Patents Assigned to The Trustees of Columbia University
  • Thermal mass for heat pre-load and time-controlled dispersion in building heating systems
    Patent number: 11624561
    Abstract: A heating and/or cooling temperature adjusting apparatus disposed proximate a point of use comprising a heat exchange structure, at least one thermal mass unit comprised of a material which changes phase at a predetermined temperature, and a housing which at least partially encloses the heat exchange structure and thermal mass unit. Additionally, a plurality of thermal mass units can be employed, each with equivalent, or differing, temperature threshold points for conversion between solid, liquid or gaseous phases. The presence of the thermal mass unit at the point of use allows for the heating/cooling system to rapidly adjust the temperature of the room while simultaneously decreasing the duty cycle of the heating/cooling generator (e.g. boiler).
    Type: Grant
    Filed: April 3, 2015
    Date of Patent: April 11, 2023
    Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventors: Marshall Cox, Ioannis Kymissis, John Sarik, David Wechsler
  • Modified bacterial protein expression system
    Patent number: 11624081
    Abstract: The present disclosure provides host cells for reliable, high yield recombinant protein production, including unstable proteins. The present host cell (e.g., a bacterial cell) is deficient in at least one protease (or a subunit of a protease) such as Clp or ClpP. The host cell may also contain an expression vector that encodes a protein or polypeptide for overexpression.
    Type: Grant
    Filed: May 28, 2020
    Date of Patent: April 11, 2023
    Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventor: Maxwell Gottesman
  • Systems and methods for single-molecule detection using nanopores
    Patent number: 11624727
    Abstract: A system and method for detecting a single-molecule using an integrated circuit which includes at least one membrane having a nanopore located between first and second reservoirs and a low-noise preamplifier having an electrode formed on the surface thereof is provided. The method includes passing a target molecule through the nanopore, and measuring a current through the nanopore to detect the presence of a biomolecular entity, if any.
    Type: Grant
    Filed: August 27, 2015
    Date of Patent: April 11, 2023
    Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventors: Jacob Rosenstein, Kenneth L. Shepard
  • Biomarkers for efficacy of prophylactic treatments against stress-induced affective disorders
    Patent number: 11622948
    Abstract: Biomarkers for assessing the efficacy of prophylactic treatments of stress-induced affective disorders are provided.
    Type: Grant
    Filed: November 8, 2018
    Date of Patent: April 11, 2023
    Assignees: The Trustees of Columbia University in the City of New York, Berg LLC, The Research Foundation for Mental Hygiene, Inc.
    Inventors: Josephine Cecelia McGowan, Christine Ann Denny, Michael Kiebish
  • Combination of Retromer Pharmacological Chaperones and Exogenous Retromer for the Treatment of Alzheimer's Disease and Other Neurodegenerative Diseases and Disorders
    Publication number: 20230104357
    Abstract: The present disclosure relates to methods and compositions for elevating and stabilizing retromer for treating and/or preventing Alzheimer's disease and other neurodegenerative diseases or disorders. Additionally, the disclosure relates to gene therapy combined with a pharmacological retromer chaperone therapy for treating and/or preventing Alzheimer's disease (AD), and other neurodegenerative diseases or disorders such as Parkinson's Disease (PD), amyotrophic lateral sclerosis (ALS), neuronal ceroid lipofuscinosis (NCL), and transmissible spongiform encephalopathies (TSEs or prion disease), multiple system atrophy (MSA), as well as tauopathies such as progressive supranuclear palsy (PSP), frontotemporal lobar dementia linked to chromosome 17q21-22 and its subtypes (FTLD-17/FTLD-Tau), and chronic traumatic encephalopathy (CTE).
    Type: Application
    Filed: August 14, 2022
    Publication date: April 6, 2023
    Applicants: The Trustees of Columbia University in the City of New York, THE RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC.
