Abstract: The invention provides a compound of formula I: or a salt or prodrug thereof, wherein Y, W, Z, Z1, Z2, Z3, Z4, and R1-R12 have any of the values described in the specification, as well as compositions comprising a compound of formula I. The compounds are useful as antibacterial agents.

Abstract: A system and method for layer-by-layer quantification of the remodeling of the human fovea comprises finding a fixed reference point in inner retina, measuring the thickness of the inner retina at the fixed reference point, for a range of finely sampled distances starting from the fixed reference point, measuring the thickness, comparing the measured thickness with a normative base and obtaining a plurality of curves, evaluating area for each curve and defining a distance from the fixed reference having highest sensitivity with respect to the fixed reference point compared to the normative base, displaying a 3D re-creation of foveal architecture-based color-coded picture in accordance with the measured thickness at each finely sampled distance, entering the measured thickness into a model having parameters, obtaining numerical solutions for each parameter, and defining percent change of the parameters for the patient versus the parameters for the control.

Abstract: The invention provides dimeric diagnostic arrays and methods for their use.

Abstract: A pipelined processor comprising a cache memory system, fetching instructions for execution from a portion of said cache memory system, an instruction commencing processing before a digital signature of the cache line that contained the instruction is verified against a reference signature of the cache line, the verification being done at the point of decoding, dispatching, or committing execution of the instruction, the reference signature being stored in an encrypted form in the processor's memory, and the key for decrypting the said reference signature being stored in a secure storage location. The instruction processing proceeds when the two signatures exactly match and, where further instruction processing is suspended or processing modified on a mismatch of the two said signatures.

Abstract: The present invention provides a method of inhibiting the growth of or promoting differentiation and destruction of cancer stem cells (CSCs) comprising contacting the cancer stem cells with a compound having the structure: or a pharmaceutically acceptable salt thereof.

Abstract: The invention provides compounds of formula (I): and salts thereof, wherein X and Y have any of the values defined herein. The compounds inhibit bacterial RNA polymerase, inhibit bacterial growth, and have applications in, analysis of RNA polymerase structure and function, control of bacterial gene expression, control of bacterial growth, antibacterial chemistry, antibacterial therapy, and drug discovery.

Abstract: Methods of producing and using Hepatitis C virus (HCV) eE2 polypeptides are described.

Abstract: A method for producing a reaction product including at least one synthetic formulation that carbonates sufficiently, said method comprising: providing a first raw material, having a first concentration of M; providing a second raw material, having a second concentration of Me; and mixing the first raw material and the second raw material to produce a reaction product that includes at least one synthetic formulation having the general formula MaMebOc, MaMeb(OH)d, MaMebOc(OH)d or MaMebO(OH)d•(H2O)e, wherein M comprises at least one metal that can react to form a carbonate and Me is at least one element that can form an oxide during the carbonation reaction, wherein the at least one synthetic formulation is capable of undergoing a carbonation reaction, and wherein the at least one synthetic formulation is capable of undergoing volume change during the carbonation reaction.

Abstract: Phytoplankton represent a potential source of bioactive compounds. The present disclosure provides, inter alia, methods for identifying glycerolipids and apoptosis-inducing sphingosine-like lipids from virally-infected phytoplankton.

Abstract: This invention discloses multi-part primers for primer-dependent nucleic acid amplification methods. Also disclosed are primer-dependent nucleic acid amplification reactions, particularly DNA amplification reactions, reaction mixtures and reagent kits for such reactions. This invention relates to primer-dependent nucleic acid amplification reactions, particularly DNA amplification reactions such as PCR, and primers, reaction mixtures and reagent kits for such reactions and assays employing same.

Abstract: Methods and compositions useful in reducing drug-induced sedation in subjects.

Abstract: This disclosure concerns novel methods for preventing or treating neurological or neurodegenerative diseases or disorders by using kombo butter acid enriched extracts derived from the seeds of African nutmeg, the main active compounds isolated from the extracts, namely sargaquinoic acid, sargachromenol, and sargahydroquinoic acid, or synthetic analogs or derivatives thereof, as neuroprotective agents. The methods for preparing the kombo butter or kombo butter acid extracts and the methods for isolating and purifying the active compounds and for preparing their acetylated derivatives are also described.

Abstract: The present invention provides electrochemical energy storage systems comprising metallolyte composites, iron fluoride composites and iron oxyfluoride composites. The present invention further provides methods for fabricating metallolyte composites.

Abstract: The invention provides compounds of Formula I: and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R5, and G are as described in the specification, as well as compositions comprising a compound of formula I, methods of making such compounds, and methods of using such compounds, e.g., as inhibitors of bacterial RNA polymerase and as antibacterial agents.

Abstract: A micromechanical structure, comprising a substrate having a through hole; a residual portion of a sacrificial oxide layer peripheral to the hole; and a polysilicon layer overlying the hole, patterned to have a planar portion; a supporting portion connecting the planar portion to polysilicon on the residual portion; polysilicon stiffeners formed extending beneath the planar portion overlying the hole; and polysilicon ribs surrounding the supporting portion, attached near a periphery of the planar portion. The polysilicon ribs extend to a depth beyond the stiffeners, and extend laterally beyond an edge of the planar portion. The polysilicon ribs are released from the substrate during manufacturing after the planar region, and reduce stress on the supporting portion.

Abstract: The present invention relates to primary and secondary electrochemical energy storage systems, particularly to such systems as battery cells, which use materials that take up and release ions as a means of storing and supplying electrical energy.

Abstract: The described invention provides a packaged electrochemical device comprising an electrochemical battery, further comprising at least one electrochemical cell stack and a barrier packaging material. The present invention further provides a method of fabricating the packaged electrochemical device. The present invention further provides a flexible multifunctional liquid-based thermogalvanic cell that converts and stores electricity derived from low grade temperature differentials that exist in ubiquitous scenarios.

Abstract: A new and distinct cultivar of strawberry plant (Fragaria×annanassa) named ‘NJ00-48-3’. The new strawberry plant is distinguished by its ability to produce large, uniform, and firm fruit with excellent flavor. This vigorous plant has an upright form, is a short day cultivar distinguished by its elongated petioles, upright plant growth and fruits, with a uniform mild red color, shiny in appearance and conical in shape.

Abstract: A new and distinct cultivar of strawberry plant (Fragaria×annanassa), was developed from seed produced by a hand pollinated cross between ‘NJ 9612-1’ and ‘Camarosa’ (U.S. Plant Pat. No. 8,708). The new strawberry named ‘NJ99-204-1’ is distinguished by its ability to produce large, uniform, and firm fruit with excellent flavor. These vigorous plants have an upright form.

Abstract: The physical manner in which the inflorescences on our new cultivar are displayed is unique as the flower heads are held erect on the rapidly elongating peduncles in the spring at nearly 90 degrees. When the telescoped vegetative bracts that protected the over-wintering flower buds have fallen, the rapidly growing peduncles elongate upward and the rapidly growing narrow pink-red floral bracts which are lightly attached at their apex enlarge upward until, with further growth, the floral bracts expand at an increased angle and look like butterflies perched on the vertical peduncles. The deep-cup shape of the floral bracts is unique among the comparative pink/red bracted clones of C. kousa ‘Rosea’, ‘Radiant Rose’, and ‘Heart Throb’ in the trade It's floral bracts are larger and darker than the C. kousa in the trade and holds its color longer than those of C. kousa which usually turn white.