Patents Assigned to The Research Foundation for The State University of New York
  • Publication number: 20200161372
    Abstract: A selector device includes a first electrode composed of a first metal having a first work function. A second electrode is composed of a second metal having a second work function. A selector layer is disposed between the first and second electrodes and is composed of a dielectric material having a conduction band and a valence band defining a band gap of at least 5 electron volts. Dopant atoms are disposed in the selector layer to form a sub-conduction band that is below the conduction band and above the work functions. When a threshold voltage is applied across the first and second electrodes, and a magnitude of the threshold voltage exceeds an energy difference between the sub-conduction band and the work functions, but does not exceed an energy difference between the conduction band and the work functions, an on-current will conduct through the selector layer.
    Type: Application
    Filed: September 23, 2019
    Publication date: May 21, 2020
    Applicant: THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK
    Inventors: Karsten BECKMANN, Nathaniel CADY
  • Publication number: 20200157625
    Abstract: This application provides methods to differentiate between subjects with autism spectrum disorder (ASD) and typically developing (TD) or developmentally delayed (DD) subjects using miRNA and/or microbiome levels detected in saliva samples and patient information. The method can be used to monitor the progress of ASD and guide its treatment. RNA-seq, qPCR, or other methods determine counts and abundance of miRNA or microbiomes. MicroRNA and/or microbiome sequencing data are refined by normalization to expression levels or abundance of time-invariant miRNAs and/or microbial RN As to control for time of sample collection or to compensate for circadian fluctuations in these levels. Multivariate logistic regression and nonlinear classification techniques are further used to select a panel of miRNAs and microbiomes that accurately differentiate between subjects with ASD, DD, and TD in subjects with an unknown ASD status. These panels of miRNAs and microbiomes may be developed into a RNA assay kit.
    Type: Application
    Filed: March 22, 2018
    Publication date: May 21, 2020
    Applicants: Quadrant Biosciences Inc., The Research Foundation for the State University of New York, Penn State Research Foundation
    Inventors: Steven D. HICKS, Frank A. MIDDLETON, Richard UHLIG, Alexander RAJAN
  • Publication number: 20200157626
    Abstract: Methods for diagnosing or monitoring a condition, disorder or disease associated with circadian, diurnal or other temporal rhythms by detecting circa-miRNAs and circa-microbiomes associated with said condition, disorder or disease. Methods for correcting or normalizing sequence data to correct for diurnal or circadian fluctuations in quantities of circa-miRNAs and/or circa-microbiomes by adjusting or normalizing values based on the time of day when a saliva sample containing these RNAs was collected.
    Type: Application
    Filed: March 20, 2018
    Publication date: May 21, 2020
    Applicants: Quadrant Biosciences Inc., The Research Foundation for the State University of New York, Penn State Research Foundation
    Inventors: Steven D. HICKS, Frank A. MIDDLETON, Richard UHLIG
  • Patent number: 10653140
    Abstract: One aspect of the present invention is directed to a composition. The composition includes a dispersion inducer comprising: H3C—(CH2)n—CHmCHmR, where is a single or double carbon-carbon bond, m is 1 or 2, n is 2 to 15, and R is a carboxylic acid, a salt, an ester, or an amide, where the ester or amide is an isostere or biostere of the carboxylic acid. The composition additionally contains an additive component selected from one or more of the group consisting of biocides, surfactants, antibiotics, antiseptics, detergents, chelating agents, virulence factor inhibitors, gels, polymers, pastes, edible products, and chewable products. The composition is formulated so that when it is contacted with a biofilm produced by a microorganism, where the biofilm comprises a matrix and microorganism on a surface, the dispersion inducer selectively acts on the microorganism and has a suitable biological response without a required direct effect on the matrix to disperse the biofilm.
