Patents Assigned to The Regents of the University of Michigan
  • Patent number: 10330685
    Abstract: Provided herein is technology relating to treatment of sepsis and particularly, but not exclusively, to methods for predicting a response of a sepsis patient to treatment with L-carnitine.
    Type: Grant
    Filed: April 28, 2015
    Date of Patent: June 25, 2019
    Assignees: THE REGENTS OF THE UNIVERSITY OF MICHIGAN, UNIVERSITY OF MISSISSIPPI MEDICAL CENTER
    Inventors: Kathleen Stringer, Alan E. Jones, Mike Puskarich
  • Patent number: 10332617
    Abstract: A data analysis method and computer system electronically mines published articles from existing medical literature sources to discover associations that may exist between various diseases and various genes and/or gene mutations or other genetic changes. The method and system then organizes, categorizes and prioritizes the discovered associations in accordance with the strength of evidence supporting these associations. The resulting information can then be integrated into the processing of genome sequencing data to more quickly determine what genome sequencing data is of most relevance for clinical decision makings.
    Type: Grant
    Filed: November 11, 2015
    Date of Patent: June 25, 2019
    Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Mark J. Kiel, Kojo Elenitoba-Johnson, Megan Lim
  • Patent number: 10333457
    Abstract: A matching technique and the field enhancement at the terminals of a bowtie nanoantenna is presented to develop compact, highly efficient, and flexible thermophotovoltaic (TPV) cells. The bowtie antenna is designed for maximum power transfer to a near infrared band of a TPV cell. In one example, a small cube of indium gallium arsenside antimode or another suitable material with a low bandgap energy of 0.52 eV is mounted at the terminals of the antenna. Such a load presents a frequency dependent impedance with a high resistance and capacitance at the desired frequency (180THz). For maximum power transfer, a high impedance bowtie antenna operating at the anti-resonance mode connected to an inductive transmission line to compensate for the load capacitance is realized. The same antenna and load configuration with the semiconductor material used in photoconductive mode is used to realize a sensitive uncooled photodetector.
    Type: Grant
    Filed: June 17, 2015
    Date of Patent: June 25, 2019
    Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Kamal Sarabandi, Sangjo Choi
  • Patent number: 10329283
    Abstract: Disclosed herein are novel GRK inhibitors and methods for their use in treating or preventing heart disease, such as cardiac failure, cardiac hypertrophy, and hypertension. In particular, disclosed herein are compounds of Formula (I) and pharmaceutically acceptable salt thereof, wherein the substituents are as described.
    Type: Grant
    Filed: June 27, 2016
    Date of Patent: June 25, 2019
    Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Scott D. Larsen, John J. G. Tesmer, Helen Waldschmidt, Kristoff Homan, Michael William Wilson
  • Publication number: 20190191524
    Abstract: A sensory networking device is provided that enables a sensory effect to be implemented across a sensory network. The sensory networking device includes a processor, a sensory output unit, a motion sensor and a transceiver that permits the device to detect a trigger movement and transmit a trigger signal that causes a sensory effect to be implemented on neighboring sensory networking devices and to re-transmit the trigger signal in order to propagate a sensory effect across a sensory network.
    Type: Application
    Filed: May 12, 2017
    Publication date: June 20, 2019
    Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Roland GRAF, Prabal DUTTA, Brad CAMPBELL, Surat KWANMUANG
  • Patent number: 10322248
    Abstract: A handheld cryoanesthesia or analgesia device for cooling a target area on cutaneous membranes, mucous membranes, and tissue of the mucocutaneous zone having an elongated body and a thermoelectric cooling system disposed within the elongated body. The thermoelectric cooling system is configured to physically contact and thermally couple the target area of the cutaneous membranes, mucous membranes, and tissue of the mucocutaneous zone to induce cryoanesthesia or analgesia. The thermoelectric cooling system includes a thermally-conductive cold tip, a thermally-conductive cooling power concentrator thermally coupled to the cold tip, at least one Peltier unit module thermally coupled to the cooling power concentrator, a heatsink thermally coupled to at least one Peltier unit module, a power source, at least one thermal sensor, and a controller operably outputting a control signal to the Peltier unit module to maintain a predetermined temperature.
    Type: Grant
    Filed: March 24, 2016
    Date of Patent: June 18, 2019
    Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Cagri Giray Besirli, Stephen Smith, Kevin P. Pipe, Gun-Ho Kim
  • Patent number: 10321835
    Abstract: A biological recording device used to monitor biological electrical activity and a method of recording neural signals. In a preferred embodiment, the biological recording device is a neural probe. The biological recording device includes a probe body with a probe shank and a recording platform that uses a delta (?) modulator and a delta sigma analog to digital converter (?? ADC). The ? modulator and the ?? ADC form a ?-?? analog front end (AFE) architecture for processing biological electrical activity. A large dynamic range (DR) of neural signals, including local field potentials (LFPs) and action potentials (APs) for example, can be compressed and subsequently reconstructed.