    Inventors: Scott A. Small, Gregory A. Petsko
  • Apparatus, method, and system for selectively effecting and/or killing bacteria
    Patent number: 11617899
    Abstract: Certain exemplary embodiments can provide an apparatus and method for generating at least one radiation. The exemplary apparatus and/or method can selectively kill and/or affect at least one bacteria. For example, a radiation source first arrangement can be provided which is configured to generate at least one radiation having one or more wavelengths provided in a range of about 190 nanometers (nm) to about 230 nm, and at least one second arrangement can be provided which is configured to prevent the at least one radiation from having any wavelength that is outside of the range.
    Type: Grant
    Filed: February 19, 2021
    Date of Patent: April 4, 2023
    Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventors: Gerhard Randers-Pehrson, David Jonathan Brenner, Alan Bigelow
  • Apparatus, method, and system for selectively effecting and/or killing bacteria
    Patent number: 11617898
    Abstract: Certain exemplary embodiments can provide an apparatus and method for generating at least one radiation. The exemplary apparatus and/or method can selectively kill and/or affect at least one bacteria. For example, a radiation source first arrangement can be provided which is configured to generate at least one radiation having one or more wavelengths provided in a range of about 190 nanometers (nm) to about 230 nm, and at least one second arrangement can be provided which is configured to prevent the at least one radiation from having any wavelength that is outside of the range.
    Type: Grant
    Filed: February 18, 2021
    Date of Patent: April 4, 2023
    Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventors: Gerhard Randers-Pehrson, David Jonathan Brenner, Alan Bigelow
  • Apparatus, method, and system for selectively effecting and/or killing bacteria
    Patent number: 11617900
    Abstract: Certain exemplary embodiments can provide an apparatus and method for generating at least one radiation. The exemplary apparatus and/or method can selectively kill and/or affect at least one bacteria. For example, a radiation source first arrangement can be provided which is configured to generate at least one radiation having one or more wavelengths provided in a range of about 190 nanometers (nm) to about 230 nm, and at least one second arrangement can be provided which is configured to prevent the at least one radiation from having any wavelength that is outside of the range.
    Type: Grant
    Filed: February 23, 2021
    Date of Patent: April 4, 2023
    Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventors: Gerhard Randers-Pehrson, David Jonathan Brenner, Alan Bigelow
  • Flexible complementary metal-oxide-semiconductor probes for chronic, large-scale neural stimulation and recording
    Patent number: 11617890
    Abstract: Systems and methods for providing neural stimulation and recording on a subject using flexible complementary CMOS probes are provided. Disclosed systems can include a flexible probe adapted for insertion into a portion of a brain of the subject, the flexible probe comprising a tail portion and a head portion. The tail portion can include a plurality of electrodes configured to be coupled to the brain and a plurality of front-end amplifiers. Each of the plurality of front-end amplifiers can be configured to amplify a signal received from a corresponding electrode of the plurality of electrodes. The head portion can include one or more inductors configured to enable two-way communication with a wireless reader through a near-field inductive link.
    Type: Grant
    Filed: October 12, 2020
    Date of Patent: April 4, 2023
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Kenneth L. Shepard, David Tsai, Hongki Kang, Jordan Thimot
  • IBOGAINE ANALOGS AS THERAPEUTICS FOR NEUROLOGICAL AND PSYCHIATRIC DISORDERS
    Publication number: 20230102206
    Abstract: The present invention provides a composition which comprises a compound which is a mixture of deuterium containing and non-deuterium containing molecules having the structure: wherein R1 is wherein at least one of H1, H2 or H3 is a deuterium-enriched —H site, or wherein at least one of H1, H2, H3, H4 or H5 is a deuterium-enriched —H site, or a pharmaceutically acceptable salt of the compound, and methods of using the composition to treat pain, depressive disorders, mood disorders, anxiety disorders, opioid use disorders, and opioid withdrawal symptoms.
