Abstract: The invention provides compounds of formula (I): and salts thereof wherein ring A, R2, HET, X, n, and R3 have any of the meanings described in the specification, as well as compositions comprising such compounds and salts, and methods for treating cancer using such compounds and salts.

Abstract: A substrate subject to degradation at temperatures above 100° C. is coated with a nanostructured ceramic coating having a thickness in excess of 100 nm, formed on a surface of the substrate, wherein a process temperature for deposition of the nanostructured coating does not exceed 90° C. The coating may be photocatalytic, photovoltaic, or piezoelectric. The coating, when moistened and exposed to ultraviolet light or sunlight, advantageously generates free radicals, which may be biocidal, deodorizing, or assist in degradation of surface deposits on the substrate after use. The substrate may be biological or organic, and may have a metallic or conductive intermediate layer.

Abstract: A photonic structure can include in one aspect one or more waveguides formed by patterning of waveguiding material adapted to propagate light energy. Such waveguiding material may include one or more of silicon (single-, poly-, or non-crystalline) and silicon nitride.

Abstract: A system and method of scheduling tasks, comprising receiving activity and performance data from registers or storage locations maintained by hardware and an operating system; storing calibration coefficients associated with the activity and performance data; computing an energy dissipation rate based on at least the activity and performance data; and scheduling tasks under the operating system based on the computed energy dissipation rate.

Abstract: Provided is a field shaping multi-well photomultiplier and method for fabrication thereof. The photomultiplier includes a field-shaping multi-well avalanche detector, including a lower insulator, an a-Se photoconductive layer and an upper insulator. The a-Se photoconductive layer is positioned between the lower insulator and the upper insulator. A light interaction region, an avalanche region, and a collection region are provided along a length of the photomultiplier, and the light interaction region and the collection region are positioned on opposite sides of the avalanche region.

Abstract: A method for delivering therapeutic radiation to a target includes positioning a multi-aperture collimator on the skin within a trajectory of orthovoltage x-rays directed at the target, thus generating an array of minibeams, each of width between 0.1 mm to 0.6 mm. The skin is irradiated with the array. An effective beam of therapeutic radiation, which may be a solid beam, is delivered to the target at a predetermined tissue depth by merging adjacent orthovoltage x-ray minibeams sufficiently to form the effective beam. The effective beam may be formed proximal to the target. The depth at which the effective, preferably, solid, beam is formed is controlled by varying one or more of the spacing of the minibeams in the array, the minibeam width, the distance from the x-ray source to the collimator, and the x-ray source spot size. Planar minibeams can be arc-scanned while continuously modulating beam shape and intensity.

Abstract: The present application provides a wireless power transfer system including a transmitter and at least one receiver, and also provides transmitters and receivers for such systems. The transmitter includes a driver coil and a transmitter coil magnetically coupled to each other and arranged along a plane, the driver coil and the transmitter coil being tuned to resonate at differing frequencies. The receiver includes a load coil and a receiver coil magnetically coupled to each other and arranged along a plane, the load coil and the receiver coil being tuned to resonate at differing frequencies. The driver coil and the transmitter coil of the transmitter, and the load and the transmitter coil of the receiver are strongly magnetically coupled to each other. The transmitter and the receiver are magnetically coupled to each to effectuate wireless power transfer from the transmitter to the receiver.

Abstract: Disclosed is an RNA aptamer, a synthetic oligonucleotide of 2?-fluoro-modified A, U, and C nucleotides, with improved stability compared to its unmodified counterpart. Like the unmodified aptamer, however, the modified version is a potent glutamate receptor antagonist. Additionally, the RNA aptamers described herein are water soluble by nature, and generally exhibit nano- to micromolar potency making them potential therapeutic agents for the treatment of neurological disorders involving glutamate receptor activity.

Abstract: There is set forth herein a method including depositing a layer formed of barrier material over a conductive material formation of a photonics structure; and removing material of the layer in a light signal transmitting region of the photonics structure. In one embodiment the barrier material can include silicon carbon nitride. In one embodiment the barrier material can include silicon nitride.

Abstract: Provided is a method of reducing autoimmunity, including reducing an amount of self-reactive B cells in a subject expressing elevated levels of an autoantibody, wherein reducing includes administering 2-hydroxyoleic acid to the subject. Also provided is a method of treatment including administering 2-hydroxyoleic acid to a subject expressing elevated levels of an auto-antibody. Also provided is a method of promoting B cell tolerance, including promoting apoptosis of self-reactive B cells in a subject, wherein promoting includes administering 2-hydoxyoleic acid to the subject.

Abstract: An optoelectronic semiconductor light source includes a semiconductor chip configured to emit primary radiation, a Bragg mirror, and a luminescence conversion element configured to convert at least part of the primary radiation into secondary radiation having a longer wavelength, wherein the Bragg mirror is arranged between the semiconductor chip and the luminescence conversion element, the Bragg mirror is reflective for the secondary radiation and transmissive for the primary radiation, the Bragg mirror includes reflector layers of at least three different materials with different refractive indices, the Bragg mirror includes at least two different kinds of layer pairs, each kind of layer pairs being made up of reflective layers of two different materials, and the different kinds of layer pairs having different Brewster angles for p-polarized radiation.

