Patents Assigned to The State University
  • Gesture recognition biofeedback
    Patent number: 9877682
    Abstract: A gesture recognition biofeedback device is provided for improving fine motor function in persons with brain injury. The system detects a physical characteristic of the patient and provides feedback based on the detected characteristic. For instance, the system may detect surface muscle pressures of the forearm to provide real-time visual biofeedback to the patient based on a comparison of the detected muscle pressure and predefined values indicative of appropriate motor function.
    Type: Grant
    Filed: October 30, 2015
    Date of Patent: January 30, 2018
    Assignee: Rutgers, The State University of New Jersey
    Inventors: William Craelius, Don Yungher, Nam H. Kim
  • Antioxidant-based poly(anhydride-esters)
    Patent number: 9862672
    Abstract: Certain embodiments of the invention provide antioxidant-based diacids and polymers comprising glycol groups as described herein, and methods of use thereof. In certain embodiments the polymers described herein are formulated as microspheres or hydrogels. Described herein is the chemical incorporation of antioxidants, e.g., coumaric acid, ferulic acid, and sinapic acid, into a polymer backbone for use, e.g., in applications for localized release and rapid delivery. As provided, the chemical composition of the linker molecules used (of which hold together two bioactives via ester linkages) may be used to vary the hydrophilicity of the polymer. The bioactive release rate may also be altered for a tunable release delivery system, allowing for increased bioactive release compared to other linkers previously utilized.
    Type: Grant
    Filed: May 29, 2014
    Date of Patent: January 9, 2018
    Assignee: Rutgers, The State University of New Jersey
    Inventors: Kathryn Uhrich, Michelle Morano
  • ALKANE DEHYDROGENATION PROCESS
    Publication number: 20180002361
    Abstract: Disclosed herein are processes for dehydrogenation of an alkane to an alkene using an iridium pincer complex. In the dehydrogenation reactions, hydrogen that is co-formed during the process must be removed for the chemical reaction to proceed and to prevent the excess hydrogen from poisoning the catalyst. In one embodiment the process comprises providing an alkane feedstock comprising at least one alkane and contacting the alkane with an iridium pincer complex in the presence of a hydrogen acceptor selected from the group consisting of ethylene, propene, or mixtures to form an alkene product. The processes disclosed herein can accomplish facile, low-temperature transfer dehydrogenation of alkanes with unprecedented selectivities and TONs at a reasonable rate of conversion.
    Type: Application
    Filed: August 22, 2017
    Publication date: January 4, 2018
    Applicants: Chevron U.S.A. Inc., Rutgers, The State University of New Jersey
    Inventors: Akshai KUMAR, Oleg MIRONOV, Robert J. SAXTON, Alan S. GOLDMAN
  • ASSAYS FOR FUNGAL INFECTION
    Publication number: 20180002766
    Abstract: Methods and kits are described for testing for the presence or absence of any fungus in a sample. Examples of fungi that can be detected include, but are not limited to, those belonging to the genera Candida, Aspergillus and Pneumocystis. The methods include obtaining a sample suspected of containing fungal nucleic acid, including at least one universal region of fungal nucleic acid, and testing for the presence or absence in the sample of the at least one universal region of fungal nucleic acid. Samples may be biological or non-biological.
    Type: Application
    Filed: May 22, 2017
    Publication date: January 4, 2018
    Applicant: Rutgers, The State University of New Jersey
    Inventors: David S. Perlin, Steven Park, David W. Denning
  • IN VITRO MODEL OF MACROSTEATOTIC (FATTY) LIVER
    Publication number: 20170370909
    Abstract: The present invention relates to a system and methods for identifying a compound for de-fatting and functional recovery of macrosteatotic hepatocytes.
    Type: Application
    Filed: July 17, 2017
    Publication date: December 28, 2017
    Applicant: Rutgers, The State University of New Jersey
    Inventors: Martin L. Yarmush, Nir I. Nativ, Francois Berthiaume, Gabriel A. Yarmush, Tim Maguire, Rene S. Schloss
  • Hydrolysis of cellulosic fines in primary clarified sludge of paper mills and the addition of a surfactant to increase the yield
    Patent number: 9850512
    Abstract: A method for processing a stream of cellulosic fines containing inorganic particles, to increase a hydrolysis yield of polysaccharide degradation enzymes, such fines in a waste stream from a recycled packaging paper mill to produce a stream of fermentable sugars, comprising treating the fines with a surfactant which selectively binds to the inorganic particles and which reduces binding to the inorganic particles by the polysaccharide degradation enzymes, and degrading polysaccharides in the waste stream with the polysaccharide degradation enzymes.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: December 26, 2017
    Assignee: The Research Foundation For The State University of New York
    Inventors: Byeong Cheol Min, Bhavin V. Bhayani, Bandaru V. Ramarao
  • CARDIAC DEFIBRILLATION WITH VAGUS NERVE STIMULATION
    Publication number: 20170361102
    Abstract: A method and system for treating cardiac arrhythmias which includes inserting one or more electrodes into a patient's neck, and connecting the electrodes to the vagus nerve in the patient's neck. A cardiac monitoring device detects a cardiac arrhythmia. A controller connected to an electrical power source provides electrical power to the electrodes to apply electrical stimulation to the vagus nerve when a cardiac arrhythmia is detected.
