Abstract: The present invention provides novel chemical compounds characterized as Rho kinase (ROCK) inhibitors, methods for their discovery, and their therapeutic, research, and diagnostic use. In particular, the present invention provides 1,4-benzodiazepine-2,5-dione compounds and related compounds having ROCK inhibitory activity, and methods of using such compounds as therapeutic agents to treat a number of conditions associated with ROCK activity.

Abstract: The present invention determined that EGFL6 functions as a tumor vascular regulator of ovarian cancer stem cells (CSC). In addition, the present invention determined that a novel EGFL6 blocking antibody was able to restrict cancer cell growth and delay disease recurrence. As such, the present invention provides compositions and methods for inhibiting cancer cell growth, proliferation and/or metastasis. In particular, the present invention provides methods for inhibiting cancer cell growth, proliferation and/or metastasis through administration of a composition comprising an agent capable of inhibiting the function of EGFL6 (e.g., thereby inhibiting related cancer cell growth). In some embodiments, the agent capable of inhibiting the function of EGFL6 is an EGFL6 blocking antibody. The agents and related compositions additionally find use in diagnostic and research settings.

Abstract: The disclosure provides devices and methods for controlled assembly of colloidal particles. A medium with colloidal particles having a charged surface is placed in physical contact with an electrically conductive material (e.g., an ITO coating). An external light source directs light towards the electrically conductive material, thus driving the colloidal particles from a first non-assembled state to a second assembled state, which may thus create organized colloidal crystals or alternatively predetermined void regions. Assembly of the colloids can be achieved with no external electric fields or external magnetic fields. Moreover, the colloidal assembly is three-dimensional, occurs rapidly, and is entirely reversible and reconfigurable based on controlling the light applied to the electrically conductive material.

Abstract: A piezoelectric MEMS microphone comprising a multi-layer sensor that includes at least one piezoelectric layer between two electrode layers, with the sensor being dimensioned such that it provides a near maximized ratio of output energy to sensor area, as determined by an optimization parameter that accounts for input pressure, bandwidth, and characteristics of the piezoelectric and electrode materials. The sensor can be formed from single or stacked cantilevered beams separated from each other by a small gap, or can be a stress-relieved diaphragm that is formed by deposition onto a silicon substrate, with the diaphragm then being stress relieved by substantial detachment of the diaphragm from the substrate, and then followed by reattachment of the now stress relieved diaphragm.

Abstract: Methods and systems for use of model predictive control (MPC) controllers utilizing hybrid, quadratic solvers to solve a linear feasibility problem corresponding to a nonlinear problem for an internal combustion engine plant such as a diesel engine air path. The MPC solves a convex, quadratic cost function having optimization variables and constraints and directs the plant per the output solutions to optimize plant operation while adhering to regulations and constraints. The problem includes a combination of iterative and direct calculations in the primal space depending on whether a partial step (iterative) or a full step (direct) is attempted. Further, primal and dual space array matrices are pre-computed and stored offline and are retrieved via use of a unique identifier associated with a specific active set for a set of constraints. Such hybrid and/or offline calculations allow for a reduction in computational power while still maintaining accuracy of solution results.

Abstract: Disclosed herein are methods for fabricating an organic photovoltaic device comprising depositing an amorphous organic layer and a crystalline organic layer over a first electrode, wherein the amorphous organic layer and the crystalline organic layer contact one another at an interface; annealing the amorphous organic layer and the crystalline organic layer for a time sufficient to induce at least partial crystallinity in the amorphous organic layer; and depositing a second electrode over the amorphous organic layer and the crystalline organic layer. In the methods and devices herein, the amorphous organic layer may comprise at least one material that undergoes inverse-quasi epitaxial (IQE) alignment to a material of the crystalline organic layer as a result of the annealing.

Abstract: Computer-implemented methods are used to analyze a medical image to assess the state of the sample region. In at least one embodiment, the method comprises receiving at least one medical image collected previously from an image source, the at least one medical image comprising a plurality of voxels, each characterized by a signal value; classifying the signal value of each voxel as representing one of healthy tissue or diseased tissue based on a threshold value; and analyzing at least one topographical feature of the at least one medical image.

Abstract: The present invention relates to methods and compositions for the stimulation of immune responses. Specifically, the present invention provides methods of inducing an immune response to human immunodeficiency virus (HIV) in a subject (e.g., a human subject) and compositions useful in such methods (e.g., a nanoemulsion comprising HIV or antigenic portion thereof).

Abstract: A fiber reinforced actuator includes first and second sets of fibers coupled with and arranged along a control volume to controllably constrain mobility of an actuator body. Fibers of the first set can be arranged with respect to fibers of the second set and with respect to a central axis to impart the actuator with various combinations of torsional and axial force responses. A third fiber may be included to form a helical actuator. A plurality of actuators can be coupled together for coordinated movement, thereby providing additional mobility directions, such as trans-actuator bending. The fiber-reinforced actuators and actuator assemblies are potential low cost, low energy consumption, lightweight, and simple replacements for existing motion devices such as servo-motor driven robots.

Abstract: Devices and methods for electric field driven on-demand separation of liquid-liquid mixtures are provided. For example, methods for separating liquid-liquid mixtures, such as free oil and water, oil-in-water emulsions and water-in-oil emulsions, are provided that have separation efficiencies up to about 99.9%. The liquid-liquid mixture is contacted with a separator membrane assembly comprising a separator membrane formed of a porous oleophobic (or superoleophobic) material and an electrically conductive member. An electrical potential is applied across the porous oleophobic (or superoleophobic) material of the separator membrane to facilitate passage and separation of at least a portion of the first component through the separator membrane. Separation devices and such separator membrane assemblies are also provided.

