Abstract: An embodiment of an electromagnetic actuator, such as a moving magnet actuator (MMA), includes a back iron, a first coil winding, a second coil winding, a mover, and a permanent magnet. The first and second coil windings are connected to the back iron, and have generally annular shapes. The mover moves relative to the back iron during use of the MMA. The permanent magnet is connected to the mover and moves with the mover during use of the MMA. The permanent magnet has a generally annular shape.

Abstract: Inhibitors of BET bromodomains and compositions containing the same are disclosed. Methods of using the BET bromodomain inhibitors in the treatment of diseases and conditions wherein inhibition of BET bromodomain provides a benefit, like cancers, also are disclosed.

Abstract: The invention provides a method of treating alveolar bone loss involving administration of a sclerostin inhibitor to a subject in need thereof.

Abstract: A microsystem includes a base layer formed from an electrical insulating material. The base layer has an inner surface defining a cavity and an external surface opposed to the inner surface, and in direct communication with an environment. A cap layer and a microelectromechanical (MEMS) device layer are formed from electrical insulating material or an other electrical insulating material. The cap has an inner surface defining a cavity, and an external surface opposed to the inner surface, and in direct communication with the environment. A MEMS device on/in the MEMS device layer is disposed between the base and the cap. Respective adjacent portions of the base, the cap and the device substrate are bonded to define an enclosed space. The enclosed space at least partially includes the base cavity or the cap cavity. At least a portion of a MEMS device on the device layer is in the enclosed space.

Abstract: An optoelectronic neutron detector and method for detecting nuclear material having a neutron capture and scatter medium receiving neutrons and producing secondary charged particles, a photodetector detecting emitted light from the secondary charged particles and outputting a detector signal, and a controller receiving the detector signal and providing an alert or quantitative indication of detected nuclear material in response to the detector signal.

Abstract: A voxel-based technique is provided for performing quantitative imaging and analysis of tissue image data. Serial image data is collected for tissue of interest at different states of the issue. The collected image data may be deformably registered, after which the registered image data is analyzed on a voxel-by-voxel basis, thereby retaining spatial information for the analysis. Various thresholds are applied to the registered tissue data to identify a tissue condition or state, such as classifying chronic obstructive pulmonary disease by disease phenotype in lung tissue, for example.

Abstract: A method of treating tinnitus includes the step administering a composition to the mammal, wherein the composition consists essentially of a biologically effective amount of vitamin A, vitamin E, vitamin C, a vasodilator comprising magnesium, and, optionally, a withanolide, and/or resveratrol.

Abstract: An adaptive power distribution system is presented for extending the dynamic range of AC/RF rectifiers. The power distribution system distributes the AC/RF input power amongst several different rectifier cells adaptively based on input power level. Consequently, high rectification efficiency can be maintained over a very wide dynamic range.

Abstract: A method for controlling an internal combustion engine using a controller that controls an air flow path by adjusting at least one of a variable geometry turbine (VGT) and an exhaust gas recirculation (EGR) flow rate during engine operation. The method determines inputs, such as engine speed and fuel rate from the sensor data, and employs a switch based gain-scheduled explicit model predictive controller (MPC) responsive to the inputs to determine the air flow path.

Abstract: A method of preparing a bulk heterojunction organic photovoltaic cell through combinations of thermal and solvent vapor annealing are described. Bulk heterojunction films may prepared by known methods such as spin coating, and then exposed to one or more vaporized solvents and thermally annealed in an effort to enhance the crystalline nature of the photoactive materials.

Abstract: Methods and devices for high speed detection of terahertz radiation are provided. A photoacoustic transducer receives a pulse of terahertz (THz) radiation. The transducer may comprise a solid, liquid, or semi-solid material. For example, the transducer may be a composite material having a polymer and radiation absorbing particles. The photoacoustic transducer produces an acoustic wave (e.g., an ultrasound wave) in response to receiving the pulse of THz radiation. An acoustic sensor receives the acoustic wave produced by the photoacoustic transducer and thus provides detection of the THz wave.

