Patents Assigned to The Provost, Fellows, Foundation Scholars, and the other members of Board, of the College of the ...
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Patent number: 10793572Abstract: Disclosed are novel compounds useful in the treatment of multiple sclerosis and other autoimmune diseases. The present invention describes compounds of formula (I) wherein: R1 is selected from H and CH3 R2 is selected from H, C4H9 alkyl, C6H13 alkyl and C3H6-phenyl, said phenyl optionally substituted by OH or OCH3, (1R,2S,5S)-5-methylcyclopent-3-ene-1,2-diol X is O or S Y is C, N or S.Type: GrantFiled: September 29, 2015Date of Patent: October 6, 2020Assignee: THE PROVOST FELLOWS FOUNDATION SCHOLARS AND THE OTHER MEMBERS OF BOARD OF THE COLLEGE OF THE HOLY AND UNDIVIDED TRINITY OF QUEEN ELIZABETHInventors: John Michael Southern, Stephen J. Connon
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Patent number: 10765084Abstract: A seed coating composition comprising a mixture of a fungal root endophyte isolated from a root of the plant found in low-nutrient, drought-stressed or multiply-stressed conditions and a carrier medium for application of said composition to a target seed, wherein the endophyte is characterised in having a nuclear ribosomal internal transcribed spacer (nr ITS) with at least a 90% sequence identity to any one of SEQ ID NOs: 3 to 15.Type: GrantFiled: August 29, 2015Date of Patent: September 8, 2020Assignees: The Provost, Fellows, Foundation Scholars & the Other Members of Board, of the College of the Holy & Undivided Trinity of Queen Elizabeth, Near Dublin, University College Dublin, National University of Ireland, DublinInventors: Brian Murphy, Trevor Hodkinson, Fiona Doohan
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Patent number: 10744179Abstract: This invention relates to the use of an agent capable of inhibiting IL-36 proteolytic processing for the treatment and/or reduction of inflammation in a subject. Advantageously, the agent prevents the production of a biologically active IL-36 to prevent and/or reduce the pro-inflammatory effects of IL-36. The invention also relates to a method for treatment and/or reduction of inflammation and compositions for treating and/or reducing inflammation.Type: GrantFiled: September 18, 2015Date of Patent: August 18, 2020Assignee: THE PROVOST, FELLOWS, FOUNDATION SCHOLARS, & THE OTHER MEMBERS OF BOARD, OF THE COLLEGE OF THE HOLYInventors: Seamus J. Martin, Conor Henry, Graeme Sullivan
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Patent number: 10729372Abstract: The invention provides a sensor assembly embeddable within an oral appliance comprising a sensing means; and a data processing means coupled to the sensing means for processing data obtained by the sensing means; wherein the sensing means and the data processing means are sealed within a deformable layer.Type: GrantFiled: October 1, 2014Date of Patent: August 4, 2020Assignee: The Provost, Fellows, Foundation Scholars & The Other Members of Board, of the College of the Holy & Undiv. Trinity of Queen Elizabeth, Near DublinInventors: Padraig Martin McAuliffe, James Joseph Doyle, Ramesh Babu Padamati, Dermot Joseph Sullivan, Paul Phillips, Brian Christopher O'Connell
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Patent number: 10682245Abstract: An implantable biocompatible expander suitable for implantation into a urinary duct, comprises an elongated sinusoidal ring comprising at least two proximal prongs and at least two distal prongs, wherein the expander is resiliently deformable from a relaxed radially expanded orientation to a radially contracted orientation suitable for transluminal delivery through the urinary duct. The expander is configured to exert an outward radial force against a wall of the urinary duct when in-situ within the urinary duct. In particular, the expander is suitable for treatment of benign prostatic hyperplasia and configured for implantation into the prostatic urethra between, and substantially spanning the prostatic urethra between, the bladder neck and external sphincter.Type: GrantFiled: November 14, 2016Date of Patent: June 16, 2020Assignee: The Provost, Fellows, Foundation Scholars, & The Other Members of Board, of the College of the Holy & Undiv. Trinity of Queen Elizabeth, Near DublinInventors: Conor Harkin, Garrett Ryan, Bruce Murphy, James Redmond, Michael Burke, Riona Ni Ghriallais
