Patents Assigned to The Stolle Research and Development Corporation
-
Patent number: 5863561Abstract: An immune suppressive product prepared by injecting an allergen or a mixture of allergens into the body of milk-producing species. Said product being the milk or a polypeptide subfraction of milk obtained from the allergen treated host. The immune suppressive product(s) is milk and or the polypeptide fractions contained therein, which is ostensively free of the intact allergen or allergens used for the treatment of the host. The immune suppressive factor(s) being a subfraction of the allergen used for the treatment. A method of preparing immune suppressive polypeptides from intact allergens, which involves injection of the specific intact allergens into a milk-producing species, collecting the immune suppressive polypeptide fractions of the intact allergens from the milk of the treated host. The immune suppressive milk containing said polypeptide fractions, and/or the polypeptide fractions obtained from said milk, are nonreactive in animals and humans as allergens.Type: GrantFiled: June 2, 1995Date of Patent: January 26, 1999Assignee: Stolle Research & Development CorporationInventors: Lee R. Beck, Ralph J. Stolle
-
Patent number: 5814345Abstract: An immune suppressive product prepared by injecting an allergen or a mixture of allergens into the body of milk-producing species. Said product being the milk or a polypeptide subfraction of milk obtained from the allergen treated host. The immune suppressive product(s) is milk and or the polypeptide fractions contained therein, which is ostensively free of the intact allergen or allergens used for the treatment of the host. The immune suppressive factor(s) being a subfraction of the allergen used for the treatment. A method of preparing immune suppressive polypeptides from intact allergens, which involves injection of the specific intact allergens into a milk-producing species, collecting the immune suppressive polypeptide fractions of the intact allergens from the milk of the treated host. The immune suppressive milk containing said polypeptide fractions, and/or the polypeptide fractions obtained from said milk, are nonreactive in animals and humans as allergens.Type: GrantFiled: June 21, 1995Date of Patent: September 29, 1998Assignee: Stolle Research & Development CorporationInventors: Lee R. Beck, Ralph J. Stolle
-
Patent number: 5650175Abstract: The invention relates to an anti-inflammatory factor isolated from milk, methods of purifying the anti-inflammatory factor resulting in substantially or highly purified preparations and to methods for using this factor to remove adhered neutrophils from endothelial cells, to prevent the emigration of cells from the vasculature and to suppress the response of lymphocytes to foreign antigens.Type: GrantFiled: October 3, 1994Date of Patent: July 22, 1997Assignee: Stolle Research & Development CorporationInventors: Lee R. Beck, J. Peter Fuhrer
-
Patent number: 5427796Abstract: A delivery system for providing growth promoters to food animals is provided and a method of promoting growth in food animals using such delivery systems is described.Type: GrantFiled: November 2, 1993Date of Patent: June 27, 1995Assignee: Stolle Research & Development CorporationInventor: Danny H. Lewis
-
Patent number: 5419910Abstract: A delivery system for providing growth promoters to food animals is provided and a method of promoting growth in food animals using such delivery systems is described.Type: GrantFiled: November 24, 1992Date of Patent: May 30, 1995Assignee: Stolle Research & Development CorporationInventor: Danny H. Lewis
-
Patent number: 5401507Abstract: A delivery system for providing growth promoters to food animals is provided and a method of promoting growth in food animals using such delivery systems is described.Type: GrantFiled: November 9, 1992Date of Patent: March 28, 1995Assignee: Stolle Research & Development CorporationInventor: Danny H. Lewis
-
Patent number: 5352462Abstract: The invention relates to an anti-inflammatory factor isolated from milk and to methods for using this factor to remove adhered neutrophils from endothelial cells, to prevent the emigration of cells from the vasculature and to suppress the response of lymphocytes to foreign antigens.Type: GrantFiled: October 27, 1992Date of Patent: October 4, 1994Assignee: Stolle Research & Development CorporationInventor: Lee R. Beck
-
Patent number: 5288496Abstract: A delivery for providing growth promoters to food animals is provided and a method of promoting growth in food animals using such delivery systems is described.Type: GrantFiled: May 15, 1990Date of Patent: February 22, 1994Assignee: Stolle Research & Development CorporationInventor: Danny H. Lewis
-
Patent number: 5242691Abstract: The invention relates to a substantially pure anti-inflammatory factor isolated from milk collected from a milk producing animal, to the purification, identification, and characterization of said factor, and to a method for treating inflammation in an animal which comprises administering to the animal an anti-inflammatorally effective amount of the anti-inflammatory factor. In a preferred embodiment, the factor is isolated from milk is produced by a milk producing animal maintained in a hyperimmunized state.Type: GrantFiled: September 11, 1990Date of Patent: September 7, 1993Assignee: Stolle Research & Development CorporationInventor: Lee R. Beck
-
Patent number: 5215746Abstract: Anti-cholesterolemic eggs are disclosed, said eggs being obtained from animals hyperimmunized against at least one anti-cholesterolemic antigen. A vaccine producing said anti-cholesterolemic egg is disclosed, said vaccine comprising at least one anti-cholesterolemic antigen. Further, a dietary supplement for humans and other animals which does not elevate serum lipid concentrations is disclosed, said supplement comprising the anti-cholesterolemic eggs or fractions thereof. A method for treating vascular disorders in humans and other animals is also disclosed which comprises administering to said subjects said anti-cholesterolemic eggs for a time and in amounts sufficient to produce anti-arteriosclerotic effects, anti-aging vascular effects, and/or serum lipid-lowering effects.Type: GrantFiled: February 15, 1991Date of Patent: June 1, 1993Assignee: Stolle Research and Development CorporationInventors: Ralph J. Stolle, Lee R. Beck
