Patents Assigned to The Rockefeller University
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Patent number: 12012451Abstract: The disclosure is directed to a histidine-mutated anti-HIV antibody having one or more mutations at the residue Y53a, D58, K96, D97, N98, or T100a in the heavy chain of ibalizumab, and at the residue S26, L30, L33, Q89, Y92, S93 or Y94 in the light chain of ibalizumab. In addition, the disclosure also is directed to two histidine mutated variants with two mutations, one with mutations at the residues Y53a and Y94, and the other with mutations at the residues D58 and L30 in the heavy and light chains of ibalizumab, respectively.Type: GrantFiled: August 19, 2020Date of Patent: June 18, 2024Assignee: The Rockefeller UniversityInventors: Craig Stuart Pace, David D. Ho
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Patent number: 12005265Abstract: The present invention provides methods and compositions for the remote control of cell function based on the use of a magnetic field to excite paramagnetic nanoparticles targeted to specific cell types. The cell type of interest expresses an ion channel wherein excitation of the paramagnetic nanoparticles results in a physical change that is transduced into a cellular response. Such cellular responses may include, for example, increases in gene expression resulting in production of one or more physiologically active proteins. The expression of such proteins can be used to treat a variety of different inherited or acquired diseases or disorders in a subject.Type: GrantFiled: August 6, 2020Date of Patent: June 11, 2024Assignees: THE ROCKEFELLER UNIVERSITY, RENSSELAER POLYTECHNIC INSTITUTEInventors: Sarah Stanley, Jeffrey Friedman, Jonathan S. Dordick, Jeremy Sauer
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Publication number: 20240187748Abstract: A volumetric imaging system implements obtaining raw image data of a sample volume of a sample material, the raw image data comprising light field data of the sample volume acquired using a microlens array disposed in front of a camera; and analyzing the raw image data using an image analysis pipeline configured to localize the objects of interest in the raw image data to obtain classified image data in which the objects of interest have been identified, the image analysis pipeline being configured to process the raw image data to improve signal extraction at depth in the scattering material to maximize localization accuracy.Type: ApplicationFiled: April 20, 2022Publication date: June 6, 2024Applicant: The Rockefeller UniversityInventors: Alipasha VAZIRI, Tobias NOEBAUER, Yuanlong ZHANG
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Publication number: 20240159674Abstract: A multi-photon imaging system includes a laser module having a first channel for outputting a two-photon excitation laser pulse and a second channel for outputting a three-photon excitation laser pulse. The system further includes a first optical path for guiding the two-photon laser pulse from the first channel of the laser module and a second optical path for guiding the three-photon laser pulse from the second channel of the laser module. A microscope is also provided for simultaneously receiving the two-photon laser pulse from the first optical path and the three-photon laser pulse from the second optical path, and simultaneously, or with well controllable delays, delivering the two-photon laser pulse and the three-photon pulse to a target volume. The system further includes a photodetector configured to collect photons generated within the target volume in response to simultaneous excitation of the target volume by both the two-photon laser pulse and the three-photon laser pulse.Type: ApplicationFiled: October 2, 2023Publication date: May 16, 2024Applicant: The Rockefeller UniversityInventors: Alipasha VAZIRI, Siegfried WEISENBURGER
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Publication number: 20240150439Abstract: This disclosure provides novel broadly neutralizing anti-SARS-CoV-2 antibodies or antigen-binding fragments thereof. The disclosed anti-SARS-CoV-2 antibodies constitute a novel therapeutic strategy in protection from SARS-CoV-2 infections.Type: ApplicationFiled: April 24, 2023Publication date: May 9, 2024Applicant: The Rockefeller UniversityInventors: Michel Nussenzweig, Davide F. Robbiani
