Patents Assigned to The Trustees of Columbia University
  • Devices, methods, and systems for detection of collagen tissue features
    Patent number: 11497403
    Abstract: The present application discloses methods, devices, and systems for generating spatially-resolved quantification of cross-linking in cartilage based on Raman scattering of excitation light. The examples presented demonstrate that the method provides a discriminating power sufficient to distinguish early onset of osteo-arthritis even before a patient is symptomatic.
    Type: Grant
    Filed: June 10, 2017
    Date of Patent: November 15, 2022
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Sinisa Vukelic, Gerard A. Ateshian
  • High performance organic pseudocapacitors
    Patent number: 11492442
    Abstract: The present invention provides organic compounds having pseudocapacitive performance and methods of preparing said compounds. The organic compounds can include perylene diamine (PDI) subunits and hexaazatrinaphthylene (HATN) subunits.
    Type: Grant
    Filed: February 19, 2021
    Date of Patent: November 8, 2022
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Colin Nuckolls, Xavier Roy, Jake Carter Russell, Samuel R. Peurifoy
  • Pharmacological prophylactics against stress-induced affective disorders in females
    Patent number: 11491120
    Abstract: Methods for prophylactically treating a stress-induced affective disorder or stress-induced psychopathology in a subject are provided. Also provided are methods for inducing and/or enhancing stress resilience in a subject. In certain embodiments, an effective amount of (R,S)-ketamine or (2R, 6R)-hydroxynorketamine ((2R, 6R)-HNK) is administered to a female or male subject prior to a stressor.
    Type: Grant
    Filed: November 9, 2018
    Date of Patent: November 8, 2022
    Assignees: The Trustees of Columbia University in the City of New York, The Research Foundation for Mental Hygiene, Inc.
    Inventors: Christine Ann Denny, Briana Kaying Chen
  • Fast probing of signal quality in a WDM network
    Patent number: 11496213
    Abstract: A method of interrogating a WDM optical communication system is provided to obtain one or more performance parameters. In accordance with the method, an optical probe wavelength is generated and possibly modulated in a prescribed manner. The probe signal is transmitted along a selected optical path through the WDM optical communication system for a duration of time that is less than a response time of network elements that impact signal quality along the selected optical path.
    Type: Grant
    Filed: December 5, 2016
    Date of Patent: November 8, 2022
    Assignees: ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA, THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventors: Daniel Kilper, Atiyah Sayyidah Ahsan, Keren Bergman
  • SYSTEMS AND METHODS FOR ENHANCED WEATHERING AND CALCINING FOR CO2 REMOVAL FROM AIR
    Publication number: 20220347650
    Abstract: A plurality of carbonation plots are positioned in communication with atmospheric carbon dioxide to facilitate sequestration thereof via ambient weathering. The carbonation plots include a composition rich in metal oxides, which are positioned within the environment, such as on non-arable land, and exposed to the environment to react with carbon dioxide in the air and form metal carbonates. After about one year of exposure, the composition is recollected and calcined to produce a carbon dioxide stream and replenish the metal oxides, which can be redistributed in the carbonation plots to sequester additional carbon dioxide. The systems and methods of the present disclosure enable capture and redistribution of carbon dioxide for industrial-scale uses for very abundant quarry minerals and enable large-scale low-cost carbon capture projects for municipalities or corporations.
    Type: Application
    Filed: June 24, 2020
    Publication date: November 3, 2022
    Applicant: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventors: Peter KELEMEN, Jennifer WILCOX, Noah McQUEEN, Greg DIPPLE, Phil RENFORTH
  • FIBROUS POLYMERIC SCAFFOLDS FOR SOFT TISSUE ENGINEERING
    Publication number: 20220331490
    Abstract: A fibrous polymeric scaffold for soft tissue engineering comprises electrospun fibers including a polymeric blend and graphite particles embedded therein.
    Type: Application
    Filed: February 9, 2022
    Publication date: October 20, 2022
    Applicant: The Trustees of Columbia University in the City of New York
    Inventors: Helen H. Lu, Christopher Z. Mosher, Romare Antrobus, James C. Hone, Theanne Schiros, Yilin Yang
  • Drug target for preventing pathologic calcium overload in cardiomyocytes and methods of screening for same
    Patent number: 11474098
    Abstract: The present invention provides, inter alia, methods for identifying a candidate agent that can treat or ameliorate the effects of a heart condition caused by the effects of abnormal beta-adrenergic receptor activation on calcium levels in cardiomyocytes in a subject. Compositions that include the candidate agents identified by the methods disclosed, and methods of treating or ameliorating the effects of a heart condition in a subject by administering to the subject the candidate agents identified by the methods disclosed, are also provided.
