Patents Assigned to The Research Foundation of State University of New York
  • Patent number: 10772722
    Abstract: A polymeric valve which may include a heart valve, and also may include a trileaflet heart valve includes a stent having a base and a plurality of outwardly extending posts from the base and equidistant from each other. A plurality of leaflets each connected to a corresponding one of the posts at one end, and each of the leaflets connected to the base. Each of the leaflets having an operative end opposite the end connected to the post, and the operative ends of the leaflets being biased in a closed position such that the operative ends abut each other. The operative ends are configured to rhythmically open and close in relation to each other, and the leaflets include multiple cross sectional thicknesses at different portions of the leaflets.
    Type: Grant
    Filed: April 20, 2017
    Date of Patent: September 15, 2020
    Assignees: The Research Foundation for The State University of New York, The Arizona Board of Regents on Behalf of the University of Arizona
    Inventors: Danny Bluestein, Thomas E. Claiborne, Marvin J. Slepian
  • Publication number: 20200284794
    Abstract: The current disclosure provides methods for detecting and analyzing K17 expression in a bladder sample obtained from a subject. The current disclosure also pertains to methods and kits for identifying a mammalian subject with bladder cancer by detecting the expression of K17 in a sample. The present methods include both cell-based and cell-free methods for determining the level of keratin 17 in a sample obtained from the bladder of a subject.
    Type: Application
    Filed: August 4, 2017
    Publication date: September 10, 2020
    Applicants: THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, KDX DIAGNOSTICS, INC.
    Inventors: Kenneth R. SHROYER, Luisa F. ESCOBAR-HOYOS, Nam KIM
  • Patent number: 10767164
    Abstract: Human pluripotent stem cells (hPSCs) are promising cell source to produce therapeutic endocrine cells for diabetes treatment. A gel solution made by decellularized tissue-specific extracellular matrix (dpECM) significantly promotes three-dimensional (3D) islet-like organogenesis during induced hPSC differentiation into endocrine lineages. Islet organoids are self-organized even in a two-dimensional (2D) culture mode. Cells derived from hPSCs differentiated on such ECM coated substrates exhibit similar cellular composition to native pancreatic islets. These cells express islet signature markers insulin, PDX-1, C-peptide, MafA, glucagon, somatostatin, and pancreatic polypeptide, and secrete more insulin in response to glucose level compared to a traditional matrix substrate (Matrigel). The dpECM facilitates generating more C-peptide+/glucagon? cells rather than C-peptide+/glucagon+ cells. Remarkably, dpECM also facilitated intra-organoid vascularity by generating endothelial cells and pericytes.
    Type: Grant
    Filed: December 13, 2017
    Date of Patent: September 8, 2020
    Assignee: The Research Foundation for The State University of New York
    Inventors: Sha Jin, Kaiming Ye, Huanjing Bi
  • Publication number: 20200277676
    Abstract: Provided are methods for detecting or diagnosing a traumatic brain injury or TBI by detecting concentration levels miRNAs associated with TBI in saliva. Methods for controlled and normalized comparisons of salivary miRNA concentration levels are further provided. Assay kits comprising salivary miRNAs, probes and/or primers for detecting salivary miRNAs are also provided.
    Type: Application
    Filed: March 23, 2018
    Publication date: September 3, 2020
    Applicants: QUADRANT BIOSCIENCES INC., THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, PENN STATE RESEARCH FOUNDATION
    Inventors: Steven D. HICKS, Frank A. MIDDLETON, Richard UHLIG
  • Publication number: 20200276621
    Abstract: Systems and methods for self-cleaning a surface of an object where an electrodynamic shield is mounted to a surface of the object. The electrodynamic shield includes one or more sets of electrodes atop a substrate, at least one or more sets of electrodes being covered in a protective film. A coating is applied to the top surface of the protection film. A signal pulse generator is connected to the one or more sets of electrodes. The signal pulse generator generates a pulse signal that causes the one or more sets of electrodes to generate an electric field. The pulse signal comprises a plurality of different pulse signals which have phase differences between consecutive signals, and the electric field causes a particle atop the coating to experience an electrostatic force and be repelled away from the coating. These pulse signals (including shapes, amplitudes, shifts, and frequencies) can be tuned to increase efficiency of removal depending on dust type and relative humidity.
