Patents Assigned to The Rockefeller University
  • Compositions and methods for use in diagnosis of alzheimer's disease
    Patent number: 10295550
    Abstract: Provided are compositions and methods useful in the diagnosis of Alzheimer's Disease (AD). The methods involve immunologically testing biological samples for an amount of high molecular weight kininogen (HK) and cleaved high molecular weight kininogen (HKc), wherein determining less HK relative to a normal control, or determining more HKc relative to a normal control, or a combination thereof, aids in diagnosis of AD. Hybridomas and monoclonal antibodies bind with specificity to either HK alone, or to both HK and HKc. Kits for use in immunological AD testing using the mAbs are also provided.
    Type: Grant
    Filed: November 17, 2015
    Date of Patent: May 21, 2019
    Assignee: The Rockefeller University
    Inventors: Daria Zamolodchikov, Sidney Strickland
  • System and method for optical detection of skin disease
    Publication number: 20190133514
    Abstract: An optical system for the detection of skin disease, such as melanoma, acquires images of a lesion on a subject's skin at different wavelengths and utilizes a sweeping arm rotating about the lesion in a clock-like sweep to produce diagnostically relevant metrics and classifiers from the image data so as to enhance detection of the skin disease.
    Type: Application
    Filed: November 2, 2018
    Publication date: May 9, 2019
    Applicant: The Rockefeller University
    Inventors: Daniel GAREAU, Justin MARTIN
  • TREATMENT AND DIAGNOSIS OF COLON CANCER
    Publication number: 20190125706
    Abstract: The present invention discloses novel agents and methods for diagnosis and treatment of colon cancer. Also disclosed are related arrays, kits, and screening methods.
    Type: Application
    Filed: January 4, 2019
    Publication date: May 2, 2019
    Applicant: The Rockefeller University
    Inventors: Sohail Tavazoie, Jia M. Loo
  • Anti-MERTK agonistic antibodies and uses thereof
    Patent number: 10221248
    Abstract: The present disclosure provides antibodies that specifically bind to Mer Tyrosine Kinase (MERTK) (e.g., human MERTK, or both human and mouse MERTK) and compositions comprising such antibodies, wherein said antibody agonizes MERTK signaling on endothelial cells. The present disclosure also provides methods for treating cancer, by administering an antibody that specifically binds to MERTK and agonizes MERTK signaling on endothelial cells.
    Type: Grant
    Filed: December 21, 2015
    Date of Patent: March 5, 2019
    Assignee: The Rockefeller University
    Inventors: Sohail Tavazoie, Nils Halberg, Masoud Tavazoie
  • METHODS FOR THE TREATMENT OF MYELOID DERIVED SUPPRESSOR CELLS RELATED DISORDERS
    Publication number: 20190029984
    Abstract: The invention features methods of treating disorders related to increased levels of myeloid derived suppressor cells such as cancer or infections. The disclosure also provides methods of treating cancer including combinations of LXR? agonists and immunotherapies such as PD1 inhibitors, PDL1 inhibitors, and adoptive T-cell transfer therapy.
    Type: Application
    Filed: January 11, 2017
    Publication date: January 31, 2019
    Applicant: The Rockefeller University
    Inventors: Sohail Tavazoie, Masoud Tavazoie
  • STING crystals and modulators
    Patent number: 10176292
    Abstract: The present invention provides STING crystals. The present invention also provides STING modulators that interact with sites present in and/or defined by such crystals. The present invention also provides methods of making and using such crystals and modulators. Other aspects and/or features of the present invention will be apparent to those skilled in the art, reading the present specification.
    Type: Grant
    Filed: July 31, 2014
    Date of Patent: January 8, 2019
    Assignees: Memorial Sloan-Kettering Cancer Center, The Rockefeller University, Rutgers, The State University of New Jersey, University of Bonn
    Inventors: Dinshaw J. Patel, Thomas Tuschl, Roger Jones, Gunther Hartmann, Winfried Barchet, Thomas Zillinger, Weiyi Wang, Pu Gao, Liang Deng, Manuel Ascano, Jr.