    Type: Application
    Filed: March 4, 2021
    Publication date: March 30, 2023
    Applicant: The Trustees of Columbia University in the City of New York
    Inventors: Dalibor Sames, Vaclav Havel
  • Next-generation biomarkers to detect sun damage and predict skin cancer risk
    Patent number: 11613784
    Abstract: The present invention provides methods of detecting ultraviolet radiation (UVR)-induced skin damage in a subject. The method includes the steps of: a) obtaining a skin sample from the subject; b) analyzing expression levels in the skin sample of UVR-induced differentially expressed genes (DEGs) listed in Table 8 or a subset thereof; and c) comparing the expression levels of the UVR-induced DEGs to a control skin sample; wherein, when the expression levels of the UVR-induced DEGs in the skin sample is above or below the level of each of the UVR-induced DEGs in the control sample, the subject is identified as likely being afflicted with UVR-induced skin damage. Also provided are methods for measuring the effectiveness of a test agent in reducing ultraviolet radiation (UVR)-induced damage.
    Type: Grant
    Filed: March 16, 2017
    Date of Patent: March 28, 2023
    Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventors: Liang Liu, Yao Shen
  • Fully implanted, wireless, flexible CMOS surface recording device
    Patent number: 11607538
    Abstract: A fully implanted integrated, wireless, flexible CMOS chip for long-term recording and stimulation of the brain in vivo and methods of manufacturing thereof are provided. The chip is an entire biocompatible system and can include the dense surface electrode array, the underlying CMOS integrated circuit architecture, integrated wireless powering and telemetry. Furthermore, miniaturization through manufacturing, permits implantation of the chip under the skull and other regions of interest with no wires or connections. Furthermore, these devices and systems can operate under a dual modality such as to be able to record and stimulate the surface of the brain and/or tissue in which they have been implanted.
    Type: Grant
    Filed: April 10, 2018
    Date of Patent: March 21, 2023
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Kenneth Shepard, David Tsai, Nanyu Zeng, Taesung Jung
  • Nucleic acid sequencing by nanopore detection of tag molecules
    Patent number: 11608523
    Abstract: This disclosure provides systems and methods for sequencing nucleic acids using nucleotide analogues and translocation of tags from incorporated nucleotide analogues through a nanopore. In aspects, this disclosure is related to compositions, methods, and systems for sequencing nucleic acids using tag molecules and detection of translocation through a nanopore of tags released from incorporation of the molecule.
    Type: Grant
    Filed: September 22, 2017
    Date of Patent: March 21, 2023
    Assignees: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK, ROCHE SEQUENCING SOLUTIONS, INC.
    Inventors: Jingyue Ju, Randall Davis, Roger Chen
  • Apparatus, method, and system for selectively effecting and/or killing bacteria
    Patent number: 11607558
    Abstract: Certain exemplary embodiments can provide an apparatus and method for generating at least one radiation. The exemplary apparatus and/or method can selectively kill and/or affect at least one bacteria. For example, a radiation source first arrangement can be provided which is configured to generate at least one radiation having one or more wavelengths provided in a range of about 190 nanometers (nm) to about 230 nm, and at least one second arrangement can be provided which is configured to prevent the at least one radiation from having any wavelength that is outside of the range.
    Type: Grant
    Filed: February 17, 2021
    Date of Patent: March 21, 2023
    Assignee: THE TRUSTEES OF THE COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventors: Gerhard Randers-Pehrson, David Jonathan Brenner, Alan Bigelow
  • Microscopy devices, methods and systems
    Patent number: 11604342
    Abstract: A pulsed beam of NIR excitation light is projected into a sample at an oblique angle and scanned by a scanning element through a volume in the sample. 2-photon excitation excites fluorescence within the sample. The fluorescence is imaged onto an intermediate image plane that remains stationary regardless of the orientation of the scanning element. The image is captured by a linear array of light detecting elements or a linear portion of a rectangular array. At any given position of the scanning element, the linear array (or portion) images all depths simultaneously. A plurality of images are captured for each of a plurality of different orientations of the scanning element. The orientation of the scanning element is controlled to move in a two dimensional pattern, which causes the beam of excitation light to sweep out a three dimensional volume within the sample.
