Patents Assigned to The Research Foundation of State University of New York
  • Patent number: 11369614
    Abstract: Provided herein are compositions and nanocarriers comprising linear-dendritic telodendrimers (TD) containing riboflavin. The nanocarriers and compositions have desirable loading properties and stabilized structure and can be used for efficient in vivo delivery.
    Type: Grant
    Filed: January 19, 2018
    Date of Patent: June 28, 2022
    Assignee: The Research Foundation for the State University of New York
    Inventors: Juntao Luo, Dandan Guo, Changying Shi
  • Publication number: 20220185180
    Abstract: A system and method for monitoring and analyzing activities of a person operating a machine, particularly driving a vehicle, is provided. A first magnet is attached to a hand of the person and a second magnet is attached to the head of the person. A smart watch having a magnetometer is attached to the other hand of the person. The magnetometer is in magnetic communication with both the first magnet and the second magnet to generate a first magnetic signal and a second magnetic signal. Both signals can be received by a processor and applied to mathematical models by the processor to generate indicators representative of positions and motions of the hands and the head. An alarm can be generated based on the indicators.
    Type: Application
    Filed: April 24, 2020
    Publication date: June 16, 2022
    Applicant: The Research Foundation for The State University of New York
    Inventor: Shan LIN
  • Patent number: 11360092
    Abstract: The current disclosure provides methods for detecting and analyzing K17 expression in a bladder sample obtained from a subject. The current disclosure also pertains to methods and kits for identifying a mammalian subject with bladder cancer by detecting the expression of K17 in a sample. The present methods include both cell-based and cell-free methods for determining the level of keratin 17 in a sample obtained from the bladder of a subject.
    Type: Grant
    Filed: August 4, 2017
    Date of Patent: June 14, 2022
    Assignees: The Research Foundation for The State University of New York, KDx Diagnostics, Inc.
    Inventors: Kenneth R. Shroyer, Luisa F. Escobar-Hoyos, Nam Kim
  • Patent number: 11350921
    Abstract: Provided is an implant, including a chamber having an interior radius wherein the interior radius has a flange, a cover slip, a cup, a setting member, a securing member, a resistance member, and an opposing member, wherein the cover slip, cup, resisting member, and setting member are attached to one another, the setting member sets on a flange and the securing member secures the setting member to the flange, the resistance member includes a flexibility and a longitudinal axis with a length wherein the flexibility permits modification of the length, and the opposing member sets a minimum length of the longitudinal axis. Also provided is a method of using said implant including affixing the chamber to a skull of a mammal.
    Type: Grant
    Filed: April 1, 2019
    Date of Patent: June 7, 2022
    Assignee: The Research Foundation for the State University of New York
    Inventors: Stephen Macknik, Olivya Caballero, Manuel Ledo, Susana Martinez-Conde
  • Patent number: 11352374
    Abstract: Disclosed is a method of delivering therapeutic carbon monoxide to the cells and tissues of a patient which comprises administering thereto a compound of the formula XBY1Y2C(O)V (I) or pharmaceutically acceptable salts thereof. In addition, disclosed is a method of delivering a drug to a diseased cell or tissue by administering a compound of formula I either wherein at least one of X is a drug containing an amino group or V is a drug containing an amino group or hydroxyl group less a hydrogen on the amino or hydroxyl group. Further disclosed are novel compounds of Formula I.
    Type: Grant
    Filed: April 30, 2020
    Date of Patent: June 7, 2022
    Assignees: THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, FLORIDA SHOUTHWESTERN STATE COLLEGE, UNIVERSITY OF ALASKA ANCHORAGE
    Inventors: Nin N. Dingra, Theppawut Israsena Na Ayudhya
  • Patent number: 11344635
    Abstract: Macrocyclic complexes and macrocyclic compounds. The macrocyclic complexes or macrocyclic compounds have a TACN moiety with one or more amine group(s) or a O- or S-substituted TACN moiety. The macrocyclic complexes have a high-spin Fe(III) atom coordinated to the TACN moiety. The macrocyclic complexes can be used in imaging methods.
