Abstract: Methods of treating a valvular heart disease are provided. Methods for treating valvular heard disease include administering to a subject a therapeutically effective amount of at least one hedgehog pathway inhibitor. Also provided are methods for reducing fibrosis in a subject, which comprise administering to the subject a therapeutically effective amount of at least one hedgehog pathway inhibitor.

Abstract: Compositions and methods for inhibiting fungal pathogen growth in honey bee colonies are provided. In particular, compositions include at least one strain of Parasaccharibacter apium (P. apium), a supernatant of the one or more strains of P. apium, or a combination of the one or more strains of P. apium and the supernatant of the one or more strains of P. apium. One or all of the strains of P. apium can be resistant to one or more antibiotics (e.g., kanamycin), and may include an exogenous antibiotic resistance-conferring transposon, gene, or functional fragment thereof. Also provided are methods, the methods generally including the step of applying an effective amount of a composition to a honey bee colony. Compositions can be fed to the bees, deposited on the hive frame, deposited on at least one surface or element within the hive, or a combination thereof.

Abstract: Embodiments herein report compositions, methods, uses and manufacturing procedures for rotavirus constructs and immunogenic compositions thereof. Some embodiments concern compositions that include, but are not limited to, chimeric rotaviruses of use in immunogenic compositions against rotavirus infection as well as against other pathogenic virus infection in a subject. In certain embodiments, constructs of use herein can be generated and used where a rotavirus expression system further includes one or more nucleic acid molecules encoding one or more polypeptides of another pathogen (e.g. another enteric or mucosal pathogen).

Abstract: Compositions and methods are provided for the early detection of neuroinflammation in a patient in a presymptomatic stage of a neurodegenerative disease. The method comprises identifying patients with elevated expression levels of a micro RNA selected from the group consisting of miR142-3p, miR142-5p, miR181a, miR181b, miR219-3p and miR219-5p. The identified patients can then be treated with a therapeutic pharmaceutical composition comprising antimiR oligonucleotides.

Abstract: A method and apparatus for processing an audio signal are disclosed. According to an example embodiment, a method of processing an audio signal may include acquiring a final audio signal for an initial audio signal using a plurality of neural network models generating output audio signals by encoding and decoding input audio signals, calculating a difference between the initial audio signal and the final audio signal in a time domain, converting the initial audio signal and the final audio signal into Mel-spectra, calculating a difference between the Mel-spectra of the initial audio signal and the final audio signal in a frequency domain, training the plurality of neural network models based on results calculated in the time domain and the frequency domain, and generating a new final audio signal distinguished from the final audio signal from the initial audio signal using the trained neural network models.

Abstract: The invention provides a modular modelling kit for drawing geometric structures using a handheld 3D printing pen, comprising construction modules (1), and is characterized in that each construction module (1) has a basically flat base (2) and at least one substantially vertical post (4) protruding from the base (2), having a contact point (4a).

Abstract: Provided are compounds of formulas (I), (II), (III), and (IV), which effectively inhibit protein arginine methyltransferase 5 (PRMT5). Also provided are methods of using the compounds, including a method of treating cancer, a method of inhibiting the activity of PRMT5 in a cell, and a method of treating a disease associated with increased activity of PRMT5.

Abstract: Disclosed are a method for coding a residual signal of LPC coefficients based on collaborative quantization and a computing device for performing the method. The residual signal coding method includes: generating encoded LPC coefficients and LPC residual signals by performing LPC analysis and quantization on an input speech; Determining a predicted LPC residual signal by applying the LPC residual signal to cross module residual learning; Performing LPC synthesis using the coded LPC coefficients and the predicted LPC residual signal; It may include the step of determining an output speech that is a synthesized output according to a result of performing the LPC synthesis.

Abstract: A method for regenerating a cathode of a used lithium-ion battery, wherein the cathode of the used lithium-ion battery has a first level of lithium ions, the method comprising providing a pre-lithiation agent to the cathode, assembling a regenerated lithium-ion battery using the cathode with the pre-lithiation agent, and cycling the regenerated lithium-ion battery through at least one full charge event and at least one full discharge event to provide the cathode of the regenerated lithium-ion battery with a second level of lithium ions, wherein the second level of lithium ions is higher than the first level of lithium ions.

Abstract: A dichotic pulsatile and analog stimulation system, comprises a first cochlear implant device implanted in one ear of a patient; and a second cochlear implant device implanted in another ear of the patient; wherein the first cochlear implant device comprises a first speech processor configured to provide single channel analog stimulation to a first electrode array mounted to a cochlea of the one ear and the second cochlear implant device comprises a second speech processor configured to provide interleaved pulse stimulation to a second electrode array mounted to a cochlea of the other ear.

