Abstract: Methods and compositions for reducing the activity or number of memory Th17 cells in ocular tissue, and for treatment and/or prevention of ocular immunoinflammatory diseases are described.
Type:
Grant
Filed:
January 6, 2017
Date of Patent:
April 19, 2022
Assignee:
The Schepens Eye Research Institute, Inc.
Abstract: The current subject matter relates to rehabilitation using a content guide for viewing video, for example as a vision rehabilitation aid for individuals with hemianopia or as a rehabilitation aid for individuals with attention disorders. The current subject matter includes providing video in which a region of interest of the image is specified with a marker, referred to herein as a content guide. The content guide can include a circle surrounding the region of interest. By providing video with a content guide to direct viewers to a region of interest in the video, information acquisition by the viewers is improved. Such an approach can aid individuals with vision deficits or attention disorders. The current subject matter can also be used as a therapy for spatial neglect. Related apparatus, systems, techniques and articles are also described.
Type:
Grant
Filed:
February 17, 2018
Date of Patent:
April 12, 2022
Assignee:
The Schepens Eye Research Institute, Inc.
Inventors:
Dylan J. Rose, Daniel R. Saunders, Russell L. Woods
Abstract: A system for providing information about an environment to a user within the environment is featured. An electronic processor is configured to receive input including a user selection of an object of interest from among potential objects of interest. The electronic processor is further configured to provide output to guide the user to move the detection apparatus to position the object of interest near a reference point on a field of view of the detection apparatus, obtain multiple images of the object of interest during the user's movement of the detection apparatus, and crop each of the images to keep the object of interest near a reference point on each of the images.
Type:
Grant
Filed:
March 16, 2018
Date of Patent:
March 8, 2022
Assignee:
The Schepens Eye Research Institute, Inc.
Abstract: There are provided inter alia compounds capable of inhibiting retinal pigment epithelium (RPE) degeneration or geography atrophy (GA) associated with age-related macular degeneration (AMD), and methods of using the same.
Type:
Grant
Filed:
October 3, 2018
Date of Patent:
March 1, 2022
Assignee:
The Schepens Eye Research Institute, Inc.
Inventors:
Yin Shan Eric Ng, Gopalan Gnanaguru, Ashley Mackey, Patricia A. D'Amore, David Scott
Abstract: The invention comprises a composition with means to inhibit the function of the inflammatory cytokine IL-17 and methods for using this composition to treat IL-17-mediated ocular inflammatory disorders. The invention also discloses devices for delivering this composition to the eye.
Type:
Grant
Filed:
December 14, 2017
Date of Patent:
February 8, 2022
Assignee:
The Schepens Eye Research Institute, Inc.
Abstract: The present subject matter provides compositions, formulations, and methods for inhibiting, treating, or preventing aberrant angiogenesis in a subject.
Type:
Grant
Filed:
November 14, 2017
Date of Patent:
January 25, 2022
Assignee:
The Schepens Eye Research Institute, Inc.
Inventors:
Joseph F. Arboleda-Velasquez, Leo A. Kim, Patricia A. D'Amore
Abstract: The present application is directed to the use of a VEGF-C inhibitor, a VEGFR-2 inhibitor and/or a VEGFR-3 inhibitor as a prophylactic or therapeutic for the treatment of eye disorders such as a maculopathy and pathogenic ocular neovascularisation. The application is also directed to the use of a VEGF-C measurement from a biological sample from a mammalian subject as a predictive marker, a selected marker, a responsive marker or a tracking marker for a disease or condition selected from the group consisting of a maculopathy and pathogenic ocular neovascularization.
Type:
Grant
Filed:
March 25, 2019
Date of Patent:
December 28, 2021
Assignees:
VEGENICS PTY LIMITED, THE SCHEPENS EYE RESEARCH INSTITUTE, INC.
Inventors:
Megan E. Baldwin, Kameran Lashkari, Jie Ma
Abstract: Methods of the invention treat, reduce, or reverse fibrosis of a bodily tissue by administering to the local affected tissue a composition comprising an inhibitor of p38 MAP kinase, which treatment leads to a reduction or reversal of fibrosis.
Type:
Grant
Filed:
October 17, 2016
Date of Patent:
October 26, 2021
Assignee:
The Schepens Eye Research Institute, Inc.
Abstract: Methods are described for predicting ancestral sequences for viruses or portions thereof. Also described are predicted ancestral sequences for adeno-associated virus (AAV) capsid polypeptides. The disclosure also provides methods of gene transfer and methods of vaccinating subjects by administering a target antigen operably linked to the AAV capsid polypeptides.
Type:
Grant
Filed:
December 17, 2019
Date of Patent:
August 31, 2021
Assignees:
The Schepens Eye Research Institute, Inc., Massachusetts Eye and Ear Infirmary
Abstract: An implementation of an optical system for expanding the field of view can include a first optical element and a second optical element. The first optical element can include a first surface and a second surface. The first surface can be configured to reflect a first light beam incident on the first surface at a first incident angle greater than a first predetermined angle, and the second surface can be configured to reflect the reflected first light beam towards a location. The second optical element can include a third surface and a fourth surface. The third surface can be configured to reflect a second light beam incident on the third surface at a second incident angle greater than a second predetermined angle, and the fourth surface can be configured to reflect the reflected second light beam towards the location. Related apparatus, systems, techniques and articles are also described.
