Patents Assigned to The Regents of the University of Michigan
  • Patent number: 11031567
    Abstract: An optoelectronic device and a method of fabricating a photosensitive optoelectronic device includes depositing a first organic semiconductor material on a first electrode to form a continuous first layer; depositing a layer of a second organic semiconductor material on the first layer to form a discontinuous second layer, portions of the first layer remaining exposed; and depositing the first organic semiconductor material on the second layer to form a discontinuous third layer, portions of at least the second layer remaining exposed. The depositing of the first and second organic semiconductor materials are alternated a number of times until a final layer of the second organic material is added to form a continuous layer. A second electrode is deposited over this final layer.
    Type: Grant
    Filed: July 19, 2007
    Date of Patent: June 8, 2021
    Assignee: The Regents of the University of Michigan
    Inventors: Kai Sun, Fan Yang, Stephen R. Forrest
  • Patent number: 11031569
    Abstract: Arrangements and techniques for providing organic emissive layers are provided, in which the emissive layer includes a first dopant having a dissociative energy level. A second dopant in the emissive layer provides a solid state sink energy level, to which doubly excited excitons and/or polarons may transition instead of to the dissociative energy level, thereby decreasing the undesirable effects of transitions to the dissociative energy level.
    Type: Grant
    Filed: November 15, 2019
    Date of Patent: June 8, 2021
    Assignees: THE REGENTS OF THE UNIVERSITY OF MICHIGAN, THE UNIVERSITY OF SOUTHERN CALIFORNIA
    Inventors: Stephen R. Forrest, Michael Slootsky, Mark E. Thompson
  • Patent number: 11028105
    Abstract: Disclosed herein are borazine, borate, and azaborinine compounds and compositions, methods of making said compounds and compositions, and methods of forming aromatic difluorocarbon compounds and difluorocarbon compounds.
    Type: Grant
    Filed: June 28, 2019
    Date of Patent: June 8, 2021
    Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Nathaniel Szymczak, Jacob Geri
  • Patent number: 11027479
    Abstract: Methods for fabricating three-dimensional microstructures are provided. The method includes disposing a reflow material on a mold, heating the reflow material, and creating a pressure gradient across the reflow material to reflow the material towards a bottom surface of the mold. The mold includes a molding region, a boundary region, and a thermal-isolating region disposed therebetween. The molding region includes a cavity and a projection projecting upwards from a bottom surface of the cavity. The thermal-isolating region includes at least one pocket formed adjacent to and along a perimeter of the cavity of the molding region. During heating, the temperature of the molding region is higher than that of the boundary region and the thermal-isolating region controls the thermal conductivity and mass therebetween. The material reflows towards the bottom surface of the cavity and the protrusion helps shapes the reflow material to form a substantially symmetrical three-dimensional microstructure.
    Type: Grant
    Filed: September 21, 2017
    Date of Patent: June 8, 2021
    Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Khalil Najafi, Jae Yoong Cho
  • Publication number: 20210162909
    Abstract: Cargo systems are provided for vehicles that include, in one embodiment: a variable cargo surface disposed within a body of the vehicle behind one or more occupant seats, the variable cargo surface including: a low friction surface that facilitates movement of cargo within the cargo system, the low friction surface having a first coefficient of friction; a high friction surface that inhibits movement of cargo within the cargo system, the high friction surface having a second coefficient of friction that is greater than the first coefficient of friction; and a control device that selectively activates the low friction surface and the high friction surface based on conditions for the vehicle; wherein the low friction surface contacts the cargo within the cargo system when the low friction surface is activated; and the high friction surface contacts the cargo within the cargo system when the high friction surface is activated.
    Type: Application
    Filed: February 17, 2021
    Publication date: June 3, 2021
    Applicants: GM GLOBAL TECHNOLOGY OPERATIONS LLC, THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: PAUL W. ALEXANDER, WONHEE M. KIM, DIANN BREI, JONATHAN E. LUNTZ, KORAY Benli, Laura Alejandra Giner Munoz
  • Patent number: 11024624
    Abstract: In a particular implementation, an apparatus to control clamping devices includes a first control circuit and a second control circuit. The first control circuit is responsive to a detection signal and generates a first drive signal to control a body diode of a clamping device. The second control circuit is responsive to the detection signal and generates a second drive signal to control the gate terminal of the clamping device.
    Type: Grant
    Filed: July 24, 2018
    Date of Patent: June 1, 2021
    Assignees: Arm Limited, The Regents of the University of Michigan
    Inventors: Parameshwarappa Anand Kumar Savanth, Fabrice Blanc, David Theodore Blaauw, Sechang Oh, In Hee Lee
  • Patent number: 11020470
    Abstract: Provided herein are membrane enveloped virus-like particles (VLPs), and methods of use and synthesis thereof. In particular, yeast-cell-derived VLPs are provided that comprise surface-displayed glycoproteins and/or multiple virally-derived proteins.