  • Treatment and diagnosis of colon cancer
    Patent number: 10172817
    Abstract: The present invention discloses novel agents and methods for diagnosis and treatment of colon cancer. Also disclosed are related arrays, kits, and screening methods.
    Type: Grant
    Filed: June 22, 2017
    Date of Patent: January 8, 2019
    Assignee: The Rockefeller University
    Inventors: Sohail Tavazoie, Jia M. Loo
  • TREATMENT AND DIAGNOSIS OF COLON CANCER
    Publication number: 20190000788
    Abstract: The present invention discloses novel agents and methods for diagnosis and treatment of colon cancer. Also disclosed are related arrays, kits, and screening methods.
    Type: Application
    Filed: June 22, 2017
    Publication date: January 3, 2019
    Applicant: The Rockefeller University
    Inventors: Sohail Tavazoie, Jia M. Loo
  • Polypeptides with enhanced anti-inflammatory and decreased cytotoxic properties and relating methods
    Patent number: 10167332
    Abstract: The invention provides a polypeptide containing at least one IgG Fc region region, said polypeptide having a higher anti-inflammatory activity and a lower cytotoxic activity as compared to an unpurified antibody and methods of production of such polypeptide.
    Type: Grant
    Filed: April 3, 2007
    Date of Patent: January 1, 2019
    Assignee: The Rockefeller University
    Inventors: Jeffrey V. Ravetch, Yoshikatsu Kaneko, Nimmerjahn Falk
  • Compositions and methods for altering second messenger signaling
    Patent number: 10131686
    Abstract: The invention relates to compositions, methods, kits, and assays related to the use and/or exploitation of isomers of cGAMP as well as the structure of the enzyme cGAS.
    Type: Grant
    Filed: December 8, 2017
    Date of Patent: November 20, 2018
    Assignees: Memorial Sloan Kettering Cancer Center, The Rockefeller University, Rutgers, The State University of New Jersey, University of Bonn
    Inventors: Dinshaw J. Patel, Thomas Tuschl, Manuel Ascano, Jr., Yang Wu, Yizhou Liu, Winfried Barchet, Gunther Hartmann, Thomas Zillinger, Roger Jones, Barbara L. Gaffney, Pu Gao
  • QUANTITATIVE DERMOSCOPIC MELANOMA SCREENING
    Publication number: 20180235534
    Abstract: A standardized, quantitative risk assessment method and apparatus for noninvasive melanoma screening. The apparatus and methods generate a melanoma Q-Score which calculates and displays a probability that a skin lesion is melanoma.
    Type: Application
    Filed: August 15, 2016
    Publication date: August 23, 2018
    Applicant: The Rockefeller University
    Inventor: Daniel GAREAU
  • Broadly-neutralizing anti-HIV antibodies
    Patent number: 10047146
    Abstract: The present invention relates to anti-HIV antibodies. Also disclosed are related methods and compositions. HIV causes acquired immunodeficiency syndrome (AIDS), a condition in humans characterized by clinical features including wasting syndromes, central nervous system degeneration and profound immunosuppression that results in life-threatening opportunistic infections and malignancies. Since its discovery in 1981, HIV type 1 (HIV-1) has led to the death of at least 25 million people worldwide.
    Type: Grant
    Filed: October 18, 2013
    Date of Patent: August 14, 2018
    Assignee: The Rockefeller University
    Inventors: Hugo Mouquet, Michel Nussenzweig, Pamela J. Bjorkman, Louise Scharf
  • INDOLOTRYPTOLINE ANTICANCER AGENTS
    Publication number: 20180193321
    Abstract: Indolotryptoline compounds of the general structure: are disclosed. In these compounds R1 is chosen from hydrogen, halogen and OH; R2 is (C1-C4)alkoxy; and R3 is chosen from hydrogen and halogen The compounds are useful for treating cancer.