-
Patent number: 5198214Abstract: A process for the production of a polyvalent vaccine effective in the prevention and treatment of mastitis in bovine animals is disclosed, which comprises periodically culturing the milk of animals exhibiting preclinical mastitis to cultivate any pathogens present therein, killing those pathogens and incorporating each strain of cultivated, killed pathogen in a pharmacological carrier together with all other strains previously identified. The process is repeated to ensure all newly appearing pathogenic strains are vaccinated against. The vaccine so produced has been demonstrated to be effective in reversal of hard udder syndrome.Type: GrantFiled: March 18, 1988Date of Patent: March 30, 1993Assignee: Stolle Research & Development CorporationInventors: Ralph J. Stolle, Lee R. Beck
-
Patent number: 5194255Abstract: The invention relates to a method for inducing the production of a milk anti-hypertensive factor in an animal, to a method for the isolation of said factor from the milk of said animal in a substantially pure form, and to the use of said factor to treat hypertension in humans and other animals, and to compositions containing the anti-hypertensive factor.Type: GrantFiled: November 6, 1989Date of Patent: March 16, 1993Assignee: Stolle Research & Development CorporationInventors: Lee R. Beck, Ralph J. Stolle
-
Patent number: 5130128Abstract: Anti-honey food products are disclosed, such food products being obtained from animals hyperimmunized against at least one antigen found in honey, and preferably whole unfractionated honey. A vaccine producing said anti-honey food product is disclosed, said vaccine comprising at least one honey antigen and preferably whole unfractionated honey. Further, a dietary supplement for humans and especially infants which protects against harmful allergens and microorganisms found in honey is disclosed, said supplement comprising the anti-honey eggs or milk or fractions thereof.Type: GrantFiled: November 6, 1989Date of Patent: July 14, 1992Assignee: Stolle Research & Development CorporationInventor: Ralph J. Stolle
-
Patent number: 5106618Abstract: The invention comprises treatment of gastrointestinal disorders of parasitic protozoan and bacterial origin in immunocompromised and immunocompetent animals by administration hyperimmune milk products.Type: GrantFiled: May 22, 1989Date of Patent: April 21, 1992Assignee: Stolle Research and Development CorporationInventors: Lee R. Beck, Donald P. Kotler
-
Patent number: 4956349Abstract: The invention relates to a substantially pure antiinflammatory factor isolated from milk collected from a milk producing animal, to the purification, identification, and characterization of said factor, and to a method for treating inflammation in an animal which comprises administering to the animal an anti-inflammatorally effective amount of the anti-inflammatory factor. In a preferred embodiment, the factor is isolated from milk is produced by a milk producing animal maintained in a hyperimmunized state.Type: GrantFiled: April 4, 1988Date of Patent: September 11, 1990Assignee: Stolle Research & Development CorporationInventor: Lee R. Beck
-
Patent number: 4919929Abstract: Mammals are brought to a specific state of immunization by administering an amount of an antigenic substance sufficient to elicit an immunization response to said mammal, said antigenic substance being incorporated within a shaped structure of a biocompatible matrix material.Type: GrantFiled: September 17, 1986Date of Patent: April 24, 1990Assignee: Stolle Research & Development CorporationInventor: Lee R. Beck
-
Patent number: 4897265Abstract: A method for treating vascular disorders or pulmonary disorders associated with smoking in an animal which comprises: administering to the animal milk collected from a bovid being maintained in a hyperimmune state, in an amount and for a time sufficient to produce anti arteriosclerotic or antiaging vascular effects or sparing effects on lung tissue.Type: GrantFiled: January 9, 1987Date of Patent: January 30, 1990Assignee: Stolle Research & Development CorporationInventors: Ralph J. Stolle, Lee R. Beck
-
Patent number: 4879110Abstract: The invention relates to a method for inducing the production of a milk anti-hypertensive factor in an animal, to a method for the isolation of said factor from the milk of said animal in a substantially pure form, and to the use of said factor to treat hypertension in humans and other animals.Type: GrantFiled: February 26, 1988Date of Patent: November 7, 1989Assignee: Stolle Research and Development CorporationInventors: Lee R. Beck, Ralph J. Stolle
-
Patent number: RE33403Abstract: A method for treating vascular disorders or pulmonary disorders associated with smoking in an animal which comprises: adminstering to the animal milk collected from a bovid being maintained in a hyperimmune state, in an amount and for a time sufficient to produce anti arteriosclerotic or antiaging vascular effects or sparing effects on lung tissue.Type: GrantFiled: January 13, 1989Date of Patent: October 23, 1990Assignee: Stolle Research & Development CorporationInventors: Ralph J. Stolle, Lee R. Beck
-
Patent number: RE33565Abstract: There is disclosed a novel method and product for the treatment and prevention of rheumatoid arthritis. The method involves passive immunization against a mixed spectrum of infectious bacteria which reside in the human gastrointestinal tract. The passive immunization is accomplished by oral.[.injestion.]. .Iadd.ingestion .Iaddend.of IgG immunoglobulin obtained from the milk of cows that have been immunized against a specific spectrum of bacterial types. A unique combination of bacterial species is formulated into a vaccine which is used to immunize dairy cattle. The IgG antibody obtained from the milk of the immunized cows constitutes the product of the invention.Type: GrantFiled: August 11, 1988Date of Patent: April 2, 1991Assignee: Stolle Research and Development CorporationInventors: Ralph J. Stolle, Lee R. Beck