Abstract: Methods and compositions relating to TIC10 are described according to aspects of the present invention. The compositions and methods have utility in treating disease, particularly cancer in a subject in need thereof, including a human subject as well as subjects of other species. The compositions have utility in treating brain cancer in a subject in need thereof.

Abstract: Embodiments can relate to a method for detecting a physiological condition by generating a Magnetic Resonance Image (MRI) contrast image comprising a T1 weighted (T1W) image/T2 weighted (T2W) ratio. Embodiments can further include using the T1W/T2W ratio to identify changes in substantia nigra pars compacta within a region of the brain.

Abstract: An impeller includes a hub, and a plurality of blades supported by the hub, the blades being arranged in at least two blade rows. The impeller has a deployed configuration in which the blades extend away from the hub, and a stored configuration in which at least one of the blades is radially compressed, for example by folding the blade towards the hub. The impeller may also have an operational configuration in which at least some of the blades are deformed from the deployed configuration upon rotation of the impeller when in the deployed configuration. The outer edge of one or more blades may have a winglet, and the base of the blades may have an associated indentation to facilitate folding of the blades.

Abstract: The present document relates to multilayered dielectric composites for high-temperature applications and related methods.

Abstract: An impeller includes a hub, and a plurality of blades supported by the hub, the blades being arranged in at least two blade rows. The impeller has a deployed configuration in which the blades extend away from the hub, and a stored configuration in which at least one of the blades is radially compressed, for example by folding the blade towards the hub. The impeller may also have an operational configuration in which at least some of the blades are deformed from the deployed configuration upon rotation of the impeller when in the deployed configuration. The outer edge of one or more blades may have a winglet, and the base of the blades may have an associated indentation to facilitate folding of the blades.

Abstract: Embodiments relate to a light-harvesting perovskite layer including having deoxyribonucleic acid (DNA) molecules incorporated within the perovskite crystal to serve as an effective carrier transport medium. Some embodiments include formation of a DNA doped MAPbI3, the DNA doped MAPbI3 being formed by using a DNA-hexadecyl trimethyl ammonium chloride (“DNA-CTMA”) complex. The DNA doped MAPbI3 can be used as the light-harvesting perovskite layer in a photovoltaic device. Other molecules such as artemisinin (ART) and melanin are also demonstrated to show the effectiveness in charge and thermal transport.

Abstract: A method and system for gastric stimulation and imaging for a user. The system having an array of millimeter-sized gastric seeds implanted in a stomach area of a user. Each gastric seed is ultrasonically powered and communicates using a transducer, and the transducer has a recorder to measure a bioelectrical activity in the stomach area of the user. A wearable unit (WU) is worn or carried by the user, and the WU wirelessly powers the gastric seeds. The WU wirelessly communicates with the gastric seeds, and the gastric seeds communicate a parameter to the WU based on the bioelectrical activity. Received pulses by the seeds can be used to localize the position of the seeds and guide the wireless power/data transmission in a self-image-guided manner. A processing unit (PU) wirelessly communicates with the WU, and the WU communicates the parameters from the gastric seeds to the PU.

Abstract: Materials that seamlessly transition from opaque to transparent or translucent, such as advanced geopolymer-based ceramics to glass structures, which can be directly and seamlessly bonded without the use of an intermediate adhesive or use of a frame are disclosed. That is, a GP-based ceramic to glass structure can be bonded directly and seamlessly and without any mechanical joints, connective tissue or adhesives such as caulking or epoxy. Such ceramic to glass materials can be prepared by sintering an engineered geopolymer with glass to form the geopolymer-based advanced ceramic-glass structure in which the interface is visually abruptly or in which the material is a graded composition with a controlled transition from one material to the other.

Abstract: Disclosed herein is a dielectric composite comprising an organic polymer that has a glass transition temperature greater than or equal to about 250° C.; and a dielectric filler present in an amount effective to impart to the dielectric composite a dielectric constant that varies by less than 5% over a temperature range of 25 ° C. to 300° C., with an applied alternating electric field having a frequency of 104 Hz and a maximum operating electric field strength of at least 250 megavolt per meter. Disclosed herein too is a method of manufacturing the dielectric composite and articles that contain the dielectric composite.

Abstract: A compound with the following general formula (I) and a general method of making this compound are provided. R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, R13 and R14 are each independently selected from the group that includes H, halogen, nitro, cyano, amido, pyridyl, alkyl, aryl, acyl, alkoxy, cycloalkyl, heteroalkyl, heterocyclyl, aralkyl, heteroaryl and heteroaralkyl.

Abstract: A haptic robotic training system includes a haptic robot arm, a position tracking system, a scanning surface, a monitor and a computer. The robotic arm includes a haptic feedback system and holds a custom syringe in place. The position tracking system includes a positon tracking probe shaped like an ultrasound probe and a motion tracker. The scanning surface is a soft pad made from a synthetic phantom tissue. A simulation software receives the positioning data for the syringe from the robotic arm, and for the virtual ultrasound probe from the position tracking system and generates a virtual environment which mimics an actual ultrasound image. The user receives a real time feedback in the form of a haptic feel through the robotic arm, a virtual ultrasound image on the screen, and a performance feedback on the simulation software.

