Patents Assigned to The Regents of University of Colorado
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Patent number: 11899406Abstract: Disclosed herein are devices, systems, and methods for fabricating alkali vapor cells. The methods disclosed herein comprise depositing a fluid into a reservoir of a device, the device comprising: a reservoir, a set of receptacles, and a set of conduits fluidly connecting each of the receptacles to the reservoir; such that, when a fluid is placed in the reservoir, the fluid flows to each of the receptacles via capillary action. Also disclosed herein are methods comprising flowing a fluid from an inlet to an outlet of a lumen of a main conduit of a device, the device further comprising a set of receptacles, each of the receptacles being in fluid communication with the lumen of the main conduit; such that, when a fluid flows from the inlet to the outlet through the lumen of the main conduit, the fluid further flows into each of the receptacles via capillary action.Type: GrantFiled: January 7, 2021Date of Patent: February 13, 2024Assignee: The Regents of the University of Colorado, a body corporateInventors: Vincent Maurice, Douglas G. Bopp
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Patent number: 11896530Abstract: A microsurgical device and methods of its use can be used for treatment of various conditions including eye diseases, such as glaucoma, using minimally invasive surgical techniques. A device can be used for cutting the trabecular meshwork (“TM”) in the eye. The device tip provides entry into the Schlemm's canal via its size (i.e., for example, 0.2-0.3 mm width) and configuration where a ramp elevates the TM away from the outer wall of the Schlemm's canal and guides the TM to first and second lateral elements for creating first and second incisions through the TM. The dimensions and configuration of the device is such that an entire strip of TM is removed without leaving TM leaflets behind and without causing collateral damage to adjacent tissues.Type: GrantFiled: November 28, 2022Date of Patent: February 13, 2024Assignee: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATEInventor: Malik Y. Kahook
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Patent number: 11898807Abstract: This disclosure describes single and multi-layer woven meshes designed to enable sucking flow condensation and capillary-driven liquid film boiling, respectively, for instance, in use in heat spreaders. The single-layer woven meshes can include a nanostructure coating and a hydrophobic coating, while the multi-layer meshes can include a microcavity coating and optionally a hydrophilic coating.Type: GrantFiled: March 8, 2022Date of Patent: February 13, 2024Assignee: The Regents of the University of Colorado, a body corporateInventors: Ronggui Yang, Rongfu Wen, Shanshan Xu, Yung-Cheng Lee
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Patent number: 11896529Abstract: A microsurgical device and methods of its use can be used for treatment of various conditions including eye diseases, such as glaucoma, using minimally invasive surgical techniques. A dual-blade device can be used for cutting the trabecular meshwork (“TM”) in the eye. The device tip provides entry into the Schlemm's canal via its size (i.e., for example, 0.2-0.3 mm width) and configuration where a ramp elevates the TM away from the outer wall of the Schlemm's canal and guides the TM to first and second lateral elements for creating first and second incisions through the TM. The dimensions and configuration of the blade is such that an entire strip of TM is removed without leaving TM leaflets behind and without causing collateral damage to adjacent tissues.Type: GrantFiled: August 13, 2021Date of Patent: February 13, 2024Assignee: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATEInventor: Malik Y. Kahook
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Patent number: 11883277Abstract: An ophthalmic implant including an IOL with haptics, and drug delivery devices secured to the haptics. The posterior-most extent of the drug delivery device is located anterior to the posterior edge or PCE barrier edge, of the IOL. In other configurations, the drug delivery devices are provided with PCO barrier edges.Type: GrantFiled: September 16, 2022Date of Patent: January 30, 2024Assignees: SpyGlass Pharma, Inc., The Regents of the University of Colorado, a body corporateInventors: Craig Alan Cable, II, Glenn R. Sussman, James R. Dennewill, Malik Y. Kahook
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Publication number: 20240026333Abstract: A polymer brush composed of statistical copolymers of hydrophilic and hydrophobic monomers for enzyme immobilization. The heterogeneous polymer brushes stabilized four different lipases against high temperatures. Notably, the statistical copolymers stabilized the four lipases to a greater extent than a homopolymer brush. Additionally, in the case of Rhizomucor miehei lipase, statistical copolymers stabilized the enzyme to a greater extent than homopolymers of either hydrophilic or hydrophobic monomers. The resulting increase in high-temperature stability enabled significant improvements in catalytic rates by operating reactions at elevated temperatures, which is desirable for enzyme catalysis and sensing applications. Additionally, stabilization against elevated temperatures implies stabilization against non-aqueous solvents, which is of critical importance to numerous applications of biocatalysts.Type: ApplicationFiled: November 15, 2021Publication date: January 25, 2024Applicant: The Regents of the University of Colorado, a body corporateInventors: JAMES S. WELTZ, JOEL L. KAAR, DANIEL K. SCHWARTZ, HECTOR SANCHEZ-MORAN
