Abstract: Advances in actuating fabrics could enable a paradigm shift in the field of smart wearables by dynamically fitting themselves to the unique topography of the human body. Active fabrics and fitting mechanisms are described herein that enable garments to conform around surface concavities without requiring high elasticity or a multiplicity of closure devices. Advanced materials and systems innovations (1) enable novel garment manufacturing and application strategies, (2) facilitate topographical fitting (spatial actuation) through garment architectural design, and (3) provide tunable NiTi-based SMA actuation temperatures to enable actuation on the surface of human skin. Such fabrics and garments are usable in a variety of fields including medical compression, technical sportswear, exosuits, space suits and components thereof, or non-garment applications.

Abstract: Systems and devices for airflow measurements in rooms and air delivery ducts with low-cost, low-power, accurate, calibration-free, and compact wireless airflow sensors are provided. The system uses room and duct flow sonic anemometers and processing to measure air velocities and temperatures as well as allow control over the environmental conditioning systems. The anemometers use arrays of transmitter/receivers to simultaneously measure multiple sound paths and determine velocity vectors and volumetric flow paths. By transmitting in both directions along the paths between transceivers, differential times of flight (TOF) are measured. These determine both the velocity and temperature of the air along each path.

Abstract: A VIVACE converter to harness energy from currents as well as from waves— that is, the present teachings provide a method and apparatus to collect energy from both currents and waves—using the same physical components. The present teachings are particularly useful in that either currents and/or waves may exist on their own nearly everywhere in the oceans and frequently coexist.

Abstract: A semiconductor device includes ferromagnetic, magnetostrictive layer that exhibits a biaxial magnetic anisotropy and an underlying structure exhibits a spin Hall effect to provide a conversion between electrical energy and magnetic energy with more than two distinctive magnetic states, wherein the underlying structure includes a piezoelectric material structure and a spin Hall metal layer.

Abstract: Provided herein are genetically engineered Pichinde viruses that include three ambisense genomic segments. The first genomic segment includes a coding region encoding a Z protein and a coding region encoding a L RdRp protein. The second genomic segment includes a coding region encoding a nucleoprotein (NP) and the third genomic segment includes a coding region encoding a glycoprotein. Each of the second and third genomic segments optionally include an additional coding region that may encode an antigen or a detectable marker. Also provided herein is a reverse genetics system for making a genetically engineered Pichinde virus, and a collection of vectors that can be used to produce a genetically engineered Pichinde virus. Further provided are methods for using a reverse genetics system, and methods for producing an immune response in a subject.

Abstract: Embodiments described and discussed herein provide methods for selectively depositing a metal oxides on a substrate. In one or more embodiments, methods for forming a metal oxide material includes positioning a substrate within a processing chamber, where the substrate has passivated and non-passivated surfaces, exposing the substrate to a first metal alkoxide precursor to selectively deposit a first metal oxide layer on or over the non-passivated surface, and exposing the substrate to a second metal alkoxide precursor to selectively deposit a second metal oxide layer on the first metal oxide layer. The method also includes sequentially repeating exposing the substrate to the first and second metal alkoxide precursors to produce a laminate film containing alternating layers of the first and second metal oxide layers. Each of the first and second metal alkoxide precursors contains a different metal selected from titanium, zirconium, hafnium, aluminum, or lanthanum.

Abstract: A method includes providing a fluid to a structure including an aperture, applying a voltage signal to a circuit that includes the fluid, applying a substantially periodic pressure signal to the fluid, detecting a current signal in the circuit as an analyte passes through the aperture in response to the substantially periodic pressure signal, and processing the current signal and the substantially periodic pressure signal to determine a switch time and a release time for the analyte. An apparatus includes a structure including an aperture to receive a fluid, a voltage source to provide a voltage signal to an electronic circuit having a path that includes the aperture, a pressure signal generator to provide a substantially periodic pressure signal to the fluid, and a system to process the periodic pressure signal and a current signal induced in the electronic circuit.

Abstract: A large-scale single-photonics-based optical switching system that occupies an area larger than the maximum area of a standard step-and-repeat lithography reticle is disclosed. The system includes a plurality of identical switch blocks, each of is formed in a different reticle field that no larger than the maximum reticle size. Bus waveguides of laterally adjacent switch blocks are stitched together at lateral interfaces that include a second arrangement of waveguide ports that is common to all lateral interfaces. Bus waveguides of vertically adjacent switch blocks are stitched together at vertical interfaces that include a first arrangement of waveguide ports that is common to all vertical interfaces. In some embodiments, the lateral and vertical interfaces include waveguide ports having waveguide coupling regions that are configured to mitigate optical loss due to stitching error.

Abstract: Techniques are disclosed concerning applied magnetic field synthesis and processing of iron nitride magnetic materials. Some methods concern casting a material including iron in the presence of an applied magnetic field to form a workpiece including at least one iron-based phase domain including uniaxial magnetic anisotropy, wherein the applied magnetic field has a strength of at least about 0.01 Tesla (T). Also disclosed are workpieces made by such methods, apparatus for making such workpieces and bulk materials made by such methods.

Abstract: A monitoring apparatus for a human body includes a node network with at least one motion sensor and at least one acoustic sensor. A processor is coupled to the node network, and receives motion information and acoustic information from the node network. The processor determines from the motion information and the acoustic information a source of acoustic emissions within the human body by analyzing the acoustic information in the time domain to identify an event envelope representing an acoustic event, determining a feature vector related to the event envelope, calculating a distance between the feature vector and each of a set of predetermined event silhouettes, and identifying one of the predetermined event silhouettes for which the distance is a minimum.