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Patent number: 10682231Abstract: A heart valve therapeutic device (1) has an elongate anchor (7) wherein the anchor has a stiffness to hold its shape and location to support the valve element. The anchor may have a stylet or a shaped or stiff collar (70) arranged to provide a desired shape to the anchor (7) and it may be lockable. A prosthetic valve element (15) has leaflets (17) and is supported on the anchor by coupler (16, 50) at a desired location. There is an actuator for changing relative axial position of the proximal and distal couplers (16, 50) on the anchor. The anchor stiffness may be sufficient to provide sufficient support to resist axial forces from the ventricle in use without necessarily having a fixing element engaging heart tissue. The prosthetic leaflets (240) may extend proximally and radially outwardly, so that there is excellent co-apting of the native leaflets (NL) against the prosthetic leaflets (240).Type: GrantFiled: June 17, 2019Date of Patent: June 16, 2020Assignee: The Provost, Fellows Foundation Scholars, And The Other Members of the Board, Of the College of the Holy and Undivided Trinity of Queen Elizabeth Near Dublin (TCD)Inventor: Martin Quinn
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Patent number: 10538487Abstract: The present invention provides for certain sulfonyl ureas and related compounds which have advantageous properties and show useful activity in the inhibition of activation of the NLRP3 inflammasome. Such compounds are useful in the treatment of a wide range of disorders in which the inflammation process, or more specifically the NLRP3 inflammasome, have been implicated as being a key factor.Type: GrantFiled: February 16, 2016Date of Patent: January 21, 2020Assignees: THE UNIVERSITY OF QUEENSLAND, THE PROVOST, FELLOWS, FOUNDATION SCHOLARS, AND THE OTHER MEMBERS OF BOARD, OF THE COLLEGE OF THE HOLY AND UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLINInventors: Luke O'Neill, Rebecca Coll, Matthew Cooper, Avril Robertson, Kate Schroder
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Cell suspension medium and cell suspension medium additive for the three dimensional growth of cells
Patent number: 10526575Abstract: The present invention relates to a cell culture medium additive comprising a xanthan polysaccharide and a mannan polysaccharide, such as a glucomannan or a galactomannan, that supports the growth of cells in suspension, and to a cell culture medium containing the additive. More particularly, but not exclusively, the present invention relates to a cell culture medium additive that supports the formation of multicellular bodies such as spheroids, and prevents sedimentation of cells without adversely affecting the physical properties of the cell culture medium.Type: GrantFiled: April 2, 2013Date of Patent: January 7, 2020Assignee: The Provost, Fellows, Foundation Scholars, and the other Members of the Board of the College of the Holy and Undivided Trinity of Queen ElizabethInventor: Anthony Davies -
Patent number: 10502672Abstract: The properties of a fluid body in the form of a surface-attached droplet/bubble can be determined. A data set is stored describing a plurality of droplets/bubbles of different shapes; each shape is captured as a combination of two or more linear dimensional measurements. For each shape the data set includes one or more parameters describing the relationship between the physical properties of a pair of fluids capable of forming that shape as a surface-attached droplet/bubble disposed in a surrounding fluid medium. A fluid body is provided in the form of a surface-attached droplet/bubble and a plurality of linear dimensional measurements are taken and provided as input to a processing apparatus. Processing apparatus determines from the data set the one or more parameters associated with the shape described by said linear dimensional measurements. Particular the surface tension of a fluid can be found in this way based on simple dimensional measurements.Type: GrantFiled: October 14, 2015Date of Patent: December 10, 2019Assignee: The Provost, Fellows, Foundation Scholars, & the Other Members of Board, of the College of the Holy & Un-Div. Trinity of Queen Elizabeth Near DublinInventors: Samuel Siedel, Anthony James Robinson
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Publication number: 20190359564Abstract: The present invention provides for certain sulfonyl ureas and related compounds which have advantageous properties and show useful activity in the inhibition of activation of the NLRP3 inflammasome. Such compounds are useful in the treatment of a wide range of disorders in which the inflammation process, or more specifically the NLRP3 inflammasome, have been implicated as being a key factor.Type: ApplicationFiled: August 7, 2019Publication date: November 28, 2019Applicants: THE UNIVERSITY OF QUEENSLAND, THE PROVOST, FELLOWS, FOUNDATION SCHOLARS, AND THE OTHER MEMBERS OF BOARD, OF THE COLLEGE OF THE HOLInventors: Luke O'NEILL, Rebecca COLL, Matthew COOPER, Avril ROBERTSON, Kate SCHRODER
