Patents Assigned to The Royal Institution for the Advancement of Learning (McGill University)
  • Patent number: 10842634
    Abstract: An implant comprising a porous microstructure is disclosed which has an external surface, where at least a region of the external surface is formed of the porous microstructure. The microstructure is defined by at least one lattice of cells. Each cell has a predetermined cell topology and a plurality of edges. One or more of the edges of each cell connect to an adjacent cell along a corresponding edge thereof. Collectively, the cells have a periodic or aperiodic arrangement within the at least one lattice.
    Type: Grant
    Filed: May 4, 2015
    Date of Patent: November 24, 2020
    Assignee: THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY
    Inventors: Damiano Pasini, Michael Tanzer, Sajad Khanoki Arabnejad, Burnett Johnston
  • Patent number: 10799363
    Abstract: A methodology integrating muitiscale analysis and design optimization to design a novel bone replacement implant made of a functionally graded cellular material that meets fatigue requirements imposed by cyclic loadings. The pore microarchitecture, described by interconnectivity, porosity, pore size as well as pore topology, is optimally designed for tissue regeneration and mechanical strength. The method can contribute to the development of a new generation of bone replacement implants with a graded cellular microstructure.
    Type: Grant
    Filed: June 20, 2014
    Date of Patent: October 13, 2020
    Assignee: THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY
    Inventors: Damiano Pasini, Sajad Arabnejad Khanoki, Michael Tanzer
  • Publication number: 20200316185
    Abstract: A method of immunizing a human against infection by parasitic worms, comprising orally administering a live attenuated recombinant bacterium, expressing at least one antigen corresponding to a parasitic worm antigen; and a sterile injectable vaccine comprising the at least one antigen corresponding to a parasitic worm antigen. The method is effective against worms, including schistosomes.
    Type: Application
    Filed: March 6, 2020
    Publication date: October 8, 2020
    Applicant: THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY
    Inventors: Brian J. Ward, Adam Hassan, Momar Ndao
  • Patent number: 10767032
    Abstract: An auxetic metamaterial including a plurality of interconnected building blocks that are deformable between a collapsed position and an expanded position upon the application of a load. The building blocks are bistable, and define a stable state in both the collapsed position and the expanded position. In the stable state, the building blocks maintain the collapsed position or the expanded position, even after removal of the load applied on the building block.
    Type: Grant
    Filed: June 2, 2017
    Date of Patent: September 8, 2020
    Assignee: THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY
    Inventors: Damiano Pasini, Ahmad Rafsanjani Abbasi
  • Patent number: 10766851
    Abstract: It is provided a method of converting a diaryl ether source such as lignin and/or polyphenylene oxide (PPO) containing 4-O-5 linkages and an inorganic chemical such as ammonia into an organic compound, comprising reacting said diaryl ether source with the inorganic chemical in presence of a catalyst, preferably palladium, transforming the 4-O-5 linkages of said diaryl ether source into the organic compound. It is provided a palladium-catalyzed synthesis of aniline derivatives from 4-O-5 linkage lignin model compounds and cheap industrial inorganic chemical ammonia via dual C(Ar)—O bond cleavage.
    Type: Grant
    Filed: August 22, 2019
    Date of Patent: September 8, 2020
    Assignee: THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING / MCGILL UNIVERSITY
    Inventors: Huiying Zeng, Chao-Jun Li, Dawei Cao
  • Patent number: 10752591
    Abstract: The invention relates to a method of inhibiting loss of muscle mass or muscle function in a subject in need thereof, or a method of treating miofibers ex vivo, the method comprising administering a therapeutically effective amount of a 18-20 member bi-polycyclic compound to the subject or to the miofibers.
    Type: Grant
    Filed: July 3, 2019
    Date of Patent: August 25, 2020
    Assignees: Haro Pharmaceuticals Inc., The Royal Institution for the Advancement of Learning/McGill University, Universite De Montreal
    Inventors: David Bettoun, Eduardo Martinez, James Gleason, Sylvie Mader, Shuo Xing
  • Patent number: 10739303
    Abstract: There is described a sensor for sensing a variable of a sample. The sensor generally has a graphene layer supported by a substrate; a parylene layer coating the graphene layer opposite the substrate; a sensing layer coating the parylene layer opposite the substrate, and being exposable to the sample; and electrical contacts at opposite ends of the graphene layer.
