Abstract: The present invention provides a compound which is a class-lla histone deacetylases (HDAC) inhibitor, a process of making the compound, a composition containing the compound and radiolabeling the compound for use in positron emission tomography (PET) imaging, said compound having the structure:

Abstract: The exemplary system, method, and computer-accessible medium for generating a multiclass image segmentation model(s) can include receiving multiple single-class image datasets, receiving a target mask for each of the single-class image datasets, receiving a condition of an object associated with each of the single-class image datasets, and generating the multiclass image segmentation model(s) based on the single-class image datasets, the target masks, and the identification of the target objects. The single-class image datasets can include computer tomography images of abdominal organs. The single-class image datasets can be non-overlapping single-class image datasets. The single-class image datasets can include medical imaging datasets or cityscape datasets.

Abstract: A hybrid radiating element may comprise a dielectric substrate having a thickness, a top surface and a bottom surface, and an electrically conductive patch disposed on the top surface of the dielectric substrate. The hybrid radiating element may further comprise a graphene stub disposed on the top surface of the dielectric substrate. The graphene stub may be contiguous with, and electrically coupled to, the electrically conductive patch. The hybrid radiating element may further comprise an electrically conductive layer disposed on the bottom surface of the dielectric substrate. An array of hybrid radiating elements may be arranged in a grid pattern of M rows and N columns. A codebook set of biasing voltages may be arranged to drive the radiating elements in the array as a phase transformation matrix, thereby manipulating the reflection of an incoming electromagnetic wave.

Abstract: Detection of synthetic content in portrait videos, e.g., deep fakes, is achieved. Detectors blindly utilizing deep learning are not effective in catching fake content, as generative models produce realistic results. However, biological signals hidden in portrait videos which are neither spatially nor temporally preserved in fake content, can be used as implicit descriptors of authenticity. 99.39% accuracy in pairwise separation is achieved. A generalized classifier for fake content is formulated by analyzing signal transformations and corresponding feature sets. Signal maps are generated, and a CNN employed to improve the classifier for detecting synthetic content. Evaluation on several datasets produced superior detection rates against baselines, independent of the source generator, or properties of available fake content.

Abstract: A method, system and apparatus are provided for estimating at least one characteristic of a wireless communication channel between at least two passive backscattering radio frequency (RF) nodes, the method including measuring backscatter channel state information (BCSI) during communication between the at least two passive RF nodes; estimating, by at least one RF node of the at least two passive RF nodes, the at least one characteristic of the wireless communication channel based on the measured BCSI.

Abstract: The disclosure relates to enhancing alkalinity of brine, e.g. seawater, using bipolar membrane electrodialysis (BPMED) without removing divalent cations that otherwise cause scaling. In one embodiment, a BPMED is employed wherein the brine volumetric flow rate through a basification compartment is greater at a given current density than that through a brine compartment which increases the pH of the brine output while keeping it below the precipitation pH. In one embodiment, the spacer located in the basification compartment is thicker than spacers elsewhere in the BPMED so as resist membrane distortion due to the increased hydrostatic pressure in the basification compartment given the greater volumetric flow. The brine output having increased alkalinity can be returned to the ocean to mitigate acidification and enable capture of atmospheric carbon dioxide.

Abstract: A bidirectional AC power converter, having a front-end comprising parallel sets of three switches in series, which connects multi-phase AC to coupling transformer through a first set of tank circuits, for synchronously bidirectionally converting electrical power between the multi-phase AC and a DC potential, and for converting electrical power between the DC potential to a bipolar electrical signal at a switching frequency, controlled such that two of each parallel set of three switches in series are soft-switched and the other switch is semi-soft switched; the coupling transformer being configured to pass the bipolar electrical power at the switching frequency through a second set of the tank circuits to a synchronous converter, which in turn transfers the electrical power to a secondary system at a frequency different from the switching frequency.

Abstract: A microelectromechanical actuator, comprising: a substrate, having a surface; a conductive beam suspended parallel to the substrate, displaceable along an axis normal to the surface of the substrate; a center electrode on the substrate under the beam; a pair of side electrodes on the substrate configured, when charged, to exert an electrostatic force normal to the surface of the substrate on the beam that repulses the beam from the substrate, and exerts a balanced electrostatic force on the beam in a plane of the surface of the substrate, the center conductive electrode being configured to shield the beam from electrostatic forces induced by the side electrodes from beneath the beam, and the center electrode being configured to have a voltage different from a voltage on the beam, to thereby induce an attractive electrostatic force on the beam.

Abstract: Systems and methods for live updating virtualization systems are disclosed. One method may include identifying a container on a first virtual machine of a virtualization system. The container may include at least one process associated with performing a task on a first virtual machine. The method may also include determining a first communication path between the process included in the container on the first virtual machine and a hypervisor of the virtualization system, and migrating the container and the process included in the container to a second virtual machine. The second virtual machine may be distinct from the first virtual machine. Additionally, the method may include determining a second communication path between the process included in the migrated container on the second virtual machine and the hypervisor of the virtualization system.

