Abstract: A method of increasing light emission efficiency in an organic light emitting diode (OLED) eliminates or reduces at least one waveguide mode selected from the group consisting of: transverse electric (TE0) mode, transverse magnetic (TM1) mode, and combinations thereof by disposing an ultrathin electrically conductive transparent metallic electrode having a first polarity within the OLED. The OLED has a transparent substrate on which the ultrathin electrically conductive transparent metallic electrode is disposed. It also has an emissive active assembly for generating photons defining first and second opposite sides. A conductive transparent metallic electrode is disposed along the first side. A second transparent electrode having a second polarity opposite to the first polarity disposed adjacent to the second side of emissive active assembly. The methods include increasing an external quantum efficiency of the organic light emitting diode to ?about 20%. OLEDs with such a design are also contemplated.

Abstract: In Multi-Policy Decision-Making (MPDM), many computationally-expensive forward simulations are performed in order to predict the performance of a set of candidate policies. In risk-aware formulations of MPDM, only the worst outcomes affect the decision making process, and efficiently finding these influential outcomes becomes the core challenge. Recently, stochastic gradient optimization algorithms, using a heuristic function, were shown to be significantly superior to random sampling. In this disclosure, it was shown that accurate gradients can be computed—even through a complex forward simulation—using approaches similar to those in dep networks. The proposed approach finds influential outcomes more reliably, and is faster than earlier methods, allowing one to evaluate more policies while simultaneously eliminating the need to design an easily-differentiable heuristic function.

Abstract: A composite material is provided. The composite material includes a hydrogel matrix having a three-dimensional geometry and fibers embedded and substantially uniformly distributed within the three-dimensional hydrogel matrix. The fibers have a substantially circular cross-sectional geometry and are anisotropically aligned. Methods of making and using the composite material are also provided.

Abstract: A method includes inputting a source into a weighted and undirected graph having a plurality of nodes and edges, inputting a target, inputting a plurality of objectives, searching the graph using a rapidly exploring random tree algorithm to determine a solution path that meets an existence constraint and an order constraint, determining a plurality of paths between the source and the target that intersects with each one of the plurality of objectives at least once that conforms with the existence constraint, assigning a travel cost for each of the determined plurality of paths, determining a visiting order of the plurality of objectives that reduces the assigned travel cost by the RRT* algorithm asymptotically decreasing with an allocated computation time by rewiring each one of the plurality of objectives and outputting the solution path to form a connected graph having the plurality of nodes.

Abstract: Upon determining calibration parameters for a single-loop controller that minimize a difference between an input to the single-loop controller and a response from the single-loop controller, calibration parameters for a cascade controller are determined based on the determined calibration parameters for the single-loop controller. The cascade controller includes a secondary controller and a primary controller. The calibration parameters for the cascade controller are provided to a second computer in a vehicle.

Abstract: All existing state-of-the-art high resolution millimeter wave imaging systems experience a trade off between image acquisition time and transceiver array complexity. The proposed dual reflector antenna breaks this trade-off by drastically reducing the array formation time while maintaining the relative simplicity that comes with using a single transceiver element. It consists of a dual mode horn feed, a rotating ellipsoidal sub-reflector and a conic main reflector. The rotating sub-reflector creates a virtual phase center that rotates about an axis to produce a synthetic circular array with a diameter of 120?. The main reflector redirects the beams from each of these virtual phase centers to overlap and illuminate the scene over a wide field of view. The proposed system can reduce the image acquisition time to the order of milliseconds/seconds which makes real-time SAR imaging a practical alternative to MIMO and phased arrays at millimeter-wave and sub-millimeter-wave frequencies.

Abstract: An automated robotic printing device for additive manufacturing or three-dimensional printing of an engineered cementitious composite (ECC) structure is provided. The device has a feeding system and an automated extrusion system configured to receive the ECC composition from the feeding system and deposit the ECC composition onto a target. The automated extrusion system comprising at least one robotic device comprising a tiltable and steerable deposition head that comprises an extrusion nozzle having a substantially rectangular opening and at least one shaping blade at a terminal end to shape and deposit the cementitious composition onto a target. Methods of additive manufacturing of a structure from the ECC compositions are also provided.

Abstract: A computer includes a processor and a memory storing instructions executable by the processor to receive a waypoint; generate a path for a vehicle from a starting point to the waypoint, the path characterized by a preset number of parameters; and instruct a propulsion and a steering system of the vehicle to actuate to navigate the vehicle along the path.

Abstract: Provided herein is technology relating to materials having microscale and/or nanoscale features and particularly, but not exclusively, to porous materials comprising microscale features, methods for producing porous materials comprising microscale features, drug delivery vehicles, and related kits, systems, and uses.

Abstract: In Multi-Policy Decision-Making (MPDM), many computationally-expensive forward simulations are performed in order to predict the performance of a set of candidate policies. In risk-aware formulations of MPDM, only the worst outcomes affect the decision making process, and efficiently finding these influential outcomes becomes the core challenge. Recently, stochastic gradient optimization algorithms, using a heuristic function, were shown to be significantly superior to random sampling. In this disclosure, it was shown that accurate gradients can be computed-even through a complex forward simulation—using approaches similar to those in dep networks. The proposed approach finds influential outcomes more reliably, and is faster than earlier methods, allowing one to evaluate more policies while simultaneously eliminating the need to design an easily-differentiable heuristic function.

