Patents Assigned to The State University
  • Peptide inhibitor of HIV reverse transcription
    Patent number: 9975922
    Abstract: Disclosed are peptides that exhibit good binding to the anticodon stem and loop of human lysine tRNA species, tRNALys3. The starting point was the 15-amino-acid sequence, RVTHHAFLGAHRTVG, found to bind selectively to hypermodified tRNALys3. The peptide backbone conformation was determined via atomistic simulation of the peptide-ASLLys3complex and then held fixed throughout the search. Analysis of the binding structure and the various contributions to the binding energy shows that: 1) two hydrophilic residues (asparagine (ASN) at site 11 and the cysteine (CYS) at site 12) “recognize” the ASLLys3 due to the VDW energy, and thereby contribute to its binding specificity, and 2) the positively-charged arginines (ARG) at sites 4 and 13 preferentially attract the negatively-charged sugar rings and the phosphate linkages, and thereby contribute to the binding affinity.
    Type: Grant
    Filed: October 21, 2014
    Date of Patent: May 22, 2018
    Assignees: The Research Foundation For The State University of New York, North Carolina State University
    Inventors: Paul F. Agris, Carol Hall, Xingqing Xiao
  • NEEDLE GUIDE DEVICE AND METHOD
    Publication number: 20180125528
    Abstract: The present disclosure provides a fluoroscopic needle guide device for use in medical procedures that facilitate the direct targeting of a pre-identified target in a subject and methods for reaching the same with a medical device. The present disclosure includes fluoroscopic needle guide devices including detachable alignment indicators and methods for using the same.
    Type: Application
    Filed: May 12, 2016
    Publication date: May 10, 2018
    Applicant: The Research Foundation for The State University of New York
    Inventor: Christopher PAGE
  • Kojic Acid Polymers
    Publication number: 20180116945
    Abstract: A controlled release system for kojic acid having improved stability has been identified. To minimize degradation, kojic acid was incorporated into a hydrolytically degradable polymer (e.g., a polycarbonate-ester)). By synthesizing polymer precursors containing kojic acid-linker-kojic acid chemical structures, versatile monomers were developed that can be used to modulate polymer properties. Additionally the synthetic method lends itself to the development of other polymer systems. Polymers having one or more groups that will yield kojic acid upon degradation of the polymer backbone, as well as methods of use thereof are described.
    Type: Application
    Filed: April 11, 2016
    Publication date: May 3, 2018
    Applicant: Rutgers, The State University of New Jersey
    Inventors: Kathryn Uhrich, Kervin Smith, Jonathan Faig
  • Bacterial efflux pump inhibitors
    Patent number: 9950993
    Abstract: Disclosed herein are compounds of formula I: and salts thereof. Also disclosed are compositions comprising of compounds of formula I and methods using compounds of formula I.
    Type: Grant
    Filed: March 11, 2016
    Date of Patent: April 24, 2018
    Assignee: Rutgers, The State University of New Jersey
    Inventors: Edmond J. LaVoie, Gifty A. Blankson, Ajit K. Parhi, Malvika Kaul, Daniel S. Pilch
  • Methods of producing a paper product
    Patent number: 9945073
    Abstract: An omnibus process of pulping and bleaching lignocellulosic materials in which a charge of a lignocellulosic material is biopulped and/or water extracted prior to pulping and bleaching. The lignocellulosic material may be mechanically pulped and bleached in the presence of an enzyme that breaks lignin-carbohydrate complexes.
    Type: Grant
    Filed: June 16, 2017
    Date of Patent: April 17, 2018
    Assignee: The Research Foundation for The State University of New York
    Inventors: Thomas E. Amidon, Raymond Francis, Gary M. Scott, Jeremy Bartholomew, Bandaru V. Ramarao, Christopher D. Wood
  • Color-encoding and in-situ interrogation of matrix-coupled chemical compounds
    Patent number: 9945051
    Abstract: A method and apparatus for the physico-chemical encoding of a collection of beaded resin (“beads”) to determine the chemical identity of bead-anchored compounds by in-situ interrogation of individual beads. The present invention provides method and apparatus to implement color-coding strategies in applications and including the ultrahigh-throughput screening of bead-based combinatorial compounds libraries as well as multiplexed diagnostic and environmental testing and other biochemical assays.
    Type: Grant
    Filed: January 28, 2015
    Date of Patent: April 17, 2018
    Assignee: Rutgers, The State University of New Jersey
    Inventor: Richard Ebright
  • HIV-1 antigens with discrete conformational forms in the V1/V2 domain and methods of use thereof
    Patent number: 9938325
    Abstract: The present invention relates to a novel composition of HIV-1 Env proteins that contain structurally and immunologically distinct VI/V2 domains. Methods of isolating such proteins, and methods of using such proteins as immunogens, therapeutic agents, vaccines, and test compounds for use in identifying a HIV antiviral are also provided.