Abstract: Described herein are peptides that can be used to treat pain or increase pain sensitivity in subject in need of treatment. Additionally, peptides of the present disclosure can be administered with an analgesic agent and/or anesthetic agent. Peptides of the present disclosure are suitable for use when a subject in need of treatment has an injury, a chronic disease, a chronic inflammation, Morton's neuroma, operative/post-operative pain, or a combination thereof.

Abstract: A composition comprising a polypeptide ligated to an oligonucleotide through a sterol linker. A method of ligating a polypeptide to an oligonucleotide, comprising a polypeptide having a hedgehog steroyl transferase catalytic domain at the C-terminal of the polypeptide with an electrophilic residue, e.g., glycine, between polypeptide and the hedgehog steroyl transferase catalytic domain, and a steroylated oligonucleotide in solution, and permitting a reaction to cleave the hedgehog steroyl transferase catalytic domain from the polypeptide while ligating the steroylated oligonucleotide to the glycine at the C-terminal of the polypeptide. The oligonucleotide may be, for example, a therapeutic, diagnostic, or affinity ligand.

Abstract: Provided herein are nucleic acid-based nanoswitches that can detect specific nucleic acids and other analytes types by for example a simple gel electrophoresis readout. Binding of the target to the nanoswitches induces a conformation change from a linear, open conformation to a looped, closed conformation. These nanoswitches may be used in diagnostic assays such as nucleic acid-based diagnostic assays, to detect, measure and/or purify a variety of targets including low abundance targets.

Abstract: Disclosed is an RFID antenna including: a central inductive circuit; and at least two lobes extending radially from the central inductive circuit.

Abstract: Mixed-phase TiO2 nanofibers prepared via a sol-gel technique followed by electrospinning and calcination are provided as photocatalysts. The calcination temperature is adjusted to control the rutile phase fraction in TiO2 nanofibers relative to the anatase phase. Post-calcined TiO2 nanofibers composed of 38 wt % rutile and 62 wt % anatase exhibited the highest initial rate constant of UV photocatalysis. This can be attributed to the combined influences of the fibers' specific surface areas and their phase compositions.

Abstract: A system and method for monitoring and analyzing activities of a person operating a machine, particularly driving a vehicle, is provided. A first magnet is attached to a hand of the person and a second magnet is attached to the head of the person. A smart watch having a magnetometer is attached to the other hand of the person. The magnetometer is in magnetic communication with both the first magnet and the second magnet to generate a first magnetic signal and a second magnetic signal. Both signals can be received by a processor and applied to mathematical models by the processor to generate indicators representative of positions and motions of the hands and the head. An alarm can be generated based on the indicators.

Abstract: The present invention provides a method of inhibiting release of a virus from a cell, comprising contacting the cell with a compound that binds an ubiquitin E2 variant (UEV) domain of a cellular polypeptide, or fragment thereof, with an affinity sufficient to inhibit or disrupt the binding of the cellular polypeptide, or fragment thereof, to ubiquitin.

Abstract: A secure processor, comprising a logic execution unit configured to process data based on instructions; a communication interface unit, configured to transfer of the instructions and the data, and metadata tags accompanying respective instructions and data; a metadata processing unit, configured to enforce specific restrictions with respect to at least execution of instructions, access to resources, and manipulation of data, selectively dependent on the received metadata tags; and a control transfer processing unit, configured to validate a branch instruction execution and an entry point instruction of each control transfer, selectively dependent on the respective metadata tags.

Abstract: A solid-state photomultiplier with a high-k dielectric hole blocking layer (HBL) is provided. The HBL may include a n-type material. The photomultiplier may comprise an amorphous selenium (a-Se) bulk layer. The HBL may be a non-insulating layer. The photomultiplier may also comprise an electron blocking layer (EBL). The EBL may comprise a p-type material. The p-type material may also have a high k dielectric. The a-Se layer may be sandwiched between the HBL and the EBL. Methods for manufacturing a solid-state photomultiplier are also provided.

Abstract: Described herein are RSV polynucleotide sequences that make use of multiple codons that are containing silent nucleotide substitutions engineered in multiple locations in the genome, wherein the substitutions introduce a numerous synonymous codons into the genome. Due to the large number of defects involved, the attenuated viruses disclosed herein provide a means of producing attenuated, live vaccines against RSV.

Abstract: There are approximately 35,000 abandoned and unplugged oil and gas wells in New York with no known location. Unplugged wells emit methane, a strong greenhouse gas, which has the potential to significantly contribute to global climate change and act as a pollutant chemical. A long-range UAV equipped with methane sensors, MagPike (atomic magnetometer), and LiDAR sensors successfully detected unmarked well sites using characteristic magnetic signals generated by vertical metal piping preserved in the ground. The optimal flight altitude and transect spacing was determined for detection driven by the total field strength of the Earth's magnetic field and the height of tree canopies determined by LiDAR. Traditional methods of identifying oil and gas wells are costly and less powerful in acquisition of data such as using large magnetometers attached to helicopters.