Patents Assigned to The Rockefeller University
  • TREATMENT AND DIAGNOSIS OF MELANOMA
    Publication number: 20180153833
    Abstract: The present invention discloses novel agents and methods for diagnosis and treatment of melanoma. Also disclosed are related arrays, kits, and screening methods.
    Type: Application
    Filed: January 26, 2018
    Publication date: June 7, 2018
    Applicant: The Rockefeller University
    Inventors: Sohail F. Tavazoie, Nora Pencheva
  • Treatment and diagnosis of melanoma
    Patent number: 9962348
    Abstract: The present invention discloses novel agents and methods for diagnosis and treatment of melanoma. Also disclosed are related arrays, kits, and screening methods.
    Type: Grant
    Filed: July 14, 2017
    Date of Patent: May 8, 2018
    Assignee: The Rockefeller University
    Inventors: Sohail F. Tavazoie, Nora Pencheva
  • IMMUNE COMPLEX
    Publication number: 20180117139
    Abstract: The present invention relates to immunogenic immune complexes, related compositions, and related methods. This invention addresses the above-described un-met need by providing an immune complex (IC) or immune complexes (ICs), which take advantages of Type II Fc receptor (FcR) interactions and signaling to elicit broader and more potent protective immune responses. In one aspect, the invention provides an immune complex comprising an antigenic agent and an isolated protein. The protein comprises an IgG Fc region and is capable of binding to a Type II Fc receptor. Preferably, the protein is an antibody or an Fc region-containing fragment thereof.
    Type: Application
    Filed: March 21, 2016
    Publication date: May 3, 2018
    Applicant: The Rockefeller University
    Inventors: Jeffrey V. Ravetch, Taia Wang, Jad Mamaary
  • Treatment of pancreatic and related cancers with 5-acyl-6,7-dihydrothieno[3,2-c]pyridines
    Patent number: 9943507
    Abstract: Methods for inhibiting the growth of pancreatic cancer cells or other cancer cells driven by Sonic hedgehog are disclosed.
    Type: Grant
    Filed: March 15, 2017
    Date of Patent: April 17, 2018
    Assignees: Memorial Sloan-Kettering Cancer Center, The Rockefeller University
    Inventors: Marilyn D. Resh, Joseph Fraser Glickman, Elissaveta Petrova, Ouathek Ouerfelli
  • Human Immunodeficiency Virus Neutralizing Antibodies and Methods of Use Thereof
    Publication number: 20180079800
    Abstract: The invention provides broadly neutralizing antibodies directed to epitopes of Human Immunodeficiency Virus, or HIV. The invention further provides compositions containing HIV antibodies used for prophylaxis, and methods for diagnosis and treatment of HIV infection.
    Type: Application
    Filed: September 29, 2017
    Publication date: March 22, 2018
    Applicants: The Rockefeller University, California Institute of Technology
    Inventors: Johannes Scheid, Michel Nussenzweig, Pamela J. Bjorkman, Ron Diskin
  • bacteriophage lysins for detection and treatment of gram positive bacteria
    Patent number: 9914915
    Abstract: The present invention provides methods, compositions and articles of manufacture useful for the prophylactic and therapeutic amelioration and treatment of gram-positive bacteria, including Streptococcus and Staphylococcus, and related conditions. The invention provides compositions and methods incorporating and utilizing Streptococcus suis derived bacteriophage lysins, particularly PlySs2 and/or PlySs1 lytic enzymes and variants thereof, including truncations thereof. Methods for treatment of humans are provided.
    Type: Grant
    Filed: April 14, 2015
    Date of Patent: March 13, 2018
    Assignee: THE ROCKEFELLER UNIVERSITY
    Inventors: Vincent A. Fischetti, Jonathan Schmitz, Daniel Gilmer, Chad Euler
  • Dimeric bacteriophage lysins
    Patent number: 9914916
    Abstract: The present invention provides isolated dimeric Streptococcus-specific phage lysins having two Streptococcus-specific phage lysin monomers covalently linked to each other, and having killing activity against one or more Streptococcus bacteria. Also provided for are pharmaceutical compositions of dimeric lysins and their use in therapeutic treatment or alleviation of infections or bacterial colonizations. The dimeric lysins may also be used to decontaminate porous and non-porous surfaces or devices.