    Type: Grant
    Filed: September 6, 2013
    Date of Patent: April 10, 2018
    Assignee: Rutgers, The State University of New York
    Inventor: Abraham Pinter
  • Nano-electrode multi-well high-gain avalanche rushing photoconductor
    Patent number: 9941428
    Abstract: Provided is a detector that includes a scintillator, a common electrode, a pixel electrode, and a plurality of insulating layers, with a plurality of nano-pillars formed in the plurality of insulating layers, a nano-scale well structure between adjacent nano-pillars, with a-Se separating the adjacent nano-pillars, and a method for operation thereof.
    Type: Grant
    Filed: May 23, 2017
    Date of Patent: April 10, 2018
    Assignee: The Research Foundation for The State University of New York
    Inventors: Amirhossein Goldan, Wei Zhao, John A. Rowlands
  • Oxyntomodulin analogs and methods of making and using same
    Patent number: 9931379
    Abstract: Provided are oxyntomodulin analogs. The peptide analogs have at least two cysteines. The two cysteines are separated by six amino acids such that they can be crosslinked using suitable crosslinking moieties. The crosslinked peptides have long half-lives and/or efficacy. For example, peptide analog compositions are used for inducing weight loss and/or reducing blood glucose levels.
    Type: Grant
    Filed: March 7, 2017
    Date of Patent: April 3, 2018
    Assignees: The Research Foundation for The State University of New York, California Institute for Biomedical Research
    Inventors: Qing Lin, Avinash Muppidi, Weijun Shen, Huafei Zou, Peter Schultz, Yulin Tian
  • Therapeutic hydroxypyridinones, hydroxypyrimidinones and hydroxypyridazinones
    Patent number: 9932323
    Abstract: The invention provides compounds of formula I: and salts and prodrugs thereof wherein R4, X1 and X2 have any of the meanings defined in the specification, as well as pharmaceutical compositions comprising the compounds or salts and methods for their use in therapy. The compounds have useful antiviral properties.
    Type: Grant
    Filed: January 13, 2017
    Date of Patent: April 3, 2018
    Assignee: Rutgers, The State University of New Jersey
    Inventors: Edmond J. Lavoie, Joseph David Bauman, Ajit Parhi, Hye Yeon Sagong, Disha Patel, Eddy Arnold, Kalyan Das, Suyambu Kesava Vijayan
  • THREE-DIMENSIONAL CARBON STRUCTURES
    Publication number: 20180086640
    Abstract: The method of the present disclosure is directed towards the formation of a three-dimensional carbon structure and includes the steps of adding a radical initiator to an amount of carbon starting material, forming a mixture, placing the mixture in a mold, maintaining the mixture and the mold at an elevated temperature for a period of time to form a thermally cross-linked molded mixture and removing the thermally cross-linked molded mixture from the mold. The disclosure also includes a three-dimensional carbon structure, with that structure including a thermally cross-linked carbon base material in a predetermined formation.
    Type: Application
    Filed: November 14, 2017
    Publication date: March 29, 2018
    Applicant: The Research Foundation for The State University of New York
    Inventors: Balaji Sitharaman, Gaurav Lalwani
  • Bacterial efflux pump inhibitors
    Patent number: 9926261
    Abstract: Disclosed herein are compounds of formula I: and salts thereof. Also disclosed are compositions comprising of compounds of formula I and methods using compounds of formula I.
    Type: Grant
    Filed: March 10, 2016
    Date of Patent: March 27, 2018
    Assignee: Rutgers, The State University of New Jersey
    Inventors: Edmond J. LaVoie, Ajit K. Parhi, Gifty A. Blankson, Malvika Kaul, Daniel S. Pilch
  • Antibacterial agents: N?-aroyl-N-aryl-phenylalaninamides
    Patent number: 9919998
    Abstract: The invention provides compounds having activity as bacterial RNA polymerase inhibitors and antibacterial agents, as well as compositions comprising the compounds and methods for their use. Specifically, phenylalanineamide and tyrosinamide compounds are disclosed that have inhibitory activity toward mycobacterium tuberculosis RNA polymerase. Use of these compounds in the treatment or prevention of M. tuberculosis infections in a mammal, is disclosed.
    Type: Grant
    Filed: February 6, 2015
    Date of Patent: March 20, 2018
    Assignee: Rutgers, The State University of New Jersey
    Inventors: Richard H. Ebright, Yon W. Ebright, Soma Mandal, Richard Wilde, Shengjian Li
  • Highly selective nucleic acid amplification primers
    Patent number: 9909159
    Abstract: This invention discloses multi-part primers for primer-dependent nucleic acid amplification methods. Also disclosed are primer-dependent nucleic acid amplification reactions, particularly DNA amplification reactions, reaction mixtures and reagent kits for such reactions. This invention relates to primer-dependent nucleic acid amplification reactions, particularly DNA amplification reactions such as PCR, and primers, reaction mixtures and reagent kits for such reactions and assays employing same.
    Type: Grant
    Filed: February 7, 2014
    Date of Patent: March 6, 2018
    Assignee: Rutgers, The State University of New Jersey
    Inventors: Salvatore Marras, Diana Vargas-Gold, Sanjay Tyagi, Fred R. Kramer
  • RNA-Seq transcriptome analysis of spirodela dormancy without reproduction and identification of molecular targets useful for improving biomass production for industrial applications
    Patent number: 9909134
    Abstract: Compositions and methods are provided for altering carbon partitioning in biomass isolated from Duckweed.
