    Inventors: Mauro Ferrari, Ennio Tasciotti, Jason Sakamoto
  • Publication number: 20170275625
    Abstract: Described herein are methods and compositions for the treatment of colon cancers.
    Type: Application
    Filed: April 11, 2017
    Publication date: September 28, 2017
    Applicants: The Ohio State University Research Foundation, The Government of the United States of America, as represented by the Secretary of the Department of
    Inventors: Carlo M. Croce, Curtis C. Harris, Aaron J. Schetter
  • Publication number: 20170211066
    Abstract: Methods and compositions for the treatment of prostate associated disorders are disclosed.
    Type: Application
    Filed: April 6, 2017
    Publication date: July 27, 2017
    Applicants: The Ohio State University Research Foundation, The Government of the United States of America, as represented by the Secretary of the Department of
    Inventors: Carlo M. Croce, Stefan Ambs
  • Patent number: 9695153
    Abstract: The present invention relates to oligooxopiperazines for reactivating p53. The oligooxopiperazines comprise two or three oxopiperazine rings and substantially mimic helix ?B of the C-terminal transactivation domain of Hypoxia-Inducible Factor 1?. Methods of using the oligooxopiperazines are also disclosed. Exemplary oligooxopiperazines include those of Formula I below (wherein A, R1, R2, R3, R4, and B are as defined herein).
    Type: Grant
    Filed: January 21, 2014
    Date of Patent: July 4, 2017
    Assignees: New York University, The Ohio State University Research Foundation, The Regents of the University of Michigan
    Inventors: Paramjit S. Arora, Quintin Pan, Anna Mapp
  • Patent number: 9610562
    Abstract: Preparation of a molecularly imprinted carbon is described. The molecularly imprinted carbon has a surface that is imprinted on the molecular level for a specific template molecule of interest, making it highly selective for analytes corresponding to at least a portion of the template molecule. Devices including the molecularly imprinted carbon and their use in methods of detecting analytes are also described. As an example, dibutyl butylphosphonate (DBBP), a surrogate for chemical warfare agents, was used as a template molecule. Electrospun molecularly imprinted SU-8 and pyrolyzed polymer (PP) solid-phase microextraction (SPME) devices were prepared; their ability to preferentially extract DBBP from an aqueous matrix, with and without interferences present, was evaluated via comparison with non-imprinted SU-8 and PP SPME fibers. The electrospun devices demonstrated a higher selectivity for DBBP, as evidenced by their extraction time profiles.
    Type: Grant
    Filed: March 2, 2011
    Date of Patent: April 4, 2017
    Assignee: THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION
    Inventors: Susan V. Olesik, Joseph W. Zewe
  • Patent number: 9605026
    Abstract: The present invention relates to peptidomimetics for reactivating p53. Methods of using the peptidomimetics are also disclosed.
    Type: Grant
    Filed: January 21, 2014
    Date of Patent: March 28, 2017
    Assignees: NEW YORK UNIVERSITY, THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION, THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Paramjit S. Arora, Quintin Pan, Anna Mapp
  • Patent number: 9574239
    Abstract: Described herein are methods and compositions for the diagnosis, prognosis and treatment of ovarian cancer. Also described are methods of identifying anti-cancer agents.
    Type: Grant
    Filed: September 15, 2014
    Date of Patent: February 21, 2017
    Assignee: The Ohio State University Research Foundation
    Inventor: Carlo M. Croce
  • Patent number: 9526824
    Abstract: A nanochannel delivery device and method of manufacturing and use. The nanochannel delivery device comprises an inlet, an outlet, and a nanochannel. The nanochannel may be oriented parallel to the primary plane of the nanochannel delivery device. The inlet and outlet may be in direct fluid communication with the nanochannel.
    Type: Grant
    Filed: May 2, 2013
    Date of Patent: December 27, 2016
    Assignees: The Board of Regents of the University of Texas System, The Ohio State University Research Foundation
    Inventors: Mauro Ferrari, Xuewu Liu, Alessandro Grattoni, Daniel Fine, Randy Goodall, Sharath Hosali, Ryan Medema, Lee Hudson
  • Patent number: 9518236
    Abstract: Novel redox based systems for fuel and chemical production with in-situ CO2 capture are provided. A redox system using one or more chemical intermediates is utilized in conjunction with liquid fuel generation via indirect Fischer-Tropsch synthesis, direct hydrogenation, or pyrolysis. The redox system is used to generate a hydrogen rich stream and/or CO2 and/or heat for liquid fuel and chemical production. A portion of the byproduct fuels and/or steam from liquid fuel and chemical synthesis is used as part of the feedstock for the redox system.
    Type: Grant
    Filed: September 8, 2010
    Date of Patent: December 13, 2016
    Assignee: THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION
    Inventors: Liang-Shih Fan, Fanxing Li, Liang Zeng
  • Patent number: 9480699
    Abstract: Provided are methods and compositions for the treatment of cancers associated with overexpression of a BCL2 gene and/or gene product in a subject, and methods and compositions for the improvement of anti-cancer therapy, such as chemotherapy and radiation therapy. Also provided are methods for determining the efficacy of a cancer therapy in a subject, methods for diagnosing cancer, methods for assessing patient prognosis, and methods for inducing apoptosis of a cell.
    Type: Grant
    Filed: July 25, 2014
    Date of Patent: November 1, 2016
    Assignee: The Ohio State University Research Foundation
    Inventors: Carlo M. Croce, George A. Calin
  • Publication number: 20160251659
    Abstract: The present invention provides novel methods and compositions for the diagnosis, prognosis and treatment of breast cancer. The invention also provides methods of identifying anti-breast cancer agents.
    Type: Application
    Filed: May 16, 2016
    Publication date: September 1, 2016
    Applicant: The Ohio State University Research Foundation
    Inventors: Carlo M. Croce, George A. Calin
  • Publication number: 20160199403
    Abstract: Methods for assessing a pathological condition in a subject include measuring one or more markers where a difference is indicative of acute lymphoblastic leukemia (ALL) or a predisposition to ALL, uses and compositions are disclosed.
    Type: Application
    Filed: March 28, 2016
    Publication date: July 14, 2016
    Applicant: The Ohio State University Research Foundation
    Inventor: Carlo M. Croce
  • Publication number: 20160186184
    Abstract: Methods and compositions for the treatment of prostate associated disorders are disclosed.
    Type: Application
    Filed: March 7, 2016
    Publication date: June 30, 2016
    Applicants: The Ohio State University Research Foundation, The Government of the United States of America, as represented by the Secretary of the Department of
    Inventors: Carlo M. Croce, Stefan Ambs
  • Publication number: 20160177305
    Abstract: Described herein are methods and compositions for the treatment of colon cancers.
    Type: Application
    Filed: March 1, 2016
    Publication date: June 23, 2016
    Applicants: The Ohio State University Research Foundation, The Government of the USA, as represented by the Secretary of the Department of Health and Human Se
    Inventors: Carlo M. Croce, Curtis C. Harris, Aaron J. Schetter
  • Publication number: 20160177311
    Abstract: Methods and compositions for the treatment of prostate associated disorders are disclosed.
    Type: Application
    Filed: March 7, 2016
    Publication date: June 23, 2016
    Applicants: The Ohio State University Research Foundation, The Government of the United States of America, as represented by the Secretary of the Department of
    Inventors: Carlo M. Croce, Stefan Ambs