    Type: Grant
    Filed: June 8, 2021
    Date of Patent: March 14, 2023
    Assignee: The Trustees of Columbia University in the City of New York
    Inventor: Elizabeth M. C. Hillman
  • Systems and methods for fabricating water-responsive actuators
    Patent number: 11603827
    Abstract: Water-responsive actuators and methods for creating water responsive actuators are disclosed. In some embodiments, the disclosed subject matter includes a first layer, for example a plastic tape, and a second layer, for example bacterial spores and cured adhesive. The second layer can be created in a pattern. The pattern can include joints, which can contract when exposed to dry air and can thereby bend the actuator, and can expand when exposed to humid air and thereby return the actuator its original position.
    Type: Grant
    Filed: May 10, 2019
    Date of Patent: March 14, 2023
    Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventors: Ozgur Sahin, Onur Cakmak, Xi Chen
  • Combination therapy of lymphoma
    Patent number: 11597933
    Abstract: The present disclosure provides for methods and compositions for treating cancer. A subject having lymphoma is administered an EZH2 inhibitor and an HDAC inhibitor. The combination of the EZH2 inhibitor and the HDAC inhibitor produces a synergistic effect on the cancer compared to the effect of the EZH2 inhibitor or the HDAC inhibitor alone.
    Type: Grant
    Filed: November 29, 2018
    Date of Patent: March 7, 2023
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Jennifer Effie Amengual, Jennifer Lue, Owen A. O'Connor
  • Detecting return-oriented programming payloads by evaluating data for a gadget address space address and determining whether operations associated with instructions beginning at the address indicate a return-oriented programming payload
    Patent number: 11599628
    Abstract: Systems, methods, and media for detecting the presence of return-oriented programming (ROP) payloads are provided, comprising: identifying a potential gadget address space; determining if a piece of the data corresponds to an address of the potential gadget address space; and in response to determining that the piece of the data corresponds to an address of the potential gadget address space: determining whether a plurality of operations, each associated one of a plurality instructions beginning at the address, indicates that an ROP payload is present in the data, and indicating that an ROP payload is present in the data in response to making a determination that a plurality of operations indicates that an ROP payload is present in the data a given number of times.
    Type: Grant
    Filed: May 7, 2021
    Date of Patent: March 7, 2023
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Michalis Polychronakis, Angelos D. Keromytis
  • Apparatus, method, and system for selectively effecting and/or killing bacteria
    Patent number: 11590359
    Abstract: Certain exemplary embodiments can provide an apparatus and method for generating at least one radiation. The exemplary apparatus and/or method can selectively kill and/or affect at least one bacteria. For example, a radiation source first arrangement can be provided which is configured to generate at least one radiation having one or more wavelengths provided in a range of about 190 nanometers (nm) to about 230 nm, and at least one second arrangement can be provided which is configured to prevent the at least one radiation from having any wavelength that is outside of the range.
    Type: Grant
    Filed: February 10, 2021
    Date of Patent: February 28, 2023
    Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventors: Gerhard Randers-Pehrson, David Jonathan Brenner, Alan Bigelow
  • SYSTEMS AND METHODS FOR FABRICATING WATER-RESPONSIVE ACTUATORS
    Publication number: 20230058338
    Abstract: Water-responsive actuators and methods for creating water responsive actuators are disclosed. In some embodiments, the disclosed subject matter includes a first layer, for example a plastic tape, and a second layer, for example bacterial spores and cured adhesive. The second layer can be created in a pattern. The pattern can include joints, which can contract when exposed to dry air and can thereby bend the actuator, and can expand when exposed to humid air and thereby return the actuator its original position.
    Type: Application
    Filed: May 10, 2019
    Publication date: February 23, 2023
    Applicant: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventors: Ozgur Sahin, Onur Cakmak, Xi Chen