    Type: Application
    Filed: July 1, 2016
    Publication date: July 12, 2018
    Applicant: The Rockefeller University
    Inventors: Sean BRADY, Daniel MONTIEL
  • Anti-Inflammatory Polypeptides
    Publication number: 20180179284
    Abstract: This invention concerns anti-inflammatory agents, compositions, and methods for treating inflammatory disorders.
    Type: Application
    Filed: December 18, 2017
    Publication date: June 28, 2018
    Applicant: The Rockefeller University
    Inventors: Jeffrey V. Ravetch, Andrew Pincetic
  • Broadly Neutralizing Anti-HIV Antibodies and Epitope Therefor
    Publication number: 20180171001
    Abstract: The present invention relates to broadly neutralizing anti-HIV-1 antibodies and isolated antigens. Also disclosed are related methods and compositions.
    Type: Application
    Filed: January 30, 2015
    Publication date: June 21, 2018
    Applicants: The Rockefeller University, California Institute of Technology
    Inventors: Michel Nussenzweig, Pamela J. Bjorkman, Louise Scharf, Johannes Scheid
  • Anti-Tumor Agents and Methods of Use
    Publication number: 20180171021
    Abstract: The present invention relates to anti-tumor agents that target certain tumor-associated macrophages. Also disclosed are methods of using such agents in treatment of cancer.
    Type: Application
    Filed: June 1, 2016
    Publication date: June 21, 2018
    Applicant: The Rockefeller University
    Inventors: Mikael KARLSSON, Jeffrey V. RAVETCH
  • TREATMENT AND DIAGNOSIS OF MELANOMA
    Publication number: 20180153833
    Abstract: The present invention discloses novel agents and methods for diagnosis and treatment of melanoma. Also disclosed are related arrays, kits, and screening methods.
    Type: Application
    Filed: January 26, 2018
    Publication date: June 7, 2018
    Applicant: The Rockefeller University
    Inventors: Sohail F. Tavazoie, Nora Pencheva
  • Treatment and diagnosis of melanoma
    Patent number: 9962348
    Abstract: The present invention discloses novel agents and methods for diagnosis and treatment of melanoma. Also disclosed are related arrays, kits, and screening methods.
    Type: Grant
    Filed: July 14, 2017
    Date of Patent: May 8, 2018
    Assignee: The Rockefeller University
    Inventors: Sohail F. Tavazoie, Nora Pencheva
  • IMMUNE COMPLEX
    Publication number: 20180117139
    Abstract: The present invention relates to immunogenic immune complexes, related compositions, and related methods. This invention addresses the above-described un-met need by providing an immune complex (IC) or immune complexes (ICs), which take advantages of Type II Fc receptor (FcR) interactions and signaling to elicit broader and more potent protective immune responses. In one aspect, the invention provides an immune complex comprising an antigenic agent and an isolated protein. The protein comprises an IgG Fc region and is capable of binding to a Type II Fc receptor. Preferably, the protein is an antibody or an Fc region-containing fragment thereof.
    Type: Application
    Filed: March 21, 2016
    Publication date: May 3, 2018
    Applicant: The Rockefeller University
    Inventors: Jeffrey V. Ravetch, Taia Wang, Jad Mamaary
  • Treatment of pancreatic and related cancers with 5-acyl-6,7-dihydrothieno[3,2-c]pyridines
    Patent number: 9943507
    Abstract: Methods for inhibiting the growth of pancreatic cancer cells or other cancer cells driven by Sonic hedgehog are disclosed.
    Type: Grant
    Filed: March 15, 2017
    Date of Patent: April 17, 2018
    Assignees: Memorial Sloan-Kettering Cancer Center, The Rockefeller University
    Inventors: Marilyn D. Resh, Joseph Fraser Glickman, Elissaveta Petrova, Ouathek Ouerfelli