Abstract: The invention provides compositions and methods for utilizing a peptide of thrombospondin-1 as an anti-inflammatory agent.

Abstract: This application discloses pharmaceutical compositions (e.g., oral, parenteral or topical ophthalmic formulations) for treating Fuchs endothelial corneal dystrophy (FECD) with one or more Nrf2 activators and/or mitochondrially targeted antioxidants. The compositions may be topically administered to the eye and are effective in the treatment of FECD. The invention further provides methods of treating FECD by in a subject in need of such treatment by topical application of one or more Nrf2 activators and/or mitochondrially of the invention.

Abstract: The present invention is directed to an adult retinal cell line isolated from extra-retinal ocular tissue, and methods of isolating adult retinal cells from extra-retinal ocular tissue. The present invention is further directed to adult retinal stem cells isolated from vestigial tissue dissected from the eye of a donor mammal suffering from persistent fetal vasculature. The present invention is further directed to a culture medium for growing or maintaining retinal stem cells, and methods of maintaining adult retinal cells in culture. The present invention is further directed to methods of treating a treating an eye with retinal dystrophy using retinal stem cells, and an eye with glaucomatous injury with retinal stem cells. The present invention is further directed to kits for harvesting extra-retinal ocular tissue comprising a sterile container and a harvesting solution, wherein the kit allows the survival of the tissue until later dissociation of cells from the tissue.

Abstract: The present invention relates to compositions comprising omega-6 and/or omega-3 fatty acids and uses thereof. The present invention also relates to methods of treatment using such compositions.

Abstract: A spectacle system is disclosed for shifting the field expansion property of peripheral prisms from the upper and lower peripheral visual fields toward the central visual field of a person with peripheral field loss, and particularly hemianopia, while maintaining the lateral field expansion. In terms of perceived image, the spectacle system includes image-shifting devices that shift the perceived images from the central missing visual fields toward the upper and lower peripheral visual fields. The image-shifting devices are placed out of the central visual field and do not interfere with the normal central or foveal vision of the wearer. The spectacle system can be fitted onto one or both carrier lenses of a pair of spectacles and includes at least one image-shifting device. The image-shifting device includes a plurality of image-shifting elements. In one embodiment, the image-shifting device includes a plurality of image-shifting mirror elements that are arranged to form a Fresnel-like mirrors based prism.

Abstract: The invention encompasses isolation, culture and characterization of goblet cells in vitro from mammalian conjuctiva. Goblet cells can be cultured from conjunctiva of such mammals as, e.g., humans, rats, mice, rabbits and the like. In another aspect of the invention, the culture of goblet cells has a concentration of pure goblet cells of 10% or greater. In a further embodiment, the invention comprises an immortalized goblet cell line.

Abstract: The present invention relates to compositions comprising omega-6 and/or omega-3 fatty acids and uses thereof. The present invention also relates to methods of treatment using such compositions.

Abstract: An image processing technique produces modified images by extracting strong features of the original image, i.e., bars and edges, and superimposing such extracted features onto the original image. The invention combines the Hilbert transform of the image data with the image data in a pre-defined manner to produce the so-called energy function whose maxima correspond to the strong features of the image. Addition of these extracted features to the original image results in obtaining an enhanced image. In addition, the invention provides techniques for enhancing the real-world view of natural scenes. Another practice of the invention employs a plurality of oriented filters for extracting luminance features of an image. An apparatus of the invention displays the extracted luminance features as contour version of the original image. Another apparatus of the invention provides a minified contour image of a natural scene to assist a patient having a restricted peripheral vision in locating objects in the scene.

Abstract: The present invention relates to conjunctival goblet cell proliferation and secretions. The present invention also relates to compositions that can modulate conjunctival goblet cell proliferation and secretions. The present invention also relates to galectins, PDGF, bFGF, and the regulation of goblet cells.

Abstract: The invention encompasses isolation, culture and characterization of goblet cells in vitro form mammalian conjuctiva. Goblet cells can be cultured from conjunctiva of such mammals as, e.g., humans, rats, mice, rabbits and the like. In another aspect of the invention, the culture of goblet cells has a concentration of pure goblet cells of 10% or greater.

Abstract: The invention relates to apparatus and methods for increasing visual acuity through the use of a bioptic telescope which is at least partially embedded in a spectacle lens. In one embodiment, the telescope includes a vision lens having a vision axis and a first surface for placement substantially in front of an eye of a user. The telescope further includes a plurality of optical elements defining an optical path for viewing an object in front of the first surface. At least one of the plurality of optical elements is positioned such that at least a portion of the optical path is located within the vision lens in a plane substantially orthogonal to the vision axis.

