Patents Assigned to The Regents of the University
  • Core assisted mesh protocol for multicast routing in ad-hoc Networks
    Patent number: 6917985
    Abstract: A method of providing multicast routing for use in ad hoc broadcast networks, such as wireless and mobile networks. The method is described within a protocol referred to as core-assisted mesh protocol, or CAMP. The method departs from traditional tree-structured multicast protocols and utilizes multicast meshes in which the network need not be flooded with control or data packets to establish routing paths. Each router configured for CAMP is capable of accepting unique packets arriving from any neighbor in the mesh, wherein packets are forwarded along reverse shortest paths to the receiver. Multiple cores may be defined for a group wherein the loss of a single core does not prevent packet flow. Routers for sender-only hosts are allowed to join the multicast mesh in simplex mode, and in certain cases may join without the sending of a join request.
    Type: Grant
    Filed: March 9, 2001
    Date of Patent: July 12, 2005
    Assignee: The Regents of the University of California
    Inventors: Ewerton L. Madruga, Joaquin J. Garcia-Luna-Aceves
  • Expression vector system and a method for optimization and confirmation of DNA delivery and quantification of targeting frequency
    Patent number: 6916611
    Abstract: An expression vector system comprising a pair of expression vectors constructed from a wild-type and a mutant version of a maker, reporter or selection gene, and a method for optimization and confirmation of DNA delivery and of gene targeting and for quantification of targeting frequency. Novel prokaryotic/eukaryotic DNA vectors used for DNA delivery and gene targeting assessment and targeting frequency quantification.
    Type: Grant
    Filed: February 26, 2001
    Date of Patent: July 12, 2005
    Assignee: The Regents of the University of California
    Inventors: Kaarin Kerr Goncz, Dieter Cotter Gruenert, Alessia Colosimo
  • Method and subsystem for processing signals utilizing a plurality of vibrating micromechanical devices
    Patent number: 6917138
    Abstract: Several MEMS-based methods and architectures which utilize vibrating micromechanical resonators in circuits to implement filtering, mixing, frequency reference and amplifying functions are provided. A method and subsystem are provided for processing RF signals utilizing a plurality of vibrating micromechanical devices typically in the form of an IF mixer-filter and an RF channel selector or an image-reject RF filter. One of the primary benefits of the use of such architectures is a savings in power consumption by trading power for high selectivity (i.e., high Q). Also, such methods and circuits can eliminate the need for a low noise amplifier in a receiver or transceiver subsystem. Consequently, the present invention relies on the use of a large number of micromechanical links in SSI networks to implement signal processing functions with basically zero DC power consumption.
    Type: Grant
    Filed: July 24, 2003
    Date of Patent: July 12, 2005
    Assignee: The Regents of the University of Michigan
    Inventor: Clark T. -C. Nguyen
  • Methods and apparatus for measuring refractive index and optical absorption differences
    Patent number: 6917428
    Abstract: Methods and instruments are provided for measuring differences in fractional reflectivity changes between transverse electric (TE or s-polarized) and transverse magnetic (TM or p-polarized components of an obliquely incident light with high sensitivity and low noise. Also provided are high sensitivity, low noise methods and instruments for measuring differences in fractional reflectivity changes between R-polarized (right-circularly polarized) and L-polarized (left-circularly polarized) components of a near-normal incident light. The methods take advantage of a nulling step to minimize harmonics of the optical signal derived from a first sample. Determination of odd and even harmonics of the optical signal derived from a second sample allows determination of refractive index and optical absorption coefficient differences between two samples to be determined with high sensitivity and low noise.
    Type: Grant
    Filed: October 15, 2002
    Date of Patent: July 12, 2005
    Assignee: The Regents of the University of California
    Inventor: Xiangdong Zhu
  • Measurement of protein synthesis rates in humans and experimental systems by use of isotopically labeled water
    Publication number: 20050147558
    Abstract: Provided herein are methods for measuring protein biosynthesis by using 2H2O or radioactive 3H2O and applicable uses thereof.