    Type: Grant
    Filed: July 18, 2013
    Date of Patent: May 19, 2020
    Assignee: The Research Foundation for The State University of New York
    Inventor: David G. Davies
  • Patent number: 10657456
    Abstract: An apparatus for performing quantum computing includes multiple qubits, each of at least a subset of the qubits comprising a loop formed of a Dirac or Weyl semimetal and having at least two stable quantum states. The apparatus further includes at least one terahertz cavity coupled with the qubits, the terahertz cavity being configured to detect the quantum states of the qubits. Each of at least the subset of qubits is configured to receive a circularly polarized radiation source. The radiation source is adapted to excite a chiral current in each of at least the subset of qubits, the quantum states of the plurality of qubits being a function of the chiral current.
    Type: Grant
    Filed: June 17, 2019
    Date of Patent: May 19, 2020
    Assignees: BROOKHAVEN SCIENCE ASSOCIATES, LLC, THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK
    Inventors: Dmitri Kharzeev, Qiang Li
  • Patent number: 10658530
    Abstract: Provided is a field shaping multi-well detector and method of fabrication thereof. The detector is configured by depositing a pixel electrode on a substrate, depositing a first dielectric layer, depositing a first conductive grid electrode layer on the first dielectric layer, depositing a second dielectric layer on the first conductive grid electrode layer, depositing a second conductive grid electrode layer on the second dielectric layer, depositing a third dielectric layer on the second conductive grid electrode layer, depositing an etch mask on the third dielectric layer. Two pillars are formed by etching the third dielectric layer, the second conductive grid electrode layer, the second dielectric layer, the first conductive grid electrode layer, and the first dielectric layer. A well between the two pillars is formed by etching to the pixel electrode, without etching the pixel electrode, and the well is filled with a-Se.
    Type: Grant
    Filed: January 9, 2017
    Date of Patent: May 19, 2020
    Assignee: The Research Foundation for The State University of New York
    Inventors: Amirhossein Goldan, Wei Zhao
  • Publication number: 20200150111
    Abstract: The present disclosure is directed to a kit and methods for using the same. The kit includes a plate including at least one well, wherein the well includes a silver nitrate and a catalyst. The method includes providing a sample of synovial fluid to a well of a plate, wherein the well includes a silver nitrate and a catalyst and determining a presence of monosodium urate (MSU) crystals, wherein the presence of MSU crystals indicates that gout is detected in the sample.
    Type: Application
    Filed: May 11, 2018
    Publication date: May 14, 2020
    Applicant: THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK
    Inventors: Srinivas PENTYALA, Lawrence HURST
  • Patent number: 10647783
    Abstract: The present disclosure provides methods for functionalizing the surfaces of cellulose nanoparticles. In embodiments, nanoparticles are aerosolized, and then passed through a flow reactor where they are contacted with gaseous reactants to functionalize the surface of the nanoparticles. In other embodiments, the nanoparticles are aerosolized, and then passed through a plasma reactor where they are contacted with gaseous reactants to functionalize the surface of the nanoparticles. Once the functionalized nanoparticles are produced, they may be combined with polymers to form polymer composites having both a polymer and the functionalized nanoparticles. Systems for producing these functionalized nanoparticles, coupled with downstream polymer processing equipment for forming the polymer composites, are also provided.
    Type: Grant
    Filed: October 26, 2016
    Date of Patent: May 12, 2020
    Assignee: The Research Foundation for the State University of New York
    Inventors: Alexander Orlov, Daniel Knopf, Robert Grubbs, Girish Ramakrishnan
  • Patent number: 10639322
    Abstract: This document provides methods and materials for reducing amyloid beta levels within a mammal (e.g. a mammal having Alzheimer's disease). For example, this document provides methods for using compositions containing a potato polysaccharide preparation to reduce one or more symptoms of Alzheimer's disease. In some cases, a composition containing a potato polysaccharide preparation provided herein can be used to increase binding, sequestration, and/or degradation of CNS-derived amyloid beta polypeptides, thereby inhibiting the formation of neurofibrillary plaques.