    Type: Grant
    Filed: October 18, 2018
    Date of Patent: August 11, 2020
    Assignee: THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY
    Inventors: Thomas Szkopek, Ibrahim Fakih
  • Publication number: 20200238217
    Abstract: A technique for separating components of a microfluid, comprises a self-intersecting micro or nano-fluidic channel defining a cyclic path for circulating the fluid over a receiving surface of a fluid component separating member; and equipment for applying coordinated pressure to the channel at a plurality of pressure control areas along the cyclic path to circulate the fluid over the receiving surface, applying a pressure to encourage a desired transmission through the separating member, and a circulating pressure to remove surface obstructions on the separating member. The equipment preferably defines a peristaltic pump. Turbulent microfluidic flow appears to be produced.
    Type: Application
    Filed: December 23, 2019
    Publication date: July 30, 2020
    Applicants: National Research Council of Canada, The Royal Institution for the Advancement of Learning/McGill University
    Inventors: Kebin LI, Teodor VERES, Tohid Fatanat DIDAR, Maryam TABRIZIAN
  • Patent number: 10725131
    Abstract: A topologically-protected traveling-wave amplifier includes resonators arranged in a two-dimensional array defining a periphery including a first edge. An output line is coupled to an output resonator disposed along the first edge spaced from an input resonator coupled to an output line. A synthetic gauge field generator associated with the resonators provides a topologically-protected edge state corresponding to propagation along the periphery in a propagation direction from the input resonator along the first edge to the output resonator. A parametric driving element creates pairs of photons in the edge state and amplifies a signal propagating along the first edge in the propagation direction. A signal incident from the input line propagates in the propagation direction along the first edge while being amplified and is detected at the output line as an amplified signal. A signal incident from the output line is attenuated before emerging at the input resonator.
    Type: Grant
    Filed: September 6, 2017
    Date of Patent: July 28, 2020
    Assignees: THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY, FRIEDRICH-ALEXANDER-UNIVERSITAT ERLANGEN-NURNBERG
    Inventors: Aashish Clerk, Martin Houde, Florian Marquardt, Vittorio Peano Cavasola
  • Patent number: 10716707
    Abstract: Active dichoptic perceptual-learning tasks or dichoptic game play have been shown to significantly improve visual acuity of amblyopic children and adults. However, these dichoptic perceptual learning tasks are intensive and repetitive such that non-compliance is high. In contrast, the invention provides dichoptic perceptual learning in a manner that the user maintains its use and compliance is increased. Further, compliance becomes automatic if the user performs tasks in a normal manner and “forgets” that they are actually undergoing treatment as it is integrated with minimal disruption to their life and activities. Accordingly, a methodology exploiting complementary dichoptic stimulation is presented.
    Type: Grant
    Filed: August 27, 2015
    Date of Patent: July 21, 2020
    Assignee: THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY
    Inventors: Robert F. Hess, Reza Farivar-Mohseni, Alexandre Reynaud
  • Patent number: 10711002
    Abstract: The present disclosure relates to novel compound of Formula I, or a pharmaceutically acceptable salt or solvate thereof; wherein R1, R2, Ra, Rb and Rc are as defined herein, pharmaceutical compositions containing same and methods for the treatment of cancer using same.
    Type: Grant
    Filed: April 21, 2017
    Date of Patent: July 14, 2020
    Assignee: THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY
    Inventors: Moulay A. Alaoui-Jamali, Krikor Bijian, Dominik Wernic
  • Patent number: 10700233
    Abstract: There is described a photodetector for detecting incoming infrared light. The photodetector generally has a substrate; an i-type semiconductor region extending along the substrate, the i-type semiconductor region being sandwiched between a p-type semiconductor region and an n-type semiconductor region; a grating coupler being optically connected to one of two ends of the i-type semiconductor region, the grating coupler redirecting incoming infrared light into and along the i-type semiconductor region via the one of the two ends of the i-type semiconductor region for propagation of infrared light along the i-type semiconductor region; and a photocurrent detection circuit electrically connected to the p-type semiconductor region and to the n-type semiconductor region for detecting a photocurrent resulting from said propagation.