    Type: Grant
    Filed: January 27, 2016
    Date of Patent: March 13, 2018
    Assignee: THE ROCKEFELLER UNIVERSITY
    Inventors: Vincent A. Fischetti, Gregory Resch
  • Anti-Inflammatory Polypeptides
    Publication number: 20180051087
    Abstract: This invention concerns anti-inflammatory agents, compositions, and methods for treating inflammatory disorders.
    Type: Application
    Filed: March 4, 2016
    Publication date: February 22, 2018
    Applicant: ROCKEFELLER UNIVERSITY (THE)
    Inventors: Jeffrey V. Ravetch, Andrew Pincetic
  • Highly active agonistic CD4 binding site anti-HIV antibodies (HAADS) comprising modified CDRH2 regions that improve contact with GP120
    Patent number: 9890207
    Abstract: Embodiments of the present invention are directed to compositions and methods for anti-HIV (anti-CD4 binding site) potent VRC01-like (PVL) antibodies targeted to gp120 having an amino acid substitution at a residue in the anti-CD4 binding site PVL antibody that is equivalent to Phe43 in CD4, these antibodies having improved potency and breadth.
    Type: Grant
    Filed: July 25, 2012
    Date of Patent: February 13, 2018
    Assignees: California Institute of Technology, The Rockefeller University
    Inventors: Ron Diskin, Pamela J. Bjorkman, Michel Nussenzweig, Johannes Scheid
  • Antibodies targeting HIV escape mutants
    Patent number: 9879068
    Abstract: Embodiments of the present invention are directed to compositions and methods for anti-HIV (anti-CD4 binding site) broadly neutralizing antibodies having improved potency and breadth for neutralizing a range of HIV strains. Combinations of broadly neutralizing antibodies can also improve potency over a single antibody composition.
    Type: Grant
    Filed: June 21, 2013
    Date of Patent: January 30, 2018
    Assignees: California Institute of Technology, The Rockefeller University
    Inventors: Ron Diskin, Anthony P. West, Michel C. Nussenzweig, Pamela J. Bjorkman
  • ANTI-MERTK AGONISTIC ANTIBODIES AND USES THEREOF
    Publication number: 20180002444
    Abstract: The present disclosure provides antibodies that specifically bind to Mer Tyrosine Kinase (MERTK) (e.g., human MERTK, or both human and mouse MERTK) and compositions comprising such antibodies, wherein said antibody agonizes MERTK signaling on endothelial cells. The present disclosure also provides methods for treating cancer, by administering an antibody that specifically binds to MERTK and agonizes MERTK signaling on endothelial cells.
    Type: Application
    Filed: December 21, 2015
    Publication date: January 4, 2018
    Applicant: The Rockefeller University
    Inventors: Sohail Tavazoie, Nils Halberg, Masoud Tavazoie
  • TREATMENT OF ANGIOGENESIS DISORDERS
    Publication number: 20170362664
    Abstract: This invention concerns pathological angiogenesis and cancer, related treatment methods, and related compositions. Also disclosed are related diagnosis kits and methods.
    Type: Application
    Filed: June 22, 2017
    Publication date: December 21, 2017
    Applicant: The Rockefeller University
    Inventors: Sohail Tavazoie, Nils Halberg, Kim Png
  • Anti-inflammatory polypeptides
    Patent number: 9845358
    Abstract: This invention concerns anti-inflammatory agents, compositions, and methods for treating inflammatory disorders.
    Type: Grant
    Filed: March 4, 2015
    Date of Patent: December 19, 2017
    Assignee: The Rockefeller University
    Inventors: Jeffrey V. Ravetch, Andrew Pincetic
  • Compositions and methods for altering second messenger signaling
    Patent number: 9840533
    Abstract: The present disclosure provides, among other things, novel cyclic-GMP-AMP (cGAMP) analogs, mimics, mimetics and variants, and compositions and kits thereof; methods of using the compounds as described herein for treating cancer, and immune disease, disorders, or conditions; methods of using the compounds as described herein for modulating cGAS and STING; and methods of designing or characterizing a cGAS modulator.