    Type: Application
    Filed: September 11, 2018
    Publication date: September 3, 2020
    Applicant: The Research Foundation for the State University of New York
    Inventors: Alexander Orlov, Shrish Patel, James F. Smith
  • Patent number: 10760162
    Abstract: Aqueous dispersions of artificially synthesized, mussel-inspired polydopamine nanoparticles were inkjet printed on flexible polyethylene terephthalate (PET) substrates. Narrow line patterns (4 ?m in width) of polydopamine resulted due to evaporatively driven transport (coffee ring effect). The printed patterns were metallized via a site-selective Cu electroless plating process at a controlled temperature (30° C.) for varied bath times. The lowest electrical resistivity value of the plated Cu lines was about 6 times greater than the bulk resistivity of Cu. This process presents an industrially viable way to fabricate Cu conductive fine patterns for flexible electronics at low temperature, and low cost.
    Type: Grant
    Filed: May 16, 2019
    Date of Patent: September 1, 2020
    Assignee: The Research Foundation for The State University of New York
    Inventors: Siyuan Ma, Liang Liu, Vadim Bromberg, Timothy Singler
  • Patent number: 10763491
    Abstract: Preparation, characterization, and an electrochemical study of Mg0.1V2O5 prepared by a novel sol-gel method with no high-temperature post-processing are disclosed. Cyclic voltammetry showed the material to be quasi-reversible, with improved kinetics in an acetonitrile-, relative to a carbonate-, based electrolyte. Galvanostatic test data under a C/10 discharge showed a delivered capacity >250 mAh/g over several cycles. Based on these results, a magnesium anode battery, as disclosed, would yield an average operating voltage ˜3.2 Volts with an energy density ˜800 mWh/g for the cathode material, making the newly synthesized material a viable cathode material for secondary magnesium batteries.
    Type: Grant
    Filed: March 30, 2015
    Date of Patent: September 1, 2020
    Assignee: The Research Foundation for the State University of New York
    Inventors: Kenneth Takeuchi, Esther Takeuchi, Amy Marschilok
  • Patent number: 10759835
    Abstract: This disclosure provides streptavidin monomers that bind biotin with high affinity and which possess slow dissociation rates. The disclosure also provides methods of making and using those monomers.
    Type: Grant
    Filed: July 25, 2017
    Date of Patent: September 1, 2020
    Assignee: The Research Foundation for The State University of New York
    Inventor: Sheldon Park
  • Patent number: 10760016
    Abstract: A gasifier system includes a reactor for receiving a wet feedstock which has a base and a container rotatably connected to the base such that a rotation of the container causes a mixing of the feedstock in an interior of the reactor. The interior is bounded by the base and the container. A space between the base and the container allows an entry of oxygen into the interior. The space has a dimension such that the feedstock is fully oxidized in a combustion area adjacent the base and such that the feedstock avoids combustion in a remainder of the interior. The reactor has a longitudinal axis inclined at an inclination angle relative to a horizontal line to promote the mixing of the feedstock in the interior.
    Type: Grant
    Filed: April 21, 2015
    Date of Patent: September 1, 2020
    Assignee: The Research Foundation of State University of New York
    Inventor: David J. Waage
  • Publication number: 20200268858
    Abstract: Disclosed herein are methods of treatment for an intraocular pressure (IOP)-associated condition in a subject, that include administering to the subject an effective amount of a tissue plasminogen activator (tPA) therapeutic agent. In one embodiment, the IOP-associated condition is glaucoma. The administration of a tPA therapeutic agent can be an extended administration intended to cause a reduction in IOP in the subject for a period of at least one day to a year or more, relative to IOP levels in the subject prior to administration of the tPA therapeutic agent. The tPA therapeutic agent can be, for example, tPA, a tPA derivative, a small molecule direct or indirect tPA agonist, or a gene therapy vector.