    Type: Grant
    Filed: March 25, 2016
    Date of Patent: May 5, 2020
    Assignee: The Research Foundation for The State University of New York
    Inventors: George B. Stefano, Richard M. Kream, Kirk J. Mantione
  • Publication number: 20200116371
    Abstract: An HVAC register airflow control system and an air flow control method are provided. A housing of the system is in fluid communication with an air source for supplying an airflow. The housing includes an air outlet to the enclosed space. A detection sensor detects occupancy information of the enclosed space. A controller generates a control signal based on the occupancy information and controls the shape change of a damper made of a shape memory material. The damper is controlled to switch between a first operative configuration for preventing the airflow from entering the enclosed space and a second operative configured for permitting the airflow to enter the enclosed space.
    Type: Application
    Filed: April 10, 2018
    Publication date: April 16, 2020
    Applicant: THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK
    Inventors: Ya WANG, Zhangjie CHEN
  • Patent number: 10620048
    Abstract: Provided are an apparatus and method for two-dimensional spectroscopy using frequency combs and optical resonators, with the apparatus including at least one cavity and a controller for controlling generating a pump excitation using at least two frequency combs, generating a probe excitation using at least one frequency comb, and generating a resonantly enhanced signal frequency comb via a nonlinear-optical response of the sample. All frequency combs are resonant with a transverse mode of the cavity, to generate cavity-enhanced two-dimensional spectroscopy signals.
    Type: Grant
    Filed: August 24, 2017
    Date of Patent: April 14, 2020
    Assignee: The Research Foundation for The State University of New York
    Inventor: Thomas K. Allison
  • Patent number: 10617640
    Abstract: Compositions and methods for inducing immune tolerance to proteins and subsequence administration of the proteins are disclosed. Compositions comprise proteins complexed with liposomes comprising PS and PC, wherein at least part of the PS is present as lyso-PS.
    Type: Grant
    Filed: April 5, 2017
    Date of Patent: April 14, 2020
    Assignee: The Research Foundation for The State University of New York
    Inventors: Sathy Balu-Iyer, Richard Bankert, Radha Ramakrishnan, Robert Dingman, Vandana Iyer, Jennifer Schneider, Fiona Yau Glassman, Nhan Hanh Nguyen
  • Patent number: 10610607
    Abstract: The present invention provides a magnetic graphene-like nanoparticle or graphitic nano- or microparticle. The magnetic graphene-like nanoparticle or graphitic nano- or microparticle of the invention exhibits a high relaxivity, and is useful as a MRI contrast agent. The present invention also provides a composition for use with MRI imaging, comprising a sufficient amount of the magnetic graphene-like nanoparticles or graphitic nano- or microparticles and one or more physiologically acceptable carriers or excipients. The present invention also provides methods of using the magnetic graphene-like nanoparticles or graphitic nano- or microparticles as MRI contrast agents. The present invention further provides methods of producing the magnetic graphene-like nanoparticle or graphitic nano- or microparticle.
    Type: Grant
    Filed: July 7, 2017
    Date of Patent: April 7, 2020
    Assignee: The Research Foundation for The State University of New York
    Inventors: Balaji Sitharaman, Bhavna S. Paratala
  • Publication number: 20200093474
    Abstract: Provided is an implant, including a chamber having an interior radius wherein the interior radius has a flange, a cover slip, a cup, a setting member, a securing member, a resistance member, and an opposing member, wherein the cover slip, cup, resisting member, and setting member are attached to one another, the setting member sets on a flange and the securing member secures the setting member to the flange, the resistance member includes a flexibility and a longitudinal axis with a length wherein the flexibility permits modification of the length, and the opposing member sets a minimum length of the longitudinal axis. Also provided is a method of using said implant including affixing the chamber to a skull of a mammal.
