Patents Assigned to The Regents of the University of Michigan
  • Publication number: 20200188090
    Abstract: Ear implants for auricular tissue reconstruction in a patient are provided. The ear implant may be a tissue scaffold multicomponent assembly for reconstruction of auricular tissue. Thus, the assembly may include both a first and a second tissue scaffold component. Each comprises a biocompatible polymeric material having a plurality of open pores configured to support cell growth. The first tissue scaffold component defines a central void region and at least a portion of an outer ear framework of the patient after implantation. The second tissue scaffold component defines a base portion. After implantation into the patient, the second tissue scaffold component seats within the central void region of the first tissue scaffold component, so that the second tissue scaffold component is secured to the first tissue scaffold component. Methods for reconstructing auricular tissue in a patient using such ear implant tissue scaffolds are also provided.
    Type: Application
    Filed: April 26, 2018
    Publication date: June 18, 2020
    Applicant: The Regents of the University of Michigan
    Inventors: David A. ZOPF, Scott J. HOLLISTER
  • Patent number: 10676527
    Abstract: Methods and compositions for modulating blood-neural barrier (BNB) for the treatment of CNS conditions such as edema, and for increased drug delivery efficacy across the BNB. The present invention further relates to improved tPA treatment of ischemic cerebrovascular and related diseases in combination with antagonism of the PDGF signaling pathway. The inventive method and composition is particularly suitable for conjunctive therapy of ischemic stroke using tPA and an anti-PDGF-C antagonist or an anti-PDGFR-? antagonist.
    Type: Grant
    Filed: February 12, 2018
    Date of Patent: June 9, 2020
    Assignees: Ludwig Institute for Cancer Research Ltd., The Regents of the University of Michigan, University of Maryland, Baltimore
    Inventors: Ulf Eriksson, Linda Fredriksson, Daniel Lawrence, Enming Su, Manuel Yepes, Dudley Strickland
  • Patent number: 10677708
    Abstract: A microfluidic device for detecting rare cells in a fluid sample comprises the rare cell and other cells. The microfluidic device comprises an inlet for receiving the fluid sample, a labyrinth channel structure in fluid communication with the inlet, and an outlet in fluid communication with the labyrinth channel structure for collecting the rare cells separated from the other cells in the fluid sample. The labyrinth channel structure comprises at least one channel through which the fluid sample flows. The at least one channel has a plurality of segments and a plurality of corners with each corner defined between adjacent segments. The presence of the plurality of corners induces separation of the rare cells from the other cells in the fluid sample as the rare cells move to a first equilibrium position within the at least one channel when a ratio of inertial lift forces (FZ) and Dean flow (FD) of the fluid sample is from 2 to 10.
    Type: Grant
    Filed: August 10, 2018
    Date of Patent: June 9, 2020
    Assignee: The Regents of the University of Michigan
    Inventors: Sunitha Nagrath, Hyeun Joong Yoon, Eric Lin, Max S. Wicha, Lianette Rivera Baez, Diane M. Simeone
  • Patent number: 10677801
    Abstract: The present invention relates to compositions and methods for-determining a treatment course of action. In particular, the present invention relates to compositions and methods for the prediction of a subject's response to cancer therapies and administration of appropriate treatments.
    Type: Grant
    Filed: January 27, 2017
    Date of Patent: June 9, 2020
    Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventor: Daniel Hayes
  • Patent number: 10680132
    Abstract: The present disclosure relates to methods and growth structures for making thin-film electronic and optoelectronic devices, such as flexible photovoltaic devices, using epitaxial lift-off (ELO). In particular, disclosed herein are wafer protection schemes that preserve the integrity of the wafer surface during ELO and increase the number of times that the wafer may be used for regrowth. The wafer protection schemes use growth structures that include at least one superlattice layer.
    Type: Grant
    Filed: January 15, 2015
    Date of Patent: June 9, 2020
    Assignee: The Regents of the University of Michigan
    Inventors: Stephen R. Forrest, Kyusang Lee, Dejiu Fan
  • Patent number: 10669320
    Abstract: Provided herein are compositions and methods for the treatment of cancer by activating the spindle assembly checkpoint (SAC) in cells. In particular, dimerized Mps1 and Spc105/KNL1 constructs are provided as tunable activators of SAC, allowing for control of chromosome segregation accuracy and prevention of aneuploidies that are common in cancer.
    Type: Grant
    Filed: November 18, 2016
    Date of Patent: June 2, 2020
    Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Ajit P. Joglekar, Pavithra Aravamudhan
  • Patent number: 10668850
    Abstract: Systems, apparatuses and methods are provided for object restraint including a trench; a pneumatic bending actuator (PBA), the PBA and the trench configured on the surface for clamping of the object to the surface; a part of the PBA constrained in the trench and a part of the PBA left unconstrained by the trench; a primary actuation mechanism for constraining in the trench the constrained part of the PBA to remain flat at the surface for resting the object on the surface, and for leaving the unconstrained part of the PBA configured as the curved segment to exert a clamping force to the object on the surface; and a secondary constraint mechanism to retain the constrained part of the PBA in the trench to prevent a portion of the constrained part of the PBA from exerting an upward force counter to the clamping of the unconstrained part of the PBA.