    Type: Application
    Filed: October 12, 2004
    Publication date: July 7, 2005
    Applicant: The Regents of the University of California
    Inventor: Marc Hellerstein
  • Scalable power generation using a pulsed detonation engine
    Publication number: 20050144959
    Abstract: A scalable power generator is described. A scalable, portable pulsed detonation engine is coupled to a turbine which drives a generator and using commonly available fuels, electric energy is provided. Additional embodiments incorporate a mechanical compressor at the intake of the pulsed detonation engine which is driven by a second turbine, the second turbine drives a shaft that powers the mechanical compressor. Other enhancements to the invention and additional embodiments are described.
    Type: Application
    Filed: December 24, 2003
    Publication date: July 7, 2005
    Applicant: Board of Regents, The University of Texas System
    Inventors: Frank Lu, Donald Wilson
  • Microelectromechanical heating apparatus and fluid preconcentrator device utilizing same
    Patent number: 6914220
    Abstract: A microelectromechanical heating apparatus and fluid preconcentrator device utilizing same wherein heating elements of the apparatus are sized and spaced to substantially uniformly heat a heating chamber within a heater of the apparatus. Tall, thermally-isolated heating elements are fabricated in Si using high aspect ratio etching technology. These tall heating elements have large surface area to provide large adsorbent capacity needed for high efficiency preconcentrators in a micro gas chromatography system (?GC). The tall heating elements are surrounded by air gaps to provide good thermal isolation, which is important for a low power preconcentrator in the ?GC system.
    Type: Grant
    Filed: March 25, 2003
    Date of Patent: July 5, 2005
    Assignee: The Regents of the University of Michigan
    Inventors: Wei-Cheng Tian, Stella W. Pang, Edward T. Zellers
  • Magneto-radar detector and method
    Patent number: 6914552
    Abstract: A varying magnetic field excites slight vibrations in an object and a radar sensor detects the vibrations at a harmonic of the excitation frequency. The synergy of the magnetic excitation and radar detection provides increased detection range compared to conventional magnetic metal detectors. The radar rejects background clutter by responding only to reflecting objects that are vibrating at a harmonic excitation field, thereby significantly improving detection reliability. As an exemplary arrangement, an ultra-wideband micropower impulse radar (MIR) is capable of being employed to provide superior materials penetration while providing range information. The magneto-radar may be applied to pre-screening magnetic resonance imaging (MRI) patients, landmine detection and finding hidden treasures.
    Type: Grant
    Filed: June 25, 2003
    Date of Patent: July 5, 2005
    Assignee: The Regents of the University of California
    Inventor: Thomas E. McEwan
  • Apparatus and methods for high resolution separation of sample components on microfabricated channel devices
    Patent number: 6913679
    Abstract: Sample component separation apparatus and methods are described. An exemplary sample component separation apparatus includes a separation channel having a turn portion configured to reduce band-broadening caused by passage of a sample through the turn portion. To reduce band broadening caused by passage of a sample through a turn portion, the turn portion may be constructed and arranged to have a sample transport characteristic that is different from the corresponding sample transport characteristic of a substantially straight portion of the separation channel. For example, the turn portion may be configured with an effective channel width that is smaller than the effective channel widths of the substantially straight portion of the separation channel.
    Type: Grant
    Filed: February 11, 1999
    Date of Patent: July 5, 2005
    Assignee: The Regents of the University of California
    Inventors: Richard A. Mathies, Brian Paegel, Peter C. Simpson, Lester Hutt
  • Nanocoated primary particles and method for their manufacture
    Patent number: 6913827
    Abstract: Particles have an ultrathin, conformal coating are made using atomic layer deposition methods. The base particles include ceramic and metallic materials. The coatings can also be ceramic or metal materials that can be deposited in a binary reaction sequence. The coated particles are useful as fillers for electronic packaging applications, for making ceramic or cermet parts, as supported catalysts, as well as other applications.