Abstract: An image processing technique produces modified images by extracting strong features of the original image, i.e., bars and edges, and superimposing such extracted features onto the original image. The invention combines the Hilbert transform of the image data with the image data in a pre-defined manner to produce the so-called energy function whose maxima correspond to the strong features of the image. Addition of these extracted features to the original image results in obtaining an enhanced image. In addition, the invention provides techniques for enhancing the real-world view of natural scenes. Another practice of the invention employs a plurality of oriented filters for extracting luminance features of an image. An apparatus of the invention displays the extracted luminance features as contour version of the original image. Another apparatus of the invention provides a minified contour image of a natural scene to assist a patient having a restricted peripheral vision in locating objects in the scene.

Abstract: Disclosed is a method of stimulating adult corneal endothelial cell proliferation, which includes incubation of corneal endothelium to a mitogen-containing medium and then to an agent that interrupts cell-cell contacts in the adult corneal endothelial cells, and subsequently, as needed, further incubation in the mitogen-containing medium. The cell-cell contact-interrupting agent is preferably a calcium chelator.

Abstract: A human cell growth medium formulation for culturing human cells of neural crest origin, most preferably corneal endothelial cells, or for accelerating the growth and proliferation of human cells of neural crest origin is disclosed. The formulation for the nutrient medium of the invention includes nerve growth factor, preferably at a concentration of 1-100 ng/ml and most preferably 20 ng/ml. The growth medium formulation preferably also includes epidermal growth factor (preferably at a concentration of 1-200 ng/ml and most preferably 5 ng/ml).

Abstract: The invention relates to methods and apparatus for determining a characteristic of an optical element. The apparatus includes a spatial light pattern generator adapted to generate a beam of light at a predetermined spatial position, at least one lenslet disposed in an array of lenslets adapted to receive the beam of light from the spatial light pattern generator, and to direct the beam of light to the optical element. The apparatus further includes a detector positioned to receive the beam of light subsequent to the beam of light encountering the optical element. The detector is adapted to detect a received spatial position at which the detector receives the beam of light. The apparatus also includes a processor adapted to compare the predetermined spatial position with the received spatial position to determine the characteristic of the optical element. The invention further relates to methods and apparatus for generating a diffraction limited image.

Abstract: A Non-Maxwellian, free viewing system capable of psychophysical measurement of visual sensitivity for the determination of ocular components is disclosed. The apparatus features electronically controlled light emitting elements whose outputs are variable with respect to intensity and temporal pattern, and can be combined by a small number of optical components. The light emitting elements can have outputs of different wavelengths, can be positioned at different retinal locations, and can be viewed through masks or apertures having different geometries. These features permit miniaturization of the device, and eliminate a major or experimental difficulty of light path alignment associated with larger systems, thus simplifying the measurement of macular pigment density compared to procedures used with a full sized optical bench.

Abstract: The topical application, at a dose rate less than or equal to 0.1 mg day, to the ocular surface or adjacent regions of the eye of a preparation containing a therapeutically effective amount of an androgen or androgen analogue or a therapeutically effective amount of TGF-.beta. is disclosed as a method of relieving the chronic and acute manifestation of dry eye signs and symptoms in keratoconjunctivitis sicca (KCS), for example in Sjogren's syndrome.

Abstract: The topical application to the ocular surface or adjacent regions of the eye of a preparation containing a therapeutically effective amount of an androgen or androgen analogue or a therapeutically effective amount of TGB-.beta. is disclosed as a method of relieving the chronic and acute manifestation of dry eye signs and symptoms in keratoconjunctivitis sicca (KCS), for example in Sjogren's syndrome. Measurement of the increased tear levels of TGF-.beta. is disclosed as a diagnostic test to monitor the therapeutic effect of topical treatment with androgen or androgen analogues.

Abstract: A monoclonal antibody has been produced that binds to apical cells of human ocular surface and vaginal epithelia. The antigen recognized by this monoclonal antibody is a mucin-like cell surface glycoprotein. The antibody is of diagnostic use in the evaluation of the ocular surface in dry eye patients, and the antigen has therapeutic potential for use in treatment of dry eye disease. In a comparison of dry eye and normal patients the pattern of antibody binding to dry eye ocular surface epithelia has been shown to differ from the binding pattern seen in normal epithelia.

Abstract: A laser source attached to an ophthalmic observation instrument, such as a fundus camera, projects a spot, and a light collector is positioned in the image field of the instrument over the spot to collect return light scattered from a homogeneous tissue bed in the image field. The collected light is directed onto a photomultiplier and digitized at a sampling rate above several kHz to provide a continuous data stream which is fed to a process/control module that operates to automatically define a number n of sample intervals, select a subset of the sample intervals for analysis, transform the selected intervals, and evaluate the shape of the transformed sample intervals. The process/control module may be implemented on a simple computer, and include a user interface which indicates status of signal acquisition, selection and evaluation during a short, e.g., one-minute illumination interval.