Patents Assigned to The Royal Institution for the Advancement of Learning (McGill University)
  • Patent number: 12012408
    Abstract: The present disclosure relates to novel compound of Formula I, (I) or a pharmaceutically acceptable salt or solvate thereof; wherein Ra, Rb, Rc, Rd, ring A and ring B are as defined herein, pharmaceutical compositions containing same and methods for the treatment of cancer using same.
    Type: Grant
    Filed: June 21, 2019
    Date of Patent: June 18, 2024
    Assignee: THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY
    Inventors: Moulay A Alaoui-Jamali, Krikor Bijian, Dominik Wernic
  • Publication number: 20240144610
    Abstract: A method for overlaying an image on a physical object is described. The method includes: instantiating a common coordinate system that unifies a first coordinate system and a second coordinate system; dynamically recognizing the physical object in the common coordinate system using at least one sensor; aligning an image map with a model map of the dynamically recognized physical object in the common coordinate system; and displaying the image in a physical space overlaid on the physical object using a display of an extended reality (XR) device. A corresponding system and a computer-readable medium are also described.
    Type: Application
    Filed: October 27, 2023
    Publication date: May 2, 2024
    Applicant: The Royal Institution for the Advancement of Learning/McGill University
    Inventors: Swajan Paul, Antonia Arnaert, Zoumanan Debe
  • Patent number: 11946560
    Abstract: A valve for a pneumatic system, has: a first enclosure defining a first chamber and a first connection port; a second enclosure defining a second chamber and a second connection port; a first shell subjected to a first pressure differential and movable from a default position to a reversed position via snap-through buckling upon the first pressure differential reaching a threshold; and a second shell having a shape different than a shape of the first shell, the second shell resiliently movable from an initial position to a deformed position when subjected to a second pressure differential, wherein a first flow rate of a fluid via the first connection port induces deformation of the second shell followed by a snapping of the first shell thereby generating a second flow rate greater than the first flow rate.
    Type: Grant
    Filed: March 22, 2022
    Date of Patent: April 2, 2024
    Assignee: THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY
    Inventors: Damiano Pasini, Lu Liu, Chuan Qiao
  • Patent number: 11895763
    Abstract: A plasma source comprising a first hollow electrode and a second hollow electrode separated by a gap and a dielectric barrier of a constant width; wherein the plasma source is configured to selectively produce a plasma in either one of a first configuration and a second configuration; wherein, i) in the first configuration, a plasma-forming gas flows in the gap while a non plasma-forming gas flows within the first hollow electrode; and ii) in the second configuration, a plasma-forming gas flows within the first hollow electrode and a non plasma-forming gas flows within the gap. The method comprises selecting at least two gases of different breakdown voltages, injecting a first gas in a first electrode separated from a second hollow electrode by a gas gap of a constant width, injecting a second gas in the gas gap under an applied power.
    Type: Grant
    Filed: August 5, 2020
    Date of Patent: February 6, 2024
    Assignees: THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY, NEXPLASMAGEN INC.
    Inventors: Jean-Sébastien Boisvert, Philip Wong, Valérie Léveillé
  • Patent number: 11891607
    Abstract: The present disclosure provides methods of treating a subject having decreased bone mineral density or at risk of developing decreased bone mineral density, and methods of identifying subjects having an increased risk of developing decreased bone mineral density.
    Type: Grant
    Filed: July 29, 2022
    Date of Patent: February 6, 2024
    Assignees: Regeneron Pharmaceuticals, Inc., The Royal Institution For the Advancement of Learning/McGill University
    Inventors: Jonas Bovijn, Olukayode Sosina, Sirui Zhou, Luca Andrea Lotta, Aris Baras, John Brent Richards
  • Publication number: 20240000824
    Abstract: The disclosure relates to synthetic oligonucleotides that bind at least a portion of a dimerization initiation site (DIS) of a retrovirus genomic ribonucleic acid (RNA) molecule. In some aspects, the synthetic oligonucleotides include a 2?-deoxy-2?-fluoroarabinonucleotide (2?-FANA)-modified nucleotide sequence. In some embodiments, the 2?-FANA-modified nucleotide sequence inhibits dimerization of retroviral genomes (e.g., an HIV genome). Other embodiments include methods of inhibiting expression of a retrovirus using the synthetic oligonucleotide, and methods of treating or preventing a retroviral infection.
    Type: Application
    Filed: June 29, 2023
    Publication date: January 4, 2024
    Applicants: CITY OF HOPE, AUM LIFE TECH, INC., THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY
    Inventors: John J. ROSSI, Masad J. DAMHA, Veenu AISHWARYA, Mayumi TAKAHASHI, Haitang LI
  • Patent number: 11802309
    Abstract: A heating mechanism for use in DNA applications such as DNA amplification, extraction and sterilization is provided. Nanoparticles having photo-thermal properties are put in contact with a reaction mixture and irradiated with an activation light beam to activate these photo-thermal properties, thereby releasing heat. Nanoparticles of several types may be used. Use of the same nanoparticles or of different one to monitor the reaction using a different light beam is also presented.