    Type: Grant
    Filed: December 9, 2003
    Date of Patent: July 5, 2005
    Assignee: The Regents of the University of Colorado
    Inventors: Steven M. George, John D. Ferguson, Alan W. Weimer, Jeffrey R. Wank
  • Extracorporeal fluid circuit and related methods
    Patent number: 6913588
    Abstract: A circuit for extracorporeal treatment of a body fluid, the circuit including in serial fluidic communication an inlet for receiving the body fluid from a patient, a first pump, a first treatment device for processing the body fluid, a second pump, an outlet for returning processed body fluid to the patient; and a shunt. The shunt is upstream from the first pump and downstream from the second pump.
    Type: Grant
    Filed: March 28, 2003
    Date of Patent: July 5, 2005
    Assignees: Nephros Therapeutics, Inc., The Regents of the University of Michigan
    Inventors: William Frederick Weitzel, H. David Humes, Emil Presley Paganini, Deborah Ann Buffington, Angela J. Funke
  • Stimulation of bone growth with thrombin peptide derivatives
    Patent number: 6914050
    Abstract: Disclosed is a method of stimulating bone growth at a site in a subject in need of osteoinduction. The method comprises the step of administering a therapeutically effective amount of an agonist of the non-proteolytically activated thrombin receptor to the site.
    Type: Grant
    Filed: July 19, 2001
    Date of Patent: July 5, 2005
    Assignee: The Board of Regents, The University of Texas System
    Inventors: Darrell H. Carney, Roger S. Crowther, David J. Simmons, Jinping Yang, William R. Redin
  • Mutants of Streptococcal toxin A and methods of use
    Patent number: 6913755
    Abstract: This invention is directed to mutant SPE-A toxins or fragments thereof, vaccine and pharmaceutical compositions, and methods of using the vaccine and pharmaceutical compositions. The preferred SPE-A toxin has at least one amino acid change and is substantially non-lethal compared with the wild type SPE-A toxin. The mutant SPE-A toxins can form vaccine compositions useful to protect animals against the biological activities of wild type SPE-A toxin.
    Type: Grant
    Filed: December 5, 1997
    Date of Patent: July 5, 2005
    Assignee: Regents of the University of Minnesota
    Inventors: Patrick M. Schlievert, Manuela Roggiani, Jennifer Stoehr Stoehr, Douglas Ohlendorf
  • Integrated low power digital gyro control electronics
    Patent number: 6915215
    Abstract: Embodiments of the invention generally encompass a digital, application specific integrated circuit (ASIC) has been designed to perform excitation of a selected mode within a vibratory rate gyroscope, damping, or “force-rebalance,” of other modes within the sensor, and signal demodulation of the in-phase and quadrature components of the signal containing the angular rate information. The ASIC filters dedicated to each channel may be individually programmed to accommodate different rate sensor designs/technology or variations within the same class of sensors. The ASIC architecture employs a low-power design, making the ASIC, particularly suitable for use in power-sensitive applications.
    Type: Grant
    Filed: June 25, 2003
    Date of Patent: July 5, 2005
    Assignees: The Boeing Company, California Institute of Technology, The Regents of the University of California
    Inventors: Robert M'Closkey, A. Dorian Challoner, Eugene Grayver, Ken J. Hayworth
  • High average power laser gain medium with low optical distortion using a transverse flowing liquid host
    Patent number: 6914926
    Abstract: A high average power, low optical distortion laser gain media is based on a flowing liquid media. A diode laser pumping device with tailored irradiance excites the laser active atom, ion or molecule within the liquid media. A laser active component of the liquid media exhibits energy storage times longer than or comparable to the thermal optical response time of the liquid. A circulation system that provides a closed loop for mixing and circulating the lasing liquid into and out of the optical cavity includes a pump, a diffuser, and a heat exchanger. A liquid flow gain cell includes flow straighteners and flow channel compression.