    Type: Grant
    Filed: December 20, 2018
    Date of Patent: October 18, 2022
    Assignees: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK, THE NEW YORK PRESBYTERIAN HOSPITAL
    Inventors: Steven Marx, Alexander Kushnir, Lin Yang, Alex Katchman, Henry M. Colecraft
  • Method of making a personalized bone graft
    Patent number: 11464640
    Abstract: An anatomically-shaped, human bone graft may be cultivated ex vivo using a bioreactor capable of perfusing large complex porous scaffolds. Scaffolds derived from image-based modeling of a target are seeded with human mesenchymal stem cells and cultivated. A bioreactor configured to house complex three-dimensional scaffold geometries provides controlled flow for perfusion of the cells. Dense uniform cellular growth can be attained throughout the entire scaffold as a result of the medium perfusion. In an embodiment, the bioreactor has a mold into which perfusion medium is pumped under pressure and multiple ports through which the medium exits the mold.
    Type: Grant
    Filed: December 18, 2019
    Date of Patent: October 11, 2022
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Gordana Vunjak-Novakovic, Warren Grayson, Keith Yeager
  • Compounds, compositions, and methods for treating T-cell acute lymphoblastic leukemia
    Patent number: 11459306
    Abstract: In an aspect, the disclosure provides for compounds (II), compositions, and methods of administering the compounds and compositions to a patient in need thereof. In another aspect, the disclosure relates to compounds and compositions for treating cancer, for example, lymphoid leukemia. The disclosure further provides for compounds which inhibit two phosphoinositide 3-kinase (PI3K) isoforms, y and ?, pharmaceutical compositions comprising said compounds, and methods of using said compounds and pharmaceutical compositions for treatment, amelioration, and/or prevention of non-Hodgkin lymphoma.
    Type: Grant
    Filed: July 31, 2018
    Date of Patent: October 4, 2022
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Donald W. Landry, Shi-Xian Deng, Xiaoming Xu, Thomas Diacovo
  • AMPLITUDE AND PHASE LIGHT MODULATOR BASED ON MINIATURE OPTICAL RESONATORS
    Publication number: 20220308370
    Abstract: The systems described herein can be used to modulate either the phase, the amplitude, or both of an input light wave using micro-resonators to achieve desired degrees and/or types of modulation.
    Type: Application
    Filed: April 2, 2020
    Publication date: September 29, 2022
    Applicant: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventors: Guozhen Liang, Heqing Huang, Michal Lipson, Nanfang Yu
  • Substituted benzo[f]imidazo[1,5-a][1,4]diazepines as GABA(a) receptor modulators
    Patent number: 11447495
    Abstract: Substituted benzo[f]imidazo[1,5-?][1,4]diazepines of formula (I?) target alpha-4 and alpha-5 GABAA receptors for use in the treatment of airway hyperresponsiveness and inflammation in asthma. Compounds selectively partition to the peripheral compartment and have reduced CNS effects.
    Type: Grant
    Filed: August 16, 2017
    Date of Patent: September 20, 2022
    Assignees: UWM Research Foundation, Inc., The Trustees of Columbia University in the City of New York
    Inventors: Alexander E. Arnold, Douglas C. Stafford, James M. Cook, Charles W. Emala, Gloria Forkuo, Rajwana Jahan, Revathi Kodali, Guanguan Li, Michael Rajesh Stephen
  • DNA SEQUENCING WITH NON-FLUORESCENT NUCLEOTIDE REVERSIBLE TERMINATORS AND CLEAVABLE LABEL MODIFIED NUCLEOTIDE TERMINATORS
    Publication number: 20220290227
    Abstract: This invention provides a process for sequencing nucleic acids using 3? modified deoxynucleotide analogues or 3? modified deoxyinosine triphosphate analogues, and 3? modified dideoxynucleotide analogues having a detectable marker attached thereto.
    Type: Application
    Filed: January 14, 2022
    Publication date: September 15, 2022
    Applicant: The Trustees of Columbia University in the City of New York
    Inventors: Jingyue Ju, Dae Hyun Kim, Jia Guo, Qinglin Meng, Zengmin Li, Huanyan Cao
  • SYSTEMS, DEVICES, AND METHODS FOR HARMONIZATION OF IMAGING DATASETS INCLUDING BIOMARKERS
    Publication number: 20220292657
    Abstract: An exemplary system, method and computer-accessible medium for harmonizing neuromelanin (NM) data using combat directly on a NM database or using combat generated coefficients to harmonize future data can include, for example, receiving imaging information of a brain of the patient(s), from one MRI scanner, receiving imaging information of a brain of the patient(s), from a second MRI scanner and using combat to harmonize the data between scanners against a reference dataset. The Neuromelanin (NM) concentration of the patient(s) can then be determined based on the harmonized data. The NM concentration can be determined using a voxel-wise analysis procedure. The voxel-wise analysis procedure can be used to determine a topographical pattern(s) within a substantia nigra (SN) of the brain of the patient(s).
    Type: Application
    Filed: March 11, 2022
    Publication date: September 15, 2022
    Applicants: TERRAN BIOSCIENCES, INC., THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK, THE RESEARCH FOUNDATION FOR MENTAL HEALTH HYGIENE, INC.