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Patent number: 11931164Abstract: An optical system for the detection of skin disease, such as melanoma, acquires images of a lesion on a subject's skin at different wavelengths and utilizes a sweeping arm rotating about the lesion in a clock-like sweep to produce diagnostically relevant metrics and classifiers from the image data so as to enhance detection of the skin disease.Type: GrantFiled: January 24, 2023Date of Patent: March 19, 2024Assignee: THE ROCKEFELLER UNIVERSITYInventor: Daniel Gareau
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Patent number: 11918631Abstract: Provided are compositions and methods for selectively reducing the amount of antibiotic resistant and/or virulent bacteria in a mixed bacteria population, or for reducing any other type of unwanted bacteria in a mixed bacteria population. The compositions and methods involve targeting bacteria that are differentiated from other members of the population by at least one unique clustered regularly interspaced short palindromic repeats (CRISPR) targeted DNA sequence. The compositions and methods can be readily adapted to target any bacteria or any bacteria plasmid, or both.Type: GrantFiled: May 20, 2016Date of Patent: March 5, 2024Assignee: THE ROCKEFELLER UNIVERSITYInventors: David Bikard, Luciano Marraffini
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Patent number: 11919945Abstract: This disclosure provides novel broadly neutralizing anti-SARS-CoV-2 antibodies or antigen-binding fragments thereof. The disclosed anti-SARS-CoV-2 antibodies constitute a novel therapeutic strategy in protection against SARS-CoV-2 infections.Type: GrantFiled: November 4, 2021Date of Patent: March 5, 2024Assignee: The Rockefeller UniversityInventor: Michel Nussenzweig
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Patent number: 11897940Abstract: This invention relates to broadly neutralizing and potent anti-HIV-1 antibodies, kits, and methods of use thereof.Type: GrantFiled: March 30, 2022Date of Patent: February 13, 2024Assignees: THE ROCKEFELLER UNIVERSITY, CALIFORNIA INSTITUTE OF TECHNOLOGYInventors: Michel Nussenzweig, Natalia T. Freund, Pamela J. Bjorkman, Louise Scharf
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Patent number: 11865094Abstract: The present invention discloses novel agents and methods for diagnosis and treatment of melanoma. Also disclosed are related arrays, kits, and screening methods.Type: GrantFiled: March 15, 2021Date of Patent: January 9, 2024Assignee: The Rockefeller UniversityInventors: Sohail Tavazoie, Nora Pencheva
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Publication number: 20240002480Abstract: This disclosure provides novel broadly neutralizing anti-tick-borne encephalitis virus (TBEV) antibodies. The disclosed anti-TBEV antibodies represent a novel therapeutic strategy for preventing or treating diseases or infections caused by various tick-borne flaviviruses, including TBEV.Type: ApplicationFiled: November 23, 2021Publication date: January 4, 2024Applicant: The Rockefeller UniversityInventors: Michel Nussenzweig, Davide F. Robbiani
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Patent number: 11827911Abstract: The present description relates to chimeric bacteriophage lysins useful for the identification and/or reduction of staphylococcal populations. For example, a chimeric bacteriophage lysin was engineered and shown to effectively kill all strains of staphylococci tested including antibiotic resistant methicillin-resistant S. Aureus and VISA.Type: GrantFiled: May 24, 2021Date of Patent: November 28, 2023Assignee: The Rockefeller UniversityInventors: Vincent A Fischetti, Anu Daniel, Chad Euler
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Publication number: 20230365661Abstract: The invention provides broadly neutralizing antibodies directed to epitopes of Human Immunodeficiency Virus, or HIV. The invention further provides compositions containing HIV antibodies used for prophylaxis, and methods for diagnosis and treatment of HIV infection.Type: ApplicationFiled: February 22, 2023Publication date: November 16, 2023Applicants: The Rockefeller University, California Institute of TechnologyInventors: Johannes Scheid, Michel Nussenzweig, Pamela J. Bjorkman, Ron Diskin
