Abstract: An improved method and a system are disclosed for recovering a three-dimensional (3D) scene structure from a plurality of two-dimensional (2D) image frames obtained from imaging means. Sets of 2D features are extracted from the image frames, and sets corresponding to successive image frames are matched, such that at least one pair of matched 2D features refers to a same 3D point in a 3D scene captured in 2D in the image frames. A 3D ray is generated by back-projection from each 2D feature, and the generated 3D rays are subjected to an anchor-based minimization process, for determining camera motion parameters and 3D scene points coordinates, thereby recovering a structure of the 3D scene.

Abstract: A focusing structure including an array of localized optical alterations that alter the propagation of light through the waveguide to diffractively focus the light as it exits the focusing structure. The array of optical alterations may be formed along either a straight or a curved line within a cross section of the focusing structure. In energy assisted magnetic recording apparatus a laser beam propagates through the waveguide to a near field transducer. The waveguide comprises a focusing element that includes an array of localized optical alterations that alter the propagation of the laser beam through the waveguide to diffractively focus the laser beam approximately at the near field transducer.

Abstract: Disclosed herein is enantioselective synthetic method comprising reacting an enolisable C4-C50 organic anhydride with a second compound selected from the group consisting of an aldehyde, a ketone, an aldimine, a ketimine or a Michael Acceptor in the presence of a bifunctional organocatalyst. The reaction may find particular utility in the enantioselective synthesis of medicinally relevant heterocycles, such as dihydroisocoumarins and dihydroisoquinolinones.

Abstract: Whilst methodologies for the Kinetic Resolution of alcohols are well established, no analogous direct methods exist for the highly selective, direct catalytic Kinetic Resolution of thiols (i.e., R—SH). The present invention relates to a method for resolving stereoisomeric mixtures of thiols. In particular, the present invention relates to purely organocatalytic mediated resolution of enantiomeric mixtures of thiols without the need for enzymes. Also disclosed are some novel catalysts. Such catalysts may comprise a cinchona alkaloid-derived moiety.

Abstract: While methodologies for the Kinetic Resolution of alcohols are well established, no analogous direct methods exist for the highly selective, direct catalytic Kinetic Resolution of thiols (i.e., R—SH). The present invention relates to a method for resolving stereoisomeric mixtures of thiols. In particular, the present invention relates to purely organocatalytic mediated resolution of enantiomeric mixtures of thiols without the need for enzymes. Also disclosed are some novel catalysts. Such catalysts may comprise a cinchona alkaloid-derived moiety.

Abstract: Non ligand binding pocket antagonists for the human androgen receptor. The androgen receptor (AR) is a member of the Nuclear Receptor (NR) family and its role is to modulate the biological effects of the endogenous androgens, testosterone (tes) and dihydrotestosterone (DHT). Synthetic androgens and anti-androgens have therapeutic value in the treatment of various androgen dependent conditions, from regulation of male fertility to prostate cancer. Current treatment of prostate cancer (PCa) typically involves administration of ‘classical’ antiandrogens, competitive inhibitors of natural AR ligands, DHT and tes, for the ligand binding pocket (LBP) in the C-terminal ligand binding domain (LBD) of the AR. However, prolonged LBP-targeting can often lead to androgen resistance and alternative therapies and therapeutic strategies are urgently required. Disclosed herein are a class of non-steroidal, small molecule AR antagonists which inhibit the transcriptional activity of the AR by non LBP-mediated modulation.

Abstract: An assay of identifying the responsiveness of a HER2-positive cancer in a patient to a HER2 targeted drug, the method comprising the step of comparing a level of NeuromedinU in a biological sample obtained from the patient with a reference level of NeuromedinU, wherein detection of a level of NeuromedinU that is increased compared to the reference level of NeuromedinU indicates that the HER2-positive cancer has reduced responsiveness to a HER2 targeted drug.

Abstract: Certain aspects of the invention pertain to the field of networked computing, and in particular to the field of data file security. Methods, systems and apparatuses are disclosed for encrypting and decrypting data stored and shared on networked data file storage devices such that the data may be accessed and manipulated by multiple users.

Abstract: The invention provides a control interface configured to cooperate with a vehicle, such as a wheelchair or mobile robot, said interface comprising at least one sensor is adapted to detect the presence of at least one finger of a user and to act as a switching mechanism between manual and autonomous control of the vehicle. The invention provides a highly intuitive and effective means of switching between automatic and manual vehicle control-no user training required. The control interface allows for user to be comfortable in an autonomous vehicle—users can instantly gain full control when needed.

Abstract: A peptide for inhibiting Toll-like receptor 4 (TLR4) signalling comprising the amino acid sequence of SEQ ID NO. 4, SEQ ID NO 55, SEQ ID NO 68, SEQ ID NO. 69, SEQ ID NO 70, SEQ ID NO 71, SEQ ID NO 72, SEQ ID NO 79, SEQ ID NO 82, SEQ ID NO 85, SEQ ID NO 88, SEQ ID NO 91, SEQ ID NO 94, SEQ ID NO 97, SEQ ID NO 100, SEQ ID NO 103, SEQ ID NO 106, SEQ ID NO 109, SEQ ID NO 112, or SEQ ID NO 115. The peptide may comprise a delivery sequence such as a cationic peptide.

Abstract: An embodiment of the present invention provides for the ad-hoc configuration of femtocells using spectrum sensing for the selection of spectrum channels. One or more embodiments of the invention determine frequency bands that are not reserved by macrocells in a location, and perform spectrum sensing to determine communication channels in unreserved frequency bands that are being used by other femtocells in range. In this manner, femtocells can be deployed and configured in an ad-hoc manner without external coordination or control between deployed femtocells.

Abstract: A magnetic recording medium for use in storing information is described, the medium comprising the use of a manganese-gallium alloy. More specifically, in one embodiment there is provided a magnetic recording medium comprising a substrate having a surface upon which is placed a magnetic recording layer, wherein the magnetic recording layer comprises a Manganese-Gallium alloy material with uniaxial anisotropy.