    Type: Grant
    Filed: April 29, 2014
    Date of Patent: December 12, 2017
    Assignees: Memorial Sloan Kettering Cancer Center, Rutgers, The State University of New Jersey, The Rockefeller University, University of Bonn
    Inventors: Dinshaw Patel, Thomas Tuschl, Manuel Ascano, Jr., Yang Wu, Yizhou Liu, Winfried Barchet, Gunther Hartmann, Thomas Zillinger, Roger Jones, Barbara L. Gaffney, Pu Gao
  • Anticancer agents of the anthracyclin family
    Patent number: 9833465
    Abstract: Anthracyclin compounds of the general structure: are disclosed. In these compounds R1 is methyl, acetyl or hydroxyacetyl; R2-R5 and R10-R13 are independently H or methyl; R6 R7 and R8 are independently H, OH or OCH3; and n is zero or one. The compounds are useful for treating cancer.
    Type: Grant
    Filed: September 26, 2016
    Date of Patent: December 5, 2017
    Assignee: The Rockefeller University
    Inventors: Sean Brady, Hahk-Soo Kang
  • CRISPR-Cas component systems, methods and compositions for sequence manipulation
    Patent number: 9822372
    Abstract: The invention provides for systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are vectors and vector systems, some of which encode one or more components of a CRISPR complex, as well as methods for the design and use of such vectors. Also provided are methods of directing CRISPR complex formation in eukaryotic cells and methods for selecting specific cells by introducing precise mutations utilizing the CRISPR/Cas system.
    Type: Grant
    Filed: January 7, 2016
    Date of Patent: November 21, 2017
    Assignees: The Broad Institute Inc., Massachusetts Institute of Technology, The Rockefeller University
    Inventors: Feng Zhang, David Benjamin Turitz Cox, Luciano Marraffini, David Olivier Bikard, Wenyan Jiang, Neville Espi Sanjana
  • Methods and compositions for translational profiling and molecular phenotyping
    Patent number: 9816096
    Abstract: Methods and compositions are provided for translational profiling and molecular phenotyping of specific tissues, cells and cell subtypes of interest. The methods provided herein facilitate the analysis of gene expression in the selected subset present within a heterogeneous sample.
    Type: Grant
    Filed: November 25, 2014
    Date of Patent: November 14, 2017
    Assignee: THE ROCKEFELLER UNIVERSITY
    Inventors: Nathaniel Heintz, Paul Greengard, Myriam Heiman, Anne Schaefer, Joseph P. Doyle, Joseph D. Dougherty
  • TREATMENT AND DIAGNOSIS OF MELANOMA
    Publication number: 20170319525
    Abstract: The present invention discloses novel agents and methods for diagnosis and treatment of melanoma. Also disclosed are related arrays, kits, and screening methods.
    Type: Application
    Filed: July 14, 2017
    Publication date: November 9, 2017
    Applicant: The Rockefeller University
    Inventors: Sohail F. Tavazoie, Nora Pencheva
  • IMPROVED AGRONOMIC CHARACTERISTICS UNDER WATER LIMITING CONDITIONS FOR PLANTS EXPRESSING PUB10 POLYPEPTIDES
    Publication number: 20170306346
    Abstract: The present invention provides methods and compositions for modulating drought tolerance and/or other agronomic traits in plants. This invention relates to compositions and methods for down-regulating the level and/or activity of PUB10 in plants for creation of plants with improved abiotic stress tolerance, preferably improved drought tolerance. Thus, in one aspect, the present invention provides an isolated nucleic acid comprising a polynucleotide sequence for use in a recombinant DNA construct or a suppression DNA construct for modulating PUB10 expression.
    Type: Application
    Filed: November 10, 2015
    Publication date: October 26, 2017
    Applicant: THE ROCKEFELLER UNIVERSITY
    Inventors: Nam-Hai CHUA, Choonkyun JUNG, Pingzhi ZHAO
  • tRNA QUANTIFICATION
    Publication number: 20170298433
    Abstract: In one embodiment, the present invention relates to a method for optimizing cell-type specific protein expression. In another embodiment, the present invention relates to a method for creating a tRNA profile of a cell.
    Type: Application
    Filed: April 13, 2017
    Publication date: October 19, 2017
    Applicant: The Rockefeller University
    Inventors: Sohail TAVAZOIE, Hani GOODARZI