    Type: Grant
    Filed: February 13, 2020
    Date of Patent: October 31, 2023
    Assignee: THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING /MCGILL UNIVERSITY
    Inventors: Philip Roche, Andrew Kirk, Lenore Beitel, Miltiadis Paliouras, Mark Trifiro, Vamsy Chodavarapu, Mohamed Najih, Joachim Thiemann
  • Patent number: 11718011
    Abstract: There is described a method and system for regulating an extrusion process by obtaining a first thickness at a first position along an extrudate as material is extruded through a die gap of a die; comparing the first thickness with an expected thickness of the extrudate at the first position to obtain a value for an error, the expected thickness modeled in real-time using a size of the die gap as input; and varying the size of the die gap when the error exceeds a threshold to compensate for the error. There is also described a method and system for determining an expected thickness of a material during an extrusion process.
    Type: Grant
    Filed: May 8, 2020
    Date of Patent: August 8, 2023
    Assignee: THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY
    Inventors: Benoit Boulet, Raffi Toukhtarian, Mostafa Darabi
  • Patent number: 11679032
    Abstract: Active dichoptic perceptual-learning tasks or dichoptic game play have been shown to significantly improve visual acuity of amblyopic children and adults. However, these dichoptic perceptual learning tasks are intensive and repetitive such that non-compliance is high. In contrast, the invention provides dichoptic perceptual learning in a manner that the user maintains its use and compliance is increased. Further, compliance becomes automatic if the user performs tasks in a normal manner and “forgets” that they are actually under-going treatment as it is integrated with minimal disruption to their life and activities. Accordingly, a methodology exploiting complementary dichoptic stimulation is presented.
    Type: Grant
    Filed: September 8, 2021
    Date of Patent: June 20, 2023
    Assignee: THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY
    Inventors: Robert F. Hess, Reza Farivar-Mohseni, Alexandre Reynaud
  • Patent number: 11672846
    Abstract: The present disclosure relates to methods of treating or preventing a biofilm-related infection and methods of preventing and treating biofilm formation on indwelling medical devices, implants, and non-medical surfaces comprising administering at least one soluble microbial protein that is encoded by an exopolysaccharide biosynthetic operon or functional gene cluster, wherein the protein comprises a glycosyl hydrolase domain. The present disclosure further provides particular soluble glycosyl hydrolases and compositions thereof.
    Type: Grant
    Filed: December 18, 2020
    Date of Patent: June 13, 2023
    Assignees: The Hospital for Sick Children, The Royal Institution for the Advancement of Learning/McGill University
    Inventors: Lynne P. Howell, Perrin Baker, Noor Alnabelseya, Natalie Bamford, Dustin Little, Donald Sheppard, Brendan Snarr, Mark Jae Lee
  • Patent number: 11656369
    Abstract: Herein provided is a radiation dosimeter and associated systems and methods. The radiation dosimeter comprises a light source configured for producing an input optical signal; a resonant cavity coupled to the light source for receiving the input optical signal, the resonant cavity configured for containing a fluid and for producing an output optical signal from the input optical signal indicative of a radiation dose absorbed by the fluid; and a light detector coupled to the optical fiber for obtaining the output optical signal.
    Type: Grant
    Filed: December 20, 2019
    Date of Patent: May 23, 2023
    Assignee: THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY
    Inventors: Shirin Abbasi Nejad Enger, Jack Childress, Lilian Childress, Julien Megroureche
  • Patent number: 11648555
    Abstract: There is disclosed a capillary microfluidic circuit including a main channel communicating with a flow inducing element. The main channel has intermediary inlets. Reservoirs for containing one or more liquids prior to being drawn into the main channel. The reservoirs include a first reservoir and at least a second reservoir. Each of the reservoirs has an upstream end connectable to vents for filling the reservoirs with the one or more liquids and a downstream end. The downstream end of each of the reservoirs is connected to the intermediary inlets of the main channel A conduit is disposed between the first reservoir and the a least a second reservoir. The conduit links the downstream end of the first reservoir with the upstream end of the at least a second reservoir.
    Type: Grant
    Filed: October 19, 2018
    Date of Patent: May 16, 2023
    Assignee: THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY
    Inventors: David Juncker, Ayokunle Olanrewaju, Mohamed Yafia Okba Salem
  • Patent number: 11651486
    Abstract: A method and apparatus of early-stage detection of glaucoma and other optic nerve or retinal diseases employs dynamic images that are processed differently by Y-like cells and X-like cells to provide a sensitive detection of early Y-like cell impairment which provides early indications of glaucoma isolated from non-specific information from X-like cells.