    Type: Application
    Filed: June 30, 2017
    Publication date: December 21, 2017
    Applicant: The Research Foundation for The State University of New York
    Inventors: Mark Stewart, Isaac Naggar, Jason Lazar
  • Proteins expressed by and not by BCG and their use as diagnostic reagents and vaccines
    Patent number: 9844604
    Abstract: The present invention is directed to reagents useful for generating immune responses to Mycobacterium tuberculosis and for diagnosing infection and disease in a subject that has been exposed to M. tuberculosis.
    Type: Grant
    Filed: February 9, 2016
    Date of Patent: December 19, 2017
    Assignee: Rutgers, The State University of New Jersey
    Inventor: Maria L. Gennaro
  • Benzimidazoles and their use in the treatment of tuberculosis
    Patent number: 9845296
    Abstract: The present invention relates to novel 2,5,6-benzimidazole derivatives and pharmaceutically acceptable salts thereof. Another aspect of the invention relates to methods of treating a patient infected by Mycobacterium tuberculosis by administering to the patient a 2,5,6-benzimidazole derivative or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: November 19, 2014
    Date of Patent: December 19, 2017
    Assignee: The Research Foundation for The State University of New York
    Inventors: Iwao Ojima, Divya Awasthi
  • METHYLENEDIOXYBENZO [I] PHENANTHRIDINE DERIVATIVES USED TO TREAT CANCER
    Publication number: 20170355706
    Abstract: The invention provides compounds of formula I: wherein A, B, X, and Y have any of the values defined in the specification, as well as pharmaceutical compositions comprising such compounds, processes for preparing such compounds, and therapeutic methods for treating cancer and other topoisomerase mediated conditions.
    Type: Application
    Filed: January 20, 2017
    Publication date: December 14, 2017
    Applicant: Rutgers, The State University of New Jersey
    Inventors: Edmond J. LaVoie, Wei Feng, Leroy F. Liu
  • ASSAYS FOR RESISTANCE TO ECHINOCANDIN-CLASS DRUGS
    Publication number: 20170356034
    Abstract: Nucleic acid amplification assays for mutations to two short sections of the fungal gene FKS1. Mutations in these target sequences have been shown to correlate with resistance to echinocandin-class drugs. Assays may include detection by sequencing or by labeled hybridization probes. Also, primers, probes and reagent kits for performing such assays.
    Type: Application
    Filed: May 22, 2017
    Publication date: December 14, 2017
    Applicants: Rutgers, The State University of New Jersey, Merck & Co., Inc.
    Inventors: David S. Perlin, Steven Park, Cameron M. Douglas, Jennifer N. Kahn, Stephen A. Parent, Rosemarie Kelly
  • METHODS OF USING GAP JUNCTIONS AS THERAPEUTIC TARGETS FOR THE TREATMENT OF DEGENERATIVE DISORDERS OF THE RETINA
    Publication number: 20170354710
    Abstract: The disclosure provides methods of treating a condition of the retina by administering an inhibitor of connexin 36 and/or an inhibitor of connexin 45 to a subject with a retinal condition. This disclosure further provides compositions for the treatment of a retinal condition which include an inhibitor of connexin 36 and/or an inhibitor of connexin 45.
    Type: Application
    Filed: August 28, 2017
    Publication date: December 14, 2017
    Applicant: The Research Foundation for The State University of New York
    Inventor: Stewart Bloomfield
  • Antibacterial agents: combination of a rifamycin and a switch region inhibitor
    Patent number: 9839634
    Abstract: It has been determined that co-administration of a rifamycin and a switch-region inhibitor 1) results in synergistic antibacterial effects, enabling efficacy at low, subtoxic doses, and/or 2) results in a low spontaneous resistance frequency, enabling treatment of high-titer infections without treatment failure due to spontaneous resistance. Accordingly, certain embodiments provide a composition comprising a rifamycin and a switch region inhibitor, as well as methods of use thereof.
    Type: Grant
    Filed: February 5, 2013
    Date of Patent: December 12, 2017
    Assignee: Rutgers, The State University of New Jersey
    Inventor: Richard H. Ebright
  • Compositions and methods for altering second messenger signaling
    Patent number: 9840533
    Abstract: The present disclosure provides, among other things, novel cyclic-GMP-AMP (cGAMP) analogs, mimics, mimetics and variants, and compositions and kits thereof; methods of using the compounds as described herein for treating cancer, and immune disease, disorders, or conditions; methods of using the compounds as described herein for modulating cGAS and STING; and methods of designing or characterizing a cGAS modulator.