    Type: Grant
    Filed: April 19, 2016
    Date of Patent: June 18, 2019
    Assignee: The Regents of the University of Michigan
    Inventors: Euisik Yoon, Sung-Yun Park
  • Patent number: 10326449
    Abstract: Various implementations described herein are directed to an integrated circuit. The integrated circuit may include clock circuitry having a first plurality of logic components arranged to receive a low voltage supply, a data input signal and a clock input signal and to provide a first plurality of intermediate signals and multiple intermediate clock signals. The integrated circuit may include level converter core circuitry having voltage biasing circuitry and voltage control circuitry arranged to receive a high voltage supply, the first plurality of intermediate signals and the multiple intermediate clock signals and to provide a second plurality of intermediate signals. The integrated circuit may include latch circuitry having a second plurality of logic components arranged to receive the high voltage supply, the low voltage supply and the second plurality of intermediate signals and to provide a data output signal.
    Type: Grant
    Filed: October 6, 2017
    Date of Patent: June 18, 2019
    Assignee: The Regents of the University of Michigan
    Inventors: Jeongsup Lee, Mehdi Saligane, David Theodore Blaauw, Dennis Michael Chen Sylvester
  • Patent number: 10324072
    Abstract: Moisture sensing color change compositions are built of nanofibers of suitable small dimension based on diacetylene monomers that are polymerized in situ in a dried film containing a hygroscopic polymer that is bound to the nanofibers either directly or through crosslinkers.
    Type: Grant
    Filed: February 20, 2015
    Date of Patent: June 18, 2019
    Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Jinsang Kim, Sungbaek Seo, Youngchang Yu
  • Patent number: 10314532
    Abstract: Non-invasive monitoring of cardiovascular health is performed by monitoring changes in the volume of blood in the venous side of the vascular system. The blood volume changes are determined from measurements of bioimpedance of limbs or neck, in particular changes in bioimpedance in response to blood modulating events performed on the limbs or neck, where bioimpedance is measured and compared before and after such events.
    Type: Grant
    Filed: July 29, 2014
    Date of Patent: June 11, 2019
    Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Kevin Ward, Mohamad Hakam Tiba, James M. Blum
  • Patent number: 10314725
    Abstract: The present disclosure provides methods and systems for receiving, with processing circuitry of an implant device, an electrical signal from a free tissue graft attached to a portion of a nerve (e.g., a nerve branch or fascicle) through an electrical conductor in electrical communication with the free tissue graft (e.g., muscle graft), the nerve having reinnervated the free tissue graft. The electrical signal from the free tissue graft has a voltage amplitude of greater than or equal to about 150 microvolts. The processing circuitry stores signal data corresponding to the electrical signal from the free tissue graft in a memory accessible to the processing circuitry.
    Type: Grant
    Filed: November 13, 2015
    Date of Patent: June 11, 2019
    Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Cynthia Anne Chestek, Melanie G. Urbanchek, Paul S. Cederna, Richard Brent Gillespie, Nicholas B. Langhals, Zachary Irwin, Daniel C. Ursu
  • Patent number: 10317361
    Abstract: Physical parameters of macromolecules are determined by measuring electrical current I over time for translocation events as the macromolecules in solution move between two liquid compartments that are separated by and fluidically coupled through a synthetic nanopore. Values of charge, volume, shape, rotational diffusion coefficient, and dipole moment are derived from the measurements.
    Type: Grant
    Filed: January 26, 2017
    Date of Patent: June 11, 2019
    Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Michael Mayer, Erik Yusko
  • Patent number: 10317406
    Abstract: A system for detecting rare cells in a fluid is disclosed. The system includes a substrate and a mixture disposed on the substrate and including a carrier and a thermo-responsive polymer for capture and release of the rare cells. Also disclosed is a method for detecting rare cells in a fluid using a system including a substrate and a mixture that is disposed on the substrate. The mixture includes a carrier and a thermo-responsive polymer. The method includes providing the system and introducing a sample of fluid containing the rare cells into the system such that the sample interacts with the carrier for capturing the rare cells.
    Type: Grant
    Filed: April 6, 2016
    Date of Patent: June 11, 2019
    Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Hyeun Joong Yoon, Apoorv Shanker, Jinsang Kim, Sunitha Nagrath, Vasudha Murlidhar
  • Patent number: 10307491
    Abstract: Provided herein are liposomal particles. In particular, provided herein are liposomal particles comprising molecules (e.g., antigens or drugs) and uses thereof (e.g., as a vaccine (e.g., intranasal vaccine) or drug delivery system). For example, in some embodiments, the present disclosure provides a composition comprising: a molecule encapsulated in a liposome comprising one or more cationic lipids and hyaluronic acid (HA). In some embodiments, the one or more lipids are DOTAP and/or DOPE. In some embodiments, the HA is thiolated. In some embodiments, the thiolated HA is conjugated to thiolated PEG.
