Patents Assigned to The Trustees of the Columbia University in the City of New York
  • Patent number: 11942321
    Abstract: Methods and systems for crystallizing a thin film provide a laser beam spot that is continually advanced across tire thin film to create a sustained complete or partial molten zone that is translated across the thin film, and crystallizes to form uniform, small-grained crystalline structures or grains.
    Type: Grant
    Filed: July 22, 2022
    Date of Patent: March 26, 2024
    Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN CITY OF NEW YORK
    Inventors: James S. Im, Wenkai Pan
  • Patent number: 11937981
    Abstract: An ultrasound phased array integrated in flexible CMOS technology is provided. The CMOS IC chip is fabricated through various chip-thinning techniques, resulting in mechanical flexibility, robustness, and minimized mechanical loading for the piezoelectric transducers. The ultrasound phased array CMOS patch can allow for the generation of high intensity focal regions for maximum penetration in regions of interest.
    Type: Grant
    Filed: December 27, 2017
    Date of Patent: March 26, 2024
    Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventors: Kenneth Shepard, Tiago Costa, Kevin Tien, Chen Shi
  • Patent number: 11940616
    Abstract: A switchable light transmission module is disclosed that includes a substrate having a first surface defining at least part of an enclosed volume, a porous layer disposed on the first surface and in fluid communication with the enclosed volume, and a reservoir in fluid communication with the enclosed volume. The reservoir is configured to supply a fluid to the sealed volume such that the fluid contacts the porous layer. The fluid has a refractive index that is close to the refractive index of the porous layer, has a high wettability for the porous layer, and does not dissolve the porous layer. When in a dry state, voids in the porous layer are filled with air which has a much different refractive index than the porous layer itself, resulting in a surface that is reflective and not very transmissive.
    Type: Grant
    Filed: December 10, 2018
    Date of Patent: March 26, 2024
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Jyotirmoy Mandal, Yuan Yang, Nanfang Yu
  • Patent number: 11939631
    Abstract: This invention provides a process for sequencing single-stranded DNA by employing a nanopore and modified nucleotides.
    Type: Grant
    Filed: August 18, 2021
    Date of Patent: March 26, 2024
    Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventors: Jingyue Ju, Dae Hyun Kim, Lanrong Bi, Qinglin Meng, Xiaoxu Li
  • Publication number: 20240093183
    Abstract: The present disclosure relates to the methods and systems for multimodal profiling. The method can include stabilizing a target, performing a tagmentation on the target using an agent, and generating a library using a reverse transcriptase enzyme. The agent can include a Tn5 transposome complex, a Tn5 transposase reagent, or a combination thereof, and the Tn5 transposome complex or the Tn5 transposase reagent can be loaded with an adapter. The reverse transcriptase enzyme can be configured to transcribe DNA from both a DNA template and an RNA template and perform a terminal transferase activity by template switching and an introduction of an adapter sequence into a cDNA and a transposed chromatin of the target.
    Type: Application
    Filed: June 22, 2023
    Publication date: March 21, 2024
    Applicant: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventors: Elena E. Kandror, Abbas Haider Rizvi, Thomas Maniatis
  • Publication number: 20240093407
    Abstract: Systems and methods for generating one or more single crystal monolayers from two-dimensional van der Waals crystals are disclosed herein. Example methods include providing a bulk material including a plurality of van der Waals crystal layers, and exfoliating one or more single crystal monolayers of van der Waals crystal from the bulk material by applying a flexible and flat metal tape to a surface of the bulk material. In certain embodiments, the one or more single crystal monolayers can be assembled into an artificial lattice. The present disclosure also provides techniques for manufacturing flexible and flat metal tape for generating one or more single crystal monolayers from two-dimensional van der Waals crystals. The present disclosure also provides compositions for creating a macroscopic artificial lattice.
    Type: Application
    Filed: November 29, 2023
    Publication date: March 21, 2024
    Applicant: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventors: Fang Liu, Xiaoyang Zhu, James Hone, Sang Hoon Chae
  • Publication number: 20240085681
    Abstract: This application describes Swept, Confocally-Aligned Planar Excitation (SCAPE) microscopy systems that incorporate a gradient index (GRIN) lens to relay images from their distal tip to their proximal tip so that 3D images of deep tissue can be captured, without undue loss of light. A zero working distance feature can be designed into the third objective to ensure that the light that exits the second objective in the SCAPE system is not lost. Alternatively, a tapered fiber bundle may be positioned between the second objective and the third objective in the SCAPE system to ensure that the light that exits the second objective is not lost. As yet another alternative, direct detection at the intermediate image plane without using a third objective can ensure that the light that exits the second objective in the SCAPE system is not lost.
