Patents Assigned to The Rockefeller University
  • Patent number: 10973904
    Abstract: The present invention relates to immunogenic immune complexes, related compositions, and related methods.
    Type: Grant
    Filed: May 10, 2019
    Date of Patent: April 13, 2021
    Assignee: The Rockefeller University
    Inventors: Jeffrey V. Ravetch, Taia Wang, Jad Mamaary
  • Patent number: 10968443
    Abstract: The disclosure provides methods for isolating nucleic acids from a biological fluid. In one aspect, the disclosure provides a method for isolating RNA. In another aspect, the disclosure provides a method for isolating DNA. In one aspect, the methods described herein utilize a protocol that combines a detergent-based initial denaturation, protease digestion, and organic extraction followed by column purification that maximizes RNA/DNA yield and preserves RNA/DNA integrity. In yet another aspect, the disclosure provides a kit for isolating RNA and/or DNA.
    Type: Grant
    Filed: December 31, 2015
    Date of Patent: April 6, 2021
    Assignee: THE ROCKEFELLER UNIVERSITY
    Inventors: Klaas Max, Karl Bertram, Kemal Akat, Thomas H. Tuschl, Jenny Li, Kimberly Bogardus
  • Patent number: 10945978
    Abstract: The present invention discloses novel agents and methods for diagnosis and treatment of melanoma. Also disclosed are related arrays, kits, and screening methods.
    Type: Grant
    Filed: December 23, 2019
    Date of Patent: March 16, 2021
    Assignee: The Rockefeller University
    Inventors: Sohail F. Tavazoie, Nora Pencheva
  • Patent number: 10947546
    Abstract: Methods and compositions are provided for translational profiling and molecular phenotyping of specific tissues, cells and cell subtypes of interest. The methods provided herein facilitate the analysis of gene expression in the selected subset present within a heterogeneous sample.
    Type: Grant
    Filed: September 29, 2017
    Date of Patent: March 16, 2021
    Assignee: The Rockefeller University
    Inventors: Nathanial Heintz, Paul Greengard, Myriam Heiman, Anne Schaefer, Joseph P. Doyle, Joseph D. Dougherty
  • Publication number: 20210074378
    Abstract: Processes to identify variants that affect biochemical regulation are described. Generally, models are used to identify variants that affect biochemical regulation, which can be used in several downstream applications. A pathogenicity of identified variants is also determined in some instances, which can also be used in several. Various methods further develop research tools, perform diagnostics, and treat individuals based on identified variants.
    Type: Application
    Filed: January 28, 2019
    Publication date: March 11, 2021
    Applicants: The Trustees of Princeton University, The Simons Foundation, Inc., The Rockefeller University
    Inventors: Jian Zhou, Christopher Y. Park, Chandra Theesfeld, Robert B. Darnell, Olga G. Troyanskaya
  • Publication number: 20210045387
    Abstract: The present invention generally relates to compositions and methods for inhibiting host-seeking behavior, blood-feeding, and biting in blood-feeding arthropods. The present invention also generally relates to compositions and methods for inhibiting the attraction of blood-feeding arthropods to a host. More particularly, the present invention relates to compositions and methods for inhibiting the host-seeking behavior and biting of mosquitos and inhibiting their attraction to humans.