    Type: Grant
    Filed: January 28, 2016
    Date of Patent: June 4, 2019
    Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: James Jaehyun Moon, Yuchen Fan, Preety Sahdev, Joseph Bazzill
  • Patent number: 10310858
    Abstract: Apparatus and a corresponding method for controlling a transition between use of first processing circuitry and second processing circuitry to execute program instructions are provided. Transition monitoring storage selects an entry for a load program instruction executed during the transition in dependence on a memory address from which a value is to be loaded and stores a program order timestamp for the load program instruction, unless a valid previously stored program order timestamp in the entry precedes the program order timestamp. Thus the oldest timestamp of an load instruction executed in the transition is held. At either the start or end (or both) of the transition the content of the transition monitoring storage is cleared.
    Type: Grant
    Filed: March 8, 2016
    Date of Patent: June 4, 2019
    Assignee: The Regents of the University of Michigan
    Inventors: Andrew Lukefahr, Shruti Padmanabha, Reetuparna Das, Scott Mahlke, Jiecao Yu
  • Patent number: 10307407
    Abstract: The present disclosure provides substituted 9H-pyrimido [4,5-b] indoles and 5H-pyrido [4,3-b] indoles and related analogs represented by Formula I and the pharmaceutically acceptable salts, hydrates, and solvates thereof, wherein R1a, W, B1, B2, G, X1, Y1, Y2, and Y3 are as defined as set forth in the specification. The present disclosure is also directed to the use of compounds of Formula I to treat a condition or disorder responsive to inhibition of BET bromodomains such as cancer. The present disclosure is also directed to the use of compound of Formula I as synthetic intermediates.
    Type: Grant
    Filed: February 26, 2016
    Date of Patent: June 4, 2019
    Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Shaomeng Wang, Yujun Zhao, Bing Zhou, Angelo Aguilar
  • Patent number: 10307288
    Abstract: Vascular pressures and oximetry are optimized through administration of fluids and other support prior to manipulating temperature in a therapeutic hypothermia procedure. Temperature and active hemodynamic management are utilized, through measurement and adjustment of temperature and hemodynamic parameters through the use of an internal cooling device, such as endovascular catheter, and/or an external temperature-altering device, to ensure that temperature management is optimized, and hemodynamics and tissue resuscitation are optimized prior to and during temperature manipulation.
    Type: Grant
    Filed: April 29, 2015
    Date of Patent: June 4, 2019
    Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Hasan Alam, Kevin Ward, Kyle Gunnerson, Kayvan Najarian
  • Patent number: 10310537
    Abstract: A sub-nW voltage reference is presented that provides inherently low process variation and enables trim-free operation for low-dropout regulators and other applications in nW microsystems. Sixty chips from three different wafers in 180 nm CMOS are measured, showing an untrimmed within-wafer ?/? of 0.26% and wafer-to-wafer ?/? of 1.9%. Measurement results also show a temperature coefficient of 48-124 ppm/° C. from ?40° C. to 85° C. Outputting a 0.986V reference voltage, the reference operates down to 1.2V and consumes 114 pW at 25° C.
    Type: Grant
    Filed: June 14, 2017
    Date of Patent: June 4, 2019
    Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Qing Dong, David T. Blaauw, Dennis Sylvester
  • Patent number: 10312082
    Abstract: Semiconductor light emitting diodes (LEDs) formed as (Al)GaN-based nanowire structures have a first semiconductor layer, a second semiconductor layer, and a thin metallic layer fabricated therebetween. The structures, operating in the deep ultraviolet (UV) spectral range, exhibit high photoluminescence efficiency at room temperature. The structures may be formed of an epitaxial metal tunnel junction operating as a reflector that enhances carrier transport to and from the semiconductor alloy layers, capable of producing external quantum efficiencies at least one order of magnitude higher than convention devices.
    Type: Grant
    Filed: May 9, 2017
    Date of Patent: June 4, 2019
    Assignee: The Regents of the University of Michigan
    Inventors: Zetian Mi, Sharif Sadaf, Yong-Ho Ra, Thomas Szkopek
  • Patent number: 10312657
    Abstract: A beam combining and pulse stacking technique is provided that enhances laser pulse energy by coherent stacking pulse bursts (i.e. non-periodic pulsed signals) in time domain. This energy enhancement is achieved by using various configurations of Fabry-Perot, Gires-Tournois and other types of resonant cavities, so that a multiple-pulse burst incident at either a single input or multiple inputs of the system produces an output with a solitary pulse, which contains the summed energy of the incident multiple pulses from all beams. This disclosure provides a substantial improvement over conventional coherent-combining methods in that it achieves very high pulse energies using a relatively small number of combined laser systems, thus providing with orders of magnitude reduction in system size, complexity, and cost compared to current combining approaches.
    Type: Grant
    Filed: October 4, 2017
    Date of Patent: June 4, 2019
    Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventor: Almantas Galvanauskas