Abstract: A VCO-Based Continuous-Time (CT) delta-sigma modulator (DSM) with a noise-shaping (NS) successive approximation register (SAR) quantizer for a 3rd order noise transfer function (NTF) is presented. An anti-aliasing filter (AAF) enables this new hybrid architecture. The 28 nm CMOS prototype NSQ VCO CT?? achieves 84.2 dB SNDR and 86.8 dB DR within a 1 MHz bandwidth while consuming 1.62 mW at 100 MS/s. The core circuit occupies only 0.024 mm2. No calibration or coefficient tuning is required.

Abstract: Systems and methods provide containers instantiated for each user equipment (UE), or on “per-UE” bases, which consolidate certain network functions for processing UE traffic into an efficient, in-network, and proximate virtualization to reduce latency and increase customizability.

Abstract: A multi-functional sensor assembly includes an electrically non-conductive substrate defining at least a distal region, intermediary region, and proximal region that are each covered with electrically conductive traces. The proximal region is configured to be exposed to a media to be sensed and the distal and intermediary regions are configured to be protected from the media. The electrically conductive traces are connected to one or more electrodes to sense one or more of alkalinity, cyanuric acid concentration, or oxidant concentration of the media.

Abstract: A capacitive sensor device is fabricated on a dielectric substrate. The capacitive sensor device may include multiple diaphragms that differ in shape and/or size. Each of the diaphragms is paired to upper and lower electrodes in included upper and lower electrode layers, respectively. The lower layer is on the dielectric substrate and couples the lower electrodes to a lower electrode terminal in parallel. The upper electrode layer is separated from the lower electrode layer by a gap defined by a removed sacrificial layer and couples the upper electrodes in parallel to an upper electrode terminal.

Abstract: A method for designing a multi-layer optical structure includes: obtaining candidate multi-layer optical structures through a sequence generator; obtaining a candidate spectrum for each candidate multi-layer optical structure; obtaining a difference between the candidate spectrum and a target spectrum; updating sequence generator parameters through reinforcement learning training and iteratively performing the obtainings and the updating in response to a first termination condition being not met; and selecting one of all obtained candidate structures to be a target multi-layer optical structure in response to the first termination condition being met. The difference between a spectrum of the target multi-layer optical structure and the target spectrum is minimized through the process. The method of the present application can perform the designs robustly and effectively.

Abstract: A nasal tissue implant for reconstruction and tissue engineering of nasal tissue in a subject includes a tissue scaffold component comprising a biocompatible polymeric material having a plurality of open pores configured to support cell growth. The tissue scaffold component conforms to a portion of the subject's nasal region and defines at least a portion of the subject's nasal anatomy. A method of making an implantable nasal tissue implant for reconstructing a portion of a nasal anatomy of a human or other animal subject is also provided that includes laser sintering or three-dimensional (3D) printing a biocompatible polymeric material to form a tissue scaffold component comprising a biocompatible polymeric material having a plurality of open pores configured to support cell growth. Again, the tissue scaffold component substantially conforms to a nasal region specific to the human or other animal subject.

Abstract: A low-power standard-compliant NB-IoT wake-up receiver (WRX) is presented. The WRX is designed as a companion radio to a full NB-IoT receiver, only operating during discontinuous RX modes (DRX and eDRX), which allows the full high-power radio to turn off while the wake-up receiver efficiently receives NB-IoT Wake-Up Signals (WUS). The fabricated receiver achieves 2.1 mW power at ?109 dBm sensitivity with 180 KHz bandwidth over the 750-960 MHz bands. The WRX is fabricated in 28 nm CMOS and consumes 5× less power than the best previously published traditional NB-IoT receivers. This disclosure is the first designed dedicated wake-up receiver for the NB-IoT protocol and demonstrates the benefits of utilizing a WRX to reduce power consumption of NB-IoT radios.