    Type: Application
    Filed: August 14, 2020
    Publication date: February 18, 2021
    Applicant: The Rockefeller University
    Inventors: Leslie VOSSHALL, Laura B. DUVALL
  • Publication number: 20210033843
    Abstract: An imaging signal extraction apparatus comprising: an interface; a processing device, the processing device operatively coupled to the interface; and a computer readable medium comprising instructions that, when executed by the processing device, perform operations comprising: a) generating a two-dimensional image from imaging information obtained from the interface, thereby estimating ballistic component of the imaging information; b) generating a three-dimensional image by remapping the two-dimensional image; c) identifying a candidate object in the three-dimensional image; d) obtaining an estimated spatial forward model of the candidate object by mapping the three-dimensional image of the candidate object with a point-spread-function associated with the imaging apparatus; e) obtaining background-corrected data by using the estimated spatial forward model of the candidate object and estimated temporal components; and f) iteratively updating the estimated spatial forward model and estimated temporal componen
    Type: Application
    Filed: October 7, 2020
    Publication date: February 4, 2021
    Applicant: The Rockefeller University
    Inventors: Alipasha Vaziri, Tobias NOEBAUER, Oliver SKOCEK
  • Patent number: 10894835
    Abstract: Provided herein are agonistic antibodies, or antigen binding portions thereof, that bind to human CD40. Such antibodies optionally comprise Fc regions with enhanced specificity for Fc?RIIb. The invention also provides methods of treatment of cancer or chronic infection by administering the antibodies of the invention to a subject in need thereof.
    Type: Grant
    Filed: June 28, 2016
    Date of Patent: January 19, 2021
    Assignee: The Rockefeller University
    Inventors: Jeffrey V. Ravetch, Rony Dahan
  • Patent number: 10894832
    Abstract: This invention concerns anti-inflammatory agents, compositions, and methods for treating inflammatory disorders.
    Type: Grant
    Filed: December 18, 2017
    Date of Patent: January 19, 2021
    Assignee: The Rockefeller University
    Inventors: Jeffrey V. Ravetch, Andrew Pincetic
  • Patent number: 10894989
    Abstract: This invention concerns pathological angiogenesis and cancer, related treatment methods, and related compositions. Also disclosed are related diagnosis kits and methods.
    Type: Grant
    Filed: May 17, 2019
    Date of Patent: January 19, 2021
    Assignee: The Rockefeller University
    Inventors: Sohail Tavazoie, Nils Halberg, Kim Png
  • Patent number: 10889633
    Abstract: The invention provides broadly neutralizing antibodies directed to epitopes of Human Immunodeficiency Virus, or HIV. The invention further provides compositions containing HIV antibodies used for prophylaxis, and methods for diagnosis and treatment of HIV infection.
    Type: Grant
    Filed: September 29, 2017
    Date of Patent: January 12, 2021
    Assignees: The Rockefeller University, California Institute of Technoloqy
    Inventors: Johannes Scheid, Michel Nussenzweig, Pamela J. Bjorkman, Ron Diskin
  • Patent number: 10882917
    Abstract: The present invention relates to anti-tumor agents that target certain tumor-associated macrophages. Also disclosed are methods of using such agents in treatment of cancer.
    Type: Grant
    Filed: June 1, 2016
    Date of Patent: January 5, 2021
    Assignee: The Rockefeller University
    Inventors: Mikael Karlsson, Jeffrey V. Ravetch
  • Patent number: 10870853
    Abstract: The invention is directed to compositions and methods for treating or reducing the likelihood of the development of epilepsy in an individual. The method comprises administering to the central nervous system of an individual in need of such treatment a therapeutically effective amount of an agent capable of increasing the expression and/or activity of miR-128.
    Type: Grant
    Filed: October 1, 2018
    Date of Patent: December 22, 2020
    Assignees: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, THE ROCKEFELLER UNIVERSITY
    Inventors: Anne Schaefer, Paul Greengard
  • Publication number: 20200389425
    Abstract: The invention provides for delivery, engineering and optimization of systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are delivery systems and tissues or organ which are targeted as sites for delivery. Also provided are vectors and vector systems some of which encode one or more components of a CRISPR complex, as well as methods for the design and use of such vectors. Also provided are methods of directing CRISPR complex formation in eukaryotic cells to ensure enhanced specificity for target recognition and avoidance of toxicity and to edit or modify a target site in a genomic locus of interest to alter or improve the status of a disease or a condition.
    Type: Application
    Filed: August 25, 2020
    Publication date: December 10, 2020
    Applicants: The Broad Institute, Inc., Massachusetts Institute of Technology, The Rockefeller University
    Inventors: Sangeeta Bhatia, Charles Rice, Feng Zhang, David Benjamin Turitz Cox, Vyas Ramanan, Robert Schwartz, Amir Shlomai
  • Patent number: 10851167
    Abstract: This invention concerns anti-inflammatory agents, compositions, and methods for treating inflammatory disorders.