    Type: Grant
    Filed: April 12, 2016
    Date of Patent: June 1, 2021
    Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Fei Wen, Eshita Khera, Brett Dallas Hill, Syed Rizvi
  • Patent number: 11021785
    Abstract: A microfluidic device for use with a microfluidic delivery system, such as an organic vapor jet printing device, includes a glass layer that is directly bonded to a microfabricated die and a metal plate via a double anodic bond. The double anodic bond is formed by forming a first anodic bond at an interface of the microfabricated die and the glass layer, and forming a second anodic bond at an interface of the metal plate and the glass layer, where the second anodic bond is formed using a voltage that is lower than the voltage used to form the first anodic bond. The second anodic bond is formed with the polarity of the voltage reversed with respect to the glass layer and the formation of the first anodic bond. The metal plate includes attachment features that allow removal of the microfluidic device from a fixture.
    Type: Grant
    Filed: December 13, 2017
    Date of Patent: June 1, 2021
    Assignees: THE REGENTS OF THE UNIVERSITY OF MICHIGAN, UNIVERSAL DISPLAY CORPORATION
    Inventors: Stephen Forrest, Gregory McGraw, Siddharth Harikrishna Mohan, Diane L. Peters
  • Patent number: 11018719
    Abstract: A broadband, dual-polarized, cavity-backed slot antenna (CBSA) array is presented for enabling full-duplex wireless communication. The antenna consists of a thin rectangular cavity appropriately loaded with metallic septa to excite multiple resonances of similar desired field distribution to achieve consistent radiation characteristics over a wide bandwidth. Four pairs of orthogonal radiating slots are cut out on one of the broad-walls of the cavity; all of which are fed by two orthogonal slots on the opposite broad-wall of the cavity. The cavity is fed by an end-launch coaxial-to-waveguide transition to excite one of the channels. The other channel is excited by a two-pronged microstrip line symmetrically crossing over the other cavity feeding slot. Due to the out-of-phase coupling from the two prongs of the microstrip line to the other port, this type of excitation is shown to provide an unpredicted level of isolation between the two channels over a wide bandwidth.
    Type: Grant
    Filed: May 17, 2020
    Date of Patent: May 25, 2021
    Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Kamal Sarabandi, Seyed M. Amjadi
  • Patent number: 11015224
    Abstract: The present disclosure relates to compositions and methods for cancer diagnosis, research and therapy, including but not limited to, cancer markers. In particular, the present disclosure relates to RAF gene fusions as diagnostic markers and clinical targets for cancer.
    Type: Grant
    Filed: December 6, 2016
    Date of Patent: May 25, 2021
    Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Arul Chinnaiyan, Nallasivam Palanisamy, Shanker Kalyana-Sundaram
  • Patent number: 11013754
    Abstract: Provided herein are compositions and methods for treating cancer. In particular, provided herein are compositions, methods, and uses of inhibitors of ARlnc1 for treating cancer.
    Type: Grant
    Filed: April 9, 2019
    Date of Patent: May 25, 2021
    Assignee: The Regents of the University of Michigan
    Inventors: Arul Chinnaiyan, Rohit Malik, Yajia Zhang, Marcin Cieslik, Sethuramasundaram Pitchiaya
  • Patent number: 11014047
    Abstract: Microdialysis sampling is an essential tool for in vivo neuro-chemical monitoring. Conventional dialysis probes are over 220 ?m in diameter and have limited flexibility in design because they are made by assembly using preformed membranes. The probe size constrains spatial resolution and governs the amount of tissue damaged caused by probe insertion. To overcome these limitations, we have developed a method to microfabricate probes in Si that are 45 ?m thick 180 ?m wide. The probes contain a buried, U-shaped channel that is 30 ?m deep 60 ?m wide and terminates in ports for external connection. A 4 mm length of the probe is covered with a 5 ?m thick nanoporous membrane. The membrane was microfabricated by deep reactive ion etching through a porous aluminum oxide layer. The microfabricated probe has cross-sectional area that is 79% less than that of the smallest conventional microdialysis probes. The probes yield 2-7% relative recovery at 100 nL/min perfusion rate for a variety of small molecules.
    Type: Grant
    Filed: November 29, 2016
    Date of Patent: May 25, 2021
    Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Robert T. Kennedy, Hyeun Joong Yoon, Thitaphat Ngernsutivorakul, Woong Hee Lee
  • Publication number: 20210148824
    Abstract: An image reconstruction method includes capturing a reference image of the specimen and capturing a set of original images based on the reference image. The method includes generating a set of analyzed images based on the set of original images by determining an intensity distribution for each pixel of each original image of the set of original images and combining the intensity distribution at each pixel location across the set of original images into an intermediate image. The method includes, identifying an object in the intermediate image. In response to identifying the object in the intermediate image, determining an intensity value of the object in each original image of the set of original images and generating an improved image of the object based on the determined intensity value of the object. The method includes generating a final image including the improved image of the object and displaying the final image.
    Type: Application
    Filed: April 12, 2019
    Publication date: May 20, 2021
    Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Somin Eunice LEE, Yunbo LIU, Yipei WANG
  • Patent number: 11008553
    Abstract: The disclosure provides biocatalysts that halogenate complex chemical compounds in specific and predictable ways. Also disclosed are halogenated complex organic compounds. The disclosure further provides methods for the halogenation of complex chemical compounds and methods of inhibiting the contraction of smooth muscle in mammals.
