Abstract: A selector device includes a first electrode composed of a first metal having a first work function. A second electrode is composed of a second metal having a second work function. A selector layer is disposed between the first and second electrodes and is composed of a dielectric material having a conduction band and a valence band defining a band gap of at least 5 electron volts. Dopant atoms are disposed in the selector layer to form a sub-conduction band that is below the conduction band and above the work functions. When a threshold voltage is applied across the first and second electrodes, and a magnitude of the threshold voltage exceeds an energy difference between the sub-conduction band and the work functions, but does not exceed an energy difference between the conduction band and the work functions, an on-current will conduct through the selector layer.

Abstract: The present invention provides a process of producing a trifluoromcthoxylated aryl or trifluoromothoxylated heteroaryl having the structure: wherein A is an aryl or heteroaryl, each with or without substitution; and R1 is —H, -(alkyl), -(alkenyl), -(alkynyl), -(aryl), -(heteroaryl), -(alkylaryl), -(alkylheteroaryl), —NH-(alkyl), —N(alkyl)2, —NH-(alkenyl), —NH-(alkynyl) —NH-(aryl), —NH-(heteroaryl), —O-(alkyl), —O-(alkenyl), —O-(alkynyl), —O-(aryl), —O-(heteroaryl), —S-(alkyl), —S-(alkenyl), —S-(alkynyl), —S-(aryl), or —S-(heteroaryl), comprising: (a) reacting a compound having the structure: with a trifluoromethylating agent in the presence of a base in a first suitable solvent under conditions to produce a compound having the structure: and (b) maintaining the compound produced in step (a) in a second suitable solvent under conditions sufficient to produce the trifluoromethoxylated aryl or trifluormethoxylated heteroaryl having the structure:

Abstract: The present disclosure is directed to one or more engineered peptide inhibitors against the lactate dehydrogenase A (LDHA) activity in cells. The disclosure also provides compositions, and kits including the one or more peptide inhibitors, and methods of using the one or more peptide inhibitors. The peptide inhibitors and compositions can be used for treatment of conditions in which there is abnormally high LDHA activity, such as cancer or metabolic diseases, infectious diseases, mendelian disorders, inflammatory diseases, neurodegenerative and neuropathological diseases, neuropsychological disorders, obesity and eating disorders, chronic diseases and genetic diseases.

Abstract: A supercapacitor apparatus within a sealed housing to provide a high-voltage EDLC energy storage unit includes cells stacked on one another, with each cell having a set of supercapacitors that are interconnected within the apparatus in a parallel-series configuration to provide an internally balanced energy storage unit that is capable of stand-off voltages of 10 volts or higher. The energy storage unit does not require balancing resistors or more complicated external balancing circuitry. The electrodes of the supercapacitors are comprised of carbon nanotubes and graphene nanoplatelets.

Abstract: A microfluidic device is disclosed which comprises a main flow channel and a partition chamber connected to a portion of same by a chamber inlet and chamber outlet. The device utilizes select cross sections to advantage capillary effects during filling and partitioning steps to isolate biological or other samples in the partition chamber for analysis and can be employed in a digital array.

Abstract: The present disclosure provides methods of treating a human having a disease or disorder that would benefit from increasing platelet counts. The method involves inhibiting the enzyme activity of biliverdin IX? reductase (BLVRB) activity or inhibiting the expression of BLVRB gene.

Abstract: Provided is a field shaping multi-well photomultiplier and method for fabrication thereof. The photomultiplier includes a field-shaping multi-well avalanche detector, including a lower insulator, an a-Se photoconductive layer and an upper insulator. The a-Se photoconductive layer is positioned between the lower insulator and the upper insulator. A light interaction region, an avalanche region, and a collection region are provided along a length of the photomultiplier, and the light interaction region and the collection region are positioned on opposite sides of the avalanche region.

Abstract: This invention provides a composition comprising the compound having the structure: ethyl 2-[19F]F-4-nitrobenzoate, and at least one acceptable carrier. This invention also provides a method of detecting the presence of or location of bacteria cells in a subject which comprises determining if an amount of the compound or determining where an amount of the compound having the structure: is present in the subject at a period of time after administration of the compound or salt thereof to the subject, thereby detecting the presence of or location of the bacteria cells based on the amount of the compound determined to be present in the subject or detecting the location of the bacteria cells based on the location of the compound determined to be present in the subject.

Abstract: A photonic structure can include in one aspect one or more waveguides formed by patterning of waveguiding material adapted to propagate light energy. Such waveguiding material may include one or more of silicon (single-, poly-, or non-crystalline) and silicon nitride.

Abstract: Compositions and methods for inducing immune tolerance to proteins and subsequence administration of the proteins are disclosed. Compositions comprise proteins complexed with liposomes comprising PS and PC, wherein at least part of the PS is present as lyso-PS.