    Type: Grant
    Filed: December 18, 2017
    Date of Patent: December 1, 2020
    Assignee: The Rockefeller University
    Inventors: Jeffrey V. Ravetch, Andrew Pincetic
  • Publication number: 20200369677
    Abstract: Pyranoyrazoles and pyrazolopyridines of formula I or formula II are disclosed: These compounds inhibit Coagulation Factor XIIa in the presence of thrombin and other coagulation factors. They are useful to treat autoimmune diseases.
    Type: Application
    Filed: November 28, 2018
    Publication date: November 26, 2020
    Applicant: The Rockefeller University
    Inventors: Manish P. PONDA, Harold SELNICK, Melissa EGBERTSON, Jan L. BRESLOW
  • Patent number: 10844125
    Abstract: This invention concerns anti-inflammatory agents, compositions, and methods for treating inflammatory disorders.
    Type: Grant
    Filed: March 4, 2016
    Date of Patent: November 24, 2020
    Assignee: The Rockefeller University
    Inventors: Jeffrey V. Ravetch, Andrew Pincetic
  • Patent number: 10802263
    Abstract: An imaging signal extraction apparatus comprising: an interface; a processing device, the processing device operatively coupled to the interface; and a computer readable medium comprising instructions that, when executed by the processing device, perform operations comprising: a) generating a two-dimensional image from imaging information obtained from the interface, thereby estimating ballistic component of the imaging information; b) generating a three-dimensional image by remapping the two-dimensional image; c) identifying a candidate object in the three-dimensional image; d) obtaining an estimated spatial forward model of the candidate object by mapping the three-dimensional image of the candidate object with a point-spread-function associated with the imaging apparatus; e) obtaining background-corrected data by using the estimated spatial forward model of the candidate object and estimated temporal components; and f) iteratively updating the estimated spatial forward model and estimated temporal componen
    Type: Grant
    Filed: May 18, 2018
    Date of Patent: October 13, 2020
    Assignee: The Rockefeller University
    Inventors: Alipasha Vaziri, Tobias Noebauer, Oliver Skocek
  • Patent number: 10786570
    Abstract: The present invention provides methods and compositions for the remote control of cell function based on the use of radiofrequency waves to excite nanoparticles targeted to specific cell types. The nanoparticles may be applied to the target cell extracellularly and/or expressed intracellularly. The cell type of interest expresses a temperature sensitive channel wherein excitation of the nanoparticles results in a localized temperature increase that is transduced into a cellular response. Such cellular responses may include, for example, increases in gene expression resulting in production of one or more physiologically active proteins. The expression of such proteins can be used to treat a variety of different inherited or acquired diseases or disorders in a subject. Accordingly, the invention provides a generic approach for treatment of any disease associated with a protein deficiency.
    Type: Grant
    Filed: July 30, 2018
    Date of Patent: September 29, 2020
    Assignee: The Rockefeller University
    Inventors: Jeffrey Friedman, Sarah Stanley
  • Patent number: 10765878
    Abstract: The present invention provides methods and compositions for the remote control of cell function based on the use of a magnetic field to excite paramagnetic nanoparticles targeted to specific cell types. The cell type of interest expresses an ion channel wherein excitation of the paramagnetic nanoparticles results in a physical change that is transduced into a cellular response. Such cellular responses may include, for example, increases in gene expression resulting in production of one or more physiologically active proteins. The expression of such proteins can be used to treat a variety of different inherited or acquired diseases or disorders in a subject.
    Type: Grant
    Filed: March 21, 2017
    Date of Patent: September 8, 2020
    Assignees: THE ROCKEFELLER UNIVERSITY, RENSSELAER POLYTECHNIC INSTITUTE
    Inventors: Sarah Stanley, Jeffrey Friedman, Jonathan S. Dordick, Jeremy Sauer