Abstract: An integrated microfluidic photoionization detector (PID) is provided including a microfluidic ionization chamber a microfluidic ultraviolet radiation chamber that is configured to generate ultraviolet photons. An ultrathin transmissive window is disposed between the microfluidic ionization chamber and the microfluidic ultraviolet radiation chamber that permits the ultraviolet photons to pass from the microfluidic ultraviolet radiation chamber into the microfluidic ionization chamber. Detection systems for one or more VOC analytes are also provided that include a gas chromatography (GC) unit including at least one gas chromatography column and an integrated microfluidic photoionization detector (PID) disposed downstream of the gas chromatography (GC) unit.

Abstract: Methods for performing non-invasive thrombolysis with ultrasound using, in some embodiments, one or more ultrasound transducers to focus or place a high intensity ultrasound beam onto a blood clot (thrombus) or other vascular inclusion or occlusion (e.g., clot in the dialysis graft, deep vein thrombosis, superficial vein thrombosis, arterial embolus, bypass graft thrombosis or embolization, pulmonary embolus) which would be ablated (eroded, mechanically fractionated, liquefied, or dissolved) by ultrasound energy. The process can employ one or more mechanisms, such as of cavitational, sonochemical, mechanical fractionation, or thermal processes depending on the acoustic parameters selected. This general process, including the examples of application set forth herein, is henceforth referred to as “Thrombolysis.

Abstract: A novel solid drug form of N-(2,6-bis(1-methylethyl)phenyl)-N?-((1-(4-(dimethylamino)phenyl)cyclopentyl)methyl)urea hydrochloride (also referred to “ATR-101”) suitable for oral dosing, and to compositions, methods and kits relating thereto. ATR-101 has particular utility in the treatment of, for example, aberrant adrenocortical cellular activity, including adrenocortical carcinoma (ACC), congenital adrenal hyperplasia (CAH) and Cushing's syndrome.

Abstract: To analyze spatial organization of chromatin a computing device may compile genomic element contacts or reads into variable size bins using a binary search tree. The bins may be selected to each represent a different cutsite increment or functional element within a genome, such as a gene, TAD, chromatin state segment, loop domain, chromatin domain, etc. Two sets of bins are selected to generate a squared genome matrix of bin pairs, where each set represent an axis of the matrix. Then a normalization method is applied to the interaction frequencies for the bin pairs having variable size and/or shape to generate normalized interaction frequencies for each bin pair. The normalized interaction frequencies may be used to identify bin pairs having enriched and depleted contacts for a variety of analyses, including the detection of target genes of genomic variants, as well as genome wide analysis of contacts.

Abstract: A sensor device includes a substrate having a plurality of cuts through the substrate to define a set of substrate sections, the substrate being flexible, and a plurality of sensor structures supported by the substrate, each sensor structure of the plurality of sensor structures being disposed at a respective substrate section of the set of substrate sections. Deformation of the substrate deforms each respective substrate section of the set of substrate sections such that each respective substrate section is deformed to a respective extent. Each sensor structure of the plurality of sensor structures is configured to provide an indication of the respective extent of the deformation.

Abstract: A device for wound irrigation and debridement includes a body extending along a longitudinal axis. The body comprises an interior region and an opening such that that the interior region and the first opening are configured to transfer an irrigation fluid. The body comprises a compliant region having a first stiffness and a debridement region having a different second stiffness. The compliant region defines a distal surface. In a first configuration, the compliant region defines a first axial dimension, the distal surface engages a target body region, and the debridement region is axially offset from the distal surface and disengaged from the target body region. In a second configuration, the compliant region is compressed to define a second axial dimension less than the first axial dimension, thereby engaging the debridement region with the target body region, and the distal surface engages the target body region.