Type:
Application
Filed:
October 11, 2018
Publication date:
July 1, 2021
Applicant:
The Schepens Eye Research Institute, Inc.
Abstract: Methods and compositions are provided that can be used to modify the assembly activating protein (AAP)-dependence of an adeno-associated virus (AAV).
Type:
Grant
Filed:
May 10, 2019
Date of Patent:
June 15, 2021
Assignees:
Massachusetts Eye and Ear Infirmary, The Schepens Eye Research Institute, Inc.
Inventors:
Luk H. Vandenberghe, Anna Claire Maurer
Abstract: Methods of treating acute thyroid eye disease (TED) by administering a inhibitor, e.g., a VEGF-A inhibitor, e.g., an anti-VEGF antibody, optionally in combination with hyaluronidase, by periorbital or intraorbital injection. Also compositions comprising a VEGF inhibitor and hyaluronidase.
Type:
Grant
Filed:
June 8, 2017
Date of Patent:
February 2, 2021
Assignees:
Massachusetts Eye and Ear Infirmary, The Schepens Eye Research Institute, Inc.
Inventors:
N. Grace Lee, Leo Kim, Patricia A. D'Amore, James A. Stefater
Abstract: A method for reducing neovascularization in an ocular tissue is carried out by contacting the tissue with an inhibitor of endomucin expression or activity.
Type:
Grant
Filed:
March 31, 2017
Date of Patent:
January 5, 2021
Assignee:
The Schepens Eye Research Institute, Inc.
Inventors:
Patricia A. D'Amore, Magali Saint-Geniez, Cindy Park-Windhol
Abstract: The disclosure features systems and methods for providing information to a user about the user's environment. The systems feature a detection apparatus configured to obtain image information about the environment, where the image information corresponds to information at multiple distances relative to a position of the user within the environment, and an electronic processor configured to obtain focal plane distance information defining a set of one or more distance values relative to the position of the user within the environment, construct one or more confocal images of the environment from the image information and the set of one or more distance values, wherein each of the one or more confocal images corresponds to a different distance value and includes a set of pixels, and transform the one or more confocal images to form one or more representative images having fewer pixels and a lower dynamic range.
Type:
Grant
Filed:
November 8, 2018
Date of Patent:
December 8, 2020
Assignee:
The Schepens Eye Research Institute, Inc.
Abstract: Disclosed is a method of promoting neuronal growth by administering IGFBPL-1, or an agent that increases or stabilizes IGFBPL-1 activity to a subject in need thereof, e.g., a subject in need of treating optic nerve degeneration.
Type:
Grant
Filed:
February 28, 2012
Date of Patent:
November 24, 2020
Assignee:
The Schepens Eye Research Institute, Inc.
Abstract: The invention provides compositions and methods for preserving, restoring, or enhancing vision of a subject by administering compositions to an injured or diseased eye.
Type:
Grant
Filed:
October 20, 2014
Date of Patent:
September 22, 2020
Assignee:
The Schepens Eye Research Institute, Inc.
Abstract: The present subject matter provides, inter alia compositions, formulations, and methods for inhibiting, treating, and preventing small vessel diseases.
Type:
Application
Filed:
March 26, 2018
Publication date:
April 2, 2020
Applicant:
The Schepens Eye Research Institute, Inc.
Abstract: Methods are described for predicting ancestral sequences for viruses or portions thereof. Also described are predicted ancestral sequences for adeno-associated virus (AAV) capsid polypeptides. The disclosure also provides methods of gene transfer and methods of vaccinating subjects by administering a target antigen operably linked to the AAV capsid polypeptides.
Type:
Grant
Filed:
November 2, 2018
Date of Patent:
January 7, 2020
Assignees:
The Schepens Eye Research Institute, Inc., Massachusetts Eye and Ear Infirmary
Abstract: This application discloses ophthalmic formulations and methods for treating and preventing corneal haze and scarring with an hepatocyte growth factor (HGF) agent.
Type:
Grant
Filed:
September 9, 2016
Date of Patent:
October 22, 2019
Assignee:
The Schepens Eye Research Institute, Inc.
Abstract: In some implementations, there is provided a method. The method may include receiving data characterizing a plurality of digital video frames; detecting a plurality of features in each of the plurality of digital video frames; determining, from the detected features, a local scale change and a translational motion of one or more groups of features between at least a pair of the plurality of digital video frames; and calculating a likelihood of collision. Related apparatus, systems, techniques, and articles are also described.
Type:
Grant
Filed:
May 9, 2017
Date of Patent:
September 3, 2019
Assignee:
The Schepens Eye Research Institute, Inc.
Inventors:
Gang Luo, Eliezer Peli, Shrinivas Pundlik