Abstract: This disclosure introduces a mapping for creating good Doppler detection capable radar codes. The mapping transfers an existing digital radar code to the warped frequency domain by expressing the code elements as magnitudes and phases of selected frequencies. These frequencies are equispaced in the warped frequency domain to preserve the code's sidelobes after mapping. The frequency warping function may convert the multiplicative Doppler shift into an additive shift of the code pattern in the warped frequency domain, which allows Doppler shift detection.

Abstract: A method for treating wastewater, comprising: (i) injecting a hydrate-forming gas (e.g., propane) into the wastewater under conditions of elevated pressure and reduced temperature to form a solid hydrate composed of the hydrate-forming gas and water from the wastewater; and (ii) separating the solid hydrate from the wastewater to result in removal of water from the wastewater, thereby resulting in partially dewatered wastewater, and optionally, (iii) lowering the pressure and/or raising the temperature of the solid hydrate to decompose the solid hydrate into reformed hydrate-forming gas and reformed water, and further optionally, recycling the reformed hydrate-forming gas for use in step (i) and/or capturing the reformed water from step (iii) and further decontaminating until suitable for release into waterway or for use in a process. The invention is also directed to an apparatus for practicing the method described above.

Abstract: The current disclosure provides methods for detecting and analyzing KRT4 and KRT17 expression in a sample obtained from a test subject. The current disclosure pertains to methods and kits for identifying a mammalian subject with cervical cancer or non-cancerous lesions of the cervix. The current disclosure further provides methods and kits for determining the likelihood of survival or treatment outcome of a subject having cervical cancer by determining the expression level of KRT17 in a sample.

Abstract: The present disclosure is directed to devices, systems and methods that include a stage and an actuator configured to transmit a orthogonal force to the stage, wherein the actuator is configured to receive a plurality of orthogonal acceleration signals, wherein the orthogonal acceleration signals comprise an actuator frequency signal and an actuator magnitude signal.

Abstract: The current disclosure provides methods for detecting and analyzing KRT17 expression in a sample obtained from a subject. The current disclosure also pertains to methods and kits for identifying a mammalian subject with head and neck squamous cell carcinoma. The current disclosure further provides methods and kits for determining the likelihood of survival of a subject having head and neck squamous cell carcinoma.

Abstract: Detection of synthetic content in portrait videos, e.g., deep fakes, is achieved. Detectors blindly utilizing deep learning are not effective in catching fake content, as generative models produce realistic results. However, biological signals hidden in portrait videos which are neither spatially nor temporally preserved in fake content, can be used as implicit descriptors of authenticity. 99.39% accuracy in pairwise separation is achieved. A generalized classifier for fake content is formulated by analyzing signal transformations and corresponding feature sets. Signal maps are generated, and a CNN employed to improve the classifier for detecting synthetic content. Evaluation on several datasets produced superior detection rates against baselines, independent of the source generator, or properties of available fake content.

Abstract: Oral compositions and methods of use thereof are provided herein. The oral compositions comprise a first component comprising at least one Eh-raising compound and a pharmaceutically acceptable carrier, and a second component comprising at least one zinc compound, an anti-microbial agent and a pharmaceutically acceptable carrier.

Abstract: Provided are methods for determining a presence of an intracranial aneurysm in a subject suspected of having an intracranial aneurysm or at risk for developing an intracranial aneurysm, or a subject in need of aneurysm monitoring. The method involves analyzing a biological sample from the subject for expression of a combination of biomarkers that provide a signature of an aneurism.

Abstract: A system and method for detecting a suspicious object, including a wireless signal transmitter with first and second transmitter antennas, a first wireless signal receiver on an opposite side of the object from the transmitter having first and second receiver antennas, and a second wireless signal receiver on a same side of the object as the transmitter having a third receiver antenna. The transmitter may emit wireless signals from each of the transmitter antennas. The signals emitted by the first transmitter antenna may be received at the first and second receiver antennas. The signals emitted by both transmitter antennas may be received at the third receiver antenna. The object's material type may be determined based on channel state information of the wireless signals received at first receiver. A size of the object may be determined based on channel state information of the wireless signals received at the second receiver.

Abstract: A capacitor may be configured with a dielectric laminate disposed on ordered or non-ordered structures. Materials for the dielectric laminate have high dielectric constant and reduce leakage current to increase breakdown voltage of the device. These materials may include titanium dioxide (TiO2) and silicon dioxide (SiO2). In one implementation, the capacitor may reside on a substrate. The capacitor may have structure (e.g., nano-tubes, nano-holes, etc;) disposed on the substrate having a surface area greater than the surface area of the substrate and a laminate conformally coating the structure, the laminate comprising a first layer and a second layer with materials that configure the capacitor with an energy density of at least 60 Wh/Kg.