    Type: Application
    Filed: November 13, 2023
    Publication date: March 14, 2024
    Applicant: The Trustees of Columbia University in the City of New York
    Inventors: Elizabeth M.C. HILLMAN, Wenxuan LIANG
  • Publication number: 20240085690
    Abstract: A structured material is provided that includes a substrate and a porous structured polymer layer disposed thereon. The porous structured polymer layer includes a plurality of voids, and has a high hemispherical reflectance a high a hemispherical thermal emittance. The structured material is thus particularly advantageous for cool-roof coatings, enabling surfaces coated by the material to stay cool, even under strong sunlight. The material can be produced via structuring of polymers in a mixture including a solvent and a non-solvent. Sequential evaporation of the solvent and the non-solvent provide a polymer layer with the plurality of voids.
    Type: Application
    Filed: August 8, 2023
    Publication date: March 14, 2024
    Applicant: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventors: Jyotirmoy MANDAL, Yuan YANG, Nanfang YU
  • Patent number: 11927593
    Abstract: The present invention is methods and assays for identifying single proteins from a sample, without the use of affinity reagents. The methods and assays combine endopeptidase-based component of conventional peptide mapping with single molecule labeling and a microreactor array platform. The invention also includes kits for performing the methods and assays.
    Type: Grant
    Filed: May 18, 2020
    Date of Patent: March 12, 2024
    Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventor: Peter A. Sims
  • Patent number: 11919913
    Abstract: The present invention provides a compound having the structure: wherein R1, R2, R3, R4, and R5 are each independently H, halogen, CF3 or C1-C4 alkyl; R4 is H, OH, or halogen; B is a substituted or unsubstituted heterobicycle, pyridazine, pyrazole, pyrazine, thiadiazole, or triazole, wherein the heterobicycle is other than chloro substituted indole; and the pyrazole, when substituted, is substituted with other than trifluoromethyl, or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: May 13, 2021
    Date of Patent: March 5, 2024
    Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventors: Konstantin Petrukhin, Christopher Cioffi, Graham Johnson, Nicoleta Dobri, Emily Freeman, Ping Chen, Michael Conlon, Lei Zhu
  • Patent number: 11918702
    Abstract: Described herein are new methods for making lung bud organoids (LBOs) that have the capacity of developing into branching airways and alveolar structures that a least partially recapitulate human lung development from mammalian, preferably human, pluripotent stem cells including embryonic stem cells (ESCs) and induced pluripotent stem cells (IPSC), either by culturing branched LBO in a 3D matrix or by transplanting the LBO under the kidney capsule of immune deficient mice. Branched LBOs contain pulmonary endoderm and mesoderm compatible with pulmonary mesenchyme, and undergo branching morphogenesis. Also described are LBOs harboring certain mutations that induce a fibrotic phenotype, and methods of making same. The mutated (B)LBOs can be used for screening agents that may treat pulmonary fibrosis.
    Type: Grant
    Filed: March 26, 2018
    Date of Patent: March 5, 2024
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Hans-Willem Snoeck, Ya-Wen Chen
  • Patent number: 11918192
    Abstract: A medical apparatus having an elongate tubular body with a proximal end, an opening at the proximal end, and a distal end defining an interior space therebetween and the distalmost end of the elongate tubular body is configured to matingly engage a filter assembly; a filter assembly configured to matingly engage the distal portion of the elongate tubular body and to provide a seal with the interior space thereof, the filter assembly comprising a filter membrane and a border that is sectionable for mounting on a slide for analysis on a microscope; and a base member configured to releasably engage the distalmost end of the elongate tubular body and to receive the filter assembly therein.
    Type: Grant
    Filed: June 27, 2022
    Date of Patent: March 5, 2024
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Anjali Saqi, Keith Yeager
  • Patent number: 11920138
    Abstract: The invention discloses oncogenic fusion proteins. The invention provides methods for treating gene-fusion based cancers.
    Type: Grant
    Filed: July 10, 2019
    Date of Patent: March 5, 2024
    Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventors: Antonio Iavarone, Anna Lasorella, Raul Rabadan
  • Patent number: 11918828
    Abstract: Certain exemplary embodiments can provide an apparatus and method for generating at least one radiation. The exemplary apparatus and/or method can selectively kill and/or affect at least one bacteria. For example, a radiation source first arrangement can be provided which is configured to generate at least one radiation having one or more wavelengths provided in a range of about 190 nanometers (nm) to about 230 nm, and at least one second arrangement can be provided which is configured to prevent the at least one radiation from having any wavelength that is outside of the range.