    Type: Grant
    Filed: December 5, 2014
    Date of Patent: March 6, 2018
    Assignee: Rutgers, The State University of New Jersey
    Inventors: Joachim Messing, Wenqin Wang
  • KERATINS AS BIOMARKERS FOR CERVICAL CANCER AND SURVIVAL
    Publication number: 20180059112
    Abstract: The current disclosure provides methods for detecting and analyzing KRT4 and KRT17 expression in a sample obtained from a test subject. The current disclosure pertains to methods and kits for identifying a mammalian subject with cervical cancer or non-cancerous lesions of the cervix. The current disclosure further provides methods and kits for determining the likelihood of survival or treatment outcome of a subject having cervical cancer by determining the expression level of KRT17 in a sample.
    Type: Application
    Filed: November 6, 2017
    Publication date: March 1, 2018
    Applicant: The Research Foundation for The State University of New York
    Inventors: Kenneth R. Shroyer, Luisa F. Escobar-Hoyos, Emily I. Chen
  • Methods for evaluating brain-wide paravascular pathway for waste clearance function and methods for treating neurodegenerative disorders based thereon
    Patent number: 9901650
    Abstract: Methods are provided for measuring glio-vascular pathway (“glymphatic system”) function in the brain of a mammal which include performing imaging of the brain and measuring cerebrospinal fluid-interstitial fluid (CSF-ISF) exchange in the brain. The methods can be used to track the exchange between CSF and ISF compartments. An imaging agent is optionally administered intrathecally. The imaging agent can be a negative or positive (paramagnetic) contrast agent and dynamic or contrast-enhanced magnetic resonance imaging (MRI) of the brain can be performed. The imaging agent can be a positron-emitting radionuclide tracer and positron emission tomography (PET) can be performed. Methods for treating diseases or disorders of the mammalian brain are also provided, in which the methods increase or decrease glymphatic clearance.
    Type: Grant
    Filed: February 21, 2014
    Date of Patent: February 27, 2018
    Assignees: University of Rochester, The Research Foundation for The State University of New York
    Inventors: Maiken Nedergaard, Jeffrey J. Iliff, Helene Benveniste, Rashid Deane
  • Imaging individual mRNA molecules using multiple singly labeled probes
    Patent number: 9896720
    Abstract: A method for probing a target sequence of messenger ribonucleic acid molecules (mRNA's) in a fixed, permeabilized cell, said target sequence including at least 30 non-overlapping probe binding regions of 15-100 nucleotides, comprising immersing said cell in an excess of at least 30 nucleic acid hybridization probes, each singly labeled with the same fluorescent label and each containing a nucleic acid sequence that is complementary to a different probe binding region of said target sequence; washing said fixed cell to remove unbound probes; and detecting fluorescence from said probes.
    Type: Grant
    Filed: September 10, 2009
    Date of Patent: February 20, 2018
    Assignee: Rutgers, The State University of New Jersey
    Inventors: Arjun Raj, Sanjay Tyagi
  • Alkane-Alkene Coupling Via Tandem Alkane-Dehydrogenation/Alkene-Dimerization Catalyzed by Pincer Iridium Catalyst Heterogenized on Solid Supports
    Publication number: 20180044261
    Abstract: Disclosed herein are processes for tandem alkene dehydrogenation/alkene dimerization using an iridium pincer complex catalyst on a support comprising magnesium silicates (e.g., Florisil®). The reaction process comprises providing an iridium pincer complex bound to a solid support comprising magnesium silicates; providing a gaseous alkane feedstock comprising at least one alkane; and contacting the gaseous alkane feedstock with the iridium pincer complex bound to the solid support in the presence of a hydrogen acceptor to form dimerized alkenes. The processes disclosed herein can accomplish facile, low-temperature tandem transfer dehydrogenation of alkanes and dimerization of alkenes with unprecedented TONs at a reasonable rate of conversion.
    Type: Application
    Filed: July 31, 2017
    Publication date: February 15, 2018
    Applicants: Chevron U.S.A. Inc., Rutgers, The State University of New Jersey
    Inventors: Oleg Mironov, Robert J. Saxton, Alan S. Goldman, Akshai Kumar
  • THERMOCLEAVABLE FRICTION MODIFIERS AND METHODS THEREOF
    Publication number: 20180037840
    Abstract: Certain embodiments of the invention provide a lubricating oil composition comprising a lubricating oil base stock and a compound of formula (I): or a salt thereof, wherein R1, R2, R3 and R4 have any of the values defined in the specification, as well as methods of use thereof.
    Type: Application
    Filed: August 7, 2017
    Publication date: February 8, 2018
    Applicants: Rutgers, The State University of New Jersey, ExxonMobil Research and Engineering Company
    Inventors: Kathryn Uhrich, Jonathan Faig, Yingyue Zhang, Shuji Luo, Man Kit Ng, Alan Schilowitz, Anne Marie Shough