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Publication number: 20190298514Abstract: A heart valve therapeutic device (1) has an elongate anchor (7) wherein the anchor has a stiffness to hold its shape and location to support the valve element. The anchor may have a stylet or a shaped or stiff collar (70) arranged to provide a desired shape to the anchor (7) and it may be lockable. A prosthetic valve element (15) has leaflets (17) and is supported on the anchor by coupler (16, 50) at a desired location. There is an actuator for changing relative axial position of the proximal and distal couplers (16, 50) on the anchor. The anchor stiffness may be sufficient to provide sufficient support to resist axial forces from the ventricle in use without necessarily having a fixing element engaging heart tissue. The prosthetic leaflets (240) may extend proximally and radially outwardly, so that there is excellent co-apting of the native leaflets (NL) against the prosthetic leaflets (240).Type: ApplicationFiled: June 17, 2019Publication date: October 3, 2019Applicant: The Provost, Fellows Foundation Scholars, and The Other Member of the Board, of the College of the HInventor: Martin QUINN
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Patent number: 10383729Abstract: A heart valve therapeutic device has an elongate anchor wherein the anchor has a stiffness to hold its shape and location to support the valve element. The anchor may have a stylet or a shaped or stiff collar arranged to provide a desired shape to the anchor and it may be lockable. A prosthetic valve element has leaflets and is supported on the anchor by coupler at a desired location. There is an actuator for changing relative axial position of the proximal and distal couplers on the anchor. The anchor stiffness may be sufficient to provide sufficient support to resist axial forces from the ventricle in use without necessarily having a fixing element engaging heart tissue. The prosthetic leaflets may extend proximally and radially outwardly, so that there is excellent co-apting of the native leaflets (NL) against the prosthetic leaflets.Type: GrantFiled: September 29, 2015Date of Patent: August 20, 2019Assignee: The Provost, Fellows Foundation Scholars, and The Other Members of the Board, of the College of The Holy and Undivided Trinity of Queen Elizabeth Near Dublin (TCD)Inventor: Martin Quinn
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Publication number: 20190224296Abstract: The present invention relates to Toll-Like Receptor 2 (TLR2) agonists, in particular, to TLR2-activating lipoproteins, and more particularly to TLR2-activating lipopeptides derived from the bacteria Bordetella pertussis. The invention further extends to the use of said TLR2-activating lipoproteins as a therapeutic or as part of a vaccine composition in the treatment and prevention of infectious diseases, cancer or allergic diseases.Type: ApplicationFiled: February 9, 2019Publication date: July 25, 2019Applicant: The Provost, Fellows, Foundation Scholars & the Other Members of Board, Of the College of the HolyInventors: Kingston MILLS, Aisling Dunne
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Patent number: 10362488Abstract: Provided a method and system for computing a bandwidth requirement for a cellular operator from shared spectrum in a cellular network, the shared spectrum comprising at least one shared spectrum class which is accessible by multiple entities, the method comprising: computing an average user throughput in the cellular network; comparing the average user throughput to a target minimum average user throughput, taking into account an average percentage of users within coverage and a coverage probability threshold; and based on the comparison, computing an additional bandwidth requirement from the at least one shared spectrum class.Type: GrantFiled: September 28, 2016Date of Patent: July 23, 2019Assignee: THE PROVOST, FELLOWS, FOUNDATION SCHOLARS AND THE OTHER MEMBERS OF THE BOARD, OF THE COLLEGE OF THE HOLY AND UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLINInventors: Jasmina McMenamy, Irene Macaluso, Linda Doyle
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Publication number: 20190198053Abstract: Disclosed herein are embodiments of a heat-assisted magnetic recording (HAMR) device comprising a waveguide and a near-field transducer (NFT) coupled to the waveguide. The NFT comprises a core layer comprising an insulator, a first metal layer adjacent to the core layer, and a second layer adjacent to the first metal layer, wherein the second layer comprises a material that is substantially mechanically and thermally stable and thereby functions as a hard jacket to mitigate deformation of the NFT. The first metal layer may comprise a plasmonic metal, such as gold. The second layer may comprise tungsten, chromium, or a dielectric material.Type: ApplicationFiled: December 23, 2017Publication date: June 27, 2019Applicants: Western Digital Technologies, Inc., The Provost, Fellows, Foundation Scholars and the other members of the Board, of the College of theInventors: Alexander KRICHEVSKY, Frank BELLO, Christopher WOLF, Fenghua ZONG, Daniel WOLF, David MCCLOSKEY, Kyle BALLANTINE, John DONEGAN