Abstract: A weighted sum is a key computation for many neural networks and other machine learning algorithms. Integrated circuit designs that perform a weighted sum are presented. Weights are stored as threshold voltages in an array of flash transistors. By putting the circuits into a well-defined voltage state, the transistors that hold one set of weights will pass current equal to the desired sum. The current flowing through a given transistor is unaffected by operation of remaining transistors in the circuit.

Abstract: The present invention provides compositions and methods for research, diagnostic, drug screening, and therapeutic applications related to paroxysmal dystonic choreoathetosis and related conditions. In particular, the present invention provides mutations in the myofibrillogenesis regulator 1 (MR-1) gene associated with such conditions.

Abstract: The invention relates to methods and systems for automatically detecting an optic disc in a retinal fundus autofluorescence image. A monochromatic image of a retina is obtained by stimulated autofluorescence. The image is processed using filters and machine learning to identify blood vessel segments and to identify pixels as possible optic disc pixels. The possible optic disc pixels are grouped into clusters, and a best fit circle (or portion thereof lying within the image) is fitted to each cluster. The circle may be enlarged to improve image contrast at the circumference of the circle. Blood vessel segments that intersect the circle are identified, and metrics are derived from such intersecting blood vessel segments. These metrics are assessed by machine learning processes to determine the probability that each cluster contains the optic disc, and the contours of the optic disc are further determined by analysis of the possible optic disc pixels.

Abstract: An organic light emitting device is described, having an OLED including an anode, a cathode, and at least one organic layer between the anode and cathode. At least a portion of an electrode surface includes a plurality of scattering structures positioned in a partially disordered pattern resembling nodes of a two dimensional lattice. The scattering structures are positioned around the nodes of the two dimensional lattice with the average distance between the position of each scattering structure and a respective node of the lattice is from 0 to 0.5 of the distance between adjacent lattice nodes. A method of manufacturing an organic light emitting device and a method of enhancing the light-extraction efficiency of an organic light emitting device are also described.

Abstract: The present disclosure relates to the field of G protein coupled receptor (GPCR) structural biology and signaling. In particular, the present disclosure relates to binding domains directed against and/or specifically binding to GPCR:G protein complexes. Also provided are nucleic acid sequences encoding such binding domains and cells expressing or capable of expressing such binding domains. The binding domains of the present disclosure can be used as universal tools for the structural and functional characterization of G-protein coupled receptors in complex with downstream heterotrimeric G proteins and bound to various natural or synthetic ligands, for investigating the dynamic features of G protein activation, as well as for screening and drug discovery efforts that make use of GPCR:G protein complexes.

Abstract: A microstructure detector and in-situ method for real-time determination of the microstructure of a material undergoing alloying or other phase transformation. The method carried out by the detector includes the steps of: (a) detecting light emitted from a plasma plume created during phase transformation of a material; (b) determining at least some of the spectral content of the detected light; and (c) determining an expected microstructure of the transformed material from the determined spectral content. Closed loop control of the phase transformation process can be carried out using feedback from the detector to achieve a desired microstructure.

Abstract: An intubation device having a main body portion defining a first longitudinal axis, a distal tip portion coupled to the main body portion and defining a second longitudinal axis, and a deflection system having a single drive member extending within at least the distal tip portion and coupled thereto. The deflection system is operable to exert a tensile force upon the distal tip portion to articulate the distal tip portion relative to the main body portion between a resting position and a positive incline position and a negative incline position.

Abstract: Inhibitors of MDM2 and MDM2-related proteins and compositions containing the same are disclosed. Methods of using the MDM2 inhibitors in the treatment of diseases and conditions wherein inhibition of an interaction between p53 and MDM2 provides a benefit, like cancers, also are disclosed.

Abstract: Recurrent gene fusions of androgen regulated genes and ETS family member genes in prostate cancer are described. Compositions and methods having utility in prostate cancer diagnosis, research, and therapy are also provided.