    Type: Application
    Filed: May 8, 2020
    Publication date: August 27, 2020
    Applicants: The Research Foundation for The State University of New York, Icahn School of Medicine at Mount Sinai
    Inventors: Ioannis DANIAS, Oscar A. CANDIA, Rosana GEROMETTA
  • Patent number: 10756283
    Abstract: A sensor including a layer of amorphous selenium (a-Se) and at least one charge blocking layer is formed by depositing the charge blocking layer over a substrate prior to depositing the amorphous selenium, enabling the charge blocking layer to be formed at elevated temperatures. Such a process is not limited by the crystallization temperature of a-Se, resulting in the formation of an efficient charge blocking layer, which enables improved signal amplification of the resulting device. The sensor can be fabricated by forming first and second amorphous selenium layers over separate substrates, and then fusing the a-Se layers at a relatively low temperature.
    Type: Grant
    Filed: December 16, 2019
    Date of Patent: August 25, 2020
    Assignee: The Research Foundation for The State University of New York
    Inventors: James Scheuermann, Wei Zhao
  • Patent number: 10755809
    Abstract: A home medication management system and method are provided comprise a home medication management device, a computing device associated with a user of medication management system, and a server in communication with the home medication management device and the computing device. The server comprises memory storing an application program interface (API) that is configured to manage the home medication of a patient including the registration of prescriptions, transmission of the registered prescriptions to the home medication management device, association of medications of the registered prescriptions with recesses of the home medication management device, presentation of alerts to the patient at scheduled times to take the medications based on the prescriptions, monitoring the patient for compliance with the alerts, determining whether the patient has taken the medication as scheduled, and presenting the determination to the user via the computing device.
    Type: Grant
    Filed: July 13, 2017
    Date of Patent: August 25, 2020
    Assignee: The Research Foundation for The State University of New York
    Inventors: Tim Kehoe, Rob Barnikel, Craig Lehmann, John Brittelli
  • Publication number: 20200261601
    Abstract: The present disclosure provides methods of treating a human having a disease or disorder that would benefit from increasing platelet counts. The method involves inhibiting the enzyme activity of biliverdin IX? reductase (BLVRB) activity or inhibiting the expression of BLVRB gene.
    Type: Application
    Filed: December 11, 2019
    Publication date: August 20, 2020
    Applicant: The Research Foundation for The State University of New York
    Inventors: Wadie F. BAHOU, Song WU
  • Publication number: 20200261384
    Abstract: Provided is a method of inhibiting protein kinase C zeta/protein kinase M zeta, including contacting a sample containing an isoform of protein kinase C zeta with a compound of formula: referred to as 1-naphthol-3,6,8-trisulphonic acid, or a pharmaceutically acceptable salt thereof. In some embodiments, contacting the sample with the compound does not inhibit protein kinase C iota/lambda. In a specific example, the sample includes neural tissue, the isoform of protein kinase C zeta is protein kinase M zeta, and inhibiting includes reducing kinase activity and further includes diminishing long-term potentiation. In some embodiment, the method includes inhibiting glucose transport. Also provided is a method of affecting memory, including administering the compounds to a mammalian organism.