Abstract: A vehicle maneuver detection application is proposed for driving assistant systems. The application can accurately and inexpensively detect and differentiate vehicle steering maneuvers by utilizing built-in sensors on smartphones or other portable computing device residing in a vehicle. By leveraging an effective bump detection algorithm and studying the nature of steering, the application is capable of differentiating various steering patterns, such as lane change, turn, and driving on curvy roads. Practicality of the application is demonstrates by two use cases: careless steering detection and fine-grained lane guidance. Thus, the application provides new functionalities without relying on cameras to provide a broader range of driving assistance.

Abstract: An ingestible gastric volume reduction device (100) is provided that is controllably adjustable between an expanded state and a contracted state. A control subsystem within the device is able to selectively transition the device between both states. Such control can be by way of a biological or chemical sensor (102) in the device, a wireless (RF) receiver (104), or timer. Thus activation of the device whether to expand and fill a gastric volume or to contract to open up the gastric volume may be achieved from internal control (within device) or external control (to the device). The device may be used for patient treatment, by administering the device (e.g., through ingestion) to a gastric region and then controllably increasing and/or decreasing the volume of the device during treatment.

Abstract: The present invention relates to compositions and methods for inducing intestinal stem cell homeogenesis and/or regeneration within intestinal tissue expressing Robo1 through administration of a Rspo1 agent and a Slit2 agent. Administration of such agents results in, for example, binding of the Rspo1 agent and Slit2 agent with Robo1, resulting in, for example, binding of the CC3 motif of Robo1 with LRP6, resulting in phosphorylation of LRP6, and ultimately, induction of intestinal stem cell homeogenesis and/or regeneration. In certain embodiments, such administration of a Rspo1 agent and a Slit2 agent is used to protect and/or prevent intestinal tissue damage resulting from exposure to an intestinal tissue damaging event (e.g., radiation). The agents and related compositions additionally find use in diagnostic and research settings.

Abstract: A miniature mechanical shutter having a chamber, a shutter member having an aperture formed therethrough that is mounted to the chamber to allow translation and rotation about an axis. A pair of cap members are disposed on opposing ends of the shutter member to support the shutter member during the translation and rotation. The shutter further comprising a plurality of magnet members, such that a first of the plurality of magnet members is disposed in a first end of the shutter member, a second of the plurality of magnet members is disposed in a second end of the shutter member opposite the first end, and a third of the plurality of magnets members is disposed external to the chamber. At least one of the plurality of magnet members is responsive to an electrical impulse to translate and/or rotate the shutter member between an opened position and a closed position.

Abstract: An active indoor location sensing technique is presented for smartphones and other types of mobile devices without requiring any additional sensors or pre-installed infrastructure. The main idea is to actively generate acoustic signatures by transmitting a sound signal with a phone's speakers and sensing its reflections with the phone's microphones. This active sensing achieves finer-grained control of the collected signatures than the widely-used passive sensing.

Abstract: A probe insertion device for implanting a probe into tissue includes a rigid base that selectively attaches to the probe due to a bond between the base and the probe, that provides a structural backbone to the probe, is longitudinally aligned with the probe, and can be adapted to receive a fluid between the base and the probe. The probe insertion device can include a surface covering at least a portion of the base that reduces the bond between the base and the probe in the presence of the fluid.

Abstract: Identification, quantification and characterization of biological micro- and nano-systems is enabled by magnetically spinning these natural, non-magnetic systems with the aid of induced magnetization. Biofriendly magnetic micro- and nano-labels enable magnetorotation in extremely weak electromagnetic fields. The spinning of these micromotors can be observed by a simple, CD-like, optical tracking system. The spinning frequency response enables real-time monitoring of single (cancer) cell morphology, with sub-microscopic resolution, yielding previously undeterminable information. Likewise, it enables super-low detection limits for any (cancer) biomarker.

Abstract: An image processing system includes a processing device having a memory device for storing computer-executable instructions. The processing device is programmed to define a first descriptor in a first image, generate a mask from the first descriptor, and define a second descriptor in a second image. The processing device is further programmed to compare the first descriptor to the second descriptor to define a first error vector, determine a second error vector by applying a mask, and compute the total error of the second error vector to determine an error between the first descriptor and the second descriptor.

Abstract: The present disclosure provides a regenerative peripheral nerve interface (RPNI) for a subject comprising an insulating substrate, at least one metallic electrode deposited onto the insulating substrate forming a thin-film array; a portion of the at least one metallic electrode surface having a layer of a first conductive polymer and a layer of decellularized small intestinal submucosa (SIS) coating a portion of the electrode, wherein a second conductive polymer is electrochemically polymerized through the SIS to form the regenerative peripheral nerve interface. The present disclosure also provides that a layer of muscle tissue contacts the regenerative peripheral nerve interface.

Abstract: Aspects of the subject disclosure may include, for example, identifying a data request to transfer data for a mobile device across a mobile network. The data request occurs within a time interval of a number of time intervals, each having a duration greater than a data transfer time across the mobile network. A volume is determined of the data requested, and compared to a data transfer capacity of the wireless access terminal. A transfer of the data is scheduled within the time interval, responsive to the volume of data requested being less than the data transfer capacity. The transfer of the data is deferred to another time interval, responsive to the volume of data requested being greater than the data transfer capacity, and the deferring of the data to another time includes resubmitting the data request in another time interval of the plurality of time intervals. Other embodiments are disclosed.