    Type: Grant
    Filed: July 18, 2019
    Date of Patent: May 18, 2021
    Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: David H. Sherman, Amy E. Fraley, Ashootosh Tripathi
  • Patent number: 11009487
    Abstract: A multi-modal biosensor system includes a vibrating plate orientated along a plane. An actuator is interfaced with the vibrating plate and operable to vibrate the vibrating plate along the plane. The actuator includes two electrodes rigidly affixed to the vibrating plate. An optical support structure is rigidly affixed to the vibrating plate, and provides an outwardly facing surface to receive a measurement sample. A light source is configured to project light onto the outwardly facing surface of the optical support structure. A light detector is configured to capture light reflected from the outwardly facing surface of the optical support structure. A controller interfaces with the two electrodes and the light detector. The controller operates to detect changes in the vibrating motion of the vibrating plate concurrently with detecting changes in the light captured by the light detector.
    Type: Grant
    Filed: September 19, 2017
    Date of Patent: May 18, 2021
    Assignees: THE REGENTS OF THE UNIVERSITY OF MICHIGAN, OAKLAND UNIVERSITY
    Inventors: Xudong Fan, Zhizheng Zhang, Xiangqun Zeng
  • Publication number: 20210128484
    Abstract: The disclosure relates to microspheres comprising a core and a shell. More particularly the disclosure relates to microspheres for extended, controlled release of a poorly water-soluble therapeutic agent having a solubility in water of 50 ?g/mL or less, the microsphere having a core comprising the therapeutic agent, and a substantially impermeable shell surrounding the core. Methods of making and using the microspheres are also provided.
    Type: Application
    Filed: November 2, 2020
    Publication date: May 6, 2021
    Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Steven P. Schwendeman, Jie Tang
  • Publication number: 20210123875
    Abstract: A multi-functional water quality sensor assembly includes an electrically non-conductive substrate carrying electrically conductive traces that comprise one or more electrodes configured to sense at least one of oxidation reduction potential (ORP) or acidity (pH) of water. The electrodes are configured to be operated according to a dynamic mode, which includes establishing constant potentials or constant currents between the electrodes and documenting potentials between the electrodes as a measure of ORP and/or pH, and/or determining a differential in the potentials between first and second times as a measure of pH of the water, wherein the dynamic mode may be carried out without use of a silver chloride reference electrode.
    Type: Application
    Filed: December 22, 2020
    Publication date: April 29, 2021
    Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Klaus Brondum, Mark A. Burns, Wen-Chi Lin, Michael McCague, Stephen Michael Stec, Brian J. Johnson, Garry Marty
  • Patent number: 10992705
    Abstract: An important new vulnerability was discovered and is applicable to several in-vehicle networks including Control Area Network (CAN), the de facto standard in-vehicle network protocol. Specifically, a bus-off attack exploits the safe mode of CAN to disconnect or shut down uncompromised (healthy) ECUs. This is an important attack that must be thwarted, since once the attacker compromises an ECU, it is easy to mount the attack on safety-critical ECUs while its prevention/detection is very difficult. Based on analysis and experimental results, a mechanism to detect and/or prevent a bus-off attack is proposed and evaluated.
    Type: Grant
    Filed: January 20, 2017
    Date of Patent: April 27, 2021
    Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Kang G. Shin, Kyong-Tak Cho
  • Patent number: 10991269
    Abstract: A fluidic logic and actuator system for outputting a displacement having a fluidic logic circuitry layer including a fluidic control input and a plurality of fluidic latching memory units. At least some of the plurality of fluidic latching memory units are configured to perform combinatorial and sequential logic functions and output a fluid response. A fluid actuator layer is provided having a plurality of fluid actuators, wherein each of the plurality of fluid actuators being movable in response to the fluid response of a corresponding one of the plurality of fluidic latching memory units.
    Type: Grant
    Filed: June 15, 2016
    Date of Patent: April 27, 2021
    Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Alexander C. Russomanno, Richard Brent Gillespie, Maire Sile O'Modhrain, Mark A. Burns
  • Patent number: 10989436
    Abstract: A vaneless ventilation system includes a rigid duct and a vent assembly in fluid communication with the duct. The vent assembly includes a rigid housing defining an outlet, a bendable duct disposed inside the rigid housing, a linkage assembly coupled to the bendable duct to allow deflection of the bendable duct upon movement of the linkage assembly, and an actuation mechanism coupled to the linkage assembly, wherein actuation of the actuation mechanism causes the linkage assembly to move, thereby deflecting the bendable duct.
    Type: Grant
    Filed: July 23, 2018
    Date of Patent: April 27, 2021
    Assignees: GM Global Technology Operations LLC, The Regents of the University of Michigan
    Inventors: Paul W. Alexander, Diann Brei, Jonathan E. Luntz, Mary McMeekin, Laura Alejandra Giner Muñoz, Koray Benli