    Type: Grant
    Filed: May 17, 2021
    Date of Patent: March 5, 2024
    Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventors: Gerhard Randers-Pehrson, David Jonathan Brenner, Alan Bigelow
  • Patent number: 11912147
    Abstract: A system may mitigate leakage currents in non-isolated charging stations for electric vehicles. The system may include a bank of one or more parallel capacitors per phase electrically coupled to an AC voltage source, wherein a neutral point of the one or more parallel capacitors is electrically coupled to a DC ground; a bank of one or more inductors per phase electrically coupled to the one or more parallel capacitors, wherein each inductor is in series with and downstream from one capacitor; a rectifier electrically coupled to and downstream from the one or more parallel inductors, wherein the rectifier converts the AC voltage source to a DC voltage for supply to a battery; a DC bus electrically coupled to the rectifier; and a controller, wherein the controller is configured to mitigate leakage currents by controlling a voltage of at least one of the bank of one or more parallel capacitors.
    Type: Grant
    Filed: February 11, 2021
    Date of Patent: February 27, 2024
    Assignees: The Trustees of Columbia University in the City of New York, Longmax Corporation LTD.
    Inventors: William-Michael Eull, Liwei Zhou, Weizhong Wang, Gangqi Cen, Matthias Preindl
  • Patent number: 11912707
    Abstract: The present invention provides a compound having the structure: or a pharmaceutically acceptable salt or ester thereof, and a method of treating a subject afflicted with pain, a depressive disorder, a mood disorder or an anxiety disorder by administering the compound to the subject.
    Type: Grant
    Filed: March 2, 2021
    Date of Patent: February 27, 2024
    Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventors: Andrew Kruegel, Dalibor Sames, Madalee G. Wulf, Jonathan A. Javitch
  • Publication number: 20240060199
    Abstract: A copper concentrate such as chalcopyrite is contacted with an aqueous solution includes acids and a reducing agent, such as vanadium (II) ions, chromium (II) ions, or tungstozincic acid (H6ZnW12O40). The aqueous solution reduces the copper in the copper concentrate, which can then dissolve into the solution for recovery therefrom, or precipitate out of solution as copper compounds or elemental copper for recovery in as a solid phase product. The solid phase product can then be isolated, dissolved, and further electrowinned to recover a copper product from the copper concentrate. Oxidized reducing agent can be recovered in an electrochemical device with ferrous iron reactants. Hydrometallurgical routes to convert copper concentrates to copper are potentially less expensive and less polluting than current pyrometallurgical processing and an advantageous response to environmental and economic pressures for increased copper production.
    Type: Application
    Filed: December 29, 2021
    Publication date: February 22, 2024
    Applicant: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventors: Jonathan VARDNER, Alan WEST, Scott BANTA
  • Publication number: 20240058199
    Abstract: Rehabilitation or ambulation assistance can be provided to a user by sensing at least one first pressure beneath the user's right foot, sensing at least one second pressure beneath the user's left foot, and predicting the user's gait based on the sensed at least one first pressure and the sensed at least one second pressure. A plurality of motors are energized at a plurality of times that are synchronized with phases of the user's gait so that the plurality of motors pull on respective cables at respective times in a coordinated sequence. Each of the cables has a first end affixed to a pelvic belt or harness that is shaped and dimensioned to fit securely on the user's pelvis, and the timing of the energizing is based on the gait predictions.
    Type: Application
    Filed: August 16, 2023
    Publication date: February 22, 2024
    Applicant: The Trustees of Columbia University in the City of New York
    Inventors: Sunil K. AGRAWAL, Danielle STRAMEL, Jesus Antonio PRADO DE LA MORA
  • Patent number: 11906698
    Abstract: Techniques for creating a replacement for optical elements with diffractive planar components based on metasurfaces are provided. In one example, a substantially flat optical component for lensing incoming electromagnetic radiation having at least one wavelength and a first phase into outgoing electromagnetic radiation having a second phase is provided.
    Type: Grant
    Filed: November 22, 2019
    Date of Patent: February 20, 2024
    Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventors: Nanfang Yu, Adam Overvig, Sajan Shrestha
  • Patent number: 11898168
    Abstract: The current invention provides for methods of promoting differentiation of human pluripotent stem cells into esophageal progenitor cells as well as the cells obtained from the methods, solutions, compositions, and pharmaceutical compositions comprising such cells. The current invention also provides for methods of using the esophageal progenitor cells for treatment and prevention of disease, and kits.
    Type: Grant
    Filed: October 10, 2018
    Date of Patent: February 13, 2024
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Jianwen Que, Yongchun Zhang