    Type: Grant
    Filed: October 3, 2018
    Date of Patent: June 30, 2020
    Assignees: THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY, VALORBEC L.P.
    Inventors: Monireh Moayedi Pour Fard, Christopher Williams, Glenn Cowan, Odile Liboiron-Ladouceur
  • Patent number: 10690255
    Abstract: A major challenge for the general use of “lab-on-a-chip” (LOAC) systems and point-of-care (POC) devices has been the generally complex and need for sophisticated peripheral equipment, such that it is more difficult than anticipated to implement low cost, robust and portable LOAC/POC solutions. It would be beneficial for chemical, medical, healthcare, and environmental applications to provide designs for inexpensive LOAC/POC solutions compatible with miniaturization and mass production, and are potentially portable, using compact possibly hand-held instruments, using reusable or disposable detectors. Embodiments of the invention address improved circuit elements for self-powered self-regulating microfluidic circuits including programmable retention valves, programmable trigger valves, enhanced capillary pumps, and flow resonators.
    Type: Grant
    Filed: October 17, 2017
    Date of Patent: June 23, 2020
    Assignee: THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY
    Inventors: David Juncker, Hosseinali Safavieh
  • Publication number: 20200093912
    Abstract: An attenuated Salmonella enterica serovar Typhimurium strain (YS1646) is repurposed to produce a vaccine. Plasmid-based candidates expressing either the TcdA or TcdB RBD were screened. Different vaccine routes and schedules were tested to achieve detectable serum and mucosal antibody titers in C57BL/6J mice. When given in a multi-modality schedule over 1 week (day 0 IM+PO, days 2 and 4 PO), several candidates provided 100% protection against lethal challenge. Substantial protection (82%) was achieved with combined PO TcdA/TcdB vaccination alone (d0, 2 and 4). These data demonstrate the potential of the YS1646-based vaccines for C. difficile.
    Type: Application
    Filed: September 19, 2019
    Publication date: March 26, 2020
    Applicant: THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY
    Inventors: Brian J. Ward, Kaitlin Grace Frances Winter
  • Patent number: 10584159
    Abstract: Bioluminescence resonance energy transfer (BRET) biosensors for assessing the intracellular localization, internalization and trafficking into cellular compartments of proteins such as receptors, and other biomolecules such as second messengers, are disclosed. These biosensors, which are dependent on the concentration/density of the BRET donor and acceptor in cellular compartments rather that specific protein-protein interactions, use a Renilla GFP/Luc BRET pair, which allows the robust and reproducible monitoring of protein trafficking/localization, with a sensitivity compatible with high-throughput screening (HTS). The use of these biosensors for various applications, including assessing/monitoring protein endocytosis, recycling and intracellular trafficking, receptor maturation/rescue by pharmacological chaperones, various endocytosis/exocytosis processes, activation/inhibition, as well as biomolecule concentration/density in different cellular compartments, is also disclosed.
    Type: Grant
    Filed: September 21, 2015
    Date of Patent: March 10, 2020
    Assignees: The Royal Institution for the Advancement of Learning/McGill University, Université de Montréal
    Inventors: Stéphane Alain Laporte, Yoon Namkung, Michel Bouvier, Christian Le Gouill, Mireille Hogue, Viktoriya Lukasheva, Hiroyuki Kobayashi, Denis Deblois, Étienne Durette
  • Patent number: 10576447
    Abstract: InGaN offers a route to high efficiency overall water splitting under one-step photo-excitation. Further, the chemical stability of metal-nitrides supports their use as an alternative photocatalyst. However, the efficiency of overall water splitting using InGaN and other visible light responsive photocatalysts has remained extremely low despite prior art work addressing optical absorption through band gap engineering. Within this prior art the detrimental effects of unbalanced charge carrier extraction/collection on the efficiency of the four electron-hole water splitting reaction have remained largely unaddressed. To address this growth processes are presented that allow for controlled adjustment and establishment of the appropriate Fermi level and/or band bending in order to allow the photochemical water splitting to proceed at high rate and high efficiency. Beneficially, establishing such material surface charge properties also reduces photo-corrosion and instability under harsh photocatalysis conditions.