Abstract: A haptic needle insertion simulator includes a syringe compartment having a cavity and a retractable needle at an end of the syringe compartment. The needle is operable to retract into the syringe compartment when pushed against a surface. The cavity is configured to provide a force profile felt by a user holding the simulator and simulating a realistic feeling of insertion force.

Abstract: There is provided a skin test diagnostic reagent comprising: at least one 40mer polypeptide consisting of any one of SEQ ID NOs: 1, 3 or 4; at least one 40mer polypeptide consisting of any one of SEQ ID NOs: 7 or 8; and at least one 40mer polypeptide consisting of any one of SEQ ID NOs: 10, 11 or 12, characterised in that the reagent elicits a positive result when administered in a skin test to an animal infected with Mycobacterium bovis or Mycobacterium tuberculosis.

Abstract: Compositions and methods that relate to improved chocolate milk are provided. The chocolate milk may be shelf stable and k-carrageenan free. The chocolate milk does not undergo visually detectable phase separation for at least 7 days. The chocolate milk that does not undergo the visually detectable phase separation contains from 1%-10% micellar casein w/v. Methods for preparing shelf stable k-carrageenan free chocolate milk are also provided and include mixing cocoa powder, sugar, milk, and micellar casein to obtain a mixture, and optionally heating and homogenizing the mixture, and subsequently subjecting the mixture to High Pressure Jet Processing (HPJ) or high pressure homogenization of at least 300 MPa, thereby producing the shelf table k-carrageenan free chocolate milk. The shelf stable k-carrageenan free chocolate milk of produced using such a method may be refrigerated temperature for at least 14 days, and does not undergo detectable phase separation for at least 14 days.

Abstract: According to aspects of the present disclosure, methods and compositions are provided which relate to treating cancer in a subject in need thereof, including: administering 1) an anti-cancer immune therapeutic agent, and 2) a stimulator of p53 levels and/or p53 activity, as a combination formulation or separately, thereby increasing levels and/or activity of p53, and activating NK cell activity in the cancer, providing therapeutic benefits, converting a “cold tumor” into a “hot tumor” leading to a TME responsive to immunotherapy via tumor cell recognition and killing that is not dependent on T-cell mediated immunity.

Abstract: A biochemical analysis system capable of sample preparation and processing can include at least one inlet channel having a non-fouling, slippery surface to autonomously transport a fluid sample to a chamber by a geometry of the at least one inlet channel. The at least one inlet channel can include a first end, which is open and exposed, and a second end connected to the chamber for mixing and reaction of the fluid sample, and the at least one inlet channel can include a converging or diverging angle.

Abstract: Methods of treating traumatic brain injury (TBI) are provided according to aspects of the present disclosure including: converting reactive astrocytes to functional neurons by providing exogenous neurogenic differentiation 1 (NeuroD1, also called ND1 herein) to at least one reactive astrocyte in a damaged region of a subject's brain, such as the brain of a human subject with a TBI. According to aspects, presence of non-functional neurons and reactive astrocytes in the damaged region of the subject's brain are not primarily due to bleeding and/or ischemia in the damaged region. According to aspects of the present disclosure, the traumatic brain injury causes a period of astrogliosis in the damaged region of the subject's brain, and the exogenous NeuroD1 is provided to reactive astrocytes in the damaged region of the subject's brain during the period of astrogliosis or within four weeks after the period of astrogliosis.

Abstract: Provided are modified virus-like particles (VLPs) of paramyxoviruses, compositions containing them, methods of using the VLPs for delivery of any particular protein of interest to any of a variety of cells, kits that contain expression vectors for making, using and detecting VLPs, and methods for screening for anti-viral compounds using the VLPs. The modified VLPs contain a contiguous recombinant polypeptide that contains i) all or a segment of a C-terminal domain of a paramyxovirus nucleocapsid protein and ii) a polypeptide sequence of a distinct protein. Non-covalent complexes of paramyxovirus M protein and fusion proteins that contain a C-terminal domain of a paramyxovirus nucleocapsid protein and a polypeptide sequence of a distinct protein are provided, as are non-covalent complexes of cells, and cell receptors, with modified VLPs.

Abstract: Methods for making metastable lead-free piezoelectric materials are presented herein.

Abstract: Apparatuses and methods to rejuvenate spent filtration media are described. The apparatuses include a filtration unit to filter a liquid having solids that need to be removed and a rejuvenation unit to heat the spent filtration media that has reduced filtering capacity. The methods include using the apparatus to rejuvenate spent filtration media by removing solids deposited on the filtration media to allow its repeated reuse rather than being discarded and replaced with new filtration media.