    Type: Grant
    Filed: November 18, 2019
    Date of Patent: May 31, 2022
    Assignee: The Research Foundation for the State University of New York
    Inventors: Janet R. Morrow, Zuiru Lin, Didar Asik, Eric M. Snyder, Elizabeth A. Kras
  • Patent number: 11349117
    Abstract: A method of synthesizing an electrode material for lithium ion batteries from Fe3O4 nanoparticles and multiwalled carbon nanotubes (MWNTs) to yield (Fe3O4-NWNTs) composite heterostructures. The method includes linking the Fe3O4 nanoparticles and multiwalled carbon nanotubes using a ?-? interaction synthesis process to yield the composite heterostructure electrode material. Since Fe3O4 has an intermediate voltage, it can be considered an anode (when paired with a higher voltage material) or a cathode (when paired with a lower voltage material).
    Type: Grant
    Filed: January 17, 2019
    Date of Patent: May 31, 2022
    Assignee: The Research Foundation for the State University of New York
    Inventors: Stanislaus Wong, Lei Wang, Coray McBean, Amy C. Marschilok, Kenneth Takeuchi, Esther S. Takeuchi
  • Patent number: 11339441
    Abstract: The present invention relates to high-throughput methods comprising direct infusion electrospray ionization mass spectrometry (ESI-MS), multistep tandem mass spectrometry (MSn), consecutive reaction monitoring (CRM), ion mobility spectrometry mass spectrometry (IMS-MS), high-resolution MS, and IMS-MS, for genome-wide (whole cell or tissue) profiling of DNA and RNA nucleotides/nucleosides having a wide variety of variant structural modifications. In particular, these methods are contemplated for providing a specific profile of variant DNA and/or RNA chemically modified nucleic acids (i.e. structures) associated with specific medical conditions. Medical conditions may include, but are not limited to: cancer; including prostate, lung, uterus, larynx, ovary, breast, kidney, and many other types of cancers; specific stages of cancer; bacterial infections; viral infections; genetic and metabolic disorders; and any condition involving changes in DNA and/or RNA structural modifications.
    Type: Grant
    Filed: May 12, 2016
    Date of Patent: May 24, 2022
    Assignee: THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK
    Inventors: Rebecca Rose, Daniele Fabris
  • Publication number: 20220152327
    Abstract: The present disclosure is directed to systems and methods of controlling supplemental oxygen supply devices, the methods include: receiving data from one or more sensors of a patient device operably connected to a patient; using the data as an input to a machine learning model that predicts whether or not a change to a supply amount of an oxygen enriched gas from the supplemental oxygen supply device is to be made; and transmitting a control signal to the supplemental oxygen supply device based on the predicted change.
    Type: Application
    Filed: November 16, 2021
    Publication date: May 19, 2022
    Applicants: The Research Foundation for The State University of New York, Neektec, LLC.
    Inventors: John Brittelli, Dante T. Vigliotti, Michael A. Kamchu
  • Publication number: 20220158819
    Abstract: A processing unit and a method of operating a processing unit. In an embodiment, the processing unit comprises a SIMON block cipher for transforming plaintext data into encrypted data. A key expansion module generates and outputs one or more encryption keys; and the key expansion module includes a first series of adiabatic registers for holding key generation data values, and for using adiabatic switching to transmit the key generation data values through the first series of adiabatic registers. A round function module receives the plaintext data and the one or more encryption keys, encrypts the plaintext data to generate the encrypted data, and outputs the encrypted data; and the round function module includes a second series of adiabatic registers for holding encryption data, and for using adiabatic switching to transmit the encryption data through the second series of adiabatic registers.
    Type: Application
    Filed: March 13, 2020
    Publication date: May 19, 2022
    Applicant: The Research Foundation for The State University of New York
    Inventors: Emre SALMAN, Milutin STANACEVIC, Yasha KARIMI, Tutu WAN, Yuanfei HUANG
  • Patent number: 11331019
    Abstract: Nanoparticle-fibrous membrane composites are provided as tunable interfacial scaffolds for flexible chemical sensors and biosensors by assembling gold nanoparticles (Au NPs) in a fibrous membrane. The gold nanoparticles are functionalized with organic, polymeric and/or biological molecules. The fibrous membranes may include different filter papers, with one example featuring a multilayered fibrous membrane consisting of a cellulose nanofiber (CN) top layer, an electrospun polyacrylonitrile (PAN) nanofibrous midlayer (or alternate material), and a nonwoven polyethylene terephthalate (PET) fibrous support layer, with the nanoparticles provided on the fibrous membranes through interparticle molecular/polymeric linkages and nanoparticle-nanofibrous interactions. Molecular linkers may be employed to tune hydrogen bonding and electrostatic and/or hydrophobic/hydrophilic interactions to provide sensor specificity to gases or liquids. The sensors act as chemiresistor-type sensors.