Abstract: The present invention provides a method of producing ternary metal-based nanowire networks. The method comprises combining an aqueous mixture of a platinum hydrate, a ruthenium hydrate, and an iron hydrate with a solution of hexadecyltrimethylammonium bromide in chloroform to form an inverse micellar network; adding a reducing agent to reduce metal ions within the inverse micellar network; and isolating the nanowires. The relative amounts of the platinum, ruthenium and iron in the mixture correlate to the atomic ratio of the platinum, ruthenium and iron in the ternary nanowires. The diameters of the ternary nanowires are from about 0.5 nm to about 5 nm.

Abstract: The present invention relates to a method of determining the age of a body fluid stain in a sample. This method involves providing the sample containing a body fluid stain; providing a statistical model for determination of the age of the body fluid stain in the sample; subjecting the sample or an area of the sample containing the stain to a spectroscopic analysis to produce a spectroscopic signature for the sample; and applying the spectroscopic signature for the sample to the statistical model to ascertain the age of the body fluid stain in the sample. A method of establishing a statistical model for determination of the age of a body fluid stain in a sample is also disclosed.

Abstract: A system and method for detecting a suspicious object, including a wireless signal transmitter with first and second transmitter antennas, a first wireless signal receiver on an opposite side of the object from the transmitter having first and second receiver antennas, and a second wireless signal receiver on a same side of the object as the transmitter having a third receiver antenna. The transmitter may emit wireless signals from each of the transmitter antennas. The signals emitted by the first transmitter antenna may be received at the first and second receiver antennas. The signals emitted by both transmitter antennas may be received at the third receiver antenna. The object's material type may be determined based on channel state information of the wireless signals received at first receiver. A size of the object may be determined based on channel state information of the wireless signals received at the second receiver.

Abstract: A method of forming a microphase separated block copolymer includes exposing a block copolymer to acid vapor under conditions effective to provide the microphase separated block copolymer. The block copolymer includes a first hydrophobic block and a second hydrophobic block that is acid-sensitive. The microphase separated block copolymer includes the first hydrophobic block and a hydrophilic block derived from the second hydrophobic block. Exposing the block copolymer to the acid vapor is conducted in the solid state.

Abstract: The present disclosure is directed to a surgical device and method of using the same. The surgical device includes a proximal ring, a distal ring, wherein the distal ring is operably connected to the proximal ring with a sleeve, the sleeve extending about a circumference of the proximal ring and a circumference of the distal ring, a film, a distal end of the film attached to a portion of the distal ring, wherein the film is configured to extend past the sleeve and past the distal ring, and wherein a proximal portion of the film comprises an opening and a channel and a draw string extending through the channel and exposed to an exterior of the device through the opening.

Abstract: A system of sensors associated with a branched conductor of an AC power line using the conductor as the communication medium between different sensors. The communication is carried out at frequencies higher than the powerline frequency. At least one sensor is provided in every branch in the vicinity of every branching point of the conductor. Synchronous measurements are carried out of the root mean square current passing through every branch of the conductor and the direction of energy flow in the branch. Results of the measurements are regularly reported throughout the system. An arrangement is provided for analyzing the results of the measurements to determine the graph topology of the branched conductor and ascertain the distribution of the root mean square current passing through every branch of the graph.

Abstract: Provided are macrocyclic compounds having one or more transmembrane segment-thermoresponsive segment moiety. Also provided are dimers comprising two macrocyclic units, which have one or more transmembrane segment-thermoresponsive segment moiety, joined by one or more crosslinking moieties. The macrocyclic compounds and macrocyclic units have a macrocyclic backbone comprise alternating alpha amino acid and meta-aminobenzoic acid moieties. The macrocyclic compounds and dimers can be used to deliver a cargo (e.g., cell-interacting agents such as, for example, drugs and cryoprotectants) to, for example, an organ, tissue, or an individual, A cargo may be encapsulated in lipid vesicles.

Abstract: A polymeric valve which may include a heart valve, and also may include a trileaflet heart valve includes a stent having a base and a plurality of outwardly extending posts from the base and equidistant from each other. A plurality of leaflets each connected to a corresponding one of the posts at one end, and each of the leaflets connected to the base. Each of the leaflets having an operative end opposite the end connected to the post, and the operative ends of the leaflets being biased in a closed position such that the operative ends abut each other. The operative ends are configured to rhythmically open and close in relation to each other, and the leaflets include multiple cross sectional thicknesses at different portions of the leaflets.

Abstract: Optoelectronic devices that use very thin single-crystalline inorganic semiconductor films as phonon-absorbing layers in combination with non-lattice optical cavities are provided.