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Patent number: 11879134Abstract: A native Type I-B and heterologous Type II Clustered Regularly-Interspaced Short Palindromic Repeat/cas systems were developed and characterize to improve the ability to engineer C. thermocellum and other thermophilic microbes. The native Type I-B system was engineered for genome editing. For the Type I-B system, an engineered strain, termed LL1586, yielded 40% genome editing efficiency at the pyrF locus. When recombineering machinery was expressed the efficiency was increased to 71%. For the Type II GeoCas9 system, 12.5% genome editing efficiency was observed. When recombineering machinery was expressed, this increased to 94%. By combining the thermophilic CRISPR system (either Type I-B or Type II) with the recombinases, a new tool was developed that allows for efficient CRISPR editing. The tools provided herein enable CRISPR technologies to better engineer C. thermocellum, including engineering C. thermocellum for both increased lignocellulose degradation and biofuel production.Type: GrantFiled: September 4, 2020Date of Patent: January 23, 2024Assignee: The Regents of the University of Colorado, a body corporateInventors: Carrie Eckert, Julie E. Walker
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Publication number: 20240016495Abstract: An assembly and method for end-to-side connection to anatomical tissue is disclosed. The system and method are particularly useful in coupling a ventricular assist device pump to an aorta. The assembly and method include using a tubular graft member coupled to a connection ring having at least one of a plurality of distally projecting tines extending from a distal aspect of the connection ring, and a stent having a distal flange section configured to abut an abluminal wall surface of the aorta, and an assembly including the tubular graft member and connection ring, for delivering the end-to-side connection.Type: ApplicationFiled: August 30, 2023Publication date: January 18, 2024Applicants: The Regents of the University of Colorado, a body corporate, ConneX BioMedical, Inc.Inventors: Max Bannister Mitchell, Jeremy H. Morgan, Jeffery N. Steinmetz, Dan Sims, Christopher E. Banas
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Patent number: 11873573Abstract: Various embodiments include a device for producing structurally modified materials. In some embodiments, the device includes a floating zone furnace which holds a feed rod in contact with seed crystal. One or more laser diodes are then used to heat a portion of the feed rod and cause it to transition to a molten state. A magnetic field is applied to the floating zone to change the underlying crystal structure of the material as it solidifies upon exiting the floating zone. In some instances, the changes may include manipulating the bond angle of the crystal structure or altering the unit cell volume of the crystal. Changes in the crystal structure directly affect the electrical resistivity and/or the magnetization and other physical properties of the crystal.Type: GrantFiled: January 21, 2021Date of Patent: January 16, 2024Assignee: The Regents of the University of Colorado, a body corporateInventor: Gang Cao
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Patent number: 11870032Abstract: An all-solid-state lithium battery, thermo-electromechanical activation of Li2S in sulfide based solid state electrolyte with transition metal sulfides, and electromechanical evolution of a bulk-type all-solid-state iron sulfur cathode, are disclosed. An example all-solid-state lithium battery includes a cathode having a transition metal sulfide mixed with elemental sulfur to increase electrical conductivity. In one example method of in-situ electromechanically synthesis of Pyrite (FeS2) from Sulfide (FeS) and elemental sulfur (S) precursors for operation of a solid-state lithium battery, FeS+S composite electrodes are cycled at moderately elevated temperatures.Type: GrantFiled: February 15, 2022Date of Patent: January 9, 2024Assignee: The Regents of the University of Colorado, a body corporateInventors: Thomas A. Yersak, Se-Hee Lee, Conrad Stoldt
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Patent number: 11857461Abstract: This invention is in the field of medical intervention related to the lacrimal system. The invention relates to a lacrimal system device or system and methods of using the device for drug delivery to the eye, sinuses and/or periocular tissues.Type: GrantFiled: November 16, 2016Date of Patent: January 2, 2024Assignee: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATEInventors: Malik Y. Kahook, Andrew Schieber
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Patent number: 11851436Abstract: The present disclosure relates to a compound of Formula (0): a stereoisomer thereof, a prodrug thereof, or a pharmaceutically acceptable salt thereof. The present disclosure also relates to uses of the compound.Type: GrantFiled: June 3, 2022Date of Patent: December 26, 2023Assignee: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATEInventors: Philip Reigan, Kimberly A. Casalvieri
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Publication number: 20230404412Abstract: Novel tools and techniques are provided for assessing, predicting and/or estimating a probability that a patent is bleeding, in some cases, noninvasively. In various embodiments, tools and techniques are provided for implementing rapid detection of bleeding before, during, and after fluid resuscitation, in some instances, in real-time.Type: ApplicationFiled: August 31, 2023Publication date: December 21, 2023Applicants: Flashback Technologies, Inc., The Regents of the University of Colorado, a body corporateInventors: Isobel Jane Mulligan, Gregory Zlatko Grudic, Steven L. Moulton
