Abstract: Living cells are encapsulated by: (a) dispersing living cells in an aqueous solution of a capsule wall-forming protein; (b) forming aqueous droplets of the cell containing dispersion in an aqueous-immiscible, cell compatible continuous processing medium; and (c) crosslinking the protein with a crosslinking agent which is soluble in the continuous processing medium but substantially insoluble in the aqueous droplets. The resultant capsules containing living cells may be treated with a capsule wall degrading enzyme to enlarge pores of the capsules. The encapsulated cells may be used for administration of cells to an animal for growing the cells in the animal or for delivery to the animal of a substance produced by the cells. By the cells being encapsulated, the cells are not destroyed by the aminal immune system and immune response by the animal may be minimized.

Abstract: A process for the production of a polyvalent vaccine effective in the prevention and treatment of mastitis in bovine animals is disclosed, which comprises periodically culturing the milk of animals exhibiting preclinical mastitis to cultivate any pathogens present therein, killing those pathogens and incorporating each strain of cultivated, killed pathogen in a pharmacological carrier together with all other strains previously identified. The process is repeated to ensure all newly appearing pathogenic strains are vaccinated against. The vaccine so produced has been demonstated to be effective in reversal of hard udder syndrome.

Abstract: Antibody or antigen containing microparticles for the active or passive immunization of the internal female reproductive organs, comprising: microparticles of an antigen or antibody incorporated in a matrix material which is biocompatible and biologically degradable, said microparticles capable of being transported after deposition in the vagina by the natural transport mechanism of the internal female reproductive organs across the cervix into the uterus.

Abstract: There is disclosed a novel method and product for the treatment and prevention of rheumatoid arthritis. The method involves passive immunization against a mixed spectrum of infectious bacteria which reside in the human gastrointestinal tract. The passive immunization is accomplished by oral injestion of IgG immunoglobulin obtained from the milk of cows that have been immunized against a specific spectrum of bacterial types. A unique combination of bacterial species is formulated into a vaccine which is used to immunize dairy cattle. The IgG antibody obtained from the milk of the immunized cows constitutes the product of the invention.

Abstract: A method for treating vascular disorders or pulmonary disorders associated with smoking in an animal which comprises: adminstering to the animal milk collected from a bovid being maintained in a hyperimmune state, in an amount and for a time sufficient to produce anti arteriosclerotic or antiaging vascular effects or sparing effects on lung tissue.

Abstract: Antibody or antigen containing microparticles for the active or passive immunization of the internal female reproductive organs, comprising: microparticles of an antigen or antibody incorporated in a matrix material which is biocompatible and biologically degradable, said microparticles capable of being transported after deposition in the vagina by the natural transport mechanism of the internal female reproductive organs across the cervix into the uterus.

Abstract: A cell culture device is disclosed for the cultivation of animal, plant, microbiological or artificial cells. The device involves a three-dimensional arrangement of fibers within a housing arranged to provide maximum exposed fiber surface flow channel diameter while also reducing the tortuosity of the flow path. Cells are bound to the fibers to allow them to contact nutrient fluid solution and thereby to remove any substances originating in said cells, such as viruses and pharmaceuticals.

Abstract: An anti-inflammatory agent containing microparticle composition prepared by a process, comprising (a) dissolving or dispersing an anti-inflammatory agent in a solvent and dissolving a biocompatible and biodegradable wall forming material in said solvent; (b) dispersing said solvent containing said anti-inflammatory agent and wall forming material in a continuous phase processing medium; (c) evaporating a portion of said solvent from said dispersion of step (b), thereby forming microparticles containing said anti-inflammatory agent in the suspension; and (d) extracting the remainder of the solvent from said microcapsules.

Abstract: An anti-inflammatory agent containing microparticle composition prepared by a process, comprising (a) dissolving or dispersing an anti-inflammatory agent in a solvent and dissolving a biocompatible and biodegradable wall forming material in said solvent; (b) dispersing said solvent containing said anti-inflammatory agent and wall forming material in a continuous phase processing medium; (c) evaporating a portion of said solvent from said dispersion of step (b), thereby forming microparticles containing said anti-inflammatory agent in the suspension; and (d) extracting the remainder of the solvent from said microcapsules.

Abstract: An easy open can end having a retained tear strip extending diametrically part way across the can end defined by a score line of non-uniform depth, and a graspable pull tab, which may include fulcrum elements, one on either side of the center line of the pull tab, secured to the tear strip. Lifting of the pull tab initiates tearing of the score line which may be continued to form an opening in the can end. When the pull tab is pressed inwardly to a stored position against the can end, if desired, the tear strip doubles back upon itself to form an arcuate portion in the tear strip lying beneath the surface of the can end which operates to relieve stress and prevent metal fracture of the tear strip which could cause the strip to become separated from the can end.

Abstract: Microcapsules laden with an active agent are prepared by a method comprising: (a) dissolving or dispersing an active agent in a solvent and dissolving a wall forming material in said solvent; (b) dispersing said solvent containing said active agent and wall forming material in a continuous-phase processing medium; (c) evaporating a portion of said solvent from said dispersion of step (b), thereby forming microcapsules containing said active agent in the suspension; and (d) extracting the remainder of the solvent from said microcapsules.

Abstract: A hemoperfusion device is disclosed for the specific modification or removal of components of whole blood. The device involves a 3-dimensional arrangement of fibers within a housing arranged to provide maximum exposed fiber surface and flow-channel diameter, while also reducing the tortuosity of the flow path. Desired effector molecules are bound to the fibers to allow them to contact the target components of the blood, whereby to remove the target components. Details of the fiber and effector molecules are disclosed and a specific device is described.