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Patent number: 10304937Abstract: A process for exfoliating untreated 3-dimensional material to produce a 2-dimensional material, said process comprising the steps of mixing the untreated 3-dimensional material in a liquid to provide a mixture; applying shear force to said mixture to exfoliate the 3-dimensional material and produce dispersed exfoliated 2-dimensional material in solution; and removing the shear force applied to said mixture, such that the dispersed exfoliated 2-dimensional material remains free and unaggregated in solution.Type: GrantFiled: March 14, 2014Date of Patent: May 28, 2019Assignee: The Provost, Fellows, Foundation Scholars, and the Other Members of Board, of the College of the Holy and Undivided Trinity of Queen Elizabeth Near DublinInventors: Jonathan Coleman, Keith Paton
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Patent number: 10251604Abstract: A process for producing conductive composites, the process comprising the steps of soaking a polymer in an organic solvent and applying energy; soaking the polymer in a solution of conductive nano-material dispersed in an organic solvent:water mixture and applying energy, so that conductive nano-material is incorporated into the polymer structure; washing the conductive nano-material-incorporated polymer in deionized water and applying energy; and drying the washed conductive nano-material-incorporated polymer to produce the conductive composite, wherein the conductive composite incorporates conductive nano-material throughout the structure of the polymer without affecting the integrity of the properties of the polymer.Type: GrantFiled: March 14, 2014Date of Patent: April 9, 2019Assignee: The Provost, Fellows, Foundation Scholars, and the other Members of Board, of the College of the Holy and Undivided Trinity of Queen Elizabeth, near DublinInventors: Jonathan Coleman, Conor Boland, Umar Khan
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Publication number: 20190082236Abstract: A computer implemented method provides determining representative content to be used in representing a video divided into one or more segments. Each segment is associated with one or more items of representative content data for use in representing that respective segment. The one or more items of representative content data have an associated modality. The method comprises, for each segment, selecting, based on one or more rules depending on one or more selection factors, a respective optimized template from a set comprising one or more templates, each one of the set of templates defining a different representation setting for representing the segment using its associated representative content data, the representation settings specifying the modality of representative content data to be used in representing a segment. The method also comprises determining representative content data for each of the one or more segments based on the respective optimized template for each segment.Type: ApplicationFiled: September 11, 2018Publication date: March 14, 2019Applicant: The Provost, Fellows, Foundation Scholars, and the other members of Board, of the College of theInventors: Fahim A. Salim, Owen Conlan
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Patent number: 10220102Abstract: An isolated nucleic acid sequence encoding the yeast NDI1 protein of SEQ ID NO: 542 or a functional variant thereof is described. The nucleic acid sequence comprises at least 50 codons which are codon optimized compared with the sequence of yeast NDI1 gene of SEQ ID NO: 1.Type: GrantFiled: December 21, 2012Date of Patent: March 5, 2019Assignee: THE PROVOST FELLOWS FOUNDATION SCHOLARS AND THE OTHER MEMBERS OF BOARD OF THE COLLEGE OF THE HOLD AND UNDIVIDED TRINITY OF QUEEN ELIZABETH, NEAR DUBLIN TRINITY COLLEGE DUBLINInventors: Gwyneth Jane Farrar, Sophia Millington-Ward, Naomi Chadderton, Mathew Alan Carrigan, Paul Kenna
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Patent number: 10106519Abstract: Provided herein are 3-phenyl-7-hydroxy-isocoumarin compounds which are MIF inhibitors; compositions comprising said inhibitors and methods for treating or preventing diseases associated with MIF.Type: GrantFiled: March 27, 2015Date of Patent: October 23, 2018Assignee: The Provost, Fellows, Foundation Scholars, and the Other Members of Board, of the College of the Holy and Undivided Trinity of Queen Elizabeth, Near DublinInventors: Seamas Donnelly, David Lloyd, Ciaran O'Reilly, Darren Fayne