Abstract: This disclosure relates to methods for treatment or prevention of retinal vascular disease by photocoagulation. More specifically, this disclosure relates to an improved technique for the placement of retinal burns so as to prevent the development of hypoxia and progression of ischemia in retinal tissue, including the macula. The methods can also be employed to prevent potential ischemic tissue damage in diabetic, pre-diabetic or other patients with ischemic retinal vascular disease, or those at risk of ischemic retinal vascular disease.

Abstract: Systems and methods are provided for forecasting and managing daily electrical demands. In some embodiments, a computing platform may receive historical demand data corresponding to historical electrical demand over a first period of time. Next, the computing platform may determine a reference rate of change (ROC) and a statistical mode corresponding to a number of positive ROCs. After, the computing platform may receive current demand data corresponding to current electrical demand over a second period of time. Subsequently, the computing platform may determine an alarm condition corresponding to a daily peak electrical demand. Following, the computing platform may generate one or more commands directing a second computing platform to display the alarm condition. Afterwards, the computing platform may transmit the one or more commands directing the second computing platform to display the alarm condition.

Abstract: Aspects of the subject disclosure may include, for example, determining a first viewpoint in response to detecting a user's head movement in viewing video content, determining a capacity of a network, determining a tile schedule for receiving tiles from a server over the network according to the first viewpoint and the capacity of the network, and providing the tile schedule to the server over the network. The server schedules transmitting of the tiles according to the tile schedule and provides the tiles to the client device according to the tile schedule. In addition, embodiments include decoding the tiles according to a decoding schedule, buffering the decoded tiles in a decoded frame buffer, detecting a change in viewpoint from the first viewpoint to a second viewpoint, selecting a portion of the decoded tiles according to the second viewpoint, and presenting the selected tiles. Other embodiments are disclosed.

Abstract: A TAT-FXN fusion polypeptide useful in treating subjects diagnosed with Friedrich's Ataxia, hypertrophic cardiomyopathy, or both are disclosed, as are related methods of treatment and pharmaceutical compositions.

Abstract: Methods for calculating the radiation dose to the immune system of a patient undergoing radiotherapy are provided. In particular, the methods provide for calculating an effective dose to blood (EDIC) to circulating immune cells. The methods can be incorporated into radiotherapy (RT) treatment planning systems, which are also provided. The methods can be used to optimize patient treatment plans. Methods for treating a patient with RT with an optimized treatment plan are provided.

Abstract: The present invention introduces magnetoelectric nanoparticles into acupuncture points that interact with cells, receptors, or molecules in the presence of an applied magnetic field to treat various disorders.

Abstract: A system of tracking medication is disclosed such that the system includes a container with at least one compartment operable to contain at least one medication for administering at predetermined times, at least one sensor coupled to the container, the sensor operable to measure changes in an environment of the container, at least one microcontroller coupled to the sensor, the microcontroller operable to capture and store data recorded by the sensor, a cloud computing infrastructure, at least one wireless module coupled to the cloud computing infrastructure and the microcontroller, the wireless module operable to send and retrieve the data to and from the cloud computing infrastructure and the microcontroller, and a computing device coupled to the wireless module, the computing device operable to track the at least one medication by interacting with the data stored in at least one of the microcontroller or the cloud computing infrastructure.

Abstract: A system and method for data acquisition in a wireless sensor network include receiving measurements made by a plurality of sensor nodes in the wireless sensor network during a given time period, the measurements being carried in data packets that are routed from the plurality of sensor nodes to a base node. The system and method also include determining a plurality of routing paths for the data packets based on routing topology tomography. The system and method further include determining a measurement matrix and a representation basis, and acquiring sensor signals in the wireless sensor network based on the measurement matrix and the representation basis.

Abstract: MRI for radiotherapy simulation, planning and/or treatment guidance requires accurate motion assessment and real-time tumor monitoring. Clinical image-guided radiotherapy requires precise quality assurance of targeted tumor geometry and motion phase and amplitudes for both MRI and CT images. In various embodiments, the MRI-CT compatible phantom described herein is designed to validate the accuracy and performance of clinical procedures in both a 4D MRI sequence and 4D CT imaging, and to provide equivalent dynamic image contrast and quality for both imaging modalities. Additionally described is a PET compatible phantom.

Abstract: Disclosed is a method and apparatus for manipulating fluids. The apparatus may include a microfluidic structure including inlet channels (1 and 2) and outlet channels (306, 307, 308, 309, 310, 311, 312, 313, and 314) oriented among bifurcated (5), trifurcated (6) and merging junctions (7 and 8). The apparatus splits and merges fluids flowing in the channels to produce successive dilutions of the fluids within the outlet channels. Multiple apparatus may be combined in serial, parallel, combined serial and parallel and/or stacked configurations. One or more apparatus may be used alone or to provide various devices or chambers with the diluted fluids.