    Type: Application
    Filed: April 1, 2019
    Publication date: March 26, 2020
    Applicant: THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK
    Inventors: Stephen MACKNIK, Olivya CABALLERO, Manuel LEDO, Susana MARTINEZ-CONDE
  • Publication number: 20200093602
    Abstract: The present disclosure provides intramedullary mandibular implants for the temporomandibular joint. The mandibular implants include a stem portion, a collar portion and a head portion. The stem, collar and head portions may be integral. The stem portion may define an inferior end and the head portion may define a superior end of the implants. The head portion may be arcuate in the sagittal plane to provide an articulating surface with a fossa or a fossa component. The collar portion may be intermediate of the head and stem portions and form a channel between an interior surface of the collar portion and an exterior surface of the stem portion. In use, the stem portion may be implanted within a condyle of a mandible such that an end portion of the condyle is situated within the channel of the implant and the head portion articulates with the fossa or fossa component.
    Type: Application
    Filed: November 26, 2019
    Publication date: March 26, 2020
    Applicant: The Research Foundation for the State University of New York
    Inventors: Martin PENDOLA, Gaia SALVADORE, Rehan KHAN
  • Publication number: 20200094251
    Abstract: This disclosure provides devices and methods for the isolation of single cells or particles of interest from a solution comprising a plurality of cells or a solution composed of a homogenous population of particles. Specifically, the present disclosure is directed to microfluidic devices and methods for analyzing cells in a sample. More specifically, the present disclosure provides droplet microfluidic devices and methods for using the same to obtain (trap), encapsulate, and retrieve (isolate) single cells or particles from a sample with improved efficiency.
    Type: Application
    Filed: March 29, 2018
    Publication date: March 26, 2020
    Applicant: THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK
    Inventors: Eric BROUZES, Martin SAUZADE
  • Patent number: 10579495
    Abstract: Systems and methods for utilizing cooperation facilitators to achieve joint message and network state cooperation in accordance with various embodiments of the invention are disclosed. One embodiment of the invention includes: a plurality of transmitters; a receiver that has access to at least partial network state information and that includes a decoder configured to decode signals received via a multiple terminal channel from the plurality of transmitters using the at least partial network state information; and a cooperation facilitator. In addition, at least some of the plurality of transmitters are configured to transmit message information to the cooperation facilitator and the cooperation facilitator is configured to generate cooperation parameters based upon the message information and the manner in which state information is utilized by the receiver to decode signals received via the multiple terminal channel.
    Type: Grant
    Filed: May 18, 2018
    Date of Patent: March 3, 2020
    Assignees: California Institute of Technology, The Research Foundation for the State University of New York
    Inventors: Parham Noorzad, Michelle Effros, Michael Langberg
  • Publication number: 20200062698
    Abstract: The present invention provides a compound having the structure:
    Type: Application
    Filed: June 24, 2019
    Publication date: February 27, 2020
    Applicant: The Research Foundation for the State University of New York
    Inventors: Maurizio Del Poeta, Visesato Mor
  • Patent number: 10568963
    Abstract: A composition comprising PAA nanoparticles containing a post loaded tetrapyrollic photosensitizer and a postloaded imaging agent and methods for making and using same.
    Type: Grant
    Filed: August 3, 2012
    Date of Patent: February 25, 2020
    Assignees: HEALTH RESEARCH, INC., HE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK, REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Ravindra K. Pandey, Raoul Kopelman, Anurag Gupta, Munawwar Sajjad
  • Patent number: 10571631
    Abstract: A photonic structure can include in one aspect one or more waveguides formed by patterning of waveguiding material adapted to propagate light energy. Such waveguiding material may include one or more of silicon (single-, poly-, or non-crystalline) and silicon nitride.
    Type: Grant
    Filed: January 4, 2016
    Date of Patent: February 25, 2020
    Assignee: THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK
    Inventors: Douglas Coolbaugh, Thomas Adam, Gerald L. Leake