    Type: Grant
    Filed: April 29, 2014
    Date of Patent: December 12, 2017
    Assignees: Memorial Sloan Kettering Cancer Center, Rutgers, The State University of New Jersey, The Rockefeller University, University of Bonn
    Inventors: Dinshaw Patel, Thomas Tuschl, Manuel Ascano, Jr., Yang Wu, Yizhou Liu, Winfried Barchet, Gunther Hartmann, Thomas Zillinger, Roger Jones, Barbara L. Gaffney, Pu Gao
  • Graphene-based contrast agents for photoacoustic and thermoacoustic tomography and method of use
    Patent number: 9833522
    Abstract: The present invention provides a composition for use with photoacoustic or thermoacoustic imaging, comprising a sufficient amount of the graphene-like nanoparticles or graphitic nano- or microparticles and one or more physiologically acceptable carriers or excipients. The present invention also provides methods of using the graphene-like nanoparticles or graphitic nano- or microparticles as PAT/TAT contrast agents.
    Type: Grant
    Filed: December 23, 2014
    Date of Patent: December 5, 2017
    Assignee: The Research Foundation for The State University of New York
    Inventors: Balaji Sitharaman, Gaurav Lalwani
  • pH-insensitive glucose indicator protein
    Patent number: 9829491
    Abstract: The present invention encompasses a glucose indicator protein, a biosensor comprising one or more glucose indicator proteins, and methods of use thereof.
    Type: Grant
    Filed: May 28, 2014
    Date of Patent: November 28, 2017
    Assignee: The Research Foundation for The State University of New York
    Inventors: Kaiming Ye, Sha Jin
  • Combined therapy and prophylaxis for genital tract infections
    Patent number: 9827319
    Abstract: Provided is a method for treating and reducing the recurrence of genital tract infections such as gonococcal infections. The method comprises local application of IL-12 incorporated in polymeric microspheres. The invention relates to compositions comprising IL-12 and methods for using such compositions for treatment of genital tract infections. Infections that can be treated by the present method include those that are caused by N. gonorrhoeae, C. trachomatis or both.
    Type: Grant
    Filed: May 29, 2013
    Date of Patent: November 28, 2017
    Assignee: The Research Foundation for The State University of New York
    Inventors: Michael W. Russell, Yingru Liu, Nejat K. Egilmez
  • Catalyst complex and use thereof in alkane oligomerization
    Patent number: 9828310
    Abstract: Provided is a Group 9 novel metal catalyst complex further comprising a ketone-containing cocatalyst. The metal catalyst complex is useful in generating olefins from alkanes with great efficiency. In one embodiment, provided is an iridium catalyst complex useful in the dehydrogenation of alkanes comprising a ketone-containing cocatalyst and iridium complexed with a tridentate ligand. Also provided is a novel dehydrogenation method which utilizes the catalyst composition. In other embodiments, a novel process for preparing oligomers from alkanes utilizing the catalyst composition is provided.
    Type: Grant
    Filed: January 23, 2017
    Date of Patent: November 28, 2017
    Assignees: Chevron U.S.A. Inc., Rutgers, The State University of New Jersey
    Inventors: Alan Stuart Goldman, Robert Timothy Stibrany, Robert J. Saxton, Oleg Mironov
  • Iridium pincer complex for alkane dehydrogenation process
    Patent number: 9828400
    Abstract: Disclosed herein are processes for dehydrogenation of an alkane to an alkene using an iridium pincer complex and iridium pincer complexes. In the dehydrogenation reactions, hydrogen that is co-formed during the process must be removed for the chemical reaction to proceed and to prevent the excess hydrogen from poisoning the catalyst. In one embodiment the process comprises providing an alkane feedstock comprising at least one alkane and contacting the alkane with an iridium pincer complex in the presence of a hydrogen acceptor selected from the group consisting of ethylene, propene, or mixtures to form an alkene product. The processes disclosed herein can accomplish facile, low-temperature transfer dehydrogenation of alkanes with unprecedented selectivities and TONs at a reasonable rate of conversion.
    Type: Grant
    Filed: April 7, 2017
    Date of Patent: November 28, 2017
    Assignees: Chevron U.S.A. Inc., Rutgers, The State University of New Jersey
    Inventors: Akshai Kumar, Oleg Mironov, Robert J. Saxton, Alan S. Goldman
  • Antimicrobial agents
    Patent number: 9822108
    Abstract: The invention provides methods of treating a bacterial infection in a mammal comprising administering to the mammal a substituted bicyclic heteroaromatic ring compound of formula I: wherein two of X1 to X8 are N and the remaining of X1 to X8 are CH; or a pharmaceutically acceptable salt thereof, as well as novel compounds of formula I and salts thereof and pharmaceutical compositions comprising a compound of formula I or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: January 11, 2013
    Date of Patent: November 21, 2017
    Assignee: Rutgers, The State University of New Jersey
    Inventors: Edmond J. LaVoie, Ajit Parhi, Daniel S. Pilch, Malvika Kaul