Patents Assigned to The Rockefeller University
  • System and method for optical detection of skin disease
    Publication number: 20190133514
    Abstract: An optical system for the detection of skin disease, such as melanoma, acquires images of a lesion on a subject's skin at different wavelengths and utilizes a sweeping arm rotating about the lesion in a clock-like sweep to produce diagnostically relevant metrics and classifiers from the image data so as to enhance detection of the skin disease.
    Type: Application
    Filed: November 2, 2018
    Publication date: May 9, 2019
    Applicant: The Rockefeller University
    Inventors: Daniel GAREAU, Justin MARTIN
  • TREATMENT AND DIAGNOSIS OF COLON CANCER
    Publication number: 20190125706
    Abstract: The present invention discloses novel agents and methods for diagnosis and treatment of colon cancer. Also disclosed are related arrays, kits, and screening methods.
    Type: Application
    Filed: January 4, 2019
    Publication date: May 2, 2019
    Applicant: The Rockefeller University
    Inventors: Sohail Tavazoie, Jia M. Loo
  • Anti-MERTK agonistic antibodies and uses thereof
    Patent number: 10221248
    Abstract: The present disclosure provides antibodies that specifically bind to Mer Tyrosine Kinase (MERTK) (e.g., human MERTK, or both human and mouse MERTK) and compositions comprising such antibodies, wherein said antibody agonizes MERTK signaling on endothelial cells. The present disclosure also provides methods for treating cancer, by administering an antibody that specifically binds to MERTK and agonizes MERTK signaling on endothelial cells.
    Type: Grant
    Filed: December 21, 2015
    Date of Patent: March 5, 2019
    Assignee: The Rockefeller University
    Inventors: Sohail Tavazoie, Nils Halberg, Masoud Tavazoie
  • METHODS FOR THE TREATMENT OF MYELOID DERIVED SUPPRESSOR CELLS RELATED DISORDERS
    Publication number: 20190029984
    Abstract: The invention features methods of treating disorders related to increased levels of myeloid derived suppressor cells such as cancer or infections. The disclosure also provides methods of treating cancer including combinations of LXR? agonists and immunotherapies such as PD1 inhibitors, PDL1 inhibitors, and adoptive T-cell transfer therapy.
    Type: Application
    Filed: January 11, 2017
    Publication date: January 31, 2019
    Applicant: The Rockefeller University
    Inventors: Sohail Tavazoie, Masoud Tavazoie
  • System and method for optical detection of skin disease
    Patent number: 10182757
    Abstract: An optical system for the detection of skin disease, such as melanoma, acquires images of a lesion on a subject's skin at different wavelengths and utilizes a sweeping arm rotating about the lesion in a clock-like sweep to produce diagnostically relevant metrics and classifiers from the image data so as to enhance detection of the skin disease.
    Type: Grant
    Filed: October 10, 2013
    Date of Patent: January 22, 2019
    Assignee: THE ROCKEFELLER UNIVERSITY
    Inventors: Daniel Gareau, Justin Martin
  • STING crystals and modulators
    Patent number: 10176292
    Abstract: The present invention provides STING crystals. The present invention also provides STING modulators that interact with sites present in and/or defined by such crystals. The present invention also provides methods of making and using such crystals and modulators. Other aspects and/or features of the present invention will be apparent to those skilled in the art, reading the present specification.
    Type: Grant
    Filed: July 31, 2014
    Date of Patent: January 8, 2019
    Assignees: Memorial Sloan-Kettering Cancer Center, The Rockefeller University, Rutgers, The State University of New Jersey, University of Bonn
    Inventors: Dinshaw J. Patel, Thomas Tuschl, Roger Jones, Gunther Hartmann, Winfried Barchet, Thomas Zillinger, Weiyi Wang, Pu Gao, Liang Deng, Manuel Ascano, Jr.
  • Treatment and diagnosis of colon cancer
    Patent number: 10172817
    Abstract: The present invention discloses novel agents and methods for diagnosis and treatment of colon cancer. Also disclosed are related arrays, kits, and screening methods.