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Patent number: 11808702Abstract: A multi-photon imaging system includes a laser module having a first channel for outputting a two-photon excitation laser pulse and a second channel for outputting a three-photon excitation laser pulse. The system further includes a first optical path for guiding the two-photon laser pulse from the first channel of the laser module and a second optical path for guiding the three-photon laser pulse from the second channel of the laser module. A microscope is also provided for simultaneously receiving the two-photon laser pulse from the first optical path and the three-photon laser pulse from the second optical path, and simultaneously, or with well controllable delays, delivering the two-photon laser pulse and the three-photon pulse to a target volume. The system further includes a photodetector configured to collect photons generated within the target volume in response to simultaneous excitation of the target volume by both the two-photon laser pulse and the three-photon laser pulse.Type: GrantFiled: January 30, 2020Date of Patent: November 7, 2023Assignee: The Rockefeller UniversityInventors: Alipasha Vaziri, Siegfried Weisenburger
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Publication number: 20230338505Abstract: The present invention relates to immunogenic immune complexes, related compositions, and related methods.Type: ApplicationFiled: May 18, 2023Publication date: October 26, 2023Applicant: The Rockefeller UniversityInventors: Jeffrey V. Ravetch, Taia Wang, Jad Mamaary
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Publication number: 20230338314Abstract: The invention features methods of treating disorders related to increased levels of myeloid derived suppressor cells such as cancer or infections. The disclosure also provides methods of treating cancer including combinations of LXR? agonists and immunotherapies such as PD1 inhibitors, PDL1 inhibitors, and adoptive T-cell transfer therapy.Type: ApplicationFiled: May 3, 2023Publication date: October 26, 2023Applicant: The Rockefeller UniversityInventors: Sohail Tavazoie, Masoud Tavazoie
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Publication number: 20230331824Abstract: Single-domain antibodies that bind the severe acute respiratory syndrome corona virus 2 (SARS-CoV-2) spike protein are disclosed. The single-domain antibodies include binding domains that bind epitopes of the Spike ectodomain inside and outside the receptor binding domain. The single-domain antibodies can be used for multiple purposes including in the research, diagnosis, and prophylactic or therapeutic treatment of COVID-19.Type: ApplicationFiled: August 20, 2021Publication date: October 19, 2023Applicants: The Rockefeller University, Seattle Children's Hospital d/b/a Seattle Children's Research Institute, New York UniversityInventors: Brian T. Chait, Michael P. Rout, John Aitchison, Fred David Mast, Jean Paul Olivier, David Fenyo
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Publication number: 20230295306Abstract: This invention concerns anti-inflammatory agents, compositions, and methods for treating inflammatory disorders.Type: ApplicationFiled: February 22, 2023Publication date: September 21, 2023Applicant: The Rockefeller UniversityInventors: Jeffrey V. Ravetch, Andrew Pincetic
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Patent number: 11760805Abstract: Provided herein are agonistic antibodies, or antigen binding portions thereof, that bind to human CD40. Such antibodies optionally comprise Fc regions with enhanced specificity for Fc?RIIb. The invention also provides methods of treatment of cancer or chronic infection by administering the antibodies of the invention to a subject in need thereof.Type: GrantFiled: January 15, 2021Date of Patent: September 19, 2023Assignee: THE ROCKEFELLER UNIVERSITYInventors: Jeffrey V. Ravetch, Rony Dahan
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Publication number: 20230279082Abstract: The present invention relates to anti-HIV antibodies. Also disclosed are related methods and compositions. HIV causes acquired immunodeficiency syndrome (AIDS), a condition in humans characterized by clinical features including wasting syndromes, central nervous system degeneration and profound immunosuppression that results in life-threatening opportunistic infections and malignancies. Since its discovery in 1981, HIV type 1 (HIV-1) has led to the death of at least 25 million people worldwide.Type: ApplicationFiled: April 7, 2023Publication date: September 7, 2023Applicants: The Rockefeller University, California Institute of TechnologyInventors: Hugo Mouquet, Michel Nussenzweig, Pamela J. Bjorkman, Louise Scharf