    Type: Grant
    Filed: April 3, 2020
    Date of Patent: May 16, 2023
    Assignees: Wisconsin Alumni Research Foundation, The Royal Institution for the Advancement of Learning/McGill University
    Inventors: Peter Ari Rosenberg Maffia, Curtis Lee Baker, Ana Leticia Ramirez Hernandez
  • Patent number: 11638566
    Abstract: Methods and systems for establishing a kinetic model input function (IF) in positron emission tomography and single-photon emission computed tomography are provided. A position of interaction along a scintillating fiber coil is determined by: detecting a first plurality and second plurality of photons at first and second ends of the scintillating fiber coil; associating the first plurality of photons and the second plurality of photons with the interaction event based on a timing parameter; and determining a position of interaction for the interaction event based on a comparison between a first parameter of the first plurality of photons and a second parameter of the photons in the second plurality of photons.
    Type: Grant
    Filed: May 31, 2018
    Date of Patent: May 2, 2023
    Assignee: THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY
    Inventors: Shirin Abbasi Nejad Enger, Gustavo Adolfo Vladimir Kertzscher Schwencke
  • Publication number: 20230123617
    Abstract: A neurofeedback method, including: recording electrical signals from at least one brain region of a subject, wherein changes in the recorded electrical signals over time indicate changes in an activity level of the at least one brain region; providing an audio signal having a perceived quality based on the recorded electrical signals and according to an activity level of the at least one brain region; delivering the audio signal to the subject during said recording.
    Type: Application
    Filed: December 21, 2022
    Publication date: April 20, 2023
    Applicants: Ichilov Tech Ltd., Ramot at Tel-Aviv University Ltd., The Royal Institution For The Advancement Of Learning/McGill University
    Inventors: Talma HENDLER, Neomi SINGER, Robert ZATORRE, Alain DAGHER, Marcel FARRES-FRANCH
  • Patent number: 11614395
    Abstract: Nanofluidic flow cells and systems for single-molecule nanoconfinement and imaging of molecules in a fluid are described. The nanofluidic flow cell comprises a bottom substrate bonded to a top substrate, microchannels and a central chamber carved in the bottom or top substrate. The microchannels and the central chamber define an empty space into which a fluid can flow. The microchannels extend on opposite side of the central chamber, each microchannel comprising a central portion crossing the central chamber and a pair of arms extending outside the central chamber, these arms comprising a fluid port positioned at opposite ends of the microchannel and outside the central chamber. The central chamber comprises a nanoconfinement and imaging area including carved nanostructures configured for single-molecule nanoconfinement. Also described are nanofluidic chips, methods of confinement, pneumatic-based nanofluidic systems and manifold assembly for the nanofluidic flow cell.
    Type: Grant
    Filed: October 16, 2018
    Date of Patent: March 28, 2023
    Assignee: THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY
    Inventors: Sabrina R. Leslie, Daniel J. Berard
  • Patent number: 11597739
    Abstract: The invention encompasses ex vivo method of stimulating isolated memory T-cell, tumor-infiltrating lymphocyte (TIL), T cell receptor (TCR) engineered cell, and/or chimeric antigen receptor (CAR) engineered cell with compounds of Formula I below, which are inhibitors of the TC-PTP enzyme.
    Type: Grant
    Filed: August 24, 2018
    Date of Patent: March 7, 2023
    Assignee: THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY
    Inventors: Michel L. Tremblay, Kelly-Anne Pike, Luis Alberto Perez Quintero
  • Patent number: 11597780
    Abstract: Method for producing high molecular weight chitosan comprising milling or grinding chitin and a reagent to produce a chitin/reagent mixture; and aging said chitin/reagent mixture to produce a high molecular weight chitosan. Method for producing low molecular weight chitosan comprising amorphizing chitin; milling or grinding said amorphized chitin and a reagent to produce chitin/reagent mixture; and aging said chitin/reagent mixture producing low molecular weight chitosan.
    Type: Grant
    Filed: July 31, 2019
    Date of Patent: March 7, 2023
    Assignee: THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/McGILL UNIVERSITY
    Inventors: Audrey Moores, Thomas Di Nardo
  • Patent number: 11598155
    Abstract: A system for monitoring a bit condition in a drilling operation comprises a processor unit and a non-transitory computer-readable memory communicatively coupled to the processing unit and comprising computer-readable program instructions executable by the processing unit for: obtaining signals representative of at least vibrations of a drilling mast having at least one bit during a drilling operation; interpreting the signals into vibration values; continuously monitoring the vibration values in real time; and assessing and outputting a condition of the bit as a function of the continuous monitoring of the vibration values.
    Type: Grant
    Filed: October 2, 2018
    Date of Patent: March 7, 2023
    Assignee: THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY
    Inventors: Faramarz (Ferri) P. Hassani, Hamed Rafezi
  • Patent number: 11583511
    Abstract: The present invention relates to maresins, preferably maresin-1, for use in the treatment of CNS injuries preferably selected from spinal cord injury and traumatic brain injury.
    Type: Grant
    Filed: July 20, 2017
    Date of Patent: February 21, 2023
    Assignees: UNIVERSITAT AUTONOMA DE BARCELONA, OHIO STATE UNIVERSITY, THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY
    Inventors: Ruben Lopez Vales, Isaac Francos Quijorna, Jan Markus Schwab, Samuel David