    Type: Grant
    Filed: February 14, 2019
    Date of Patent: June 2, 2020
    Assignees: GM GLOBAL TECHNOLOGY OPERATIONS LLC, THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Paul W. Alexander, Diann Brei, Jonathan E. Luntz, Jesse Velleu
  • Patent number: 10672501
    Abstract: A method is presented for reprogramming cells of a subject. As a starting point, a biological sample of a sample cell is received from the subject, where the sample cell has a given cell type. The method includes: determining gene expression data for the sample cell from the biological sample; receiving gene expression data for a target cell having a target cell type, where the target cell type differs from the given cell type; deriving a state transition matrix which models cell dynamics; computing a regulatory set for a given transcription factor, where the regulatory set quantifies influence of the given transcription factor on a genome; expressing reprogramming of the sample cell to the target cell with a state-space representation of a linear system; and solving for the input vector in the state-space representation.
    Type: Grant
    Filed: August 16, 2017
    Date of Patent: June 2, 2020
    Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Indika Rajapakse, Geoff Patterson, Scott Ronquist
  • Patent number: 10670578
    Abstract: Improved resolution and detection of nanoparticles are achieved when a nanopore connecting liquid compartments in a device running on the Coulter principle is provided with fluid coatings such as lipid walls. Fluid lipid walls are made of a lipid bilayer, and preferably include lipid anchored mobile ligands as part of the lipid bilayer. By varying the nature and concentration of the mobile ligand in the lipid bilayer, multifunctional coatings of lipids are provided.
    Type: Grant
    Filed: April 8, 2019
    Date of Patent: June 2, 2020
    Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Michael Mayer, Erik Yusko, Jerry Yang
  • Patent number: 10668252
    Abstract: An integrated vascular delivery system having a frame configured to receive a catheter insertable in a patient to deliver fluid at an insertion site. The frame includes a first hub, a second hub, and a pair of flexible lateral members extending between the hubs and including a tubular lateral member. The system also includes a fluidic channel that fluidically communicates with the catheter, wherein the fluidic channel passes through the tubular lateral member and at least one of the hubs, and includes a fixed turnabout portion in which fluid flows in a direction different from that within the catheter. The first and second hubs provide anchoring points on the patient distributed around the insertion site and on opposite ends of the catheter, thereby anchoring the frame to the patient and stabilizing the catheter. A method is provided for using an integrated vascular delivery system.
    Type: Grant
    Filed: April 12, 2018
    Date of Patent: June 2, 2020
    Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Steven B. White, Adrienne Harris, Merrell Sami, Elyse Kemmerer White
  • Patent number: 10660895
    Abstract: Provided herein are methods for treating, delaying progression of, or reducing the severity of amyotrophic lateral sclerosis (ALS) in a subject through administration of therapeutically effective amounts of agents (e.g., JAK kinase inhibitors (e.g., tofacitinib)) capable of interfering with central nervous system related natural killer cell (NK) levels and function.
    Type: Grant
    Filed: August 13, 2019
    Date of Patent: May 26, 2020
    Assignee: The Regents of the University of Michigan
    Inventors: Eva L. Feldman, Ben Murdock, Stephen Goutman, Stacey Jacoby
  • Patent number: 10662086
    Abstract: A system for water purification having a water inlet being distributed into a plurality of streams defining extended dielectric barrier layers with high surface area to volume ratios and a plasma disposed between at least a pair of the plurality of water streams forming a surface plasma attachment producing radicals that treat the water via diffusion.
    Type: Grant
    Filed: May 27, 2016
    Date of Patent: May 26, 2020
    Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: John E. Foster, Selman Mujovic
  • Patent number: 10662183
    Abstract: Disclosed herein are inhibitors of gene transcription mediated by myocardin-related transcription factor and serum response factor, or both myocardin-related transcription factor and serum response factor (“MRTF/SRF”), and methods for their use in treating or preventing cancer and fibrosis. In particular, disclosed herein are compounds of Formula (I) and Formula (II), and pharmaceutically acceptable salts thereof: wherein the substituents are as described.
    Type: Grant
    Filed: November 6, 2015
    Date of Patent: May 26, 2020
    Assignees: THE REGENTS OF THE UNIVERSITY OF MICHIGAN, BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY
    Inventors: Scott D. Larsen, Richard Neubig, Andrew Haak, Kim Hutchings, Walajapet Rajeswaran, Dinesh Khanna, Erika Mathes Lisabeth
  • Patent number: 10661273
    Abstract: Methods of forming two-dimensional nanopatterns are provided. The method may comprise periodically contacting a vibrating tool comprising a patterned grating edge with a substrate along a first direction in a grating-vibrational indentation patterning process. The patterned grating edge defines a plurality of rows and a plurality of interspersed troughs. The periodic contacting creates a two dimensional array of discontinuous voids in a single-stroke across the surface of the substrate. In other aspects, a microfluidic device for selective arrangement of a microspecies or nanospecies is provided, that includes a substrate comprising a surface defining a two-dimensional pattern of microvoids or nanovoids. In yet other aspects, the present disclosure provides a method for selective arrangement of a microspecies or nanospecies on a substrate.