    Type: Application
    Filed: October 15, 2018
    Publication date: August 20, 2020
    Applicant: THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK
    Inventors: Todd SACKTOR, Mildred ACEVEDO-DUNCAN
  • Publication number: 20200262784
    Abstract: The present invention provides a process of producing a trifluoromcthoxylated aryl or trifluoromothoxylated heteroaryl having the structure: wherein A is an aryl or heteroaryl, each with or without substitution; and R1 is —H, -(alkyl), -(alkenyl), -(alkynyl), -(aryl), -(heteroaryl), -(alkylaryl), -(alkylheteroaryl), —NH-(alkyl), —N(alkyl)2, —NH-(alkenyl), —NH-(alkynyl) —NH-(aryl), —NH-(heteroaryl), —O-(alkyl), —O-(alkenyl), —O-(alkynyl), —O-(aryl), —O-(heteroaryl), —S-(alkyl), —S-(alkenyl), —S-(alkynyl), —S-(aryl), or —S-(heteroaryl), comprising: (a) reacting a compound having the structure: with a trifluoromethylating agent in the presence of a base in a first suitable solvent under conditions to produce a compound having the structure: and (b) maintaining the compound produced in step (a) in a second suitable solvent under conditions sufficient to produce the trifluoromethoxylated aryl or trifluormethoxylated heteroaryl having the structure:
    Type: Application
    Filed: May 6, 2020
    Publication date: August 20, 2020
    Applicant: The Research Foundation for the State University of New York
    Inventors: Ming-Yu Ngai, Katarzyna N. Hojczyk
  • Patent number: 10745722
    Abstract: Methods and systems for producing prescribed unit size poly(3-hydroxyalkanoate) (PHA) polymers and copolymers are provided. The methods and systems can employ recombinant bacteria that are not native producers of PHA or lack enzymes to degrade PHA once synthesized, metabolize short to long chain fatty acids without induction, and express an (R)-specific enoyl-CoA hydratase and a PHA synthase, the (R)-specific enoyl-CoA hydratase and PHA synthase having wide substrate specificities. The recombinant bacteria are fed at least one fatty acid substrate that is equal in carbon length to the prescribed or desired unit size of the PHA polymer to be produced. The prescribed unit size PHA that is produced is then isolated and/or purified.
    Type: Grant
    Filed: July 14, 2017
    Date of Patent: August 18, 2020
    Assignee: The Research Foundation for The State University of New York
    Inventors: Christopher T. Nomura, Ryan C. Tappel, Qin Wang
  • Patent number: 10731165
    Abstract: Disclosed herein are RNA molecules with particular nucleotide sequences that, through Watson-Crick base pairing, enable the RNAs to form a hydrogel.
    Type: Grant
    Filed: October 6, 2017
    Date of Patent: August 4, 2020
    Assignee: THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK
    Inventors: Li Niu, Zhen Huang
  • Patent number: 10729695
    Abstract: Amino, amido, and heterocyclic compounds are disclosed. The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, diabetes complications, inflammation, and neurodegeneration, obesity, cancer, ischemia/reperfusion injury, cardiovascular disease and other diseases related to RAGE activity.
    Type: Grant
    Filed: April 15, 2019
    Date of Patent: August 4, 2020
    Assignees: The Research Foundation for the State University of New York, New York University
    Inventors: Ann Marie Schmidt, Ravichandran Ramasamy, Alexander Shekhtman, Vivek Rai, Michaele B. Manigrasso
  • Patent number: 10735505
    Abstract: A cluster of nodes, comprising: a plurality of nodes, each having a security policy, and being associated task processing resources; a registration agent configured to register a node and issue a node certificate to the respective node; a communication network configured to communicate certificates to authorize access to computing resources, in accordance with the respective security policy; and a processor configured to automatically dynamically partition the plurality of nodes into subnets, based on at least a distance function of at least one node characteristic, each subnet designating a communication node for communicating control information and task data with other communication nodes, and to communicate control information between each node within the subnet and the communication node of the other subnets.
    Type: Grant
    Filed: March 20, 2017
    Date of Patent: August 4, 2020
    Assignee: The Research Foundation for the State University of New York
    Inventors: Nael Abu-Ghazaleh, Weishuai Yang, Michael Lewis
  • Publication number: 20200243783
    Abstract: A sensor including a layer of amorphous selenium (a-Se) and at least one charge blocking layer is formed by depositing the charge blocking layer over a substrate prior to depositing the amorphous selenium, enabling the charge blocking layer to be formed at elevated temperatures. Such a process is not limited by the crystallization temperature of a-Se, resulting in the formation of an efficient charge blocking layer, which enables improved signal amplification of the resulting device. The sensor can be fabricated by forming first and second amorphous selenium layers over separate substrates, and then fusing the a-Se layers at a relatively low temperature.
    Type: Application
    Filed: December 16, 2019
    Publication date: July 30, 2020
    Applicant: The Research Foundation for The State University of New York
    Inventors: James Scheuermann, Wei Zhao