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Patent number: 11844727Abstract: The present invention relates to an ophthalmic knife and methods of its use for treatment of various conditions including eye diseases, such as glaucoma, using minimally invasive surgical techniques. The device is configured for cutting the tissues within the eye, for example, a trabecular meshwork (TM).Type: GrantFiled: November 28, 2022Date of Patent: December 19, 2023Assignees: The Regents of the University of Colorado, a body corporate, New World Medical, Inc.Inventors: Malik Y. Kahook, Khalid Mansour, Suhail Abdullah, Eric Porteous, Vijay R. Balan
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Patent number: 11848174Abstract: Various embodiments of the present technology generally relate to devices and methods for generating and directing energetic electrons toward a target. More specifically, some embodiments relate to devices, systems, and methods for generating and directing energetic electrons based in the photoelectric effect and directing electric field-focused beams of the energetic electrons toward a target. Electron guns according to the present technology include one or more light sources to stimulate electron transmission, and a series of differentially charged stages to provide a hollow path allowing electrons generated by the photoelectric effect of the light irradiated on interior surfaces defining the path through the stages to travel to an exit of the electron gun. Each of the differentially charged stages have a different potential, thereby providing electrons having two or more different and tunable energy levels exiting as a beam from the electron gun.Type: GrantFiled: February 26, 2021Date of Patent: December 19, 2023Assignee: The Regents of the University of Colorado, a body corporateInventors: Kieran Wilson, Miles Bengtson, Hanspeter Schaub, Dalton Turpen
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Patent number: 11842813Abstract: Embodiments of the present technology include a wearable physiological monitoring device, related algorithms and software that are tied to a portable electronic device for readout. The wearable device can perform real-time measurement of a number of physiological and environmental parameters including heart rate, pulse oximetry, respiration, movement, environmental particulate matter, moisture, temperature (e.g., ambient air and body temperatures) and geospatial location. Some embodiments may establish a physiological baseline for a patient by measuring the above parameters during a healthy state. Collected data can be wirelessly transmitted to a portable electronic device or monitoring and feedback platform where software will analyze the data and make assessments of the device wearer's health based upon the wearer's baseline.Type: GrantFiled: October 23, 2020Date of Patent: December 12, 2023Assignee: The Regents Of The University Of ColoradoInventors: Robin Deterding, Tam Vu
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Patent number: 11842579Abstract: Systems and methods for battery-based vehicle diagnostics are provided. Various embodiments include a battery-based diagnostics system that guards vehicles against anomalies with a cyber-physical approach. The diagnostics system can be implemented as an add-on module of commodity vehicles attached to automotive batteries, thus providing vehicles an additional layer of protection. The automotive battery can operate in strong dependency with many physical components of the vehicle, which is observable as correlations between battery voltage and the vehicle's corresponding operational parameters, e.g., a faster revolutions-per-minute (RPM) of the engine, in general, leads to a higher battery voltage. These embodiments exploit such physically induced correlations to diagnose vehicles by cross-validating the vehicle information with battery voltage and may be based on a set of data-driven norm models constructed online.Type: GrantFiled: December 20, 2019Date of Patent: December 12, 2023Assignee: The Regents of the University of Colorado, a body corporateInventor: Liang He
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Patent number: 11839491Abstract: Systems and methods for a shape-memory in-ear biosensor for polysomnography and monitoring physiological signals are provided. Various embodiments include an earpiece made from a shape memory or temperature-dependent phase transition material embedded into polydimethylsiloxane elastomer body. The earpiece can use electrodes to detect physiological signals by making direct contact with a user's skin and without the use of electrically conductive gel. When heated above the glass transition temperature of the shape memory polymer, various embodiments of the biosensor may be folded. When cooled, the biosensor will maintain the folded shape. The folded biosensor may then be inserted into the ear canal of a user where, in response to heating by the user's body, it partially unfolds to conform to the shape of the ear canal.Type: GrantFiled: October 7, 2020Date of Patent: December 12, 2023Assignee: The Regents of the University of Colorado, a body corporateInventors: Andres Villada, Dana Stamo, Zhanan Zou, Jianliang Xiao
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Patent number: D1013704Type: GrantFiled: July 9, 2021Date of Patent: February 6, 2024Assignee: The Regents of the University of Colorado, a body corporateInventors: Viral Shah, Satish K. Garg
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Patent number: D1014518Type: GrantFiled: July 9, 2021Date of Patent: February 13, 2024Assignee: The Regents of the University of Colorado, a body corporateInventor: Satish K. Garg