Abstract: A method and an osseointegrated prosthesis system having an osseointegrated prosthesis member are provided having a monitoring system operably coupled to the osseointegrated prosthesis member configured to quantitatively assess the osseointegration of the osseointegrated prosthesis member, a wave-generating element coupled to the osseointegrated prosthesis member and configured to output guided waves along the osseointegrated prosthesis member interrogating an interface between bone and the osseointegrated prosthesis member, and a sensing system configured to sense a condition of the interface between bone and the prosthesis.

Abstract: Micro-scale thermoelectric devices having high thermal resistance and efficiency for use in cooling and energy harvesting applications and relating fabricating methods are disclosed. The thermoelectric devices include first substrates substantially parallel with second substrates. Scaffold members are deposited between the first and second substrate. The scaffold members include a plurality of cavities having sidewalls. The scaffold members may be formed from the second substrate. The sidewalls are substantially vertical with respect to the second substrate. The sidewalls may be substantially parallel. Thermoelectric materials are deposited on the sidewalls.

Abstract: The present disclosure provides methods of inhibiting the interaction of menin with MLL1, MLL2 and MLL-fusion oncoproteins with compositions of Formula (II-A). The methods are useful for the treatment of leukemia, solid cancers, diabetes and other diseases dependent on activity of MLL1, MLL2, MLL fusion proteins, and/or menin. Compositions of Formula (II-A) for use in these methods are also provided.

Abstract: The present disclosure provides compositions and methods employing stem cell-derived amnion tissue. In some embodiments, compositions (e.g., scaffolds and devices) and methods of generating amnion-like tissues from hPSCs are provided. In some embodiments, uses of such cells for research, compound screening and analysis, and therapeutics are provided.

Abstract: An uncertainty-aware framework is presented for high-variance planning problems with multiple dynamic agents. Planning when surrounded by multiple uncertain dynamic agents is hard because one cannot be certain of either the initial states or the future actions of those agents, leading to an exponential explosion in possible futures. Many important real-world problems, such as autonomous driving, fit this model. To address these difficulties, Multi-policy Decision Making (MPDM) and Monte Carlo tree search (MCTS) are combined and a policy tree search performed with marginal action cost estimation and repeated belief particles.

Abstract: Ear implants for auricular tissue reconstruction in a patient are provided. The ear implant may be a tissue scaffold multicomponent assembly for reconstruction of auricular tissue. Thus, the assembly may include both a first and a second tissue scaffold component. Each comprises a biocompatible polymeric material having a plurality of open pores configured to support cell growth. The first tissue scaffold component defines a central void region and at least a portion of an outer ear framework of the patient after implantation. The second tissue scaffold component defines a base portion. After implantation into the patient, the second tissue scaffold component seats within the central void region of the first tissue scaffold component, so that the second tissue scaffold component is secured to the first tissue scaffold component. Methods for reconstructing auricular tissue in a patient using such ear implant tissue scaffolds are also provided.

Abstract: A system and method for simulating a real roadway environment that can be used for testing of a real connected autonomous vehicle (CAV) on roadways using augmented reality to add simulated virtual environmental objects such as additional vehicles, pedestrians, and other obstructions to the nearby surroundings seen by the CAV under test. The method carried out by the system includes: receiving vehicle status information indicating the location of a connected real vehicle as it moves along a roadway; and generating a simulated environment of the real vehicle on the roadway using a mapped model of the roadway and the vehicle status information. The simulated environment includes one or more virtual objects such as vehicles, pedestrians, or other obstructions, and these simulated virtual objects may be sent to the real vehicle for testing of its response without requiring the use of real vehicles, pedestrians, or other obstructions.

Abstract: There is disclosed an electrical device and a method in which a battery is warmed up when operating from a sub-zero temperature. The electrical device may include a battery; an electrical storage element; and a battery management system including a controller in electrical communication with the battery and the electrical storage element. The controller can be configured to execute a program stored in the controller to shuttle energy between the battery and the electrical storage element until a power capability threshold of the battery has been reached, Shuttling the energy raises a temperature of the battery to meet power demand.

Abstract: Provided are methods for increasing the amount or activity of FMR1 RNA, and in certain instances of increasing the amount of FMRP protein, in an animal Such methods are useful to prevent or ameliorate at least one symptom of a Fragile X-Spectrum disorder. Such Fragile X-Spectrum disorders include FXS, FXTAS, and FXPOI.

Abstract: A microphone including a casing having a front wall, a back wall, and a side wall joining the front wall to the back wall, a transducer mounted to the front wall, the transducer including a substrate and a transducing element, the transducing element having a transducer acoustic compliance dependent on the transducing element dimensions, a back cavity cooperatively defined between the back wall, the side wall, and the transducer, the back cavity having a back cavity acoustic compliance. The transducing element is dimensioned such that the transducing element length matches a predetermined resonant frequency and the transducing element width, thickness, and elasticity produces a transducer acoustic compliance within a given range of the back cavity acoustic compliance.