Abstract: The present invention provides novel GM-CSF constructs and methods of using the same. In certain embodiments, the constructs of the invention comprise certain peptide fragments from GM-CSF. In other embodiments, the invention provides certain GM-CSF peptides that act as GM-CSF mimetics.

Abstract: A spinal cord stimulator includes: (1) a flexible substrate; (2) a power source embedded in the flexible substrate; (3) a controller embedded in the flexible substrate and connected to the power source; and (4) an array of electrodes, including an array of stimulation electrodes, disposed over the flexible substrate and connected to the controller, wherein the controller is configured to direct the array of stimulation electrodes to deliver a stimulation pattern to a spinal cord of a patient.

Abstract: A method and system for downloading the information stored on an IoT device is presented. All in-system programming pins are identified by inspection with visible light or using a computed tomography scan of the device using X-radiation. Based on this inspection, a 3D fixture is fabricated that accommodates spring-loaded pin connectors for contacting the identified in-system programming taps on the main printed circuit board of the device. The 3D test jig, in conjunction with a logic analyzer, can extract data from the internet of things (IoT) device.

Abstract: A computer-implemented method is presented for determining sampling rate for at least one of a camera and a receiver of a global navigation satellite system deployed in an autonomous vehicle. A Kalman filter is used for predicting a local sampling rate for the camera and a global sampling rate for the receiver in the global navigation satellite system. The method includes: retrieving length of the lane being traversed by the autonomous vehicle from a graph, where nodes of the graph represent intersection in a road network and edges of the graph represent paths in the road network; measuring speed of the autonomous vehicle as it traverses the lane; estimating the local sampling rate and the global sampling rate using the measured speed and the Kalman filter; and capturing, by the camera, images in accordance with the local sampling rate estimated by the Kalman filter.

Abstract: Duchenne muscular dystrophy (DMD) is a fatal muscle disease caused by the lack of dystrophin, which maintains muscle membrane integrity. Provided herein are methods of using adenine base editor (ABE) to modify splice sites of the dystrophin gene, causing skipping or refraining of common DMD exon deletion mutations, restoring dystrophin expression. Also provided herein are methods of using prime editing to reframe the dystrophin open reading frame and restore dystrophin expression.

Abstract: 3D MRI images of the brain may be created and acquired. After administration of contrast, brain lesions and other abnormalities may be identified and isolated from the 3D MRI images, with each lesion serving as a region of interest (ROI). 3D region of contrast enhancement images may be created from segmented 3D MRI images and different regions of contrast enhancement of the brain lesion may be depicted. Saved regions of contrast enhancement may be converted into stereolithography format, maximum intensity projection (MIP) images, and/or orthographic projection images. Data corresponding to these resulting 3D region of contrast enhancement images may be used to create 3D printed models of the isolated region of contrast enhancement. Analysis of the 3D brain region of contrast enhancement images and the 3D printed region of contrast enhancement models may enable a more efficient and accurate way of determining brain lesion risk factors and effective treatment regimens.

Abstract: Aspects of the subject disclosure may include, for example, training a first machine learning model based on a combination of labeled training data and unlabeled training data, the first machine learning model producing augmented training data, training a second machine learning model based on a combination of the labeled training data and the augmented training data, receiving, at a client device, customer information about a service degradation at a user equipment (UE) device of a customer in a cellular network, providing the customer information to the second machine learning model, receiving, at the client device, from the second machine learning model, information identifying a root cause of the service degradation, and modifying a network component of the cellular network or the UE device, based on the information identifying a root cause of the service degradation. Other embodiments are disclosed.

Abstract: The present disclosure provides a novel IKK2 inhibitor that does not target the kinase domain of IKK2 molecule. The novel IKK2 inhibitor is a cell penetrating NEMOActPep comprising a small segment (residues 384-389) of human NEMO to mediate interaction with and promote activation loop phosphorylation of IKK2. The NEMOActPep is derived from the second interaction interface of NEMO:IKK2 that is dependent upon NEMO binding to linear polyubiquitin. Methods of use the novel IKK2 inhibitor, and composition thereof, for preventing and/or treating inflammation in various diseases involving IKK-NF-?B signaling pathways are also provided.

Abstract: Peptidic positive allosteric modulators of TRPV1 are provided. Methods for the design of TPRV1 allosteric modulators are also described, as well as methods for the treatment of conditions such as pain, pruritus, and cancer.

Abstract: This disclosure relates to methods and agents for modulating adoptive immunotherapy to enable bioengineered immune cells to utilize xenobiotic fuel, e.g., in a low glucose environment. The immune cells may be used, e.g., for treatment of a tumor or cancer, such as part of a therapeutic treatment of cancer or for treatment of a bacterial, fungal, or viral infection, alone or in combination with a low glucose (e.g., ketogenic) diet. They may also be used to treat a tumor, a cancer, an infection, an autoimmune disease, or an inflammatory or neuroinflammatory disease or condition in a patient on a low glucose diet. The immune cells may be used in combination with a scaffold or platform or with a microparticle or nanoparticle for localization of treatment or xenobiotic nutrients or for controlled release, as well as for other therapeutic uses.