    Type: Grant
    Filed: June 22, 2017
    Date of Patent: January 8, 2019
    Assignee: The Rockefeller University
    Inventors: Sohail Tavazoie, Jia M. Loo
  • TREATMENT AND DIAGNOSIS OF COLON CANCER
    Publication number: 20190000788
    Abstract: The present invention discloses novel agents and methods for diagnosis and treatment of colon cancer. Also disclosed are related arrays, kits, and screening methods.
    Type: Application
    Filed: June 22, 2017
    Publication date: January 3, 2019
    Applicant: The Rockefeller University
    Inventors: Sohail Tavazoie, Jia M. Loo
  • Polypeptides with enhanced anti-inflammatory and decreased cytotoxic properties and relating methods
    Patent number: 10167332
    Abstract: The invention provides a polypeptide containing at least one IgG Fc region region, said polypeptide having a higher anti-inflammatory activity and a lower cytotoxic activity as compared to an unpurified antibody and methods of production of such polypeptide.
    Type: Grant
    Filed: April 3, 2007
    Date of Patent: January 1, 2019
    Assignee: The Rockefeller University
    Inventors: Jeffrey V. Ravetch, Yoshikatsu Kaneko, Nimmerjahn Falk
  • Compositions and methods for altering second messenger signaling
    Patent number: 10131686
    Abstract: The invention relates to compositions, methods, kits, and assays related to the use and/or exploitation of isomers of cGAMP as well as the structure of the enzyme cGAS.
    Type: Grant
    Filed: December 8, 2017
    Date of Patent: November 20, 2018
    Assignees: Memorial Sloan Kettering Cancer Center, The Rockefeller University, Rutgers, The State University of New Jersey, University of Bonn
    Inventors: Dinshaw J. Patel, Thomas Tuschl, Manuel Ascano, Jr., Yang Wu, Yizhou Liu, Winfried Barchet, Gunther Hartmann, Thomas Zillinger, Roger Jones, Barbara L. Gaffney, Pu Gao
  • Compositions and methods for modulating neuronal excitability and motor behavior
    Patent number: 10087443
    Abstract: The invention is directed to compositions and methods for treating or reducing the likelihood of the development of epilepsy in an individual. The method comprises administering to the central nervous system of an individual in need of such treatment a therapeutically effective amount of an agent capable of increasing the expression and/or activity of miR-128.
    Type: Grant
    Filed: October 28, 2014
    Date of Patent: October 2, 2018
    Assignees: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, THE ROCKEFELLER UNIVERSITY
    Inventors: Anne Schaefer, Paul Greengard
  • Compositions and methods to modulate cell activity
    Patent number: 10064941
    Abstract: The present invention provides methods and compositions for the remote control of cell function based on the use of radiofrequency waves to excite nanoparticles targeted to specific cell types. The nanoparticles may be applied to the target cell extracellularly and/or expressed intracellularly. The cell type of interest expresses a temperature sensitive channel wherein excitation of the nanoparticles results in a localized temperature increase that is transduced into a cellular response. Such cellular responses may include, for example, increases in gene expression resulting in production of one or more physiologically active proteins. The expression of such proteins can be used to treat a variety of different inherited or acquired diseases or disorders in a subject. Accordingly, the invention provides a generic approach for treatment of any disease associated with a protein deficiency.
    Type: Grant
    Filed: May 31, 2016
    Date of Patent: September 4, 2018
    Assignee: THE ROCKEFELLER UNIVERSITY
    Inventors: Jeffrey Friedman, Sarah Stanley
  • QUANTITATIVE DERMOSCOPIC MELANOMA SCREENING
    Publication number: 20180235534
    Abstract: A standardized, quantitative risk assessment method and apparatus for noninvasive melanoma screening. The apparatus and methods generate a melanoma Q-Score which calculates and displays a probability that a skin lesion is melanoma.