    Type: Grant
    Filed: July 31, 2015
    Date of Patent: March 3, 2020
    Assignee: THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY
    Inventors: Zetian Mi, Md Golam Kibria, Mohammad Faqrul Alam Chowdhury
  • Patent number: 10577349
    Abstract: Provided herein are compounds and pharmaceutical compositions comprising quinolinones. The quinolinones and compositions thereof are useful as eukaryotic translation initiation factor 4F (eIF4F) complex modulators.
    Type: Grant
    Filed: March 1, 2016
    Date of Patent: March 3, 2020
    Assignees: SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE, THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY, THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
    Inventors: Ze'ev Ronai, Anthony B. Pinkerton, Yongmei Feng, Ivan Topisirovic, Kevin Brown, Christian A. Hassig
  • Patent number: 10569225
    Abstract: A technique for separating components of a microfluid, comprises a self-intersecting micro or nano-fluidic channel defining a cyclic path for circulating the fluid over a receiving surface of a fluid component separating member; and equipment for applying coordinated pressure to the channel at a plurality of pressure control areas along the cyclic path to circulate the fluid over the receiving surface, applying a pressure to encourage a desired transmission through the separating member, and a circulating pressure to remove surface obstructions on the separating member. The equipment preferably defines a peristaltic pump. Turbulent microfluidic flow appears to be produced.
    Type: Grant
    Filed: March 27, 2014
    Date of Patent: February 25, 2020
    Assignees: National Research Council of Canada, The Royal Institution for the Advancement of Learning/McGill University
    Inventors: Kebin Li, Teodor Veres, Tohid Fatanat Didar, Maryam Tabrizian
  • Patent number: 10567010
    Abstract: Methods and systems for encoding data are described herein. The method comprises inputting data to a first pipeline of a non-systematic polar encoder capable of encoding a polar code of length nmax, extracting, via at least one first multiplexer of size log nmax×1, a first polar code of length n<nmax at a first location along the first pipeline to generate a first encoded output, modifying the first encoded output to set frozen bits to a known value to obtain a modified first encoded output, inputting the modified first encoded output to a second pipeline of the non-systematic polar encoder, and extracting, via at least one second multiplexer of size log nmax×1, a second polar code of length n<nmax at a second location along the second pipeline to generate a second encoded output, the second encoded output corresponding to a systematically encoded polar code of length n.
    Type: Grant
    Filed: December 7, 2018
    Date of Patent: February 18, 2020
    Assignee: THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY
    Inventors: Warren Gross, Gabi Sarkis, Pascal Giard
  • Patent number: 10553751
    Abstract: GaN-based nanowire heterostructures have been intensively studied for applications in light emitting diodes (LEDs), lasers, solar cells and solar fuel devices. Surface charge properties play a dominant role on the device performance and have been addressed within the prior art by use of a relatively thick large bandgap AlGaN shell covering the surfaces of axial InGaN nanowire LED heterostructures has been explored and shown substantial promise in reducing surface recombination leading to improved carrier injection efficiency and output power. However, these lead to increased complexity in device design, growth and fabrication processes thereby reducing yield/performance and increasing costs for devices. Accordingly, there are taught self-organising InGaN/AlGaN core-shell quaternary nanowire heterostructures wherein the In-rich core and Al-rich shell spontaneously form during the growth process.
    Type: Grant
    Filed: April 2, 2019
    Date of Patent: February 4, 2020
    Assignee: THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY
    Inventors: Zetian Mi, Songrui Zhao, Renjie Wang