    Type: Grant
    Filed: August 7, 2018
    Date of Patent: May 17, 2022
    Assignee: The Research Foundation for The State University of New York
    Inventors: Chuan-Jian Zhong, Mark D. Poliks, Benjamin S. Hsiao, Ning Kang, Shan Yan, Jing Li, Shiyao Shan, Jin Luo
  • Publication number: 20220145304
    Abstract: The present disclosure provides modified microRNA nucleic acid compositions that have one or more cytosine and/or uracil bases replaced with gemcitabine or a 5-halouracil, respectively. More specifically, the present disclosure reveals that the replacement of cytosine nucleotides within a microRNA nucleotide sequence with a gemcitabine molecule increases the ability of the microRNA to inhibit cancer progression and tumorigenesis. In addition, the present disclosure reveals that the replacement of cytosine nucleotides within a microRNA nucleotide sequence with a gemcitabine molecule and replacement of uracil bases with 5-halouracil increases the ability of the microRNA to inhibit cancer development. As such, the present disclosure provides various modified nucleic acid (e.g., microRNA) compositions having gemcitabine molecules incorporated in their nucleic acid sequences and methods for using the same.
    Type: Application
    Filed: March 13, 2020
    Publication date: May 12, 2022
    Applicant: The Research Foundation for The State University of New York
    Inventors: Jingfang JU, Andrew FESLER
  • Patent number: 11321049
    Abstract: In this paper, binary stackers and counters are presented. In an embodiment, a counter uses 3-bit stacking circuits which group T bits together, followed a symmetric method to combine pairs of 3-bit stacks into 6-bit stacks. The bit stacks are then converted to binary counts, producing 6:3 and 7:3 Counter circuits with no XOR gates on the critical path. This avoids of XOR gates results in faster designs with efficient power and area utilization. In VLSI simulations, the presently-disclosed counters were 30% faster and at consumed at least 20% less power than existing parallel counters. Additionally, using the presently-disclosed counter in existing Counter Based Wallace tree multiplier architectures reduce latency and improves efficiency in term of power-delay product for 64-bit and 128-bit multipliers.
    Type: Grant
    Filed: May 4, 2018
    Date of Patent: May 3, 2022
    Assignee: The Research Foundation for The State University of New York
    Inventors: Christopher Fritz, Adly T. Fam
  • Publication number: 20220119941
    Abstract: Provided are methods for producing n-doped graphene films. The method comprises contacting a graphene layer with an alkali metal-doped polymer layer. Compositions comprising (i) a substrate, (ii) a doped polymer, and (iii) graphene are also provided. The methods of the invention produce n-doped graphene films that are resistant to degradation, have high electrical conductivity, and low sheet resistance without altering the optical transmission of graphene.
    Type: Application
    Filed: November 29, 2019
    Publication date: April 21, 2022
    Applicants: The Research Foundation for The State of University New York, The Research Foundation for The State of University New York
    Inventors: Matthew Eisaman, Jan Folkson, Joseph Andrade
  • Publication number: 20220119897
    Abstract: The present disclosure relates to a method of detecting and quantifying a virus-of-interest from human viral shed in a community, including: concentrating viral material from a wastewater sample to form a viral nucleic acid material; measuring an amount of a virus-of-interest nucleic acid in the viral nucleic acid material to obtain a first amount; measuring an amount of a marker or bacteriophage nucleic acid in the viral nucleic acid material to obtain a second amount; and forming a ratio of the first amount to the second amount to estimate a level of virus-of-interest from human viral shed within a community. In embodiments, methods for quantifying, monitoring, and/or identifying virus-of-interest such as SARS-CoV-2 are also disclosed.