    Inventors: Samuel CLARK, Kenneth WENGLER, Guillermo HORGA HERNANDEZ
  • Wireless and retrofittable in-shoe system for real-time estimation of kinematic and kinetic gait parameters
    Patent number: 11439325
    Abstract: A quantitative gait training and/or analysis system includes one or more footwear modules that may include a piezoresistive sensor, an inertial sensor and an independent logic unit. The footwear module functions to permit the extraction of gait kinematics and evaluation thereof in real time, or data may be stored for later reduction and analysis. Embodiments relating to calibration-based estimation of kinematic gait parameters are described.
    Type: Grant
    Filed: June 28, 2019
    Date of Patent: September 13, 2022
    Assignees: THE TRUSTEES OF THE STEVENS INSTITUTE OF TECHNOLOGY, THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventors: Damiano Zanotto, Sunil K. Agrawal, Huanghe Zhang
  • Monitoring treatment of peripheral artery disease (PAD) using diffuse optical imaging
    Patent number: 11439312
    Abstract: A plurality of modules are simultaneously positioned at locations that correspond to different angiosomes. Each of these modules has a front surface shaped and dimensioned for contacting a person's skin, a plurality of different-wavelength light sources aimed in a forward direction, and a plurality of light detectors aimed to detect light arriving from in front of the front surface. Each module is supported by a support structure (e.g., a strap or a clip) that is shaped and dimensioned to hold the front surface adjacent to the person's skin at a respective position. Perfusion in each of the angiosomes is monitored using these modules, and the surgeon can rely on this information to guide his or her intervention.
    Type: Grant
    Filed: April 23, 2017
    Date of Patent: September 13, 2022
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Andreas H. Hielscher, Christopher J. Fong, Jennifer Hoi, Hyun K. Kim, Michael Khalil
  • Methods and systems for spot beam crystallization
    Patent number: 11437236
    Abstract: Methods and systems for crystallizing a thin film provide a laser beam spot that is continually advanced across the thin film to create a sustained complete or partial molten zone that is translated across the thin film, and crystallizes to form uniform, small-grained crystalline structures or grains.
    Type: Grant
    Filed: January 9, 2017
    Date of Patent: September 6, 2022
    Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THF CITY OF NEW YORK
    Inventors: James S. Im, Wenkai Pan
  • SYSTEMS AND METHODS FOR OPENING TISSUES
    Publication number: 20220273929
    Abstract: The present subject matter relates to techniques for opening target tissue. The disclosed system can include a navigation guidance device configured to locate and/or monitor the target tissue, a single-element transducer for stimulating the target tissue with focused ultrasound (FUS), and a processor configured to determine a cavitation mode. The navigation guidance device can include a cavitation detector and an arm. The single-element transducer can be attached to the arm and be configured to induce the FUS with a predetermined parameter to open the target tissue.
    Type: Application
    Filed: April 21, 2022
    Publication date: September 1, 2022
    Applicant: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventor: Elisa E. Konofagou
  • Systems, methods, and media for decoding observed spike counts for spiking cells
    Patent number: 11429847
    Abstract: Mechanisms including: receiving a first set of observed spike counts (FSoOSCs) for the spiking cells; determining a set of probabilities (SoPs) by: retrieving the SoPs from stored information (SI); or calculating the SopS based on the SI, wherein the SI regards possible biological states (BSs) of a subject, wherein each of the possible BSs belongs to at least one of a plurality of time sequences (PoTSs) of BSs, wherein each of the PoTSs of BSs corresponds to a possible action of the subject, and wherein each probability in the set of probabilities indicates a likelihood of observing a possible spike count for one of the plurality of spiking cells; identifying using a hardware processor a first identified BS of the subject from the possible BSs based on the FSoOSCs and the set of probabilities; and determining an action to be performed based on the first identified BS.
    Type: Grant
    Filed: January 31, 2022
    Date of Patent: August 30, 2022
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Sean Perkins, Mark Churchland, Karen Schroeder, John Patrick Cunningham
  • Engineered Bacteria Containing Biosensors for Precision Targeting and Containment
    Publication number: 20220265730
    Abstract: The disclosure herein relates to engineered biosensor-containing bacteria, which is bacteria that contain at least one biosensor circuit, and uses thereof. A biosensor circuit can comprise an essential gene of the bacteria operably linked to an inducible promoter. Additionally, the bacteria can be engineered to be deficient in the endogenous copy of the at least one essential gene.
    Type: Application
    Filed: May 5, 2022
    Publication date: August 25, 2022
    Applicant: The Trustees of Columbia University in the City of New York
    Inventors: Tal Danino, Tiffany CHIEN, Tetsuhiro HARIMOTO
  • Apparatus for perforation and aspiration of inner ear
    Patent number: 11413191
    Abstract: An apparatus for controlled perforation and aspiration of the inner ear.
    Type: Grant
    Filed: December 27, 2016
    Date of Patent: August 16, 2022
    Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventors: Hirobumi Watanabe, Anil K. Lalwani, James P. Stevens, Jeffrey W. Kysar