Abstract: An autonomous driving robot based on a two-wheel SEGWAY self-balancing scooter. Sensors including LiDAR, camera, encoder, and IMU were implemented together with digital servos as actuators. The robot was tested simultaneously with the functionality features including obstacle avoidance based on fuzzy logic and 2D grid map, data fusion based on co-calibration, 2D simultaneously localization and mapping (SLAM) and path planning under different scenarios both indoor and outdoor. As a result, the robot initially has the ability of self-exploration with avoiding obstacles and constructing 2D grid map simultaneously. A simulation of the robot with same 10 functionalities except data fusion has also been tested and performed based on robot operating system (ROS) and Gazebo as the simple comparison of the robot in real world.

Abstract: The present disclosure provides compounds represented by Formula I: wherein R1, R2, R3, and R4 are as defined in the specification, and the salts and solvates thereof. Compounds of Formula I are EED inhibitors. EED inhibitors are useful for the treatment of cancer and other diseases.

Abstract: A ride-sourcing method including receiving a plurality of ride-sourcing requests; grouping a first set of the plurality of ride-sourcing requests into a first cluster and a second set of the plurality of ride-sourcing requests into a second cluster; computing a tour formation for each of the first cluster and the second cluster to define a series of stations and a cost function; applying trips to the first cluster and the second cluster under uniformity constraints; repeating the computing and applying steps until the cost function between consecutive iterations is below a threshold to define a first cluster of trips and a second cluster of trips; and assigning the first cluster of trips to a first driver and the second cluster of trips to a second driver.

Abstract: A tissue scaffold implant for expanding a stenotic lumen is provided that includes a bridge structure defining at least two angled sides and a lateral anchor integrally formed with the bridge structure. The lateral anchor is configured to be disposed against at least a portion of an external circumference of the stenotic lumen in a region near an opening formed in the stenotic lumen. At least two seat regions are defined between the at least two angled sides of the bridge structure and the lateral anchor. The at least two seat regions are configured to be received within and support the opening within the stenotic lumen, and the bridge structure and lateral anchor comprise a bioacceptable material.

Abstract: There is disclosed ultrahigh-efficiency single- and multi-junction thin-film solar cells. This disclosure is also directed to a substrate-damage-free epitaxial lift-off (“ELO”) process that employs adhesive-free, reliable and lightweight cold-weld bonding to a substrate, such as bonding to plastic or metal foils shaped into compound parabolic metal foil concentrators. By combining low-cost solar cell production and ultrahigh-efficiency of solar intensity-concentrated thin-film solar cells on foil substrates shaped into an integrated collector, as described herein, both lower cost of the module as well as significant cost reductions in the infrastructure is achieved.

Abstract: A composite solid electrolyte for a solid-state electrochemical cell is provided. The electrolyte may include a plurality of aramid nanofibers, such as a branched aramid nanofiber network, an ionically conductive polymer, such as poly(ethylene oxide) or quaternary ammonia functionalized polyvinyl alcohol (QAFPVA), and an optional divalent ion salt. The electrolyte is particularly suitable for use with zinc ions, where the divalent ion salt may comprise zinc trifluoromethanesulfonate Zn(CF3SO3)2. An electrochemical cell or battery is provided incorporating such a composite solid electrolyte that cycles ions, such as zinc ions or hydroxide ions, suppresses or minimizes dendrite formation, while having good ionic conductivity and being flexible. This flexibility provides the ability to create deformations in the electrochemical cell, such as protrusions and recesses that may define a corrugated pattern.

Abstract: A transvaginal stimulation device comprises a probe body sized to fit entirely within a vaginal cavity of a female patient. The probe body has a stimulating side defined by a length and a width of the probe body. The transvaginal stimulation device further comprises a pair of electrodes disposed on the stimulating side of the probe body and laterally spaced from each other. A method for treating stress urinary incontinence in a female patient comprises inserting the intravaginal device into a vaginal cavity of the female patient, positioning the pair of electrodes against an anterior wall of the vagina of the female patient, and conveying stimulation energy between the pair of electrodes to stimulate at least one muscle of a urethral sphincter muscle of the female patient without substantially stimulating pelvic floor muscles of the female patient.