    Type: Grant
    Filed: May 30, 2003
    Date of Patent: July 5, 2005
    Assignee: The Regents of the University of California
    Inventors: Brian J. Comaskey, Earl R. Ault, Thomas C. Kuklo
  • Vapor-deposited porous films for energy conversion
    Patent number: 6913998
    Abstract: Metallic films are grown with a “spongelike” morphology in the as-deposited condition using planar magnetron sputtering. The morphology of the deposit is characterized by metallic continuity in three dimensions with continuous and open porosity on the submicron scale. The stabilization of the spongelike morphology is found over a limited range of the sputter deposition parameters, that is, of working gas pressure and substrate temperature. This spongelike morphology is an extension of the features as generally represented in the classic zone models of growth for physical vapor deposits. Nickel coatings were deposited with working gas pressures up 4 Pa and for substrate temperatures up to 1000 K. The morphology of the deposits is examined in plan and in cross section views with scanning electron microscopy (SEM).
    Type: Grant
    Filed: July 1, 2003
    Date of Patent: July 5, 2005
    Assignee: The Regents of the University of California
    Inventors: Alan F. Jankowski, Jeffrey P. Hayes, Jeffrey D. Morse
  • Thrombolytic agents and methods of treatment for thrombosis
    Publication number: 20050142210
    Abstract: The foregoing invention relates to a new microbubble preparation and thrombolytic therapy which relies on microbubbles and ultrasound for its lytic activity. The pharmaceutical composition of the invention comprises a liquid solution of microbubbles with an internal atmosphere enhanced with the perfluorocarbon gas which cavitate in the presence of an ultrasound field following intravenous injection or infusion of said composition into said host. For thrombolysis the area of a thrombus is exposed to an ultrasound field in the presence of the microbubbles and significant lysis is experienced. The method and pharmaceutical composition of the invention exhibit thrombolytic properties similar to those of other thrombolytic agents such as urokinase and are less toxic and are clot specific in that they do not introduce a systemic lytic state to a said animal.
    Type: Application
    Filed: February 25, 2005
    Publication date: June 30, 2005
    Applicant: BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA
    Inventor: Thomas Porter
  • Aptamers and methods for their in vitro selection and uses thereof
    Publication number: 20050142582
    Abstract: The present method is an improved in vitro selection protocol that relies on magnetic separations for DNA aptamer production that is relatively easy and scalable without the need for expensive robotics. The ability of aptamers selected by this method to recognize and bind their target protein with high affinity and specificity, and detail their uses in a number of assays is also described. Specific TTF1 and His6 aptamers were selected using the method described, and shown to be useful for enzyme-linked assays, Western blots, and affinity purification.
    Type: Application
    Filed: September 3, 2004
    Publication date: June 30, 2005
    Applicant: The Regents of the University of California
    Inventors: Sharon Doyle, Michael Murphy
  • Sperm-specific cation channel, catSper2, and uses therefor
    Publication number: 20050142566
    Abstract: Nucleic acid and protein sequences relating to a cation channel which is sperm-specific (CatSper2) are disclosed. The CatSper2 protein is shown to be specifically expressed in sperm. Nucleic acids, vectors, transformed cells, transgenic animals, polypeptides, and antibodies relating to the CatSper2 gene and protein are disclosed. Also provided are methods of in vitro fertilization and contraception, methods of identifying modulators of CatSper2 activity, methods of genotyping subjects with respect to CatSper2, methods of diagnosing and treating CatSper2-mediated disorders, including infertility, as well as methods of doing business related to CatSper2-mediated disorders.
    Type: Application
    Filed: April 21, 2004
    Publication date: June 30, 2005
    Applicants: Children's Medical Center Corporation, Board of Regents, The University of Texas System
    Inventors: Dejian Ren, David Clapham, David Garbers, Timothy Quill
  • Indole antiviral compositions and methods
    Publication number: 20050143329
    Abstract: The present invention provides novel chemical compounds, and methods for their use. In particular, the present invention provides indole derivatives (e.g. as shown in Formula (I)) and related compounds and methods of using indole derivatives and related compounds as therapeutic agents to treat a number of conditions, including those associated with viral infection and cardiovascular diseases.
    Type: Application
    Filed: October 6, 2004
    Publication date: June 30, 2005
    Applicant: The Regents of the University of Michigan
    Inventors: Leroy Townsend, John Drach