    Type: Application
    Filed: June 15, 2021
    Publication date: April 21, 2022
    Applicant: The Research Foundation for the State University of New York
    Inventors: Hyatt C. GREEN, Frank A. MIDDLETON
  • Patent number: 11308931
    Abstract: A metamaterial comprising, a plurality of acoustic vector field sensors, each configured to sense an acoustic vector field of a fluid within a fluid-filled space in response to fluid waves, and producing an electrical signal corresponding to the sensed acoustic vector field; a processor configured to perform a time and space transform on the electrical signal; and at least one phased array transducer, configured to emit fluid waves according to a produced acoustic vector field pattern dependent on a result of the time and space transform, a within a portion of the fluid.
    Type: Grant
    Filed: February 24, 2020
    Date of Patent: April 19, 2022
    Assignee: The Research Foundation for The State University of New York
    Inventor: Steven M. Hoffberg
  • Patent number: 11305000
    Abstract: The invention relates to the development of chimeric OspA molecules for use in a new Lyme vaccine. More specifically, the chimeric OspA molecules comprise the proximal portion from one OspA serotype, together with the distal portion from another OspA serotype, while retaining antigenic properties of both of the parent polypeptides. The chimeric OspA molecules are delivered alone or in combination to provide protection against a variety of Borrelia genospecies. The invention also provides methods for administering the chimeric OspA molecules to a subject in the prevention and treatment of Lyme disease or borreliosis.
    Type: Grant
    Filed: January 19, 2018
    Date of Patent: April 19, 2022
    Assignees: Brookhaven Science Associates, LLC, The Research Foundation of State University of New York, Baxalta Incorporated, Baxalta GmbH
    Inventors: Brian A. Crowe, Ian Livey, Maria O'Rourke, Michael Schwendinger, John J. Dunn, Benjamin J. Luft
  • Patent number: 11310883
    Abstract: An apparatus method for driving light emitting diodes (LEDs), comprising: receiving an alternating current input; producing a DC current having a voltage with an AC-DC boost power-factor correction stage, having a variable-frequency operation, and a set of switches controlled in dependence on the voltage to limit a peak LED current; and producing an LED drive current with a DC-DC power conversion stage having a set of switches to selectively pulse-width modulate the LEDs to control a brightness, wherein the set of switches in the AC-DC boost power-factor correction stage and the set of switches in the DC-DC power conversion stage are each controlled to switch at zero current.
    Type: Grant
    Filed: May 14, 2021
    Date of Patent: April 19, 2022
    Assignee: The Research Foundation for The State University of New York
    Inventor: Pritam Das
  • Patent number: 11292962
    Abstract: Doped nanoparticles, methods of making such nanoparticles, and uses of such nanoparticles. The nanoparticles exhibit a metal-insulator phase transition at a temperature of ?200° C. to 350° C. The nanoparticles have a broad range of sizes and various morphologies. The nanoparticles can be used in coatings and in device structures.
    Type: Grant
    Filed: October 1, 2012
    Date of Patent: April 5, 2022
    Assignee: The Research Foundation for The State University of New York
    Inventors: Sarbajit Banerjee, Luisa Whittaker-Brooks, Christopher J. Patridge, Peter Marley
  • Patent number: 11289700
    Abstract: An electrode comprising: NaVOPO4 having orthorhombic crystalline symmetry and space group Pna21, as an active intercalation host material, wherein the electrode is capable of electrochemical insertion and release of greater than one sodium ion per vanadium, wherein the NaVOPO4 is formed by a solid phase synthesis process from a heated powdered mixture of ammonium metavanadate, ammonium phosphate monobasic, and potassium carbonate, to yield KVOPO4 having corner-sharing VO6 octahedra and PO4 tetrahedra, defining two types of tunnels comprising a first type of tunnel formed of rings of two PO4 tetrahedra and a second type of tunnel formed of rings of three PO4 tetrahedra and three VO6 octahedra, followed by substitution of the potassium ions with sodium ions.
    Type: Grant
    Filed: June 26, 2017
    Date of Patent: March 29, 2022
    Assignee: The Research Foundation for The State University of New York
    Inventors: M. Stanley Whittingham, Jia Ding