    Type: Application
    Filed: August 15, 2016
    Publication date: August 23, 2018
    Applicant: The Rockefeller University
    Inventor: Daniel GAREAU
  • Chimeric bacteriophage lysin with activity against staphylococci bacteria
    Patent number: 10053681
    Abstract: The present disclosure relates to chimeric bacteriophage lysins useful for the identification and/or reduction of staphylococcal populations. For example, a chimeric bacteriophage lysin was engineered and shown to effectively kill all strains of staphylococci tested including antibiotic resistant methicillin-resistant S. Aureus and VISA.
    Type: Grant
    Filed: September 9, 2014
    Date of Patent: August 21, 2018
    Assignee: THE ROCKEFELLER UNIVERSITY
    Inventors: Vincent A. Fischetti, Anu Daniel, Chad Euler
  • Broadly-neutralizing anti-HIV antibodies
    Patent number: 10047146
    Abstract: The present invention relates to anti-HIV antibodies. Also disclosed are related methods and compositions. HIV causes acquired immunodeficiency syndrome (AIDS), a condition in humans characterized by clinical features including wasting syndromes, central nervous system degeneration and profound immunosuppression that results in life-threatening opportunistic infections and malignancies. Since its discovery in 1981, HIV type 1 (HIV-1) has led to the death of at least 25 million people worldwide.
    Type: Grant
    Filed: October 18, 2013
    Date of Patent: August 14, 2018
    Assignee: The Rockefeller University
    Inventors: Hugo Mouquet, Michel Nussenzweig, Pamela J. Bjorkman, Louise Scharf
  • Amyloid protofibril antibodies and methods of use thereof
    Patent number: 10035847
    Abstract: The invention relates to methods for obtaining antibodies that recognize amyloid protofibrils and antibodies that recognize one or more amyloid protofibrils. Also provided are methods of using the antibodies to prevent or inhibit amyloid disease in a subject, to diagnose amyloid disease in a subject, and to detect amyloid protofibrils in a sample.
    Type: Grant
    Filed: October 2, 2014
    Date of Patent: July 31, 2018
    Assignee: THE ROCKEFELLER UNIVERSITY
    Inventors: W. Vallen Graham, Thomas P. Sakmar
  • INDOLOTRYPTOLINE ANTICANCER AGENTS
    Publication number: 20180193321
    Abstract: Indolotryptoline compounds of the general structure: are disclosed. In these compounds R1 is chosen from hydrogen, halogen and OH; R2 is (C1-C4)alkoxy; and R3 is chosen from hydrogen and halogen The compounds are useful for treating cancer.
    Type: Application
    Filed: July 1, 2016
    Publication date: July 12, 2018
    Applicant: The Rockefeller University
    Inventors: Sean BRADY, Daniel MONTIEL
  • Anti-Inflammatory Polypeptides
    Publication number: 20180179284
    Abstract: This invention concerns anti-inflammatory agents, compositions, and methods for treating inflammatory disorders.
    Type: Application
    Filed: December 18, 2017
    Publication date: June 28, 2018
    Applicant: The Rockefeller University
    Inventors: Jeffrey V. Ravetch, Andrew Pincetic
  • Broadly Neutralizing Anti-HIV Antibodies and Epitope Therefor
    Publication number: 20180171001
    Abstract: The present invention relates to broadly neutralizing anti-HIV-1 antibodies and isolated antigens. Also disclosed are related methods and compositions.
    Type: Application
    Filed: January 30, 2015
    Publication date: June 21, 2018
    Applicants: The Rockefeller University, California Institute of Technology
    Inventors: Michel Nussenzweig, Pamela J. Bjorkman, Louise Scharf, Johannes Scheid
  • Anti-Tumor Agents and Methods of Use
    Publication number: 20180171021
    Abstract: The present invention relates to anti-tumor agents that target certain tumor-associated macrophages. Also disclosed are methods of using such agents in treatment of cancer.
    Type: Application
    Filed: June 1, 2016
    Publication date: June 21, 2018
    Applicant: The Rockefeller University
    Inventors: Mikael KARLSSON, Jeffrey V. RAVETCH