    Type: Grant
    Filed: October 13, 2016
    Date of Patent: May 26, 2020
    Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Jong G. Ok, Lingjie J. Guo, Long Chen, Ashwin Panday
  • Publication number: 20200158641
    Abstract: Laser emission based microscope devices and methods of using such devices for detecting laser emissions from a tissue sample are provided. The scanning microscope has first and second reflection surfaces and a scanning cavity holding a stationary tissue sample with at least one fluorophore/lasing energy responsive species. At least a portion of the scanning cavity corresponds to a high quality factor (Q) Fabry-Pérot resonator cavity. A lasing pump source directs energy at the scanning cavity while a detector receives and detects emissions generated by the fluorophore(s) or lasing energy responsive species. The second reflection surface and/or the lasing pump source are translatable with respect to the stationary tissue sample for generating a two-dimensional scan of the tissue sample. Methods for detecting multiplexed emissions or quantifying one or more biomarkers in a histological tissue sample, for example for detection and diagnosis of cancer, or other disorders/diseases are provided.
    Type: Application
    Filed: December 27, 2017
    Publication date: May 21, 2020
    Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Xudong FAN, Yu-Cheng CHEN, Qiushu CHEN
  • Patent number: 10656117
    Abstract: Physical parameters of macromolecules are determined by measuring electrical current I over time for translocation events as the macromolecules in solution move between two liquid compartments that are separated by and fluidically coupled through a synthetic nanopore. Values of charge, volume, shape, rotational diffusion coefficient, and dipole moment are derived from the measurements.
    Type: Grant
    Filed: June 10, 2019
    Date of Patent: May 19, 2020
    Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Michael Mayer, Erik Yusko
  • Publication number: 20200153805
    Abstract: Aspects of the subject disclosure may include, for example, a method in which a processing system parses a network trace to collect packet information for an encrypted adaptive bite rate (ABR) video stream encoded into a plurality of tracks; detects request packets corresponding to a sequence of requests for video segments to be downloaded at a network client; and determines a traffic volume downloaded at the network client to obtain a sequence of traffic volumes. The processing system identifies, for each of the sequence of traffic volumes, a set of candidate segments each having a size meeting a size-matching criterion; selects a segment from the set of candidate segments to determine a segment sequence meeting an index-matching criterion; and infers characteristics of the sequence of traffic volumes based on the segment sequence. Other embodiments are disclosed.
    Type: Application
    Filed: November 14, 2018
    Publication date: May 14, 2020
    Applicants: AT&T Intellectual Property I, L.P., The Regents of the University of Michigan
    Inventors: Subhabrata Sen, Shichang Xu, Zhuoqing Morley Mao
  • Publication number: 20200147844
    Abstract: Methods to increase structural performance, strength, and durability of textile-reinforced composite materials are provided. The textile reinforcement may be knitted, for example, in a flat bed weft knitting machine. The method may include pre-stressing a textile reinforcement preform by applying tension. A polymeric precursor may be introduced to the pre-stressed textile reinforcement preform. The polymeric precursor may then be cured or consolidated, followed by releasing of the applied tension to form the composite article comprising polymer and the pre-stressed textile reinforcement. In other aspects, a composite article is provided that has a pre-stressed textile reinforcement structure and a cured polymer. The textile reinforcement may be a knitted, lightweight, seamless, unitary structure.
    Type: Application
    Filed: January 17, 2020
    Publication date: May 14, 2020
    Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Anthony M. WAAS, Sean AHLQUIST, Jonathan Wesley MCGEE
  • Patent number: 10650512
    Abstract: Computer-implemented methods are used to analyze a medical image to assess the state of the sample region. In at least one embodiment, the method comprises receiving at least one medical image collected previously from an image source, the at least one medical image comprising a plurality of voxels, each characterized by a signal value; classifying the signal value of each voxel as representing one of healthy tissue or diseased tissue based on a threshold value; and analyzing at least one topographical feature of the at least one medical image.
    Type: Grant
    Filed: June 14, 2017
    Date of Patent: May 12, 2020
    Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Benjamin A. Hoff, Craig Galban, Brian D. Ross
  • Patent number: 10651449
    Abstract: Ion conducting membranes based on aramid nanofibers (ANFs) can be prepared using layer-by-layer assembly, sol-gel processing, evaporation, spin coating, doctor blading, or other methods. Porosity is controlled through choice of additives and processing.
    Type: Grant
    Filed: February 19, 2015
    Date of Patent: May 12, 2020
    Assignee: The Regents of the University of Michigan
    Inventors: Nicholas A. Kotov, Siu-On Tung, Szu-Shen Ho, Samantha Rahmani